Pandemic COVID-19 Joins History's Pandemic Legion.

abstract：:Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity and mortality and tend to be challenging to treat. Candida albicans and Staphylococcus aureus specifically are considered leading opportunistic fungal and bacterial pathogens, respect...

journal_title：mBio

authors： Kong EF,Tsui C,Kucharíková S,Andes D,Van Dijck P,Jabra-Rizk MA

更新日期：2016-10-11 00:00:00

abstract：UNLABELLED:A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal dr...

journal_title：mBio

authors： Abdolrasouli A,Rhodes J,Beale MA,Hagen F,Rogers TR,Chowdhary A,Meis JF,Armstrong-James D,Fisher MC

更新日期：2015-06-02 00:00:00

abstract：UNLABELLED:Heteroresistance refers to phenotypic heterogeneity of microbial clonal populations under antibiotic stress, and it has been thought to be an allocation of a subset of "resistant" cells for surviving in higher concentrations of antibiotic. The assumption fits the so-called bet-hedging strategy, where a bacte...

journal_title：mBio

authors： Wang X,Kang Y,Luo C,Zhao T,Liu L,Jiang X,Fu R,An S,Chen J,Jiang N,Ren L,Wang Q,Baillie JK,Gao Z,Yu J

更新日期：2014-02-11 00:00:00

abstract：:A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A to...

journal_title：mBio

authors： Huq A,Yunus M,Sohel SS,Bhuiya A,Emch M,Luby SP,Russek-Cohen E,Nair GB,Sack RB,Colwell RR

更新日期：2010-05-18 00:00:00

abstract：:The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studi...

journal_title：mBio

authors： Alter HJ,Mikovits JA,Switzer WM,Ruscetti FW,Lo SC,Klimas N,Komaroff AL,Montoya JG,Bateman L,Levine S,Peterson D,Levin B,Hanson MR,Genfi A,Bhat M,Zheng H,Wang R,Li B,Hung GC,Lee LL,Sameroff S,Heneine W,Coffin J

更新日期：2012-09-18 00:00:00

abstract：:The biosynthesis of antioxidant pigments, namely, betalains, was believed to be restricted to Caryophyllales plants. This paper changes this paradigm, and enzyme mining from bacterial hosts promoted the discovery of bacterial cultures producing betalains. The spectrum of possible sources of betalain pigments in nature...

journal_title：mBio

authors： Contreras-Llano LE,Guerrero-Rubio MA,Lozada-Ramírez JD,García-Carmona F,Gandía-Herrero F

更新日期：2019-03-19 00:00:00

abstract：:Mucormycosis, caused by Rhizopus species, is a life-threatening fungal infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy, immunosuppressive therapy, hematologic malignancies, or severe trauma. Inhaled Rhizopus spores cause pulmonary infections in patients with h...

journal_title：mBio

authors： Alqarihi A,Gebremariam T,Gu Y,Swidergall M,Alkhazraji S,Soliman SSM,Bruno VM,Edwards JE Jr,Filler SG,Uppuluri P,Ibrahim AS

更新日期：2020-06-02 00:00:00

abstract：:Since the discovery of symbioses between sulfur-oxidizing (thiotrophic) bacteria and invertebrates at hydrothermal vents over 40 years ago, it has been assumed that autotrophic fixation of CO2 by the symbionts drives these nutritional associations. In this study, we investigated "Candidatus Kentron," the clade of symb...

journal_title：mBio

authors： Seah BKB,Antony CP,Huettel B,Zarzycki J,Schada von Borzyskowski L,Erb TJ,Kouris A,Kleiner M,Liebeke M,Dubilier N,Gruber-Vodicka HR

更新日期：2019-06-25 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. Septins are a group of 13 GTP-binding proteins that assemble into oligomeric complexes and that can form higher-order filaments. We report here that the septins SEPT2, -9, -11, and p...

journal_title：mBio

authors： Volceanov L,Herbst K,Biniossek M,Schilling O,Haller D,Nölke T,Subbarayal P,Rudel T,Zieger B,Häcker G

更新日期：2014-10-07 00:00:00

abstract：:Cryptococcus gattii, the sister species of Cryptococcus neoformans, is an emerging pathogen which gained importance in connection with the ongoing cryptococcosis outbreak on Vancouver Island. Many molecular studies have divided this species into for major lineages: VGI, VGII, VGIII, and VGIV. This commentary summarize...

