Identification of new FGF1 binding partners-Implications for its intracellular function.

abstract：:The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cell...

journal_title：IUBMB life

authors： de Figueiredo IR,Freire JM,Flores L,Veiga AS,Castanho MARB

更新日期：2014-03-01 00:00:00

abstract：:5-Hydroxytryptamine 2C (5-HT2C ) receptor agonists have been suggested to possess an antipsychotic activity in several acute preclinical tests of antipsychotic drugs with low extra-pyramidal side effect liability. However, little is known about the long-term effect associated with chronic use of 5-HT2C receptor agonis...

journal_title：IUBMB life

authors： Chen W,Wang X,Yan M,Wang Y,Xie S,Li H,Li M

更新日期：2016-12-01 00:00:00

abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...

journal_title：IUBMB life

authors： Li YX,Liu DQ,Zheng C,Zheng SQ,Liu M,Li X,Tang H

更新日期：2011-07-01 00:00:00

abstract：:The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of trans...

journal_title：IUBMB life

authors： Acconcia F,Bocedi A,Ascenzi P,Marino M

更新日期：2003-01-01 00:00:00

abstract：:Recently the crystal structure of creatine kinase from Torpedocalifornica was determined to 2.1 A. The dimeric structure revealed two different forms in the unit cell: one monomer was bound to a substrate, MgADP, and the other monomer was bound to a transition-state analogue complex composed of MgADP, nitrate and crea...

journal_title：IUBMB life

authors： Wang PF,Flynn AJ,McLeish MJ,Kenyon GL

更新日期：2005-04-01 00:00:00

abstract：:Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...

journal_title：IUBMB life

authors： Zhou R,Wang L,Zhao G,Chen D,Song X,Momtazi-Borojeni AA,Yuan H

更新日期：2020-12-01 00:00:00

abstract：:Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half-lives of hours. We report here, that after 10 h at 37 °C, reaction of estradiol-3,4-qu...

journal_title：IUBMB life

authors： Cavalieri E,Saeed M,Zahid M,Cassada D,Snow D,Miljkovic M,Rogan E

更新日期：2012-02-01 00:00:00

abstract：:Over the years, microRNA-20b-3p (miR-20b-3p) has been found to play an essential role in human diseases; we aimed to investigate the effect of miR-20b-3p on the progression of diabetic retinopathy (DR). The DR rat models were established by streptozotocin injection and treated with miR-20b-3p mimics, silenced, or over...

journal_title：IUBMB life

authors： Wang S,Du S,Lv Y,Wang W,Zhang F

更新日期：2020-07-01 00:00:00

abstract：:Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....

journal_title：IUBMB life

authors： Duval E,Bouyoucef M,Leclercq S,Baugé C,Boumédiene K

更新日期：2016-09-01 00:00:00

abstract：:Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improveme...

journal_title：IUBMB life

authors： Fan X,Xiao X,Mao X,Chen D,Yu B,Wang J,Yan H

更新日期：2021-02-01 00:00:00

abstract：:Although proteins and nucleic acids consist of different chemical components, proteins can mimic structures and possibly also functions of nucleic acids. Recently, structural mimicry was observed between two elongation factors in bacterial protein biosynthesis leading to the introduction of the concept of macromolecul...

journal_title：IUBMB life

authors： Pedersen GN,Nyborg J,Clark BF

更新日期：1999-07-01 00:00:00

abstract：:This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1beta)-induced suppression of type II collagen expression in articular chondrocytes. IL-1beta inhibited type II collagen ex...

journal_title：IUBMB life

authors： Hwang SG,Song SM,Kim JR,Park CS,Song WK,Chun JS

更新日期：2007-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the brain. The beta-amyloid peptide (Abeta) is the primary constituent of the senile plaques, and has been proposed to be a key contributor to the neurodegeneration observed in AD. The molecular mechanisms underl...

journal_title：IUBMB life

authors： Gong X,Lu X,Zhan L,Sui H,Qi X,Ji Z,Niu X,Liu L

更新日期：2010-03-01 00:00:00

abstract：:The effect of streptozotocin-induced diabetes on cholinesterases activities was studied in the retina and, for comparison, in other nervous and nonnervous tissues. Streptozotocin diabetes did not affect acetylcholinesterase activity in the retina but increased its activity in the cerebral cortex (100%) and in serum (5...

journal_title：IUBMB life

authors： Sánchez-Chávez G,Salceda R

更新日期：2000-04-01 00:00:00

abstract：:The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in mitochondria of fungi, plants and animals and belongs...

journal_title：IUBMB life

authors： Harborne SPD,Kunji ERS

更新日期：2018-12-01 00:00:00

abstract：:Heat shock proteins (Hsps) are a highly conserved family of proteins. The regulation of expression of Hsps in Mycobacterium tuberculosis, is regulated both positively and negatively by alternate sigma factors and transcriptional DNA repressors, respectively. HspR is a negative regulator of expression of hsps, DnaK, Cl...

journal_title：IUBMB life

authors： Parijat P,Batra JK

更新日期：2015-11-01 00:00:00

abstract：:Peroxynitrite is an inorganic toxin of physiological interest, formed from the diffusion-controlled reaction of superoxide and nitrogen monoxide with a rate constant of (1.6 +/- 0.3) x 10(10) M(-1) s(-1). On the basis of three experiments we conclude that homolysis of the O-O bond in peroxynitrous acid is unlikely: (1...

