Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance.

abstract：:Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor composed of three subunits, namely, NF-YA, NF-YB, and NF-YC, which are conserved throughout evolution. In higher eukaryotes, NF-Y plays important roles in several cellular processes (development, cell cycle regulation, apoptosis, and response to growth, ...

journal_title：mBio

authors： Manna D,Singh U

更新日期：2019-06-18 00:00:00

abstract：UNLABELLED:Toll-like receptor 4 is thought to have a primary role in host defense against Escherichia coli bladder colonization, based on mouse models of urinary tract infection using C3H/HeJ female mice. This strain carries a point mutation in the Tlr4 gene, which renders the mice unresponsive to lipopolysaccharide (L...

journal_title：mBio

authors： Suhs KA,Marthaler BR,Welch RA,Hopkins WJ

更新日期：2011-05-31 00:00:00

abstract：:Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic understanding of how bacteria evolve resistance against multiple phages is lacking, ...

journal_title：mBio

authors： Wright RCT,Friman VP,Smith MCM,Brockhurst MA

更新日期：2019-09-24 00:00:00

abstract：UNLABELLED:The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface for interactions between these pathogens and the respi...

journal_title：mBio

authors： Heyl KA,Klassert TE,Heinrich A,Müller MM,Klaile E,Dienemann H,Grünewald C,Bals R,Singer BB,Slevogt H

更新日期：2014-08-26 00:00:00

abstract：UNLABELLED:The urinary tract is one of the most frequent sites of bacterial infection in humans. Uropathogenic Escherichia coli (UPEC) strains are the leading cause of urinary tract infections (UTIs) and are responsible for greater than 80% of uncomplicated cases in adults. Infection of the urinary tract occurs in an a...

journal_title：mBio

authors： Walters MS,Lane MC,Vigil PD,Smith SN,Walk ST,Mobley HL

更新日期：2012-02-07 00:00:00

abstract：:Neisseria meningitidis (the meningococcus) is primarily a commensal of the human oropharynx that sporadically causes septicemia and meningitis. Meningococci adapt to diverse local host conditions differing in nutrient supply, like the nasopharynx, blood, and cerebrospinal fluid, by changing metabolism and protein repe...

journal_title：mBio

authors： Pannekoek Y,Huis In 't Veld RA,Schipper K,Bovenkerk S,Kramer G,Brouwer MC,van de Beek D,Speijer D,van der Ende A

更新日期：2017-03-21 00:00:00

abstract：:Legionella pneumophila grows within cells ranging from environmental amoebae to human macrophages. In spite of this conserved strategy of pathogenesis, identification of host factors that restrict L. pneumophila intracellular replication has not been extended outside components of the mammalian innate immune response....

journal_title：mBio

authors： de Jesús-Díaz DA,Murphy C,Sol A,Dorer M,Isberg RR

更新日期：2017-08-22 00:00:00

abstract：UNLABELLED:Singlet oxygen ((1)O(2)) is a reactive oxygen species generated by energy transfer from one or more excited donors to molecular oxygen. Many biomolecules are prone to oxidation by (1)O(2), and cells have evolved systems to protect themselves from damage caused by this compound. One way that the photosyntheti...

journal_title：mBio

authors： Nam TW,Ziegelhoffer EC,Lemke RA,Donohue TJ

更新日期：2013-01-08 00:00:00

abstract：UNLABELLED:Epstein-Barr virus (EBV), along with other members of the herpesvirus family, requires a set of viral glycoproteins to mediate host cell attachment and entry. Viral glycoprotein B (gB), a highly conserved glycoprotein within the herpesvirus family, is thought to be the viral fusogen based on structural compa...

journal_title：mBio

authors： Garcia NJ,Chen J,Longnecker R

更新日期：2013-01-22 00:00:00

abstract：:HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4+ T cells by cytotoxic T lymphocytes (CTLs). To evade killing, many HIV-1 group M strains decrease HLA-C surface levels using their accessory protein Vpu. However, some HIV-1 group M isolates lack this activity, p...

