Genetic control of translesion synthesis on leading and lagging DNA strands in plasmids derived from Epstein-Barr virus in human cells.

abstract：UNLABELLED:Sensing of and responding to environmental changes are of vital importance for microbial cells. Consequently, bacteria have evolved a plethora of signaling systems that usually sense biochemical cues either via direct ligand binding, thereby acting as "concentration sensors," or by responding to downstream e...

journal_title：mBio

authors： Fritz G,Dintner S,Treichel NS,Radeck J,Gerland U,Mascher T,Gebhard S

更新日期：2015-07-21 00:00:00

abstract：:The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels an...

journal_title：mBio

authors： Andrade DV,Katzelnick LC,Widman DG,Balmaseda A,de Silva AM,Baric RS,Harris E

更新日期：2017-09-19 00:00:00

abstract：:Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynt...

journal_title：mBio

authors： Shrivastava-Ranjan P,Bergeron É,Chakrabarti AK,Albariño CG,Flint M,Nichol ST,Spiropoulou CF

更新日期：2016-12-20 00:00:00

abstract：UNLABELLED:Methicillin-resistant Staphylococcus aureus (MRSA) strains are leading causes of hospital-acquired infections in the United States, and clonal cluster 5 (CC5) is the predominant lineage responsible for these infections. Since 2002, there have been 12 cases of vancomycin-resistant S. aureus (VRSA) infection i...

journal_title：mBio

authors： Kos VN,Desjardins CA,Griggs A,Cerqueira G,Van Tonder A,Holden MT,Godfrey P,Palmer KL,Bodi K,Mongodin EF,Wortman J,Feldgarden M,Lawley T,Gill SR,Haas BJ,Birren B,Gilmore MS

更新日期：2012-05-22 00:00:00

abstract：:Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available to probe its biology. However, S. cerevisiae has proven difficult ...

journal_title：mBio

authors： Cernak P,Estrela R,Poddar S,Skerker JM,Cheng YF,Carlson AK,Chen B,Glynn VM,Furlan M,Ryan OW,Donnelly MK,Arkin AP,Taylor JW,Cate JHD

更新日期：2018-09-25 00:00:00

abstract：UNLABELLED:Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses. Complement, an important arm of innate immunity, plays a significant role in fungal pathogenesis, especially the...

journal_title：mBio

authors： Agarwal S,Specht CA,Haibin H,Ostroff GR,Ram S,Rice PA,Levitz SM

更新日期：2011-08-30 00:00:00

abstract：:Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely unknown owing to the complexity of the process. Here, using a represen...

journal_title：mBio

authors： Zhang L,Liu Y,Zhao R,Zhang C,Jiang W,Gu Y

更新日期：2020-08-18 00:00:00

abstract：:Increasing evidence has indicated that single nucleotide polymorphisms (SNPs) are related to the susceptibility of sepsis and might provide potential evidence for the mechanisms of sepsis. Our recent preliminary study showed that the ADAM10 genetic polymorphism was clinically associated with the development of sepsis,...

journal_title：mBio

authors： Chen F,Wang Y,Zhang W,Cai Y,Zhao T,Mai H,Tao S,Wei W,Li J,Chen X,Li X,Tang P,Fan W,Yang J,Ou M,Lu F,Lai Z,Chen H,Zou T,Sun F,Shao Y,Cui L

更新日期：2019-08-06 00:00:00

abstract：:Enterococcus faecalis strains resistant to penicillin and ampicillin are rare and have been associated with increases in quantities of low-affinity penicillin-binding protein 4 (PBP4) or with amino acid substitutions in PBP4. We report an E. faecalis strain (LS4828) isolated from a prosthetic knee joint that was subje...

journal_title：mBio

authors： Rice LB,Desbonnet C,Tait-Kamradt A,Garcia-Solache M,Lonks J,Moon TM,D'Andréa ÉD,Page R,Peti W

更新日期：2018-04-03 00:00:00

abstract：UNLABELLED:Enterococcus faecium, natively a gut commensal organism, emerged as a leading cause of multidrug-resistant hospital-acquired infection in the 1980s. As the living record of its adaptation to changes in habitat, we sequenced the genomes of 51 strains, isolated from various ecological environments, to understa...

