Dectin-1 is expressed in human lung and mediates the proinflammatory immune response to nontypeable Haemophilus influenzae.

abstract：:1-Butanol is a large-volume, intermediate chemical with favorable physical and chemical properties for blending with or directly substituting for gasoline. The per-volume value of butanol, as a chemical, is sufficient for investing into the recommercialization of the classical acetone-butanol-ethanol (ABE) (E. M. Gree...

journal_title：mBio

authors： Tracy BP

更新日期：2012-12-11 00:00:00

abstract：UNLABELLED:As diet is considered the major regulator of the gut ecosystem, the overall objective of this work was to demonstrate that a detailed knowledge of the phytochemical composition of food could add to our understanding of observed changes in functionality and activity of the gut microbiota. We used metatranscri...

journal_title：mBio

authors： Ni Y,Li J,Panagiotou G

更新日期：2015-10-27 00:00:00

abstract：UNLABELLED:Osteomyelitis is a difficult-to-eradicate bone infection typically caused by Staphylococcus aureus. In this study, we investigated the in vivo transcriptional adaptation of S. aureus during bone infection. To this end, we determined the transcriptome of S. aureus during the acute (day 7) and chronic (day 28)...

journal_title：mBio

authors： Szafranska AK,Oxley AP,Chaves-Moreno D,Horst SA,Roßlenbroich S,Peters G,Goldmann O,Rohde M,Sinha B,Pieper DH,Löffler B,Jauregui R,Wos-Oxley ML,Medina E

更新日期：2014-12-23 00:00:00

abstract：:With great apprehension, the world is now watching the birth of a novel pandemic already causing tremendous suffering, death, and disruption of normal life. Uncertainty and dread are exacerbated by the belief that what we are experiencing is new and mysterious. However, deadly pandemics and disease emergences are not ...

journal_title：mBio

authors： Morens DM,Daszak P,Markel H,Taubenberger JK

更新日期：2020-05-29 00:00:00

abstract：:SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as the primary receptor to enter host cells and initiate the infection. The critical binding region of ACE2 is an ∼30-amino-acid (aa)-long helix. Here, we report the design of four stapled peptides based on the ACE2 helix, which is expected to bind to SARS-C...

journal_title：mBio

authors： Curreli F,Victor SMB,Ahmed S,Drelich A,Tong X,Tseng CK,Hillyer CD,Debnath AK

更新日期：2020-12-11 00:00:00

abstract：UNLABELLED:The prominent host muramidase lysozyme cleaves bacterial peptidoglycan (PG), and the enzyme is abundant in mucosal secretions. The lytic enzyme susceptibility of Gram-negative bacteria and mechanisms they use to thwart lytic enzyme activity are poorly studied. We previously characterized a Helicobacter pylor...

journal_title：mBio

authors： Wang G,Lo LF,Forsberg LS,Maier RJ

更新日期：2012-12-04 00:00:00

abstract：UNLABELLED:Investigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial inhabitant, Propionibacterium acnes, which is thought to contribute to th...

journal_title：mBio

authors： Marinelli LJ,Fitz-Gibbon S,Hayes C,Bowman C,Inkeles M,Loncaric A,Russell DA,Jacobs-Sera D,Cokus S,Pellegrini M,Kim J,Miller JF,Hatfull GF,Modlin RL

更新日期：2012-09-25 00:00:00

abstract：UNLABELLED:Male circumcision reduces female-to-male HIV transmission. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. We compared the coronal sulcus microbiota of men from a group of uncircumcised controls (n = 77) a...

journal_title：mBio

authors： Liu CM,Hungate BA,Tobian AA,Serwadda D,Ravel J,Lester R,Kigozi G,Aziz M,Galiwango RM,Nalugoda F,Contente-Cuomo TL,Wawer MJ,Keim P,Gray RH,Price LB

更新日期：2013-04-16 00:00:00

abstract：:Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel vaccine development. These antibodies have been observed in humans after natura...

