Toxicity of 99Tc: can it represent a risk to man?

Abstract:

:The movement through the environment and the toxicity to plants of 99Tc have been studied. However, information is scanty on 99Tc toxicity to mammals even though this is the decisive criterion for assessing the consequences of releases of Tc. A critical tissue could be the thyroid because of its preferential accumulation of Tc and the developing organism because of its greater radiosensitivity; moreover, this toxicity might be enhanced under conditions of a low iodine (I) diet. These questions were studied in rats given large amounts of 99Tc in either a normal or an I-deficient diet for several months starting 2 wk before mating. Newborns were continued on these diets after weaning. The parameters determined were: occurrence of pregnancy and litter size, triiodothyronine and thyroxin in serum, uptake of 131I by the thyroid 24 h after injection, histology of the thyroid and concentration of Tc in tissues of the mothers and their decendants. Thyroid damage, as well as the effects on pregnancy, could be observed after amounts of 10 micrograms Tc g-1 food. Iodine deficiency only slightly influences the 99Tc toxicity. The chemical and radiological toxicity of 99Tc to rats is small. Consequently, it seems unlikely that contamination levels in the environment would ever reach levels that could lead to serious non-stochastic effects, even in the developing organism.

journal_name

Health Phys

journal_title

Health physics

authors

Gerber GB,Hegela M,Vankerkom J,Kirchmann R,Maisin JR,Lambiet-Collier M

doi

10.1097/00004032-198908000-00014

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

345-50

issue

2

eissn

0017-9078

issn

1538-5159

journal_volume

57

pub_type

杂志文章
  • Directional detector of gamma ray sources.

    abstract::This work describes the design, development, and characterization of an ionization chamber to detect and locate gamma ray sources with intensities down to 100 mu Gy h(-1). The results show that sources of x ray and gamma radiation in the energy range of 14 to 1,250 keV can be located. The directional sensitivity of th...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199604000-00007

    authors: Kronenberg S,Bruckner GJ,Bechtel E,Gentner F

    更新日期:1996-04-01 00:00:00

  • Dose response and temporal patterns of radiation-associated solid cancer risks.

    abstract::Findings of the Life Span Study (LSS) cohort of atomic-bomb survivors are a primary source for quantitative risk estimates that underlie radiation protection. Because of the size and length of follow-up, the LSS provides considerable information on both the nature of the dose response and on how radiation-associated e...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-200307000-00010

    authors: Preston DL,Pierce DA,Shimizu Y,Ron E,Mabuchi K

    更新日期:2003-07-01 00:00:00

  • Lung, liver and bone cancer mortality after plutonium exposure in beagle dogs and nuclear workers.

    abstract::The Mayak Production Association (MPA) worker registry has shown evidence of plutonium-induced health effects. Workers were potentially exposed to plutonium nitrate [(239)Pu(NO(3))(4)] and plutonium dioxide ((239)PuO(2)). Studies of plutonium-induced health effects in animal models can complement human studies by prov...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181b97318

    authors: Wilson DA,Mohr LC,Frey GD,Lackland D,Hoel DG

    更新日期:2010-01-01 00:00:00

  • Measurement of the attenuation coefficient for Livermore Thoracic Phantom lungs fabricated using contemporary materials.

    abstract::The University of Cincinnati has reproduced the original formulation for the Livermore Thoracic Phantom lungs using contemporary materials and has adopted the linear attenuation coefficient as the primary quality assurance parameter for evaluating the performance capabilities of these new lung phantoms. The Livermore ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199407000-00005

    authors: Spitz H,Glover S,Liu N,Smith B,Hickman D,Kruchten D,Anderson L

    更新日期:1994-07-01 00:00:00

  • Review of Cases of Occult Radiation Exposure and an Analysis of Time to Diagnosis.

    abstract::Radiation sickness is challenging to diagnose, and the diagnosis is often based on nonclinical data. In accidents where patients are not aware of their exposure to radiation (so-called "occult exposures"), a correct diagnosis can take weeks or months. The purpose of this study is to review the time to diagnosis of rad...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/HP.0000000000000861

    authors: Kunkler J,Adams TG,Manger M,Casagrande R

    更新日期:2018-08-01 00:00:00

  • Background atmospheric 222Rn concentrations outdoors and indoors: a review.