journal_title：mBio

authors： Lebreton F,van Schaik W,McGuire AM,Godfrey P,Griggs A,Mazumdar V,Corander J,Cheng L,Saif S,Young S,Zeng Q,Wortman J,Birren B,Willems RJ,Earl AM,Gilmore MS

更新日期：2013-08-20 00:00:00

abstract：:Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution K432E. This substitution exists in 99.25% of seasonal influenza ...

journal_title：mBio

authors： Jiang H,Peng W,Qi J,Chai Y,Song H,Bi Y,Rijal P,Wang H,Oladejo BO,Liu J,Shi Y,Gao GF,Townsend AR,Wu Y

更新日期：2020-10-06 00:00:00

abstract：:Microbial carbon degradation and methanogenesis in wetland soils generate a large proportion of atmospheric methane, a highly potent greenhouse gas. Despite their potential to mitigate greenhouse gas emissions, knowledge about methane-consuming methanotrophs is often limited to lower-resolution single-gene surveys tha...

journal_title：mBio

authors： Smith GJ,Angle JC,Solden LM,Borton MA,Morin TH,Daly RA,Johnston MD,Stefanik KC,Wolfe R,Gil B,Wrighton KC

更新日期：2018-11-06 00:00:00

abstract：UNLABELLED:The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens that protect mice from sepsis. In this study, we characterized one of ...

journal_title：mBio

authors： Nesta B,Spraggon G,Alteri C,Moriel DG,Rosini R,Veggi D,Smith S,Bertoldi I,Pastorello I,Ferlenghi I,Fontana MR,Frankel G,Mobley HL,Rappuoli R,Pizza M,Serino L,Soriani M

更新日期：2012-04-10 00:00:00

abstract：:All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for ...

journal_title：mBio

authors： Guerardel Y,Sadovskaya I,Maes E,Furlan S,Chapot-Chartier MP,Mesnage S,Rigottier-Gois L,Serror P

更新日期：2020-04-28 00:00:00

abstract：:Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which concentrate all the proteins of the polymerase complex as well as some cellular proteins, were initially considered aggresomes formed by viral dead...

journal_title：mBio

authors： Galloux M,Risso-Ballester J,Richard CA,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2020-09-22 00:00:00

abstract：:Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy. They can also use poised electrodes as their electron donor via phototrophic extracellular electron uptake (phototrophic EEU). The e...

journal_title：mBio

authors： Gupta D,Sutherland MC,Rengasamy K,Meacham JM,Kranz RG,Bose A

更新日期：2019-11-05 00:00:00

abstract：:Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence. The role of cyclic diguanylate signaling in the lifestyle of Legionella pne...

journal_title：mBio

authors： Levi A,Folcher M,Jenal U,Shuman HA

更新日期：2011-01-11 00:00:00

abstract：:The apparent mislocalization or excretion of cytoplasmic proteins is a commonly observed phenomenon in both bacteria and eukaryotes. However, reports on the mechanistic basis and the cellular function of this so-called "nonclassical protein secretion" are limited. Here we report that protein overexpression in recombin...

journal_title：mBio

authors： Morra R,Del Carratore F,Muhamadali H,Horga LG,Halliwell S,Goodacre R,Breitling R,Dixon N

更新日期：2018-01-30 00:00:00

abstract：UNLABELLED:Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-stage para...

journal_title：mBio

authors： LaMonte G,Lim MY,Wree M,Reimer C,Nachon M,Corey V,Gedeck P,Plouffe D,Du A,Figueroa N,Yeung B,Bifani P,Winzeler EA

更新日期：2016-07-05 00:00:00

abstract：:Many Gram-negative bacterial pathogens require a type 3 secretion system (T3SS) to deliver effector proteins into eukaryotic cells. Contact of the tip complex of the T3SS with a target eukaryotic cell initiates secretion of the two bacterial proteins that assemble into the translocon pore in the plasma membrane. The t...

