abstract：:Regulated organization of the chromosome is essential for faithful propagation of genetic information. In the model bacterium Caulobacter crescentus, the replication terminus of the chromosome is spatially arranged in close proximity to the cytokinetic Z-ring during the cell cycle. Although the Z-ring-associated prote...

journal_title：mBio

authors： Ozaki S,Wakasugi Y,Katayama T

更新日期：2021-01-26 00:00:00

abstract：:Formation of multispecies communities allows nearly every niche on earth to be colonized, and the exchange of molecular information among neighboring bacteria in such communities is key for bacterial success. To clarify the principles controlling interspecies interactions, we previously developed a coculture model wit...

journal_title：mBio

authors： Ranava D,Backes C,Karthikeyan G,Ouari O,Soric A,Guiral M,Cárdenas ML,Giudici-Orticoni MT

更新日期：2021-01-19 00:00:00

abstract：:5-Aminosalicylic acid (5-ASA), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is a widely used first-line medication for the treatment of ulcerative colitis, but its anti-inflammatory mechanism is not fully resolved. Here, we show that 5-ASA ameliorates colitis in dextran sulfate sodium (DSS)-tre...

journal_title：mBio

authors： Cevallos SA,Lee JY,Velazquez EM,Foegeding NJ,Shelton CD,Tiffany CR,Parry BH,Stull-Lane AR,Olsan EE,Savage HP,Nguyen H,Ghanaat SS,Byndloss AJ,Agu IO,Tsolis RM,Byndloss MX,Bäumler AJ

更新日期：2021-01-19 00:00:00

abstract：:As the GroES/GroEL chaperonin system is the only bacterial chaperone that is essential under all conditions, we have been interested in the development of GroES/GroEL inhibitors as potential antibiotics. Using Escherichia coli GroES/GroEL as a surrogate, we have discovered several classes of GroES/GroEL inhibitors tha...

journal_title：mBio

authors： Sivinski J,Ambrose AJ,Panfilenko I,Zerio CJ,Machulis JM,Mollasalehi N,Kaneko LK,Stevens M,Ray AM,Park Y,Wu C,Hoang QQ,Johnson SM,Chapman E

更新日期：2021-01-12 00:00:00

abstract：:Exudative cutaneous ulcers (CU) in yaws-endemic areas are associated with Treponema pallidum subsp. pertenue (TP) and Haemophilus ducreyi (HD), but one-third of CU cases are idiopathic (IU). Using mass drug administration (MDA) of azithromycin, a yaws eradication campaign on Lihir Island in Papua New Guinea reduced bu...

journal_title：mBio

authors： Griesenauer B,González-Beiras C,Fortney KR,Lin H,Gao X,Godornes C,Nelson DE,Katz BP,Lukehart SA,Mitjà O,Dong Q,Spinola SM

更新日期：2021-01-12 00:00:00

abstract：:Streptococcus gallolyticus subsp. gallolyticus is an emerging opportunistic pathogen responsible for septicemia and endocarditis in the elderly. Invasive infections by S. gallolyticus subsp. gallolyticus are strongly linked to the occurrence of colorectal cancer (CRC). It was previously shown that increased secondary ...

journal_title：mBio

authors： Harrington A,Proutière A,Mull RW,du Merle L,Dramsi S,Tal-Gan Y

更新日期：2021-01-05 00:00:00

abstract：:The fungus Paracoccidioides is a prevalent human pathogen endemic to South America. The genus is composed of five species. In this report, we use 37 whole-genome sequences to study the allocation of genetic variation in Paracoccidioides We tested three genome-wide predictions of advanced speciation, namely, that all s...

journal_title：mBio

authors： Mavengere H,Mattox K,Teixeira MM,Sepúlveda VE,Gomez OM,Hernandez O,McEwen J,Matute DR

更新日期：2020-12-22 00:00:00

abstract：:The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the potential of modulating the...

journal_title：mBio

authors： Domínguez-Andrés J,van Crevel R,Divangahi M,Netea MG

更新日期：2020-12-22 00:00:00

abstract：:Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spectrum antibacterial activity....

