当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers.

The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers.

Abstract：

:Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal brain development, little is known about how this transcription factor is regulated. To investigate post-translational mechanisms for FOXP2 regulation, we searched for protein interaction partners of FOXP2, and identified members of the PIAS family as novel FOXP2 interactors. PIAS proteins mediate post-translational modification of a range of target proteins with small ubiquitin-like modifiers (SUMOs). We found that FOXP2 can be modified with all three human SUMO proteins and that PIAS1 promotes this process. An aetiological FOXP2 mutation found in a family with speech and language disorder markedly reduced FOXP2 SUMOylation. We demonstrate that FOXP2 is SUMOylated at a single major site, which is conserved in all FOXP2 vertebrate orthologues and in the paralogues FOXP1 and FOXP4. Abolishing this site did not lead to detectable changes in FOXP2 subcellular localization, stability, dimerization or transcriptional repression in cellular assays, but the conservation of this site suggests a potential role for SUMOylation in regulating FOXP2 activity in vivo.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Estruch SB,Graham SA,Deriziotis P,Fisher SE

doi

10.1038/srep20911

subject

Has Abstract

pub_date

2016-02-12 00:00:00

pages

20911

issn

2045-2322

pii

srep20911

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Kunitz type protease inhibitor from the canine tapeworm as a potential therapeutic for melanoma.

    abstract：:Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52609-4

    authors： Ranasinghe SL,Rivera V,Boyle GM,McManus DP

    更新日期：2019-11-07 00:00:00

  • Early outcomes after small incision lenticule extraction and photorefractive keratectomy for correction of high myopia.

    abstract：:We prospectively compared visual and refractive outcomes in patients with high myopia and myopic astigmatism after small-incision lenticule extraction (SMILE) and photorefractive keratetctomy (PRK) with mitomycin C. Sixty-six eyes of 33 patients (mean age, 29.7 ± 5.6 years) were included (SMILE: 34 eyes, PRK 32 eyes)....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32820

    authors： Chan TC,Yu MC,Ng A,Wang Z,Cheng GP,Jhanji V

    更新日期：2016-09-07 00:00:00

  • Nondestructive tribochemistry-assisted nanofabrication on GaAs surface.

    abstract：:A tribochemistry-assisted method has been developed for nondestructive surface nanofabrication on GaAs. Without any applied electric field and post etching, hollow nanostructures can be directly fabricated on GaAs surfaces by sliding a SiO2 microsphere under an ultralow contact pressure in humid air. TEM observation o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09020

    authors： Song C,Li X,Dong H,Yu B,Wang Z,Qian L

    更新日期：2015-03-12 00:00:00

  • Fourier ptychographic reconstruction using Poisson maximum likelihood and truncated Wirtinger gradient.

    abstract：:Fourier ptychographic microscopy (FPM) is a novel computational coherent imaging technique for high space-bandwidth product imaging. Mathematically, Fourier ptychographic (FP) reconstruction can be implemented as a phase retrieval optimization process, in which we only obtain low resolution intensity images correspond...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27384

    authors： Bian L,Suo J,Chung J,Ou X,Yang C,Chen F,Dai Q

    更新日期：2016-06-10 00:00:00

  • Gellan sulfate inhibits Plasmodium falciparum growth and invasion of red blood cells in vitro.

    abstract：:Here, we assessed the sulfated derivative of the microbial polysaccharide gellan gum and derivatives of λ and κ-carrageenans for their ability to inhibit Plasmodium falciparum 3D7 and Dd2 growth and invasion of red blood cells in vitro. Growth inhibition was assessed by means of flow cytometry after a 96-h exposure to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04723

    authors： Recuenco FC,Kobayashi K,Ishiwa A,Enomoto-Rogers Y,Fundador NG,Sugi T,Takemae H,Iwanaga T,Murakoshi F,Gong H,Inomata A,Horimoto T,Iwata T,Kato K

    更新日期：2014-04-17 00:00:00

  • Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells.

    abstract：:Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiPSCs) with various t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45514-3

    authors： Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA

    更新日期：2019-06-20 00:00:00

  • Triangular Black Phosphorus Atomic Layers by Liquid Exfoliation.