journal_title：mBio

authors： Russo BC,Duncan JK,Goldberg MB

更新日期：2019-05-28 00:00:00

abstract：:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), also known as A20, is a ubiquitin-editing enzyme capable of ubiquitination or deubiquitination of its target proteins. In this study, we show that hepatitis C virus (HCV) infection could induce the expression of A20 via the activation of the A20 promoter. The in...

journal_title：mBio

authors： Lee J,Chan ST,Kim JY,Ou JJ

更新日期：2019-07-23 00:00:00

abstract：:Candida albicans has developmental programs that govern transitions between yeast and filamentous morphologies and between unattached and biofilm lifestyles. Here, we report that filamentation, intercellular adherence, and biofilm development were inhibited during interactions between Candida albicans and Pseudomonas ...

journal_title：mBio

authors： Morales DK,Grahl N,Okegbe C,Dietrich LE,Jacobs NJ,Hogan DA

更新日期：2013-01-29 00:00:00

abstract：UNLABELLED:Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and outcome. As in many infectious diseases, this variability is commonly assigned to host factors. To investigate whether the diversity of Cryptococcus neoformans clinical (ClinCn) isolates influences the interaction with ...

journal_title：mBio

authors： Alanio A,Desnos-Ollivier M,Dromer F

更新日期：2011-08-09 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:Microbial photoautotroph-heterotroph interactions underlie marine food webs and shape ecosystem diversity and structure in upper ocean environments. Here, bacterial community composition, lifestyle preference, and genomic- and proteomic-level metabolic characteristics were investigated for an open ocean Synechococcus ...

journal_title：mBio

authors： Zheng Q,Wang Y,Lu J,Lin W,Chen F,Jiao N

更新日期：2020-02-18 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the most common etiologic agent of uncomplicated urinary tract infection (UTI). An important mechanism of gene regulation in UPEC is phase variation that involves inversion of a promoter-containing DNA element via enzymatic activity of tyrosine recombinases, resulting in biphas...

journal_title：mBio

authors： Battaglioli EJ,Goh KGK,Atruktsang TS,Schwartz K,Schembri MA,Welch RA

更新日期：2018-08-07 00:00:00

abstract：UNLABELLED:The outer membrane (OM) of Gram-negative bacteria provides protection against toxic molecules, including reactive oxygen species (ROS). Decreased OM permeability can promote bacterial survival under harsh circumstances and protects against antibiotics. To better understand the regulation of OM permeability, ...

journal_title：mBio

authors： van der Heijden J,Reynolds LA,Deng W,Mills A,Scholz R,Imami K,Foster LJ,Duong F,Finlay BB

更新日期：2016-08-09 00:00:00

abstract：UNLABELLED:A change in viral hemagglutinin (HA) receptor binding specificity from α2,3- to α2,6-linked sialic acid is necessary for highly pathogenic avian influenza (AI) virus subtype H5N1 to become pandemic. However, details of the human-adaptive change in the H5N1 virus remain unknown. Our database search of H5N1 cl...

journal_title：mBio

authors： Watanabe Y,Arai Y,Daidoji T,Kawashita N,Ibrahim MS,El-Gendy Eel-D,Hiramatsu H,Kubota-Koketsu R,Takagi T,Murata T,Takahashi K,Okuno Y,Nakaya T,Suzuki Y,Ikuta K

更新日期：2015-04-07 00:00:00

abstract：:The human fungal pathogen Candida albicans causes lethal systemic infections because of its ability to grow and disseminate in a host. The C. albicans plasma membrane is essential for virulence by acting as a protective barrier and through its key roles in interfacing with the environment, secretion of virulence facto...

journal_title：mBio

authors： Douglas LM,Wang HX,Keppler-Ross S,Dean N,Konopka JB

更新日期：2011-12-27 00:00:00

abstract：:To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we constructed a genome encyclopedia describing the core supragingival plaque microb...

journal_title：mBio

authors： Espinoza JL,Harkins DM,Torralba M,Gomez A,Highlander SK,Jones MB,Leong P,Saffery R,Bockmann M,Kuelbs C,Inman JM,Hughes T,Craig JM,Nelson KE,Dupont CL

更新日期：2018-11-27 00:00:00