journal_title：mBio

authors： Meyer W

更新日期：2015-11-17 00:00:00

abstract：UNLABELLED:A change in viral hemagglutinin (HA) receptor binding specificity from α2,3- to α2,6-linked sialic acid is necessary for highly pathogenic avian influenza (AI) virus subtype H5N1 to become pandemic. However, details of the human-adaptive change in the H5N1 virus remain unknown. Our database search of H5N1 cl...

journal_title：mBio

authors： Watanabe Y,Arai Y,Daidoji T,Kawashita N,Ibrahim MS,El-Gendy Eel-D,Hiramatsu H,Kubota-Koketsu R,Takagi T,Murata T,Takahashi K,Okuno Y,Nakaya T,Suzuki Y,Ikuta K

更新日期：2015-04-07 00:00:00

abstract：UNLABELLED:Staphylococcus aureus is a human commensal that at times turns into a serious bacterial pathogen causing life-threatening infections. For the delicate control of virulence, S. aureus employs the agr quorum-sensing system that, via the intracellular effector molecule RNAIII, regulates virulence gene expressio...

journal_title：mBio

authors： Paulander W,Nissen Varming A,Bæk KT,Haaber J,Frees D,Ingmer H

更新日期：2013-01-02 00:00:00

abstract：:Uncultured and therefore uncharacterized Bacteroidetes lineages are ubiquitous in many natural ecosystems which specialize in lignocellulose degradation. However, their metabolic contribution remains mysterious, as well-studied cultured Bacteroidetes have been shown to degrade only soluble polysaccharides within the h...

journal_title：mBio

authors： Naas AE,Mackenzie AK,Mravec J,Schückel J,Willats WG,Eijsink VG,Pope PB

更新日期：2014-08-05 00:00:00

abstract：:Antimicrobial resistance is a major health threat as it limits treatment options for infection. At the forefront of this serious issue is Acinetobacter baumannii, a Gram-negative opportunistic pathogen that exhibits the remarkable ability to resist antibiotics through multiple mechanisms. As bacterial ribosomes repres...

journal_title：mBio

authors： Morgan CE,Huang W,Rudin SD,Taylor DJ,Kirby JE,Bonomo RA,Yu EW

更新日期：2020-01-21 00:00:00

abstract：:Interindividual variation in the composition of the human gut microbiome was examined in relation to demographic and anthropometric traits, and to changes in dietary saturated fat intake and protein source. One hundred nine healthy men and women aged 21 to 65, with BMIs of 18 to 36, were randomized, after a two-week b...

journal_title：mBio

authors： Lang JM,Pan C,Cantor RM,Tang WHW,Garcia-Garcia JC,Kurtz I,Hazen SL,Bergeron N,Krauss RM,Lusis AJ

更新日期：2018-12-11 00:00:00

abstract：UNLABELLED:This study demonstrates the prevalence, phylogenetic diversity, and physiology of nitrate-reducing microorganisms capable of utilizing reduced humic acids (HA) as electron donors in agricultural soils. Most probable number (MPN) enumeration of agricultural soils revealed large populations (10(4) to 10(6) cel...

journal_title：mBio

authors： Van Trump JI,Wrighton KC,Thrash JC,Weber KA,Andersen GL,Coates JD

更新日期：2011-07-12 00:00:00

abstract：:The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the potential of modulating the...

journal_title：mBio

authors： Domínguez-Andrés J,van Crevel R,Divangahi M,Netea MG

更新日期：2020-12-22 00:00:00

abstract：UNLABELLED:Elevated intracellular levels of the bacterial second messenger c-di-GMP are known to suppress motility and promote sessility. Bacterial chemotaxis guides motile cells in gradients of attractants and repellents over broad concentration ranges, thus allowing bacteria to quickly adapt to changes in their surro...

journal_title：mBio

authors： Russell MH,Bible AN,Fang X,Gooding JR,Campagna SR,Gomelsky M,Alexandre G

更新日期：2013-03-19 00:00:00

abstract：:Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a genome-wide CRISPR-Cas9 screening approach to identify host fact...

journal_title：mBio

authors： Ma H,Qian W,Bambouskova M,Collins PL,Porter SI,Byrum AK,Zhang R,Artyomov M,Oltz EM,Mosammaparast N,Miner JJ,Diamond MS

更新日期：2020-03-10 00:00:00

abstract：UNLABELLED:Small colony variants (SCVs) are naturally occurring subpopulations of bacteria. The clinical characteristics and treatment outcomes of patients with prosthetic joint infection (PJI) caused by staphylococcal SCVs are unknown. This study was a retrospective series of 113 patients with staphylococcal PJI, with...

