Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration.

abstract：:Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks. How host immune responses are orchestrated after alphaviral infections and lead to musculoskeletal inflammation remains poorly understood. Her...

journal_title：mBio

authors： Zaid A,Tharmarajah K,Mostafavi H,Freitas JR,Sheng KC,Foo SS,Chen W,Vider J,Liu X,West NP,Herrero LJ,Taylor A,Mackay LK,Getts DR,King NJC,Mahalingam S

更新日期：2020-03-03 00:00:00

abstract：:The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...

journal_title：mBio

authors： Ausiello CM,Cassone A

更新日期：2014-06-10 00:00:00

abstract：UNLABELLED:DNA lesions in the template strand block synthesis by replicative DNA polymerases (Pols). Eukaryotic cells possess a number of specialized translesion synthesis (TLS) Pols with the ability to replicate through DNA lesions. The Epstein-Barr virus (EBV), a member of the herpesvirus family, infects human B cell...

journal_title：mBio

authors： Yoon JH,Prakash S,Prakash L

更新日期：2012-09-11 00:00:00

abstract：:Once HIV-1 enters a cell, the viral core is uncoated by a poorly understood mechanism and the HIV-1 genomic RNA is reverse transcribed into DNA. Host cell factors are essential for these processes, although very few reverse transcription complex binding host cell factors have been convincingly shown to affect uncoatin...

journal_title：mBio

authors： Rawle DJ,Li D,Swedberg JE,Wang L,Soares DC,Harrich D

更新日期：2018-03-27 00:00:00

abstract：:The yeast Yarrowia lipolytica is a potent accumulator of lipids, and lipogenesis in this organism can be influenced by a variety of factors, such as genetics and environmental conditions. Using a multifactorial study, we elucidated the effects of both genetic and environmental factors on regulation of lipogenesis in Y...

journal_title：mBio

authors： Kerkhoven EJ,Kim YM,Wei S,Nicora CD,Fillmore TL,Purvine SO,Webb-Robertson BJ,Smith RD,Baker SE,Metz TO,Nielsen J

更新日期：2017-06-20 00:00:00

abstract：UNLABELLED:Competence for genetic transformation in Streptococcus pneumoniae develops in response to accumulation of a secreted peptide pheromone and was one of the initial examples of bacterial quorum sensing. Activation of this signaling system induces not only expression of the proteins required for transformation b...

journal_title：mBio

authors： Stevens KE,Chang D,Zwack EE,Sebert ME

更新日期：2011-09-20 00:00:00

abstract：:SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Streptococcus pyogenes,...

journal_title：mBio

authors： Port GC,Cusumano ZT,Tumminello PR,Caparon MG

更新日期：2017-03-28 00:00:00

abstract：:Pseudomonas aeruginosa, known as one of the leading causes of disease in cystic fibrosis (CF) patients, secretes a variety of proteases. These enzymes contribute significantly to P. aeruginosa pathogenesis and biofilm formation in the chronic colonization of CF patient lungs, as well as playing a role in infections of...

journal_title：mBio

authors： Esoda CN,Kuehn MJ

更新日期：2019-11-19 00:00:00

abstract：UNLABELLED:Mycoplasma pneumoniae, a pathogenic bacterium, glides on host surfaces using a unique mechanism. It forms an attachment organelle at a cell pole as a protrusion comprised of knoblike surface structures and an internal core. Here, we analyzed the three-dimensional structure of the organelle in detail by elect...

journal_title：mBio

authors： Kawamoto A,Matsuo L,Kato T,Yamamoto H,Namba K,Miyata M

更新日期：2016-04-12 00:00:00

abstract：:Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment of a type IV secretion system (T4SS). However, the mechanism by which the T4SS elicits inflammation remains unknown. Here we show that translocation of the T4SS substrate VceC into host cells induces proinflammatory resp...

journal_title：mBio

authors： de Jong MF,Starr T,Winter MG,den Hartigh AB,Child R,Knodler LA,van Dijl JM,Celli J,Tsolis RM