journal_title：IUBMB life

authors： Kissner R,Nauser T,Kurz C,Koppenol WH

更新日期：2003-10-01 00:00:00

abstract：:Occlusion of a coronary artery if maintained for longer period of time results in damage of the cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself induce further cardiac damage, a phenomenon known as myocardial reperfusion injury. Cardiac homoeostasis is supported by a network ...

journal_title：IUBMB life

authors： Rohrbach S,Troidl C,Hamm C,Schulz R

更新日期：2015-02-01 00:00:00

abstract：:Retinitis pigmentosa comprises a large and exceptionally heterogeneous group of hereditary disorders of the retina. As a result of an extensive investigation around the world, primary genetic lesions have been described in many genes. Some of these genes encode enzymes that are involved in the signal transduction path...

journal_title：IUBMB life

authors： Shastry BS

更新日期：2000-06-01 00:00:00

abstract：:In this article, we discuss single molecule observation of rotational catalysis by E. coli ATP synthase (F-ATPase) using small gold beads. Studies involving a low viscous drag probe showed the stochastic properties of the enzyme in alternating catalytically active and inhibited states. The importance of subunit intera...

journal_title：IUBMB life

authors： Nakanishi-Matsui M,Sekiya M,Futai M

更新日期：2013-03-01 00:00:00

abstract：:The physiological role of neuroglobin and cytoglobin, two vertebrate globins discovered in the last 5 years, is not yet clearly understood. In this work, we review the structural information on these globins and its implication on the possible protein function, obtained by electron paramagnetic resonance and resonance...

journal_title：IUBMB life

authors： Van Doorslaer S,Vinck E,Trandafir F,Ioanitescu I,Dewilde S,Moens L

更新日期：2004-11-01 00:00:00

abstract：:Diarrhea-predominant irritable bowel syndrome (IBS-D) is one of the most common gastrointestinal disorders in the world, lacking effective therapies. The crucial roles of microRNAs (miRNAs) in IBS-D have attracted increasing attention. The aim of this study is to investigate the effects of miR-495 on the visceral sens...

journal_title：IUBMB life

authors： Fei L,Wang Y

更新日期：2020-07-01 00:00:00

abstract：:In many organisms the processes of DNA replication and recombination are closely linked. For instance, in bacterial and eukaryotic systems, replication forks can become stalled or damaged, in many cases leading to the formation of double stranded breaks. Replication restart is an essential mechanism in which the recom...

journal_title：IUBMB life

authors： Wilkinson DE,Weller SK

更新日期：2003-08-01 00:00:00

abstract：:Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic β-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mec...

journal_title：IUBMB life

authors： Poirel L,Bonnin RA,Nordmann P

更新日期：2011-12-01 00:00:00

abstract：:Red blood cells of yellow-spotted river turtles (Podocnemis unifilis, Pleurodira, Chelonia, REPTILIA) have two hemoglobin (Hb) components, Hb A and Hb D. We purified the hemoglobin component homologous to amniote (reptiles, birds, and mammals) adult Hb A which comprises two identical α(A) -globin polypeptides and two ...

journal_title：IUBMB life

authors： Hasegawa T,Shishikura F,Kuwada T

更新日期：2011-03-01 00:00:00

abstract：:We investigated signaling pathways leading to tumor necrosis factor (TNF) alpha-induced intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression in chondrosarcoma cells, and determined the functional significance of their expression by examining Jurkat T cell adhesion. TNFalpha ...

journal_title：IUBMB life

authors： Ju JW,Kim SJ,Jun CD,Chun JS

更新日期：2002-11-01 00:00:00

abstract：:The extensive post-transcriptional modification of U2 snRNA is required for spliceosome assembly and pre-mRNA splicing in vertebrates. However, the rare modification of U2 snRNA in yeast implies a different mechanism for regulating spliceosome biogenesis in single-celled eukaryotes. To understand the evolutionary patt...

journal_title：IUBMB life

authors： Huang ZP,Zhou H,Qu LH

更新日期：2005-10-01 00:00:00

abstract：:Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of ...

journal_title：IUBMB life

authors： Zidan HE,Abdul-Maksoud RS,Elsayed WSH,Desoky EAM

更新日期：2018-05-01 00:00:00

abstract：:Members of the GATA family of transcription factors play key roles in the differentiation of specific cell lineages by regulating the expression of target genes. Three GATA factors play distinct roles in hematopoietic differentiation. In order to better understand how these GATA factors function to regulate genes thro...

journal_title：IUBMB life

authors： Hardison RC,Zhang Y,Keller CA,Xiang G,Heuston EF,An L,Lichtenberg J,Giardine BM,Bodine D,Mahony S,Li Q,Yue F,Weiss MJ,Blobel GA,Taylor J,Hughes J,Higgs DR,Göttgens B

更新日期：2020-01-01 00:00:00

abstract：:Researchers have started focusing on investigating the anticarcinogenic effects of natural products with the slightest side effects possible, because current breast cancer treatment approaches are unable to achieve absolute success especially on aggressive subtypes. Propolis is among these products with its antimicrob...

journal_title：IUBMB life

authors： Seyhan MF,Yılmaz E,Timirci-Kahraman Ö,Saygılı N,Kısakesen Hİ,Gazioğlu S,Gören AC,Eronat AP,Begüm Ceviz A,Öztürk T,Yılmaz-Aydoğan H,Öztürk O

更新日期：2019-05-01 00:00:00