Abstract:
:A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experimental data for bone marrow and blood lymphocytes of rats continuously exposed to gamma radiation in a wide range of dose rates. The model reproduces the lymphopoiesis dynamics that we observed in our experiment, in particular, the radiation hormesis at low dose rates, the reduction of lymphopoiesis at intermediate dose rates, and extinction of lymphopoiesis at high dose rates of continuous radiation. The possible explanation of the hormesis is suggested by the framework of the model. The model can be used for predicting the lymphopoiesis dynamics in mammals under continuous irradiation.
journal_name
Health Physjournal_title
Health physicsauthors
Zukhbaya TM,Smirnova OAdoi
10.1097/00004032-199107000-00009subject
Has Abstractpub_date
1991-07-01 00:00:00pages
87-95issue
1eissn
0017-9078issn
1538-5159journal_volume
61pub_type
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