更新日期：2013-02-19 00:00:00

abstract：UNLABELLED:The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening meningitis in immunocompromised individuals. The expression of virulence factors, including capsule and melanin, is in part regulated by the cyclic-AMP/protein kinase A (cAMP/PKA) signal transduction pathway. In this study, we ...

journal_title：mBio

authors： Geddes JM,Caza M,Croll D,Stoynov N,Foster LJ,Kronstad JW

更新日期：2016-01-12 00:00:00

abstract：:Plant roots support complex microbial communities that can influence plant growth, nutrition, and health. While extensive characterizations of the composition and spatial compartmentalization of these communities have been performed in different plant species, there is relatively little known about the impact of abiot...

journal_title：mBio

authors： Santos-Medellín C,Edwards J,Liechty Z,Nguyen B,Sundaresan V

更新日期：2017-07-18 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic of chlamydial infection is the propensity to cause persistent in...

journal_title：mBio

authors： Yang C,Kari L,Lei L,Carlson JH,Ma L,Couch CE,Whitmire WM,Bock K,Moore I,Bonner C,McClarty G,Caldwell HD

更新日期：2020-08-18 00:00:00

abstract：:Cholera continues to be an important cause of human infections, and outbreaks are often observed after natural disasters, such as the one following the 2010 earthquake in Haiti. Once the cholera outbreak was confirmed, rumors spread that the disease was brought to Haiti by a battalion of Nepalese soldiers serving as U...

journal_title：mBio

authors： Hendriksen RS,Price LB,Schupp JM,Gillece JD,Kaas RS,Engelthaler DM,Bortolaia V,Pearson T,Waters AE,Upadhyay BP,Shrestha SD,Adhikari S,Shakya G,Keim PS,Aarestrup FM

更新日期：2011-09-01 00:00:00

abstract：:Paramyxoviruses are negative-sense single-stranded RNA viruses that comprise many important human and animal pathogens, including human parainfluenza viruses. These viruses bud from the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is transported from the cytoplasm to the cell memb...

journal_title：mBio

authors： Genoyer E,Kulej K,Hung CT,Thibault PA,Azarm K,Takimoto T,Garcia BA,Lee B,Lakdawala S,Weitzman MD,López CB

更新日期：2020-08-25 00:00:00

abstract：:EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) o...

journal_title：mBio

authors： McCarthy KR,Timpona JL,Jenni S,Bloyet LM,Brusic V,Johnson WE,Whelan SPJ,Robinson-McCarthy LR

更新日期：2020-11-17 00:00:00

abstract：UNLABELLED:The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens cause an increasing number of nosocomial infections worldwide since they escape the inhibitory effect of the available antibiotics and the immun...

journal_title：mBio

authors： Behroozian S,Svensson SL,Davies J

更新日期：2016-01-26 00:00:00

abstract：:Low doses of antibiotics can trigger secondary metabolite biosynthesis in bacteria, but the underlying mechanisms are generally unknown. We sought to better understand this phenomenon by studying how the antibiotic trimethoprim activates the synthesis of the virulence factor malleilactone in Burkholderia thailandensis...

journal_title：mBio

authors： Li A,Mao D,Yoshimura A,Rosen PC,Martin WL,Gallant É,Wühr M,Seyedsayamdost MR

更新日期：2020-02-25 00:00:00

abstract：:ZipA is an essential cell division protein in Escherichia coli Together with FtsA, ZipA tethers dynamic polymers of FtsZ to the cytoplasmic membrane, and these polymers are required to guide synthesis of the cell division septum. This dynamic behavior of FtsZ has been reconstituted on planar lipid surfaces in vitro, v...

journal_title：mBio

authors： Krupka M,Sobrinos-Sanguino M,Jiménez M,Rivas G,Margolin W

更新日期：2018-06-19 00:00:00

abstract：:A voluntary 60-day pause on avian H5N1 influenza virus transmission research was announced in January 2012 by the international community of influenza scientists engaged in this work to provide time to explain the benefits of such work and the risk mitigation measures in place. Subsequently, the pause was extended to ...