    abstract::The sources of outdoor and indoor atmospheric radon are examined. The variation of outdoor atmospheric radon with time of day, time of year, altitude and geographic location is quantitatively assessed. Average values of outdoor atmospheric radon concentrations are examined and it is estimated that the mean value for n...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198308000-00002

    authors: Gesell TF

    更新日期:1983-08-01 00:00:00

  • Elimination of tritiated thymidine from birds.

    abstract::The kinetics with which tritiated thymidine is eliminated from birds and the concentration of radioactivity remaining in the carcass after 350-430 h were measured. Birds injected with tritiated thymidine eliminated 98% of the radioactivity injected within 28 h. Ninety-eight percent was identified in the excreta, and l...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199704000-00017

    authors: Party E,Barnea A,Linins I,Gershey EL

    更新日期:1997-04-01 00:00:00

  • Reconstruction of Enriched Uranium Released to Air from the Former Apollo Facility, Apollo, Pennsylvania.

    abstract::The former Apollo facility converted enriched uranium hexafluoride into uranium oxide for shipment to nuclear fuel fabrication plants from 1957 to 1983. This paper describes quantification of the source term from the Apollo facility in terms of quantities of uranium released, particle size, and solubility characterist...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001343

    authors: Caffrey EA,Voillequé PG,Rood AS,Grogan HA,Mohler HJ,Meyer KR,Till JE

    更新日期:2020-12-11 00:00:00

  • Relationships between 222Rn dissolved in ground water supplies and indoor 222Rn concentrations in some Colorado front range houses.

    abstract::Indoor 222Rn concentrations were measured in 37 houses with alpha track detectors placed in water-use rooms near water sources (bathrooms, laundry rooms, and kitchens) and in non-water-use living rooms, dining rooms, and bedrooms away from water sources. Results show that relative contributions of 222Rn to indoor air ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199409000-00004

    authors: Folger PF,Nyberg P,Wanty RB,Poeter E

    更新日期:1994-09-01 00:00:00

  • Structural differences between human and rat lungs: implications for Monte Carlo modeling of aerosol deposition.

    abstract::The geometrical structure of the lung is one of the main factors governing inhaled particle deposition; structural differences among different species are, therefore, of great importance for extrapolation modeling. A statistical analysis of morphometric data for the human and rat tracheobronchial tree reveals signific...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198907001-00005

    authors: Hofmann W,Koblinger L,Martonen TB

    更新日期:1989-01-01 00:00:00

  • An evaluation of the Kearny Fallout Meter (KFM), a radiation detector constructed from commonly available household materials.

    abstract::A radiation detector constructed of common household materials was developed at Oak Ridge National Laboratory (ORNL) by Cresson H. Kearny and has been referred to as the Kearny Fallout Meter (KFM). Developed during the height of the Cold War, the KFM was intended to place a radiation meter capable of measuring fallout...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200411002-00006

    authors: McDonald JT,West WG,Kearfott KJ

    更新日期:2004-11-01 00:00:00

  • Uranium in drinking water: effects on mouse oocyte quality.

    abstract::The aim of this work was to evaluate the reproductive toxicological effects of uranium (U) at 2.5, 5, and 10 mgU/kg/d chronically administered in drinking water for 40 d. Swiss female control mice (n = 28) and mice chronically contaminated with uranyl nitrate in drinking water (n = 36) were tested. The number and qual...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000342827.76950.b3

    authors: Kundt MS,Martinez-Taibo C,Muhlmann MC,Furnari JC

    更新日期:2009-05-01 00:00:00

  • Effective thresholds for induction of skeletal malignancies by radionuclides.

    abstract::Our analysis of data from the beagle project completed at the University of Utah has provided some comparisons that appear to be useful in testing the model proposed by Raabe of effective thresholds for induction of skeletal malignancy by bone-seeking radionuclides in beagles. Raabe's model predicted that cumulative s...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200012000-00019

    authors: Lloyd RD,Taylor GN,Fisher DR,Schlenker RA,Miller SC

    更新日期:2000-12-01 00:00:00

  • Evaluation of a technique for separating organic material from mineral bone in individuals occupationally exposed to Pu.