    abstract：:Few-layer black phosphorus (BP) is the most promising material among the two-dimensional materials due to its layered structure and the excellent semiconductor properties. Currently, thin BP atomic layers are obtained mostly by mechanical exfoliation of bulk BP, which limits applications in thin-film based electronics...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23736

    authors： Seo S,Lee HU,Lee SC,Kim Y,Kim H,Bang J,Won J,Kim Y,Park B,Lee J

    更新日期：2016-03-30 00:00:00

  • Time-dependent X-ray diffraction studies on urea/hen egg white lysozyme complexes reveal structural changes that indicate onset of denaturation.

    abstract：:Temporal binding of urea to lysozyme was examined using X-ray diffraction of single crystals of urea/lysozyme complexes prepared by soaking native lysozyme crystals in solutions containing 9 M urea. Four different soak times of 2, 4, 7 and 10 hours were used. The five crystal structures (including the native lysozyme)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32277

    authors： Raskar T,Khavnekar S,Hosur M

    更新日期：2016-08-30 00:00:00

  • Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation.

    abstract：:Thymoquinone has been reported to exhibit antioxidant and anti-inflammatory effects. Inflammation plays an important role in pathogenesis of diabetic peripheral neuropathy. This study investigated the effects of TQ on proliferation and apoptosis of Schwann cells exposed to high glucose conditions and electrophysiologi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31656

    authors： Chen L,Li B,Chen B,Shao Y,Luo Q,Shi X,Chen Y

    更新日期：2016-08-22 00:00:00

  • Optimization and evaluation of a non-invasive tool for peste des petits ruminants surveillance and control.

    abstract：:Peste des petits ruminants (PPR) is a highly contagious and devastating viral disease affecting mainly sheep and goats, but also a large number of wild species within the order Artiodactyla. A better understanding of PPR transmission dynamics in multi-host systems is necessary to efficiently control the disease, in pa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41232-y

    authors： Bataille A,Kwiatek O,Belfkhi S,Mounier L,Parida S,Mahapatra M,Caron A,Chubwa CC,Keyyu J,Kock R,Jones BA,Libeau G

    更新日期：2019-03-18 00:00:00

  • Heuristics guide the implementation of social preferences in one-shot Prisoner's Dilemma experiments.

    abstract：:Cooperation in one-shot anonymous interactions is a widely documented aspect of human behaviour. Here we shed light on the motivations behind this behaviour by experimentally exploring cooperation in a one-shot continuous-strategy Prisoner's Dilemma (i.e. one-shot two-player Public Goods Game). We examine the distribu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06790

    authors： Capraro V,Jordan JJ,Rand DG

    更新日期：2014-10-28 00:00:00

  • Origin of sample size effect: Stochastic dislocation formation in crystalline metals at small scales.

    abstract：:In crystalline metals at small scales, the dislocation density will be increased by stochastic events of dislocation network, leading to a universal power law for various material structures. In this work, we develop a model obeyed by a probability distribution of dislocation density to describe the dislocation format...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39242

    authors： Huang GR,Huang JC,Tsai WY

    更新日期：2016-12-15 00:00:00

  • Structural basis of small RNA hydrolysis by oligoribonuclease (CpsORN) from Colwellia psychrerythraea strain 34H.

    abstract：:Cells regulate their intracellular mRNA levels by using specific ribonucleases. Oligoribonuclease (ORN) is a 3'-5' exoribonuclease for small RNA molecules, important in RNA degradation and re-utilisation. However, there is no structural information on the ligand-binding form of ORNs. In this study, the crystal structu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39641-0

    authors： Lee CW,Park SH,Jeong CS,Cha SS,Park H,Lee JH

    更新日期：2019-02-25 00:00:00

  • Complex inheritance in Pulmonary Arterial Hypertension patients with several mutations.

    abstract：:Pulmonary Arterial Hypertension (PAH) is a rare and progressive disease with low incidence and prevalence, and elevated mortality. PAH is characterized by increased mean pulmonary artery pressure. The aim of this study was to analyse patients with combined mutations in BMPR2, ACVRL1, ENG and KCNA5 genes and to establi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33570

    authors： Pousada G,Baloira A,Valverde D

    更新日期：2016-09-15 00:00:00

  • Increased future occurrences of the exceptional 2018-2019 Central European drought under global warming.

