Cryptococcus gattii in the Age of Whole-Genome Sequencing.

abstract：UNLABELLED:The prominent host muramidase lysozyme cleaves bacterial peptidoglycan (PG), and the enzyme is abundant in mucosal secretions. The lytic enzyme susceptibility of Gram-negative bacteria and mechanisms they use to thwart lytic enzyme activity are poorly studied. We previously characterized a Helicobacter pylor...

journal_title：mBio

authors： Wang G,Lo LF,Forsberg LS,Maier RJ

更新日期：2012-12-04 00:00:00

abstract：:SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as the primary receptor to enter host cells and initiate the infection. The critical binding region of ACE2 is an ∼30-amino-acid (aa)-long helix. Here, we report the design of four stapled peptides based on the ACE2 helix, which is expected to bind to SARS-C...

journal_title：mBio

authors： Curreli F,Victor SMB,Ahmed S,Drelich A,Tong X,Tseng CK,Hillyer CD,Debnath AK

更新日期：2020-12-11 00:00:00

abstract：:Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in the mammalian adaptation of AIVs. The H7N9 AIVs that emerged in 2013 in China easily acquired the PB2 E627K mutation u...

journal_title：mBio

authors： Liang L,Jiang L,Li J,Zhao Q,Wang J,He X,Huang S,Wang Q,Zhao Y,Wang G,Sun N,Deng G,Shi J,Tian G,Zeng X,Jiang Y,Liu L,Liu J,Chen P,Bu Z,Kawaoka Y,Chen H,Li C

更新日期：2019-06-18 00:00:00

abstract：UNLABELLED:Salmonella enterica serovar Typhimurium is one of the most common S. enterica serovars associated with U.S. foodborne outbreaks. S. Typhimurium bacteria isolated from humans exhibit wide-ranging virulence phenotypes in inbred mice, leading to speculation that some strains are more virulent in nature. However...

journal_title：mBio

authors： Hayden HS,Matamouros S,Hager KR,Brittnacher MJ,Rohmer L,Radey MC,Weiss EJ,Kim KB,Jacobs MA,Sims-Day EH,Yue M,Zaidi MB,Schifferli DM,Manning SD,Walson JL,Miller SI

更新日期：2016-03-08 00:00:00

abstract：UNLABELLED:The human pathogen Streptococcus pneumoniae (pneumococcus) exhibits a high degree of genomic diversity and plasticity. Isolates with high genomic similarity are grouped into lineages that undergo homologous recombination at variable rates. PMEN1 is a pandemic, multidrug-resistant lineage. Heterologous gene e...

journal_title：mBio

authors： Eutsey RA,Powell E,Dordel J,Salter SJ,Clark TA,Korlach J,Ehrlich GD,Hiller NL

更新日期：2015-06-16 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00

abstract：:Plant-infecting viruses utilize various strategies involving multiple viral and host factors to achieve successful systemic infections of their compatible hosts. Lettuce infectious yellows virus (LIYV), genus Crinivirus, family Closteroviridae, has long, filamentous flexuous virions and causes phloem-limited infection...

journal_title：mBio

authors： Qiao W,Medina V,Kuo YW,Falk BW

更新日期：2018-11-20 00:00:00

abstract：UNLABELLED:A mechanistic understanding of the determination and maintenance of the simplest bacterial cell shape, a sphere, remains elusive compared with that of more complex shapes. Cocci seem to lack a dedicated elongation machinery, and a spherical shape has been considered an evolutionary dead-end morphology, as a ...

journal_title：mBio

authors： Pereira AR,Hsin J,Król E,Tavares AC,Flores P,Hoiczyk E,Ng N,Dajkovic A,Brun YV,VanNieuwenhze MS,Roemer T,Carballido-Lopez R,Scheffers DJ,Huang KC,Pinho MG

更新日期：2016-09-06 00:00:00

abstract：:Posttranslational modification of a protein, either alone or in combination with other modifications, can control properties of that protein, such as enzymatic activity, localization, stability, or interactions with other molecules. N-ε-Lysine acetylation is one such modification that has gained attention in recent ye...

journal_title：mBio

authors： Christensen DG,Baumgartner JT,Xie X,Jew KM,Basisty N,Schilling B,Kuhn ML,Wolfe AJ

更新日期：2019-04-09 00:00:00

abstract：:Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of ...

journal_title：mBio

authors： Cobián Güemes AG,Lim YW,Quinn RA,Conrad DJ,Benler S,Maughan H,Edwards R,Brettin T,Cantú VA,Cuevas D,Hamidi R,Dorrestein P,Rohwer F

更新日期：2019-04-16 00:00:00

abstract：UNLABELLED:Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors durin...

journal_title：mBio

authors： Serapio-Palacios A,Navarro-Garcia F

更新日期：2016-06-21 00:00:00

abstract：:Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease. During enterotoxemia, the nearly inactive ETX prototoxin is produced in the intestines but then must be activated by proteolytic ...

journal_title：mBio

authors： Freedman JC,Li J,Uzal FA,McClane BA

更新日期：2014-10-21 00:00:00

abstract：:The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where t...

journal_title：mBio

authors： Alagaili AN,Briese T,Mishra N,Kapoor V,Sameroff SC,Burbelo PD,de Wit E,Munster VJ,Hensley LE,Zalmout IS,Kapoor A,Epstein JH,Karesh WB,Daszak P,Mohammed OB,Lipkin WI

更新日期：2014-02-25 00:00:00

abstract：UNLABELLED:The route taken by papillomaviruses from the cell surface to the nucleus during infection is incompletely understood. Here, we developed a novel human papillomavirus 16 (HPV16) pseudovirus in which the carboxy terminus of the minor capsid protein L2 is exposed on the exterior of the intact capsid prior to ce...

