Abstract：
PURPOSE:Oncologic outcomes in advanced testicular cancer (TC) depend on appropriate and timely care. Often this care is referred to tertiary academic medical centers (AMCs). The aim of this study was to compare oncologic outcomes of adolescent and young adult (AYA) patients with TC treated from the outset at an AMC to those whose care was initiated elsewhere with subsequent referral. METHODS:An institutional TC database was reviewed, and those AYA patients initiating TC care either inside or outside an AMC were compared. Patients were classified as initiating care outside if they had any non-orchiectomy surgery, chemotherapy, or radiotherapy for TC outside an AMC. RESULTS:A total of 183 patients were reviewed, of whom 59 initiated TC care outside and 124 were managed initially at an AMC. Patients initiating care outside were more likely to have non-seminoma histology and more often presented with metastatic disease (Stage II [30.5%] or III [35.6%] vs. Stage II [19.4%] or III [19.4%]; p = 0.007). Lower 3-year event-free survival (EFS) was observed in those initiating treatment outside an AMC (60.6% vs. 78.7%; p = 0.027). However, on multivariate analysis adjusting for stage and histology, the location of initiating TC care was no longer significant (hazard ratio = 1.5, 95% confidence interval 0.8-2.9). CONCLUSION:AYA patients initially treated for TC in the community and subsequently referred to an AMC were initially observed to experience worse EFS than those who were managed at an AMC from the outset. However, on multivariate analysis, these findings were largely explained by referral bias, where AYA patients with advanced disease were more likely to be referred to AMCs.
journal_name
J Adolesc Young Adult Oncoljournal_title
Journal of adolescent and young adult oncologyauthors
Cost NG,Caldwell BT,Adibi M,Raj GV,Sagalowsky AI,Margulis Vdoi
10.1089/jayao.2015.0057subject
Has Abstractpub_date
2016-09-01 00:00:00pages
248-53issue
3eissn
2156-5333issn
2156-535Xjournal_volume
5pub_type
杂志文章abstract：: Purpose: Rates of obesity and obesity-related health consequences, including type 2 diabetes (T2D) and cancer, continue to rise. While cancer patients are at an increased risk of developing T2D, the prevalence of T2D and insulin prescription among young patients with cance...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2020.0071
更新日期：2020-07-29 00:00:00
abstract：: Purpose: Survivors of cancer diagnosed during adolescence and young adulthood (AYA; aged 15-39) may experience quality of life (QOL) limitations; however, little is known about QOL for AYA survivors who are now middle-aged or among racial/ethnic minority survivors. We eval...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2013.0035
更新日期：2014-06-01 00:00:00
abstract：:Many adolescent female cancer patients will survive into their reproductive years. Pediatric oncologists are advised to discuss oncofertility during treatment planning. In this pilot study, 19 adolescent females completed a retrospective survey assessing recall of a fertility discussion, satisfaction with fertility kn...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0079
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:Patients with testicular seminoma may face fertility issues because of their underlying disease as well as treatments they undergo. The current patterns of practice among U.S. radiation oncologists aimed at assessing and preserving fertility in patients with Stage I seminoma are unknown. METHODS:We surveyed pr...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0122
更新日期：2018-06-01 00:00:00
abstract：:Radiation-induced phantosmia has been reported both in children and adults. A fraction of these patients have nausea and vomiting triggered by phantosmia. Radiation-induced phantosmia, although transient, can be distressing enough to prevent a patient from staying still during radiation therapy. To date, specific inte...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2019.0103
更新日期：2020-04-01 00:00:00
abstract：:Hypogammaglobulinemia is a poorly described complication of chemotherapy in adolescents and young adults (AYAs, 15-39 years) with acute lymphoblastic leukemia (ALL). The majority of AYAs treated on a Berlin-Frankfurt-Munster-based ALL regimen experienced hypogammaglobulinemia (65.0% [13/20]). Febrile neutropenia episo...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2020.0060
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:Hodgkin lymphoma (HL) is the commonest cancer in adolescents and young adults (AYAs), aged 15-29 years. While the survival rate is high, many survivors experience adverse late effects of therapy. Yet, this age group in general makes limited use of health services. This study sought to determine whether the need...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2015.0039
更新日期：2016-06-01 00:00:00
abstract：: Purpose: Testicular germ cell tumors (TGCT) are the most common solid organ malignancy in young men. It is a largely curable disease, so the extent to which it affects quality of life-including male fertility-is important. Abnormal semen analysis is highly predictive of ma...