journal_title：mBio

authors： Park JK,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Rosas LA,Cervantes-Medina A,Taubenberger JK,Memoli MJ

更新日期：2018-01-23 00:00:00

abstract：:Protein ubiquitylation regulates not only endocellular trafficking and proteasomal degradation but also the catalytic activity of enzymes. In Saccharomyces cerevisiae, we analyzed the composition of the ubiquitylated proteomes in strains lacking acetyltransferase Gcn5p, Ub-protease Ubp8p, or both to understand their i...

journal_title：mBio

authors： De Palma A,Fanelli G,Cretella E,De Luca V,Palladino RA,Panzeri V,Roffia V,Saliola M,Mauri P,Filetici P

更新日期：2020-08-11 00:00:00

abstract：:Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro Human Pneumocystis infections present major challenges because of a limited therapeutic arsenal and the rise of drug resistance. To inv...

journal_title：mBio

authors： Cissé OH,Ma L,Wei Huang D,Khil PP,Dekker JP,Kutty G,Bishop L,Liu Y,Deng X,Hauser PM,Pagni M,Hirsch V,Lempicki RA,Stajich JE,Cuomo CA,Kovacs JA

更新日期：2018-05-08 00:00:00

abstract：UNLABELLED:West Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune responses to WNV infection have been well studied in C57BL/6J inbred mice, but this model lacks the variations in susceptibility, immunity, and outcome t...

journal_title：mBio

authors： Graham JB,Thomas S,Swarts J,McMillan AA,Ferris MT,Suthar MS,Treuting PM,Ireton R,Gale M Jr,Lund JM

更新日期：2015-05-05 00:00:00

abstract：UNLABELLED:In infection experiments with genetically distinct Mycobacterium tuberculosis complex (MTBC) strains, we identified clade-specific virulence patterns in human primary macrophages and in mice infected by the aerosol route, both reflecting relevant model systems. Exclusively human-adapted M. tuberculosis linea...

journal_title：mBio

authors： Reiling N,Homolka S,Walter K,Brandenburg J,Niwinski L,Ernst M,Herzmann C,Lange C,Diel R,Ehlers S,Niemann S

更新日期：2013-07-30 00:00:00

abstract：:The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics. Despite intensive studies since (p)ppGpp was discovered over 4 decades ago, (p)ppGpp binding proteins have not been systematically identi...

journal_title：mBio

authors： Zhang Y,Zborníková E,Rejman D,Gerdes K

更新日期：2018-03-06 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:The pharmacopeia used by physicians and laypeople in medieval Europe has largely been dismissed as placebo or superstition. While we now recognize that some of the materia medica used by medieval physicians could have had useful biological properties, research in this area is limited by the labor-intensive process of ...

journal_title：mBio

authors： Connelly E,Del Genio CI,Harrison F

更新日期：2020-02-11 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that can cause life-threatening invasive lung infections in immunodeficient patients. The cellular and molecular processes of infection during onset, establishment, and progression of A. fumigatus infections are highly complex and depend on both fungal attribut...

journal_title：mBio

authors： Amich J,Mokhtari Z,Strobel M,Vialetto E,Sheta D,Yu Y,Hartweg J,Kalleda N,Jarick KJ,Brede C,Jordán-Garrote AL,Thusek S,Schmiedgen K,Arslan B,Pinnecker J,Thornton CR,Gunzer M,Krappmann S,Einsele H,Heinze KG,Beilhack

更新日期：2020-02-04 00:00:00

abstract：UNLABELLED:Streptococcus pneumoniae (pneumococcus) is a frequent colonizer of the nasopharynx and one of the leading causative agents of otitis media, pneumonia, and meningitis. The current literature asserts that S. pneumoniae is transmitted person to person via respiratory droplets; however, environmental surfaces (f...

journal_title：mBio

authors： Walsh RL,Camilli A

更新日期：2011-05-24 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent report in mBio (E. A. Cameron, M...

