Abstract:
AIM:To compare the efficacy and safety between laser therapy and anti-vascular endothelial growth factor (VEGF) agents intravitreal injection monotherapy in type-1 retinopathy of prematurity (ROP) and aggressive posterior retinopathy of prematurity (APROP). METHODS:A systematic literature search was performed in PubMed, Cochrane Library, and Embase for original comparable studies. We included studies that compare laser therapy and intravitreal injections of anti-VEGF agents monotherapy in ROP regardless of languages and publication types. RESULTS:Complication incidence was significantly higher in laser therapy group (OR: 0.38; 95%CI: 0.19-0.75; P=0.005). Spherical equivalent (SE) was higher in laser therapy [weighted mean difference (WMD): 2.40, 95%CI: 0.88-3.93; P=0.002]. The time between treatment and retreatment was longer in laser therapy group (WMD: 8.45, 95%CI: 5.35-11.55; P<0.00001). Recurrence incidence (OR: 0.97; 95%CI: 0.45-2.09; P=0.93) and retreatment incidence (OR: 1.24; 95%CI: 0.56-2.73; P=0.59) were similar in two approaches. Subgroup analysis between type-1 ROP and APROP was not significant except SE reported in the included studies (P<0.0001). CONCLUSION:This Meta-analysis outcome indicates anti-VEGF agents are as effective as laser treatment, and safer than laser in type-1 ROP and APROP. The degree of myopia in APROP is higher than type-1 ROP. More randomized controlled trials in large sample size should be conducted in the future.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Wang SD,Zhang GM,Shenzhen Screening for Retinopathy of Prematurity Cooperative Group.doi
10.18240/ijo.2020.05.17subject
Has Abstractpub_date
2020-05-18 00:00:00pages
806-815issue
5eissn
2222-3959issn
2227-4898pii
ijo-13-05-806journal_volume
13pub_type
杂志文章abstract:AIM:To investigate the role of heparanase-1 in laser-induced choroidal neovascularization (CNV). METHODS:Experimental CNV was induced by krypton laser photocoagulation in 15 male Brown Norway rats. Fundus fluorescein angiography and histopathological examination were performed in observing the CNV development. The exp...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2013.02.04
更新日期:2013-04-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章,评审
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journal_title:International journal of ophthalmology
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2015.02.20
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2011.03.22
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2018.03.06
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2011.01.13
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2010.03.11
更新日期:2010-01-01 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2018.04.23
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2013.03.16
更新日期:2013-06-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2013.03.26
更新日期:2013-06-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2015.06.19
更新日期:2015-12-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2010.02.03
更新日期:2010-01-01 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2014.06.12
更新日期:2014-12-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
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更新日期:2018-12-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
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更新日期:2020-07-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2016.12.14
更新日期:2016-12-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2014.04.05
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pub_type: 杂志文章
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2014.03.12
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2017.04.02
更新日期:2017-04-18 00:00:00
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
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journal_title:International journal of ophthalmology
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doi:10.18240/ijo.2020.07.15
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2015.03.14
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2016.02.08
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pub_type: 杂志文章
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journal_title:International journal of ophthalmology
pub_type: 杂志文章
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更新日期:2017-06-18 00:00:00