journal_title：Journal of adolescent and young adult oncology
pub_type： 评审
doi：10.1089/jayao.2014.0012
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:As many as two-thirds of male childhood cancer survivors are at risk for fertility impairment as a consequence of treatment. Despite this, survivorship guidelines lack concrete recommendations as to when fertility status conversations should happen between patients and providers and what should be discussed. Th...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2018.0094
更新日期：2019-02-01 00:00:00
abstract：:Adult hepatoblastoma (AHB) is a rare liver tumor with a poor prognosis in adolescents and adults. This contrasts with hepatoblastoma in children and is not fully understood. Here we describe two adolescents with AHB who were treated in our hospital. Adolescents are likely to receive less intensive chemotherapy protoco...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0125
更新日期：2018-06-01 00:00:00
abstract：: Purpose: This study describes the prevalence trends of electronic cigarette (e-cigarette) use in young adult cancer survivors and compares these to the prevalence among young adults without a cancer history. It also examines the association between conventional cigarette u...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2020.0104
更新日期：2020-09-30 00:00:00
abstract：:The inclusion of asparaginase in chemotherapy regimens to treat acute lymphoblastic leukemia (ALL) has had a positive impact on survival in pediatric patients. Historically, asparaginase has been excluded from most treatment protocols for adolescent and young adult (AYA) patients because of perceived toxicity in this ...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章,评审
doi：10.1089/jayao.2015.0014
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:Limited research exists on the social information needs of adolescents and young adults (AYAs, aged 15-39 at diagnosis) with cancer. METHODS:The Adolescent and Young Adult Health Outcomes and Patient Experiences (AYA HOPE) Study recruited 523 patients to complete surveys 6-14 months after cancer diagnosis. Par...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2012.0029
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:This study describes the prevalence of religious and/or spiritual (R/S) struggle in long-term young adult (YA) survivors following hematopoietic cell transplantation (HCT) as well as existential concerns (EC), social support, and demographic, medical, and emotional correlates of R/S struggle. METHODS:Data were...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0069
更新日期：2018-04-01 00:00:00
abstract：:Fertility impairment and loss due to cancer or its treatment is a significant survivorship consideration for many pediatric, adolescent, and young adult cancer survivors. Chemotherapeutics, radiation, and surgery can impact the future fertility of men, women, and children with cancer. The field of oncofertility, found...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2012.0035
更新日期：2013-03-01 00:00:00
abstract：:Following a presentation with abdominal pain, a 22-year-old female was diagnosed with a massive primary liver immature teratoma with evidence of omental and pelvic metastases. Despite chemotherapy, the teratoma continued to rapidly increase in size. Significant treatment-associated myelosuppression was challenging as ...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2019.0081
更新日期：2020-02-01 00:00:00
abstract：: Introduction: Children and adolescents/young adults (AYAs) with cancer are a vulnerable population susceptible to numerous late effects, such as fatigue and depression, which may diminish their long-term psychological, physical, spiritual, and emotional health. A well-roun...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2020.0184
更新日期：2021-01-18 00:00:00
abstract：PURPOSE:An insufficient transition to normal life after cancer treatment in adolescent and young adults (AYAs) may lead to decreased occupational and educational opportunities throughout a survivor's lifespan. Key informant interviews were used to access unique knowledge of the healthcare, educational, and social syste...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0128
更新日期：2018-08-01 00:00:00
abstract：:Childhood cancer survivors (CCS) are at increased risk of subsequent malignant neoplasms (SMNs). However, the impact of SMNs on long-term psychosocial functioning is unknown. In a cohort of 322 young adult CCS, survivors who developed a SMN (n = 43, 13.4%) did not report a significantly higher burden of fatigue, insom...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2020.0046
