Abstract:
AIM:To study the histopathological changes in the retina and flash electroretinogram (F-ERG) features of ozone-treated streptozotocin (STZ)-induced diabetic rats. METHODS:Seventy male Sprague Dawley rats were grouped as follows: blank group (GB, n=10), model control group (GM, n=18), ozone group (GO3, n=19), and oxygen group (GO2, n=18). The model was induced by single intraperitoneal injection of STZ. Ozone or oxygen enteroclysm was given twice per week for 4wk. F-ERG and histopathological examinations were performed one month after treatment. RESULTS:Under dark adaption, as compared to GB, the other groups each had differential decreases in the a-wave amplitudes (P<0.05); the latencies were delayed in GM, GO2, and GO3 rats (P<0.05). Similar results were observed under light adaption, with the exception that the a-wave of the amplitudes (F=0.28, P>0.05). There were significant differences in the apoptosis index among the groups (P<0.05). Under ozone treatment, apoptosis was decreased in GO3 as compared to GM and GO2. CONCLUSION:Ozone administration alleviates nerve damage and reduces pathology and apoptosis in the retinas of diabetic rats.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Xie TY,Li Q,Chen XYdoi
10.18240/ijo.2016.06.04subject
Has Abstractpub_date
2016-06-18 00:00:00pages
816-20issue
6eissn
2222-3959issn
2227-4898pii
ijo-09-06-816journal_volume
9pub_type
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journal_title:International journal of ophthalmology
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