journal_title：mBio

authors： Reithuber E,Nannapaneni P,Rzhepishevska O,Lindgren AEG,Ilchenko O,Normark S,Almqvist F,Henriques-Normark B,Mellroth P

更新日期：2020-12-15 00:00:00

abstract：:SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as the primary receptor to enter host cells and initiate the infection. The critical binding region of ACE2 is an ∼30-amino-acid (aa)-long helix. Here, we report the design of four stapled peptides based on the ACE2 helix, which is expected to bind to SARS-C...

journal_title：mBio

authors： Curreli F,Victor SMB,Ahmed S,Drelich A,Tong X,Tseng CK,Hillyer CD,Debnath AK

更新日期：2020-12-11 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying permeabilized retrovirus parti...

journal_title：mBio

authors： Jennings J,Shi J,Varadarajan J,Jamieson PJ,Aiken C

更新日期：2020-12-01 00:00:00

abstract：:Sodium-translocating NADH:quinone oxidoreductase (Na+-NQR) functions as a unique redox-driven sodium pump, generating membrane potential, which is related to aminoglycoside antibiotic resistance. However, whether it modulates other metabolisms to confer antibiotic resistance is unknown. The present study showed that l...

journal_title：mBio

authors： Jiang M,Kuang SF,Lai SS,Zhang S,Yang J,Peng B,Peng XX,Chen ZG,Li H

更新日期：2020-11-17 00:00:00

abstract：:EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) o...

journal_title：mBio

authors： McCarthy KR,Timpona JL,Jenni S,Bloyet LM,Brusic V,Johnson WE,Whelan SPJ,Robinson-McCarthy LR

更新日期：2020-11-17 00:00:00

abstract：:Nutritional immunity is an elegant host mechanism used to starve invading pathogens of necessary nutrient metals. Calprotectin, a metal-binding protein, is produced abundantly by neutrophils and is found in high concentrations within inflammatory sites during infection. Group B Streptococcus (GBS) colonizes the gastro...

journal_title：mBio

authors： Burcham LR,Le Breton Y,Radin JN,Spencer BL,Deng L,Hiron A,Ransom MR,Mendonça JDC,Belew AT,El-Sayed NM,McIver KS,Kehl-Fie TE,Doran KS

更新日期：2020-11-10 00:00:00

abstract：:The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an immunoproteasome (iProteasome). iProteasome-degraded products are...

journal_title：mBio

authors： Yang Y,Liu W,Hu D,Su R,Ji M,Huang Y,Shereen MA,Xu X,Luo Z,Zhang Q,Liu F,Wu K,Liu Y,Wu J

更新日期：2020-10-27 00:00:00

abstract：:UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar moiety is incorporated into glycosylphosphatidylinositol (GPI) glycolipids and N- and O-linked glycans. Apicomplexan parasites have a hexosamine pathway compa...

journal_title：mBio

authors： Chi J,Cova M,de Las Rivas M,Medina A,Borges RJ,Leivar P,Planas A,Usón I,Hurtado-Guerrero R,Izquierdo L

更新日期：2020-10-20 00:00:00

abstract：:Unlike all other archaeal lineages, ammonia-oxidizing archaea (AOA) of the phylum Thaumarchaeota are widespread and abundant in all moderate and oxic environments on Earth. The evolutionary adaptations that led to such unprecedented ecological success of a microbial clade characterized by highly conserved energy and c...

journal_title：mBio

authors： Abby SS,Kerou M,Schleper C

更新日期：2020-10-13 00:00:00

abstract：:Merozoites formed after asexual division of the malaria parasite invade the host red blood cells (RBCs), which is critical for initiating malaria infection. The process of invasion involves specialized organelles like micronemes and rhoptries that discharge key proteins involved in interaction with host RBC receptors....

journal_title：mBio

authors： Ekka R,Gupta A,Bhatnagar S,Malhotra P,Sharma P

更新日期：2020-10-06 00:00:00

abstract：:Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution K432E. This substitution exists in 99.25% of seasonal influenza ...

