Ocular manifestations of Alport syndrome.

Abstract:

AIM:To analyze the clinical manifestation of Alport syndrome, especially the ocular features. METHODS:The physical, ophthalmologic and audiologic examination results of thirty-two patients with Alport syndrome were analyzed retrospectively. RESULTS:Thirty (93.7%) patients had some family history. All patients had renal disease: eighteen (56.3%) patients with chronic renal failure, four (12.5%) patients with renal insufficiency, and the other ten (31.3%) patients with hematuria. Twenty (62.5%) patients had sensorineural deafness. Thirteen (40.6%) patients had ocular deformity, five (15.7%) patients had typical ocular changes: three patients with anterior lenticonus, and two patients with macular flecks. CONCLUSION:Ocular anomalies are not requisite for the diagnosis of Alport syndrome. But its typical ocular features should be recognized by the ophthalmologists which supports the diagnosis.

journal_name

Int J Ophthalmol

authors

Xu JM,Zhang SS,Zhang Q,Zhou YM,Zhu CH,Ge J,Wang L

doi

10.3980/j.issn.2222-3959.2010.02.13

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

149-51

issue

2

eissn

2222-3959

issn

2227-4898

pii

ijo-03-02-149

journal_volume

3

pub_type

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