Abstract:
:This article reviews studies of progenitor mobilization with gamma-tocotrienol (GT3), a tocol under advanced development as a radiation countermeasure for acute radiation syndrome (ARS). GT3 protects mice against high doses of ionizing radiation and induces high levels of granulocyte colony-stimulating factor (G-CSF). GT3-induced G-CSF in conjunction with AMD3100 (a chemokine receptor antagonist clinically used to improve the yield of mobilized progenitors) mobilizes progenitors; these mobilized progenitors mitigate injury when infused to mice exposed to acute, high-dose ionizing radiation. The administration of a G-CSF antibody to GT3-injected donor mice abrogated the radiomitigative efficacy of blood or peripheral blood mononuclear cells (PBMC) in irradiated recipient mice. The efficacy of GT3-injected donor mice blood or PBMC was comparable to a recently published article involving blood or mononuclear cells obtained from mice injected with G-CSF. The injected progenitors were found to localize in various tissues of irradiated hosts. The authors demonstrate the efficacy of a bridging therapy in a preclinical animal model that allows the lymphohematopoietic system of severely immunocompromised mice to recover. This suggests that GT3 is a highly effective agent for radioprotection and mobilizing progenitors with significant therapeutic potential. Therefore, GT3 may be considered for further translational development and ultimately for use in humans.
journal_name
Health Physjournal_title
Health physicsauthors
Singh VK,Fatanmi OO,Verma A,Newman VL,Wise SY,Romaine PL,Berg ANdoi
10.1097/HP.0000000000000458subject
Has Abstractpub_date
2016-08-01 00:00:00pages
85-92issue
2eissn
0017-9078issn
1538-5159pii
00004032-201608000-00003journal_volume
111pub_type
杂志文章相关文献
HEALTH PHYSICS文献大全abstract::Radioactive sources have been inadvertently incorporated into consignments of scrap metal in various locations throughout the world. In 1990, a 3.7 GBq 137 Cs source, due for transfer from a Scottish industrial establishment to one in England, was mistakenly included in a scrap consignment destined for Irish Steel, a ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199604000-00017
更新日期:1996-04-01 00:00:00
abstract::Mixed radioactive and chemical wastes generated by biomedical research were characterized, and various treatment methods for reducing their volume were evaluated. These wastes consist primarily of organic solvents used in the extraction and purification of radiolabeled biomolecules that are contaminated with low level...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199109000-00014
更新日期:1991-09-01 00:00:00
abstract::In order to estimate the uncertainty of the radiation risk associated with the photon energy in epidemiological studies, photon-fluence-weighted LET values were quantified for photon radiation fields with the target organs and irradiation conditions taken into consideration. The photon fluences giving a unit absorbed ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000683
更新日期:2017-08-01 00:00:00
abstract::In recent years, regulatory emphasis on the prevention of loss, theft and intentional misuse of radioactive materials at academic institutions has forced radiation safety personnel to devote increasing amounts of time and effort to address security issues. NRC regulations require that radioactive materials used or sto...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200311002-00009
更新日期:2003-11-01 00:00:00
abstract::The method presented provides an alternative to the shadow shield method for experimentally measuring the contribution due to scattering radiation in a calibration range. Scattering of 0.6616 MeV photons from a Cs irradiator in a calibration range does not only occur due to the walls and floor of the range. It also oc...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0b013e318294453e
更新日期:2013-09-01 00:00:00
abstract::Global concerns over energy supply and climate change have given rise to an increase in uranium prospecting, mining and extraction. The changing world economy is spreading the use of advanced nuclear and radiation-related technologies to many parts of the world, giving rise to global initiatives on nuclear energy and ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0b013e3181f56d14