    abstract::The shaft portion of the left femur from an individual occupationally exposed to Pu was used to investigate the suitability of an ethylenediamine extraction technique to separate mineral bone from organic material. Marrow in the lumen was removed before the extraction technique was used and was analyzed separately for...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198706000-00006

    authors: Miglio JJ,Willis LC

    更新日期:1987-06-01 00:00:00

  • A Case Study of the NCRP 156 Wound Model of Embedded DU Using Data From Urine Uranium Concentrations of Wounded Veterans.

    abstract::Depleted uranium (DU) munitions were initially used by the United States (U.S.) military during the first Persian Gulf War in 1991 in order to penetrate heavily armored vehicles. However, as a result of friendly fire, several U.S. military personnel received intakes from DU munitions. One of the ongoing concerns for t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000816

    authors: Walkingstick MT,Krage ES,Brey RR

    更新日期:2018-03-01 00:00:00

  • Electron paramagnetic resonance dosimetry for a large-scale radiation incident.

    abstract::With possibilities for radiation terrorism and intensified concerns about nuclear accidents since the recent Fukushima Daiichi event, the potential exposure of large numbers of individuals to radiation that could lead to acute clinical effects has become a major concern. For the medical community to cope with such an ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182588d92

    authors: Swartz HM,Flood AB,Williams BB,Dong R,Swarts SG,He X,Grinberg O,Sidabras J,Demidenko E,Gui J,Gladstone DJ,Jarvis LA,Kmiec MM,Kobayashi K,Lesniewski PN,Marsh SD,Matthews TP,Nicolalde RJ,Pennington PM,Raynolds T,Sal

    更新日期:2012-09-01 00:00:00

  • Internal dose following a major nuclear war.

    abstract::The PATHWAY model results were used, in conjunction with a hypothetical major nuclear attack on the U.S., to arrive at the ratio of internal to external dose for humans from early (48 h) fallout. Considered were the four nuclides (137Cs, 89Sr, 90Sr, 131I) that account for most of the reconstructed whole-body committed...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199201000-00004

    authors: Peterson KR,Shapiro CS

    更新日期:1992-01-01 00:00:00

  • The influence of bone-density on in vivo K x-ray fluorescence bone-lead measurements.

    abstract::Mathematical simulations and benchmark measurements were performed to assess the impact that normal variations in human calcium content have on in vivo K x-ray fluorescence measurements of lead in bone. Four sets of cortical bone tissue simulants were fabricated containing from 20.8% to 23.8% calcium (by weight) for m...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181f725af

    authors: Lodwick CJ,Lodwick JC,Spitz HB

    更新日期:2011-05-01 00:00:00

  • Rapid radiation dose assessment for radiological public health emergencies: roles of NIAID and BARDA.

    abstract::A large-scale radiological incident would result in an immediate critical need to assess the radiation doses received by thousands of individuals to allow for prompt triage and appropriate medical treatment. Measuring absorbed doses of ionizing radiation will require a system architecture or a system of platforms that...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000348001.60905.c0

    authors: Grace MB,Moyer BR,Prasher J,Cliffer KD,Ramakrishnan N,Kaminski J,Coleman CN,Manning RG,Maidment BW,Hatchett R

    更新日期:2010-02-01 00:00:00

  • Network-based real-time radiation monitoring system in Synchrotron Radiation Research Center.

    abstract::The real-time radiation monitoring system (RMS) in the Synchrotron Radiation Research Center (SRRC) has been upgraded significantly during the past years. The new framework of the RMS is built on the popular network technology, including Ethernet hardware connections and Web-based software interfaces. It features virt...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200310000-00013

    authors: Sheu RJ,Wang JP,Chen CR,Liu J,Chang FD,Jiang SH

    更新日期:2003-10-01 00:00:00

  • Significance of contaminated food in collective dose after a severe reactor accident.

    abstract::The importance of the ingestion dose pathways in collective effective dose due to severe reactor accidents is evaluated by studying two different radioactive accidental releases. A short description of the ingestion dose pathway model is also given. Typically, exposure via contaminated food without countermeasures cau...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198602000-00004

    authors: Partanen JP,Savolainen I

    更新日期:1986-02-01 00:00:00

  • Proposed revision to the radiation dosimetry of 82Rb.