journal_title：mBio

authors： Hopfensperger K,Richard J,Stürzel CM,Bibollet-Ruche F,Apps R,Leoz M,Plantier JC,Hahn BH,Finzi A,Kirchhoff F,Sauter D

更新日期：2020-07-14 00:00:00

abstract：:Photosynthetic bacteria are capable of producing their own food via photosynthesis. Unsurprisingly, they evolved the ability to move toward better light conditions (i.e., phototaxis). In a recent article in mBio, Chau et al. tuned the wavelength, flux, direction, and timing of light input and characterized the motilit...

journal_title：mBio

authors： Kim M

更新日期：2017-04-11 00:00:00

abstract：:Commensal bacteria in the human nasal cavity are known to suppress opportunistic pathogen colonization by competing for limited space and nutrients. It has become increasingly apparent that some commensal bacteria also produce toxic compounds that directly inhibit or kill incoming competitors. Numerous studies suggest...

journal_title：mBio

authors： Hardy BL,Dickey SW,Plaut RD,Riggins DP,Stibitz S,Otto M,Merrell DS

更新日期：2019-01-08 00:00:00

abstract：:Mucormycosis is an emerging lethal fungal infection in immunocompromised patients. Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to understand genetics in Mucorales. Calcineurin is a conserved virulence factor in many pathogenic fungi, and calcineurin inhibition or deletion of the...

journal_title：mBio

authors： Vellanki S,Billmyre RB,Lorenzen A,Campbell M,Turner B,Huh EY,Heitman J,Lee SC

更新日期：2020-01-28 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and interconnected quorum sensing (QS) regulatory circuits to produce a battery of virulence factors such as elastase, phenazines, and rhamnol...

journal_title：mBio

authors： Cruz RL,Asfahl KL,Van den Bossche S,Coenye T,Crabbé A,Dandekar AA

更新日期：2020-04-07 00:00:00

abstract：UNLABELLED:Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had an increased risk of HIV transmission, raised concerns about endpoints used to evaluate microbicide safety. A possible explanation for the increased ...

journal_title：mBio

authors： Ravel J,Gajer P,Fu L,Mauck CK,Koenig SS,Sakamoto J,Motsinger-Reif AA,Doncel GF,Zeichner SL

更新日期：2012-12-18 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significant...

journal_title：mBio

authors： Vaillancourt M,Jorth P

更新日期：2020-08-07 00:00:00

abstract：:Mycoviruses infect fungi, and while most persist asymptomatically, there are examples of mycoviruses having both beneficial and detrimental effects on their host. Virus-infected Saccharomyces and Ustilago strains exhibit a killer phenotype conferring a growth advantage over uninfected strains and other competing yeast...

journal_title：mBio

authors： Applen Clancey S,Ruchti F,LeibundGut-Landmann S,Heitman J,Ianiri G

更新日期：2020-09-01 00:00:00

abstract：UNLABELLED:Despite their high genomic diversity, all known viruses are structurally constrained to a limited number of virion morphotypes. One morphotype of viruses infecting bacteria, archaea, and eukaryotes is the tailless icosahedral morphotype with an internal membrane. Although it is considered an abundant morphot...

journal_title：mBio

authors： Demina TA,Pietilä MK,Svirskaitė J,Ravantti JJ,Atanasova NS,Bamford DH,Oksanen HM

更新日期：2016-07-19 00:00:00

abstract：:History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic reassortment. Going back to the...

journal_title：mBio

authors： Morens DM,Taubenberger JK,Fauci AS

更新日期：2010-09-28 00:00:00

abstract：:Vibrio vulnificus, an opportunistic pathogen, is the causative agent of a life-threatening septicemia and a rising problem for aquaculture worldwide. The genetic factors that differentiate its clinical and environmental strains remain enigmatic. Furthermore, clinical strains have emerged from every clade of V. vulnifi...