journal_title：mBio

authors： Tande AJ,Osmon DR,Greenwood-Quaintance KE,Mabry TM,Hanssen AD,Patel R

更新日期：2014-09-30 00:00:00

abstract：UNLABELLED:The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface for interactions between these pathogens and the respi...

journal_title：mBio

authors： Heyl KA,Klassert TE,Heinrich A,Müller MM,Klaile E,Dienemann H,Grünewald C,Bals R,Singer BB,Slevogt H

更新日期：2014-08-26 00:00:00

abstract：UNLABELLED:A 32-nucleotide (nt) RNA motif located at the 3' end of the transmissible gastroenteritis coronavirus (TGEV) genome was found to specifically interact with the host proteins glutamyl-prolyl-tRNA synthetase (EPRS) and arginyl-tRNA synthetase (RRS). This RNA motif has high homology in sequence and secondary st...

journal_title：mBio

authors： Marquez-Jurado S,Nogales A,Zuñiga S,Enjuanes L,Almazán F

更新日期：2015-03-10 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii employs a vast array of effector proteins from the rhoptry and dense granule organelles to modulate host cell biology; these effectors are known as ROPs and GRAs, respectively. To examine the individual impacts of ROPs and GRAs on host gene expression, we developed a robust...

journal_title：mBio

authors： Rastogi S,Xue Y,Quake SR,Boothroyd JC

更新日期：2020-06-09 00:00:00

abstract：:Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobact...

journal_title：mBio

authors： Hagan AK,Tripathi A,Berger D,Sherman DH,Hanna PC

更新日期：2017-09-12 00:00:00

abstract：:Biological nitrogen fixation is catalyzed by nitrogenase, a complex metalloenzyme found only in prokaryotes. N2 fixation is energetically highly expensive, and an energy-generating process such as photosynthesis can meet the energy demand of N2 fixation. However, synthesis and expression of nitrogenase are exquisitely...

journal_title：mBio

authors： Liu D,Liberton M,Yu J,Pakrasi HB,Bhattacharyya-Pakrasi M

更新日期：2018-06-05 00:00:00

abstract：:An operon comprising two genes, CA_P0037 and CA_P0036, that encode proteins of unknown function that were previously shown to be highly expressed in acidogenic cells and repressed in solventogenic and alcohologenic cells is located on the pSOL1 megaplasmid of Clostridium acetobutylicum upstream of adhE2 A CA_P0037::in...

journal_title：mBio

authors： Nguyen NP,Linder S,Flitsch SK,Schiel-Bengelsdorf B,Dürre P,Soucaille P

更新日期：2016-10-04 00:00:00

abstract：:Sinorhizobium meliloti is an alphaproteobacterium belonging to the Rhizobiales Bacteria from this order elongate their cell wall at the new cell pole, generated by cell division. Screening for protein interaction partners of the previously characterized polar growth factors RgsP and RgsM, we identified the inner membr...

journal_title：mBio

authors： Krol E,Yau HCL,Lechner M,Schäper S,Bange G,Vollmer W,Becker A

更新日期：2020-06-30 00:00:00

abstract：:5-Aminosalicylic acid (5-ASA), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is a widely used first-line medication for the treatment of ulcerative colitis, but its anti-inflammatory mechanism is not fully resolved. Here, we show that 5-ASA ameliorates colitis in dextran sulfate sodium (DSS)-tre...

journal_title：mBio

authors： Cevallos SA,Lee JY,Velazquez EM,Foegeding NJ,Shelton CD,Tiffany CR,Parry BH,Stull-Lane AR,Olsan EE,Savage HP,Nguyen H,Ghanaat SS,Byndloss AJ,Agu IO,Tsolis RM,Byndloss MX,Bäumler AJ

更新日期：2021-01-19 00:00:00

abstract：:Mobile elements-plasmids and phages-are important components of microbial function and evolution via traits that they encode and their capacity to shuttle genetic material between species. We here report the unusually rich array of mobile elements within the genome of Arsenophonus nasoniae, the son-killer symbiont of ...

journal_title：mBio

authors： Frost CL,Siozios S,Nadal-Jimenez P,Brockhurst MA,King KC,Darby AC,Hurst GDD

更新日期：2020-03-24 00:00:00

abstract：:The chemistry underpinning microbial interactions provides an integrative framework for linking the activities of individual microbes, microbial communities, plants, and their environments. Currently, we know very little about the functions of genes and metabolites within these communities because genome annotations a...

journal_title：mBio

authors： Zhalnina K,Zengler K,Newman D,Northen TR

更新日期：2018-07-17 00:00:00