    abstract：:Since the spring 2018, a large part of Europe has been in the midst of a record-setting drought. Using long-term observations, we demonstrate that the occurrence of the 2018-2019 (consecutive) summer drought is unprecedented in the last 250 years, and its combined impact on the growing season vegetation activities is ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68872-9

    authors： Hari V,Rakovec O,Markonis Y,Hanel M,Kumar R

    更新日期：2020-08-06 00:00:00

  • Control of Radiative Exciton Recombination by Charge Transfer Induced Surface Dipoles in MoS2 and WS2 Monolayers.

    abstract：:Due to the two dimensional confinement of electrons in a monolayer of 2D materials, the properties of monolayer can be controlled by electrical field formed on the monolayer surface. F4TCNQ was evaporated on MoS2 and WS2 monolayer forming dipoles between strong acceptor, F4TCNQ, and monolayers of MoS2 or WS2. The stro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24105

    authors： Hu P,Ye J,He X,Du K,Zhang KK,Wang X,Xiong Q,Liu Z,Jiang H,Kloc C

    更新日期：2016-04-07 00:00:00

  • Lattice dynamics and elasticity for ε-plutonium.

    abstract：:Lattice dynamics and elasticity for the high-temperature ε phase (body-centered cubic; bcc) of plutonium is predicted utilizing first-principles electronic structure coupled with a self-consistent phonon method that takes phonon-phonon interaction and strong anharmonicity into account. These predictions establish the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01034-6

    authors： Söderlind P

    更新日期：2017-04-25 00:00:00

  • Comprehensive profiling of lysine ubiquitome reveals diverse functions of lysine ubiquitination in common wheat.

    abstract：:Protein ubiquitination, which is a major post-translational modifications that occurs in eukaryotic cells, is involved in diverse biological processes. To date, large-scale profiling of the ubiquitome in common wheat has not been reported, despite its status as the major cereal crop in the world. Here, we performed th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13992-y

    authors： Zhang N,Zhang L,Shi C,Tian Q,Lv G,Wang Y,Cui D,Chen F

    更新日期：2017-10-19 00:00:00

  • Transferred monolayer MoS2 onto GaN for heterostructure photoanode: Toward stable and efficient photoelectrochemical water splitting.

    abstract：:Solar-driven photoelectrochemical water splitting (PEC-WS) using semiconductor photoelectrodes is considered a promising solution for sustainable, renewable, clean, safe and alternative energy sources such as hydrogen. Here, we report the synthesis and characterization of a novel heterostructure MoS2/GaN to be used as...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56807-y

    authors： Hassan MA,Kim MW,Johar MA,Waseem A,Kwon MK,Ryu SW

    更新日期：2019-12-27 00:00:00

  • Improving understanding of the functional diversity of fisheries by exploring the influence of global catch reconstruction.

    abstract：:Functional diversity is thought to enhance ecosystem resilience, driving research focused on trends in the functional composition of fisheries, most recently with new reconstructions of global catch data. However, there is currently little understanding of how accounting for unreported catches (e.g. small-scale and il...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10723-1

    authors： Nash KL,Watson RA,Halpern BS,Fulton EA,Blanchard JL

    更新日期：2017-09-06 00:00:00

  • Highly hydrophilic poly(vinylidene fluoride)/meso-titania hybrid mesoporous membrane for photocatalytic membrane reactor in water.

    abstract：:The high hydrophobicity of poly(vinylidene fluoride) (PVDF) membrane remains an obstacle to be applied in some purification processes of water or wastewater. Herein, a highly hydrophilic hybrid mesoporous titania membrane composed of mesoporous anatase titania (meso-TiO2) materials inside the three-dimensional (3D) ma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19148

    authors： Wang M,Yang G,Jin P,Tang H,Wang H,Chen Y

    更新日期：2016-01-12 00:00:00

  • Kinetic 15N-isotope effects on algal growth.

    abstract：:Stable isotope labeling is a standard technique for tracing material transfer in molecular, ecological and biogeochemical studies. The main assumption in this approach is that the enrichment with a heavy isotope has no effect on the organism metabolism and growth, which is not consistent with current theoretical and e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44181

    authors： Andriukonis E,Gorokhova E

    更新日期：2017-03-10 00:00:00

  • Genome-wide divergence, haplotype distribution and population demographic histories for Gossypium hirsutum and Gossypium barbadense as revealed by genome-anchored SNPs.