journal_title：mBio

authors： López-Pérez M,Jayakumar JM,Haro-Moreno JM,Zaragoza-Solas A,Reddi G,Rodriguez-Valera F,Shapiro OH,Alam M,Almagro-Moreno S

更新日期：2019-02-19 00:00:00

abstract：:Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers...

journal_title：mBio

authors： Fedson DS,Jacobson JR,Rordam OM,Opal SM

更新日期：2015-06-23 00:00:00

abstract：:Nonflagellar type III secretion systems (nf T3SSs) form a cell surface needle-like structure and an associated translocon that deliver bacterial effector proteins into eukaryotic host cells. This involves a tightly regulated hierarchy of protein secretion. A switch involving SctP and SctU stops secretion of the needle...

journal_title：mBio

authors： Yu XJ,Grabe GJ,Liu M,Mota LJ,Holden DW

更新日期：2018-10-02 00:00:00

abstract：:The human fungal pathogen Candida albicans causes lethal systemic infections because of its ability to grow and disseminate in a host. The C. albicans plasma membrane is essential for virulence by acting as a protective barrier and through its key roles in interfacing with the environment, secretion of virulence facto...

journal_title：mBio

authors： Douglas LM,Wang HX,Keppler-Ross S,Dean N,Konopka JB

更新日期：2011-12-27 00:00:00

abstract：UNLABELLED:The ability to cultivate food is an innovation that has produced some of the most successful ecological strategies on the planet. Although most well recognized in humans, where agriculture represents a defining feature of civilization, species of ants, beetles, and termites have also independently evolved sy...

journal_title：mBio

authors： Aylward FO,Suen G,Biedermann PH,Adams AS,Scott JJ,Malfatti SA,Glavina del Rio T,Tringe SG,Poulsen M,Raffa KF,Klepzig KD,Currie CR

更新日期：2014-11-18 00:00:00

abstract：UNLABELLED:A mechanistic understanding of the determination and maintenance of the simplest bacterial cell shape, a sphere, remains elusive compared with that of more complex shapes. Cocci seem to lack a dedicated elongation machinery, and a spherical shape has been considered an evolutionary dead-end morphology, as a ...

journal_title：mBio

authors： Pereira AR,Hsin J,Król E,Tavares AC,Flores P,Hoiczyk E,Ng N,Dajkovic A,Brun YV,VanNieuwenhze MS,Roemer T,Carballido-Lopez R,Scheffers DJ,Huang KC,Pinho MG

更新日期：2016-09-06 00:00:00

abstract：:The apparent mislocalization or excretion of cytoplasmic proteins is a commonly observed phenomenon in both bacteria and eukaryotes. However, reports on the mechanistic basis and the cellular function of this so-called "nonclassical protein secretion" are limited. Here we report that protein overexpression in recombin...

journal_title：mBio

authors： Morra R,Del Carratore F,Muhamadali H,Horga LG,Halliwell S,Goodacre R,Breitling R,Dixon N

更新日期：2018-01-30 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：:The clonal population structure of Candida albicans suggests that (para)sexual recombination does not play an important role in the lifestyle of this opportunistic fungal pathogen, an assumption that is strengthened by the fact that most C. albicans strains are heterozygous at the mating type locus (MTL) and therefore...

journal_title：mBio

authors： Popp C,Ramírez-Zavala B,Schwanfelder S,Krüger I,Morschhäuser J

更新日期：2019-02-05 00:00:00

abstract：UNLABELLED:Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems. However, the structural specificity of these systems for sugar substrates has hindered their appl...

journal_title：mBio

authors： Pan C,Sun P,Liu B,Liang H,Peng Z,Dong Y,Wang D,Liu X,Wang B,Zeng M,Wu J,Zhu L,Wang H

更新日期：2016-04-26 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00