    abstract::Three models for the biodistribution and dosimetry of 82Rb-chloride were reviewed and a proposal is made for the best dosimetry for this agent to be adopted. Data from three proposed biokinetic models for 82Rb-chloride were used to calculate dose estimates for the compound, and the results were compared. The blood con...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181e47b33

    authors: Stabin MG

    更新日期:2010-12-01 00:00:00

  • Retinal damage from intense visible light.

    abstract::Studies of laboratory animal retinal exposure to green monochromatic laser radiation show an increasing stability of tissue with increasing pulse duration up to 10(-1) s. This mechanism of biological response of the eye to light damage is fundamental to living systems. It does not manifest itself in animals under deep...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-198905000-00004

    authors: Zheltov G,Glazkov V,Podol'tzef A,Linnik L,Privalov A

    更新日期:1989-05-01 00:00:00

  • Impact of comparison group on cohort dose response regression: an example using risk estimation in atomic-bomb survivors.

    abstract::Cohort-based dose-response analyses can be biased if based on a comparison group that is not comparable to the exposed persons with respect to uncontrolled factors related to disease incidence or mortality. When data exist over a range of doses including the very low dose region, internal regression standardized analy...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200105000-00010

    authors: Cologne JB,Preston DL

    更新日期:2001-05-01 00:00:00

  • Neyman-Pearson confidence intervals for extreme low-level, paired counting.

    abstract::Neyman-Pearson principles are briefly discussed and 95% confidence intervals of the form [0, ##.##] are presented. Use is made of the fact that the probability of the difference of two random variables, each with a Poisson distribution, can be expressed in terms of modified Bessel functions of integral order and eleme...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199902000-00011

    authors: Potter WE

    更新日期:1999-02-01 00:00:00

  • A review of the risks of leukemia in relation to parental pre-conception exposure to radiation.

    abstract::The apparent risk of childhood leukemia resulting from paternal pre-conception radiation exposure found among children of the Sellafield (West Cumbria, UK) workforce is compared with the apparent risk in a number of other epidemiological studies. In particular, the extent of the incompatibility of the leukemia pre-con...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-199503000-00001

    authors: Little MP,Charles MW,Wakeford R

    更新日期:1995-03-01 00:00:00

  • Development of 241Am lung monitoring system using an imaging plate.

    abstract::A new 241Am lung monitoring system without shielding was devised by using an imaging plate system. The Lawrence Livermore National Laboratory's realistic torso phantom containing a 241Am lung was covered by imaging plates sealed in lightproof bags. The imaging plate system displayed 241Am lung images characteristic of...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000258917.88579.a3

    authors: Hirota M,Kurihara O,Takada C,Takasaki K,Momose T,Deji S,Ito S,Saze T,Nishizawa K

    更新日期:2007-07-01 00:00:00

  • Investigation of neutron scattering for a multisphere spectrometer.

    abstract::Count rates were measured as a function of distance from a planar concrete reflector for a set of eight Bonner-sphere detectors and four isotopic neutron sources. These data can be used to determine the contributions of scattered neutrons to the response of moderated detectors used in environments bounded by concrete....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199009000-00008

    authors: Sun RK

    更新日期:1990-09-01 00:00:00

  • Role of the International Radiation Protection Association.

    abstract::Global concerns over energy supply and climate change have given rise to an increase in uranium prospecting, mining and extraction. The changing world economy is spreading the use of advanced nuclear and radiation-related technologies to many parts of the world, giving rise to global initiatives on nuclear energy and ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181f56d14

    authors: Kase KR,Metcalf P

    更新日期:2011-01-01 00:00:00

  • A proposed modification of the cavity theory for electrons.

    abstract::An empirical expression of cavity theory for electron fields is developed in a fashion similar to Burlin's general theory of cavity ionization for photons. It incorporates a term that relates the absorbed dose ratio in the cavity and material medium to the differences in electron scattering. This new expression correl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198511000-00024

    authors: Ogunleye OT,Paliwal BR

    更新日期:1985-11-01 00:00:00