journal_title：mBio

authors： Palmer LD,Skaar EP

更新日期：2019-02-26 00:00:00

abstract：:Binding of Staphylococcus aureus to the large plasma glycoprotein von Willebrand factor (vWF) is controlled by hydrodynamic flow conditions. Currently, we know little about the molecular details of this shear-stress-dependent interaction. Using single-molecule atomic force microscopy, we demonstrate that vWF binds to ...

journal_title：mBio

authors： Viela F,Prystopiuk V,Leprince A,Mahillon J,Speziale P,Pietrocola G,Dufrêne YF

更新日期：2019-04-30 00:00:00

abstract：:Posttranslational modification of a protein, either alone or in combination with other modifications, can control properties of that protein, such as enzymatic activity, localization, stability, or interactions with other molecules. N-ε-Lysine acetylation is one such modification that has gained attention in recent ye...

journal_title：mBio

authors： Christensen DG,Baumgartner JT,Xie X,Jew KM,Basisty N,Schilling B,Kuhn ML,Wolfe AJ

更新日期：2019-04-09 00:00:00

abstract：:Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resista...

journal_title：mBio

authors： Somprasong N,Hall CM,Webb JR,Sahl JW,Wagner DM,Keim P,Currie BJ,Schweizer HP

更新日期：2020-04-14 00:00:00

abstract：:Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages an...

journal_title：mBio

authors： Frazão SO,Sousa HR,Silva LGD,Folha JDS,Gorgonha KCM,Oliveira GP Jr,Felipe MSS,Silva-Pereira I,Casadevall A,Nicola AM,Albuquerque P

更新日期：2020-09-08 00:00:00

abstract：UNLABELLED:Rarely, if ever, has a single bacterial cell been confirmed to simultaneously host two fundamentally different predators. Two such predators are viruses and the predatory prokaryotes known as Bdellovibrio and like organisms. Viruses or bacteriophage are particles requiring prey cells in an active metabolic s...

journal_title：mBio

authors： Chen H,Williams HN

更新日期：2012-04-17 00:00:00

abstract：:Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by the enzyme UDP-4-keto-6-deo...

journal_title：mBio

authors： Ma L,Salas O,Bowler K,Bar-Peled M,Sharon A

更新日期：2017-11-21 00:00:00

abstract：:ZipA is an essential cell division protein in Escherichia coli Together with FtsA, ZipA tethers dynamic polymers of FtsZ to the cytoplasmic membrane, and these polymers are required to guide synthesis of the cell division septum. This dynamic behavior of FtsZ has been reconstituted on planar lipid surfaces in vitro, v...

journal_title：mBio

authors： Krupka M,Sobrinos-Sanguino M,Jiménez M,Rivas G,Margolin W

更新日期：2018-06-19 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen whose success is largely attributed to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the human host. The expression of these virulence factors is controlled by the quorum sensing accessory gene regulator (Agr) system. ...

journal_title：mBio

authors： Gor V,Takemura AJ,Nishitani M,Higashide M,Medrano Romero V,Ohniwa RL,Morikawa K

更新日期：2019-08-06 00:00:00

abstract：UNLABELLED:Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems. However, the structural specificity of these systems for sugar substrates has hindered their appl...

journal_title：mBio

authors： Pan C,Sun P,Liu B,Liang H,Peng Z,Dong Y,Wang D,Liu X,Wang B,Zeng M,Wu J,Zhu L,Wang H

更新日期：2016-04-26 00:00:00

abstract：:The 1977-1978 influenza epidemic was probably not a natural event, as the genetic sequence of the virus was nearly identical to the sequences of decades-old strains. While there are several hypotheses that could explain its origin, the possibility that the 1977 epidemic resulted from a laboratory accident has recently...

journal_title：mBio

authors： Rozo M,Gronvall GK

更新日期：2015-08-18 00:00:00

abstract：:We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by using chromatin immunoprecipitation experiments, that both PRC2 and euchromatic...

journal_title：mBio

authors： Nguyen K,Das B,Dobrowolski C,Karn J

更新日期：2017-02-28 00:00:00