更新日期：2020-08-14 00:00:00
abstract：:Communication plays an essential role in social relationships. Yet it is unclear how young cancer patients and survivors communicate with peers, and whether this contributes to increased rates of social difficulties. We aimed to analyze how childhood cancer patients and survivors communicate about their cancer with fa...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0131
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Surveillance for long-term complications related to previous cancer therapy can help diagnose/manage chronic health conditions in childhood cancer survivors and improve survivor quality of life. However, a challenge to delivering long-term care to childhood cancer survivors is loss to follow-up; many patients d...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2016.0023
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to examine racial/ethnic disparities in the incidence rates and trends of soft tissue sarcoma (STS) by gender, age, and histological type among adolescents and young adults (AYAs) aged 15-29 years. METHODS:The 1995-2008 incidence data from 25 population-based cancer registries, coveri...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2012.0031
更新日期：2013-09-01 00:00:00
abstract：: Purpose: Cancer-related fatigue is a burdensome late effect of cancer treatment. A pilot study showed the effectiveness of cognitive-behavioral therapy (CBT) in fatigued survivors of childhood cancer (CCS). The aim of this study is to investigate whether the six cognitive-...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2020.0094
更新日期：2020-08-27 00:00:00
abstract：:Adolescents and young adults (AYAs) 15-39 years old face unique challenges during cancer treatment as developmental and social needs are often disrupted to achieve cure. Developmentally appropriate supportive care for AYAs across the cancer trajectory is needed. The purpose of this review is to identify and describe i...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章,评审
doi：10.1089/jayao.2017.0127
更新日期：2018-06-01 00:00:00
abstract：: Purpose: Young adults with cancer often experience stress, depression, and anxiety. Mindfulness meditation is an effective intervention for these outcomes, and maintenance support may be needed for long-term improvements. eHealth technologies provide a promising delivery s...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2020.0102
更新日期：2020-12-21 00:00:00
abstract：PURPOSE:Adolescents with cancer have unique developmental considerations. These include brain development, particularly in the frontal lobe, and a focus on completing education and entering the workforce. Cancer and treatment at this stage may prove to uniquely affect survivors' experience of cognitive and occupational...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0043
更新日期：2018-02-01 00:00:00
abstract：: Purpose: To explore and highlight the opportunities and challenges that underlie the development of survivorship care for adolescent and young adult cancer. Methods: A multimethod approach was used, with perspectives of survivo...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2019.0031
更新日期：2019-10-01 00:00:00
abstract：:Little is known about young adults with cancer at the end-of-life, but life review and legacy making may be important modalities to process the emotions associated with anticipatory grief. The study analyzed the illness blogs of five young women (aged 25-39 years) at the end-of-life using a narrative approach. Key ele...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2015.0003
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:Cancer is a significant health concern for adolescents and young adults (AYAs; aged 15-24 years). Monitoring population-level changes in incidence, mortality, and survival is complicated by the lack of published data presenting statistics separately for AYAs. This study synthesizes and reviews data on AYA cance...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2017.0095
更新日期：2018-06-01 00:00:00
abstract：: Purpose: With an increasing focus on developing survivorship services tailored for adolescent and young adult (AYA) cancer survivors, incorporation of viewpoints from both survivors and health care professionals (HCPs) is important. This study aims to explore the perceptio...
journal_title：Journal of adolescent and young adult oncology
pub_type： 杂志文章
doi：10.1089/jayao.2019.0145
更新日期：2020-06-01 00:00:00