    abstract：:Use of 10,129 singleton SNPs of known genomic location in tetraploid cotton provided unique opportunities to characterize genome-wide diversity among 440 Gossypium hirsutum and 219 G. barbadense cultivars and landrace accessions of widespread origin. Using the SNPs distributed genome-wide, we examined genetic diversit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41285

    authors： Reddy UK,Nimmakayala P,Abburi VL,Reddy CV,Saminathan T,Percy RG,Yu JZ,Frelichowski J,Udall JA,Page JT,Zhang D,Shehzad T,Paterson AH

    更新日期：2017-01-27 00:00:00

  • Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.

    abstract：:Evasion of the potent tumour suppressor activity of p53 is one of the hurdles that must be overcome for cancer cells to escape normal regulation of cellular proliferation and survival. In addition to frequent loss of function mutations, p53 wild-type activity can also be suppressed post-translationally through several...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28002-y

    authors： Gerhart SV,Kellner WA,Thompson C,Pappalardi MB,Zhang XP,Montes de Oca R,Penebre E,Duncan K,Boriack-Sjodin A,Le B,Majer C,McCabe MT,Carpenter C,Johnson N,Kruger RG,Barbash O

    更新日期：2018-06-26 00:00:00

  • Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.

    abstract：:Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep17438

    authors： Hung HC,Lu FH,Wu HT,Ou HY,Yang YC,Wu JS,Chang CJ

    更新日期：2015-12-01 00:00:00

  • High-Efficiency Visible Light Manipulation Using Dielectric Metasurfaces.

    abstract：:The development of a miniaturised device that provides efficient beam manipulation with high transmittance is extremely desirable for the broad range of applications including holography, metalens, and imaging. Recently, the potential of dielectric metasurfaces has been unleashed to efficiently manipulate the beam wit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42444-y

    authors： Aoni RA,Rahmani M,Xu L,Zangeneh Kamali K,Komar A,Yan J,Neshev D,Miroshnichenko AE

    更新日期：2019-04-24 00:00:00

  • Linking landscape-scale conservation to regional and continental outcomes for a migratory species.

    abstract：:Land-use intensification on arable land is expanding and posing a threat to biodiversity and ecosystem services worldwide. We develop methods to link funding for avian breeding habitat conservation and management at landscape scales to equilibrium abundance of a migratory species at the continental scale. We apply thi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61058-3

    authors： Mattsson BJ,Devries JH,Dubovsky JA,Semmens D,Thogmartin WE,Derbridge JJ,Lopez-Hoffman L

    更新日期：2020-03-18 00:00:00

  • Stable semiconductor black phosphorus (BP)@titanium dioxide (TiO2) hybrid photocatalysts.

    abstract：:Over the past few decades, two-dimensional (2D) and layered materials have emerged as new fields. Due to the zero-band-gap nature of graphene and the low photocatalytic performance of MoS2, more advanced semiconducting 2D materials have been prompted. As a result, semiconductor black phosphorus (BP) is a derived cutti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08691

    authors： Lee HU,Lee SC,Won J,Son BC,Choi S,Kim Y,Park SY,Kim HS,Lee YC,Lee J

    更新日期：2015-03-03 00:00:00

  • A potent synthetic inorganic antibiotic with activity against drug-resistant pathogens.

    abstract：:The acronymously named "ESKAPE" pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated emergence, but also due to their ability to "eskape" antibiotic treatment. The evolution of multi-drug resistance in these pathogens alone has gr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41999

    authors： Hubick S,Jayaraman A,McKeen A,Reid S,Alcorn J,Stavrinides J,Sterenberg BT

    更新日期：2017-02-06 00:00:00

  • Pre-RC Protein MCM7 depletion promotes mitotic exit by Inhibiting CDK1 activity.

    abstract：:MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03148-3

    authors： Zheng D,Ye S,Wang X,Zhang Y,Yan D,Cai X,Gao W,Shan H,Gao Y,Chen J,Hu Z,Li H,Li J

    更新日期：2017-06-06 00:00:00