journal_title：mBio

authors： Jiang H,Peng W,Qi J,Chai Y,Song H,Bi Y,Rijal P,Wang H,Oladejo BO,Liu J,Shi Y,Gao GF,Townsend AR,Wu Y

更新日期：2020-10-06 00:00:00

abstract：:Estrogen, a major female sex steroid hormone, has been shown to promote the selection of mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases, including cystic fibrosis. This results in long-term persistence, poorer clinical outcomes, and limited therapeutic options. In this study...

journal_title：mBio

authors： Vidaillac C,Yong VFL,Aschtgen MS,Qu J,Yang S,Xu G,Seng ZJ,Brown AC,Ali MK,Jaggi TK,Sankaran J,Foo YH,Righetti F,Nedumaran AM,Mac Aogáin M,Roizman D,Richard JA,Rogers TR,Toyofuku M,Luo D,Loh E,Wohland T,Czarny

更新日期：2020-09-29 00:00:00

abstract：:The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mechanism is how completion of the prepore is sensed to initiate its conversion to the pore. We identified a motif that is conserved between the CDCs and a diverse family of nearly 300 unchara...

journal_title：mBio

authors： Evans JC,Johnstone BA,Lawrence SL,Morton CJ,Christie MP,Parker MW,Tweten RK

更新日期：2020-09-29 00:00:00

abstract：:Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which concentrate all the proteins of the polymerase complex as well as some cellular proteins, were initially considered aggresomes formed by viral dead...

journal_title：mBio

authors： Galloux M,Risso-Ballester J,Richard CA,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2020-09-22 00:00:00

abstract：:Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ), and acyl carrier protein (ACP), are utilized to elongate the p...

journal_title：mBio

authors： Hua K,Liu X,Zhao Y,Gao Y,Pan L,Zhang H,Deng Z,Jiang M

更新日期：2020-09-15 00:00:00

abstract：:Malaria parasites increase their host erythrocyte's permeability to various nutrients, fueling intracellular pathogen development and replication. The plasmodial surface anion channel (PSAC) mediates this uptake and is linked to the parasite-encoded RhopH complex, consisting of CLAG3, RhopH2, and RhopH3. While interac...

journal_title：mBio

authors： Ahmad M,Manzella-Lapeira J,Saggu G,Ito D,Brzostowski JA,Desai SA

更新日期：2020-09-08 00:00:00

abstract：:Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages an...

journal_title：mBio

authors： Frazão SO,Sousa HR,Silva LGD,Folha JDS,Gorgonha KCM,Oliveira GP Jr,Felipe MSS,Silva-Pereira I,Casadevall A,Nicola AM,Albuquerque P

更新日期：2020-09-08 00:00:00

abstract：:Mycoviruses infect fungi, and while most persist asymptomatically, there are examples of mycoviruses having both beneficial and detrimental effects on their host. Virus-infected Saccharomyces and Ustilago strains exhibit a killer phenotype conferring a growth advantage over uninfected strains and other competing yeast...

journal_title：mBio

authors： Applen Clancey S,Ruchti F,LeibundGut-Landmann S,Heitman J,Ianiri G

更新日期：2020-09-01 00:00:00

abstract：:Paramyxoviruses are negative-sense single-stranded RNA viruses that comprise many important human and animal pathogens, including human parainfluenza viruses. These viruses bud from the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is transported from the cytoplasm to the cell memb...

journal_title：mBio

authors： Genoyer E,Kulej K,Hung CT,Thibault PA,Azarm K,Takimoto T,Garcia BA,Lee B,Lakdawala S,Weitzman MD,López CB

更新日期：2020-08-25 00:00:00

abstract：:The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell wall-acting antibiotics. In rich medium, c-di-AMP is essential; however, muta...

journal_title：mBio

authors： Peterson BN,Young MKM,Luo S,Wang J,Whiteley AT,Woodward JJ,Tong L,Wang JD,Portnoy DA

更新日期：2020-08-25 00:00:00

abstract：:Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely unknown owing to the complexity of the process. Here, using a represen...