更新日期:2011-01-01 00:00:00
abstract::The immersion doses from external exposure to a Gaussian plume of noble gases accidentally released into the atmosphere have been calculated. A numerical integration procedure employing Gauss-Legendre of 64th order has been used. The numerical procedure allows calculating the dose rate at any downwind horizontal or ve...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.hp.0000165448.00478.f9
更新日期:2005-09-01 00:00:00
abstract::The primary objectives of two companion manuscripts were to assess the natural history of delayed radiation-induced lung injury in a nonhuman primate model of acute high-dose, partial-body irradiation with 5% bone marrow sparing, to include the clinical, radiographic, and histopathological evidence and the effect of N...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000968
更新日期:2019-03-01 00:00:00
abstract::Mechanic workers are exposed to exhaust fumes when controlling vehicle engines in motion inside repair shops. To assess radiation doses due to radon short-lived progeny from the inhalation of exhaust fumes by mechanic workers, concentrations of these radionuclides were measured in petrol (gasoline) and gas-oil exhaust...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000285
更新日期:2015-06-01 00:00:00
abstract::Nine elementary schools in Maine were examined to track the release of 222Rn and to determine the transfer coefficient from water into air. Water-use simulations were performed by running sinks and sprayers for 1 h in a kitchen. The 222Rn in air was measured over 24 h throughout the school. The subsequent release of 2...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000251250.62369.89
更新日期:2007-04-01 00:00:00
abstract::Program Area Committee 5 of the National Council on Radiation Protection and Measurements (NCRP) focuses its activities on environmental radiation and radioactive waste issues. The Committee completed a number of reports in these subject areas, most recently NCRP Report No. 175, Decision Making for Late-Phase Recovery...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000418
更新日期:2016-02-01 00:00:00
abstract::The standard mathematical treatment of the buildup and decay of airborne radionuclides on a filter paper uses the solutions of the so-called Bateman equations adapted to the sampling process. These equations can be interpreted as differential equations for the expectation of an underlying stochastic process, which des...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199612000-00013
更新日期:1996-12-01 00:00:00
abstract::In 193 cases autopsied between 1945 and 1980, all persons who had been intravascularly injected with Thorotrast in life, the authors found 131 malignant hepatic tumors, 20 liver cirrhoses, 6 myeloid leukemias, 4 erythroleukemias, 5 aplastic anemias, 4 lung cancers, 1 mesothelioma and 1 osteosarcoma. The causes of deat...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198306001-00025
更新日期:1983-01-01 00:00:00
abstract::Newborn (1-2 days old) and weanling (6 wk old) miniature pigs were injected intravenously with 239Pu citrate. Animals from each age group were killed at intervals over a 28-day period to obtain distribution and retention data. The most notable difference between the two age groups was in hepatic deposition and retenti...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198305000-00007
更新日期:1983-05-01 00:00:00
abstract::A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experiment...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199107000-00009
更新日期:1991-07-01 00:00:00
abstract::The Nuclear Regulatory Commission's Regulatory Guide 8.39, "Release of Patients Administered Radioactive Materials," permits licensees to authorize the release of patients treated with 131I [(T 1/2)p = 8.04 d] if the total dose equivalent to another individual from the released individual is not likely to exceed 5 mil...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200107000-00004
更新日期:2001-07-01 00:00:00
abstract::Fallout 239,240Pu concentrations in some autopsy tissues from the general population in Japan are described. Body burden and relative distribution among tissues of plutonium were obtained by extrapolating using the mass of relevant tissues of the normal Japanese adult. 239,240Pu-to-90Sr body burden ratio was obtained....