journal_title：mBio

authors： Fouchier RA,García-Sastre A,Kawaoka Y

更新日期：2012-11-01 00:00:00

abstract：:Cryptococcus gattii, the sister species of Cryptococcus neoformans, is an emerging pathogen which gained importance in connection with the ongoing cryptococcosis outbreak on Vancouver Island. Many molecular studies have divided this species into for major lineages: VGI, VGII, VGIII, and VGIV. This commentary summarize...

journal_title：mBio

authors： Meyer W

更新日期：2015-11-17 00:00:00

abstract：:Cellular sensing of bacterial RNA is increasingly recognized as a determinant of host-pathogen interactions. The intracellular pathogen Listeria monocytogenes induces high levels of type I interferons (alpha/beta interferons [IFN-α/β]) to create a growth-permissive microenvironment during infection. We previously demo...

journal_title：mBio

authors： Frantz R,Teubner L,Schultze T,La Pietra L,Müller C,Gwozdzinski K,Pillich H,Hain T,Weber-Gerlach M,Panagiotidis GD,Mostafa A,Weber F,Rohde M,Pleschka S,Chakraborty T,Abu Mraheil M

更新日期：2019-10-08 00:00:00

abstract：:The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell wall-acting antibiotics. In rich medium, c-di-AMP is essential; however, muta...

journal_title：mBio

authors： Peterson BN,Young MKM,Luo S,Wang J,Whiteley AT,Woodward JJ,Tong L,Wang JD,Portnoy DA

更新日期：2020-08-25 00:00:00

abstract：:Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural origin, discovering new natural products is challenging, and there is a need to expand the chemical ...

journal_title：mBio

authors： Cleto S,Lu TK

更新日期：2017-10-10 00:00:00

abstract：:Catabolite control protein A (CcpA) is the master regulator in Gram-positive bacteria that mediates carbon catabolite repression (CCR) and carbon catabolite activation (CCA), two fundamental regulatory mechanisms that enable competitive advantages in carbon catabolism. It is generally regarded that CcpA exerts its reg...

journal_title：mBio

authors： Yang Y,Zhang L,Huang H,Yang C,Yang S,Gu Y,Jiang W

更新日期：2017-01-24 00:00:00

abstract：UNLABELLED:Infection by alphaherpesviruses, including herpes simplex virus (HSV) and pseudorabies virus (PRV), typically begins at epithelial surfaces and continues into the peripheral nervous system (PNS). Inflammatory responses are induced at the infected peripheral site prior to invasion of the PNS. When the periphe...

journal_title：mBio

authors： Song R,Koyuncu OO,Greco TM,Diner BA,Cristea IM,Enquist LW

更新日期：2016-02-02 00:00:00

abstract：UNLABELLED:Promiscuous plasmids replicate in a wide range of bacteria and therefore play a key role in the dissemination of various host-beneficial traits, including antibiotic resistance. Despite the medical relevance, little is known about the evolutionary dynamics through which drug resistance plasmids adapt to new ...

journal_title：mBio

authors： Hughes JM,Lohman BK,Deckert GE,Nichols EP,Settles M,Abdo Z,Top EM

更新日期：2012-07-03 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and interconnected quorum sensing (QS) regulatory circuits to produce a battery of virulence factors such as elastase, phenazines, and rhamnol...

journal_title：mBio

authors： Cruz RL,Asfahl KL,Van den Bossche S,Coenye T,Crabbé A,Dandekar AA

更新日期：2020-04-07 00:00:00

abstract：UNLABELLED:Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense mole...

journal_title：mBio

authors： Warren TK,Whitehouse CA,Wells J,Welch L,Heald AE,Charleston JS,Sazani P,Reid SP,Iversen PL,Bavari S

更新日期：2015-02-10 00:00:00

abstract：:Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor composed of three subunits, namely, NF-YA, NF-YB, and NF-YC, which are conserved throughout evolution. In higher eukaryotes, NF-Y plays important roles in several cellular processes (development, cell cycle regulation, apoptosis, and response to growth, ...

journal_title：mBio

authors： Manna D,Singh U

更新日期：2019-06-18 00:00:00