journal_title：mBio

authors： Zhang W,Kazakov T,Popa A,DiMaio D

更新日期：2014-09-16 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. P. aeruginosa infections are difficult to treat due to a number of antibiotic resistance mechanisms and the organism's propensity to form multicellular biofilms. Epidemic strains of P....

journal_title：mBio

authors： Oluyombo O,Penfold CN,Diggle SP

更新日期：2019-01-29 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii employs a vast array of effector proteins from the rhoptry and dense granule organelles to modulate host cell biology; these effectors are known as ROPs and GRAs, respectively. To examine the individual impacts of ROPs and GRAs on host gene expression, we developed a robust...

journal_title：mBio

authors： Rastogi S,Xue Y,Quake SR,Boothroyd JC

更新日期：2020-06-09 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated ...

journal_title：mBio

authors： Alves R,Sousa-Silva M,Vieira D,Soares P,Chebaro Y,Lorenz MC,Casal M,Soares-Silva I,Paiva S

更新日期：2020-05-12 00:00:00

abstract：:Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with M. tuberculosis, and about 15 million people with latent tuberculosis infection (LTBI) reside in the United States. An estimated 10% of indiv...

journal_title：mBio

authors： Ayyappan JP,Ganapathi U,Lizardo K,Vinnard C,Subbian S,Perlin DS,Nagajyothi JF

更新日期：2019-04-16 00:00:00

abstract：UNLABELLED:The protein YfeX from Escherichia coli has been proposed to be essential for the process of iron removal from heme by carrying out a dechelation of heme without cleavage of the porphyrin macrocycle. Since this proposed reaction is unique and would represent the first instance of the biological dechelation of...

journal_title：mBio

authors： Dailey HA,Septer AN,Daugherty L,Thames D,Gerdes S,Stabb EV,Dunn AK,Dailey TA,Phillips JD

更新日期：2011-11-08 00:00:00

abstract：UNLABELLED:The urinary tract is one of the most frequent sites of bacterial infection in humans. Uropathogenic Escherichia coli (UPEC) strains are the leading cause of urinary tract infections (UTIs) and are responsible for greater than 80% of uncomplicated cases in adults. Infection of the urinary tract occurs in an a...

journal_title：mBio

authors： Walters MS,Lane MC,Vigil PD,Smith SN,Walk ST,Mobley HL

更新日期：2012-02-07 00:00:00

abstract：:Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados)...

journal_title：mBio

authors： Wurster S,Tatara AM,Albert ND,Ibrahim AS,Heitman J,Lee SC,Shetty AC,McCracken C,Graf KT,Mikos AG,Bruno VM,Kontoyiannis DP

更新日期：2020-06-30 00:00:00

abstract：:A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying permeabilized retrovirus parti...

journal_title：mBio

authors： Jennings J,Shi J,Varadarajan J,Jamieson PJ,Aiken C

更新日期：2020-12-01 00:00:00

abstract：:Two recently submitted (but as yet unpublished) studies describe success in creating mutant isolates of H5N1 influenza A virus that can be transmitted via the respiratory route between ferrets; concern has been raised regarding human-to-human transmissibility of these or similar laboratory-generated influenza viruses....

journal_title：mBio

authors： Osterholm MT,Kelley NS

更新日期：2012-02-24 00:00:00

abstract：UNLABELLED:The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is req...

journal_title：mBio

authors： Ekici S,Yang H,Koch HG,Daldal F

更新日期：2012-01-31 00:00:00

abstract：UNLABELLED:Mycobacterium tuberculosis depends on aerobic respiration for growth and utilizes an aa3-type cytochrome c oxidase for terminal electron transfer. Cytochrome c maturation in bacteria requires covalent attachment of heme to apocytochrome c, which occurs outside the cytoplasmic membrane. We demonstrate that in...

journal_title：mBio

authors： Small JL,Park SW,Kana BD,Ioerger TR,Sacchettini JC,Ehrt S

更新日期：2013-09-17 00:00:00

abstract：:Recent studies have greatly extended our understanding of the microbiota present in and on the human body. Here, advanced sequencing strategies have provided unprecedented analytical power. The important implications that the emerging data have for human health emphasize the need to intensify research in this area (D....

journal_title：mBio

authors： Rogers GB,Bruce KD

更新日期：2012-11-06 00:00:00

abstract：UNLABELLED:Elongins B and C are members of complexes that increase the efficiency of transcriptional elongation by RNA polymerase II (RNAPII) and enhance the monoubiquitination of histone H2B, an epigenetic mark of actively transcribed genes. Here we show that, in addition to its role in facilitating transcription of t...

journal_title：mBio

authors： Hwang J,Saffert RT,Kalejta RF

更新日期：2011-03-29 00:00:00

abstract：UNLABELLED:Exploiting mechanisms of utilizing the sugar d-galactose in Escherichia coli as a model system, we explored the consequences of accumulation of critical intermediates of the d-galactose metabolic pathways by monitoring cell growth, metabolites, and transcript profiles. These studies revealed both metabolic n...

journal_title：mBio

authors： Lee SJ,Trostel A,Adhya S

更新日期：2014-01-28 00:00:00

abstract：UNLABELLED:The bacterial flagellum is driven by a bidirectional rotary motor, which propels bacteria to swim through liquids or swarm over surfaces. While the functions of the major structural and regulatory components of the flagellum are known, the function of the well-conserved FliL protein is not. In Salmonella and...

journal_title：mBio

authors： Partridge JD,Nieto V,Harshey RM

更新日期：2015-02-24 00:00:00