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198306001-00043
更新日期:1983-01-01 00:00:00
abstract::While it is implicitly recognized that the benefits of diagnostic imaging far outweigh any theoretical radiogenic risks, quantitative estimates of the benefits are rarely, if ever, juxtaposed with quantitative estimates of risk. This alone - expression of benefit in purely qualitative terms versus expression of risk i...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000416
更新日期:2016-03-01 00:00:00
abstract::The aim of this paper is to evaluate the risks and doses for the internal contamination of the radiochemistry staff in a high workload medical cyclotron facility. The doses from internal contamination derive from the inhalation of radioactive gas leakage from the cells by personnel involved in the synthesis processes ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0b013e3181ad8192
更新日期:2009-10-01 00:00:00
abstract::The (90)Sr and (137)Cs activities of soil, plant, and milk samples from the village of Dolon, located close to the Semipalatinsk Nuclear Test Site in Kazakhstan, were determined. The areal deposition at the nine sampling sites is in the range of <500 to 6,100 Bq m(-2) and 300 to 7,900 Bq m-2 for (90)Sr and (137)Cs, re...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200009000-00005
更新日期:2000-09-01 00:00:00
abstract::The movement through the environment and the toxicity to plants of 99Tc have been studied. However, information is scanty on 99Tc toxicity to mammals even though this is the decisive criterion for assessing the consequences of releases of Tc. A critical tissue could be the thyroid because of its preferential accumulat...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198908000-00014
更新日期:1989-08-01 00:00:00
abstract::Expressions are derived in three cases for the expectation and uncertainty of body burdens and doses calculated from a linear model of environmental transport and human metabolism in terms of expectation and uncertainty in inputs of discrete, stochastic random variables. Three cases are compared to determine the relat...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199307000-00007
更新日期:1993-07-01 00:00:00
abstract::Standardized activated charcoal canisters (according to the U.S. EPA) have been used to collect radon exhaled from concrete surfaces covered with thin plaster (categorically different from thick plaster) of 32 buildings of different ages (0.5-31 y) in Hong Kong. Concrete surfaces covered with thin plaster is the commo...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199505000-00013
更新日期:1995-05-01 00:00:00
abstract::A high-pressure ion chamber filled with 2.5825 X 10(5) kg m-2 argon as used to measure the dose rates of several sites of interest in an attempt to evaluate the dose rates contributed by cosmic rays. Observation sites included two water reservoirs deeper than 110 m, Mount Ali which is higher than 2500 m, airliners fly...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198703000-00009
更新日期:1987-03-01 00:00:00
abstract::The Human Monitoring Laboratory (HML) has had a number of BOMAB phantoms built over the years. Upon characterization, it has been found that the dimensions of the phantoms are always slightly different. This study has looked at the effect of these small variances in dimensions of the phantoms and compared the results ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000305820.67206.31
更新日期:2008-06-01 00:00:00
abstract::Aerosol samples were collected and analyzed to characterize the spatial and temporal variations in the concentrations of plutonium and selected inorganic substances in the atmosphere around the Waste Isolation Pilot Plant (WIPP). High-volume aerosol sampling was conducted at three sites: (1) On Site, (2) Near Field, a...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200210000-00003
更新日期:2002-10-01 00:00:00
abstract::The longterm behavior of 137Cs in milk of a Bavarian farm (farm A) deposited as a consequence of the Chernobyl accident has been followed from April 1986 until August 1994. On the basis of activity measurements in milk and feed, transfer coefficients for the different seasons have been estimated in order to see any ch...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199609000-00015
更新日期:1996-09-01 00:00:00
abstract::CR-39 plastic was attached to household glass objects to learn whether residual radioactivity from radon decay products could be measured and correlated with cumulative radon exposures over defined time periods. Such an approach could be used to increase the completeness of exposure data collected in epidemiologic stu...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199304000-00005
更新日期:1993-04-01 00:00:00
abstract::This paper examines in humans the proposition emanating from studies in beagles that initial retention of radium varies in proportion to the calcium addition rate at the time of intake. Human calcium addition rates were scaled from those in beagles, the relative calcium accretion rates in the two species at equivalent...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198306001-00008
更新日期:1983-01-01 00:00:00
abstract::A uranium in vitro bioassay (urinalysis) action level was derived for use at the Department of Energy's Uranium Mill Tailings Remedial Action Project sites to identify chronic inhalation intakes of uranium mill tailings causing 0.5 mSv (50 mrem) annual effective dose equivalent. All radionuclides in the 238U decay cha...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199210000-00003
更新日期:1992-10-01 00:00:00