journal_title：mBio

authors： Zhang L,Liu Y,Zhao R,Zhang C,Jiang W,Gu Y

更新日期：2020-08-18 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic of chlamydial infection is the propensity to cause persistent in...

journal_title：mBio

authors： Yang C,Kari L,Lei L,Carlson JH,Ma L,Couch CE,Whitmire WM,Bock K,Moore I,Bonner C,McClarty G,Caldwell HD

更新日期：2020-08-18 00:00:00

abstract：:Protein ubiquitylation regulates not only endocellular trafficking and proteasomal degradation but also the catalytic activity of enzymes. In Saccharomyces cerevisiae, we analyzed the composition of the ubiquitylated proteomes in strains lacking acetyltransferase Gcn5p, Ub-protease Ubp8p, or both to understand their i...

journal_title：mBio

authors： De Palma A,Fanelli G,Cretella E,De Luca V,Palladino RA,Panzeri V,Roffia V,Saliola M,Mauri P,Filetici P

更新日期：2020-08-11 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significant...

journal_title：mBio

authors： Vaillancourt M,Jorth P

更新日期：2020-08-07 00:00:00

abstract：:Methylglyoxal (MG) is a detrimental metabolic by-product that threatens most organisms (in humans MG causes diabetes). MG is predominantly detoxified by the glyoxalase pathway. This process begins with the conjugation of MG with glutathione (GSH), yielding a hemithioacetal product that is subsequently transformed by t...

journal_title：mBio

authors： Kammerscheit X,Hecker A,Rouhier N,Chauvat F,Cassier-Chauvat C

更新日期：2020-08-04 00:00:00

abstract：:Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference (RNAi) response are poorly understood. Here, we characterized antiviral RN...

journal_title：mBio

authors： Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW

更新日期：2020-08-04 00:00:00

abstract：:DNA supercoiling (DS) is essential for life because it controls critical processes, including transcription, replication, and recombination. Current methods to measure DNA supercoiling in vivo are laborious and unable to examine single cells. Here, we report a method for high-throughput measurement of bacterial DNA su...

journal_title：mBio

authors： Duprey A,Groisman EA

更新日期：2020-07-28 00:00:00

abstract：:Colicins are toxins produced and released by Enterobacteriaceae to kill competitors in the gut. While group A colicins employ a division of labor strategy to liberate the toxin into the environment via colicin-specific lysis, group B colicin systems lack cognate lysis genes. In Salmonella enterica serovar Typhimurium ...

journal_title：mBio

authors： Spriewald S,Stadler E,Hense BA,Münch PC,McHardy AC,Weiss AS,Obeng N,Müller J,Stecher B

更新日期：2020-07-21 00:00:00

abstract：:HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4+ T cells by cytotoxic T lymphocytes (CTLs). To evade killing, many HIV-1 group M strains decrease HLA-C surface levels using their accessory protein Vpu. However, some HIV-1 group M isolates lack this activity, p...

journal_title：mBio

authors： Hopfensperger K,Richard J,Stürzel CM,Bibollet-Ruche F,Apps R,Leoz M,Plantier JC,Hahn BH,Finzi A,Kirchhoff F,Sauter D

更新日期：2020-07-14 00:00:00

abstract：:In Escherichia coli, FtsEX coordinates peptidoglycan (PG) synthesis and hydrolysis at the septum. It acts on FtsA in the cytoplasm to promote recruitment of septal PG synthetases and recruits EnvC, an activator of septal PG hydrolases, in the periplasm. Following recruitment, ATP hydrolysis by FtsEX is thought to regu...

journal_title：mBio

authors： Du S,Pichoff S,Lutkenhaus J

更新日期：2020-07-07 00:00:00

abstract：:Sinorhizobium meliloti is an alphaproteobacterium belonging to the Rhizobiales Bacteria from this order elongate their cell wall at the new cell pole, generated by cell division. Screening for protein interaction partners of the previously characterized polar growth factors RgsP and RgsM, we identified the inner membr...

journal_title：mBio

authors： Krol E,Yau HCL,Lechner M,Schäper S,Bange G,Vollmer W,Becker A

更新日期：2020-06-30 00:00:00