Mechanisms, Detection, and Relevance of Protein Acetylation in Prokaryotes.

abstract：:The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where t...

journal_title：mBio

authors： Alagaili AN,Briese T,Mishra N,Kapoor V,Sameroff SC,Burbelo PD,de Wit E,Munster VJ,Hensley LE,Zalmout IS,Kapoor A,Epstein JH,Karesh WB,Daszak P,Mohammed OB,Lipkin WI

更新日期：2014-02-25 00:00:00

abstract：:Escherichia coli mazEF is an extensively studied stress-induced toxin-antitoxin (TA) system. The toxin MazF is an endoribonuclease that cleaves RNAs at ACA sites. Thereby, under stress, the induced MazF generates a stress-induced translation machinery (STM), composed of MazF-processed mRNAs and selective ribosomes tha...

journal_title：mBio

authors： Oron-Gottesman A,Sauert M,Moll I,Engelberg-Kulka H

更新日期：2016-11-15 00:00:00

abstract：:Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an important phase in their development. Here, we present a systemati...

journal_title：mBio

authors： Obaldia N 3rd,Meibalan E,Sa JM,Ma S,Clark MA,Mejia P,Moraes Barros RR,Otero W,Ferreira MU,Mitchell JR,Milner DA,Huttenhower C,Wirth DF,Duraisingh MT,Wellems TE,Marti M

更新日期：2018-05-08 00:00:00

abstract：UNLABELLED:Epstein-Barr virus (EBV), along with other members of the herpesvirus family, requires a set of viral glycoproteins to mediate host cell attachment and entry. Viral glycoprotein B (gB), a highly conserved glycoprotein within the herpesvirus family, is thought to be the viral fusogen based on structural compa...

journal_title：mBio

authors： Garcia NJ,Chen J,Longnecker R

更新日期：2013-01-22 00:00:00

abstract：:SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Streptococcus pyogenes,...

journal_title：mBio

authors： Port GC,Cusumano ZT,Tumminello PR,Caparon MG

更新日期：2017-03-28 00:00:00

abstract：:Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated ...

journal_title：mBio

authors： Alves R,Sousa-Silva M,Vieira D,Soares P,Chebaro Y,Lorenz MC,Casal M,Soares-Silva I,Paiva S

更新日期：2020-05-12 00:00:00

abstract：UNLABELLED:Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level. Here, we present an analysis of CME in the human fungal pathogen Candida albicans that shows the same modular structure as those in other fungi and mammalian cells. Intriguingly, C. albic...

journal_title：mBio

authors： Epp E,Nazarova E,Regan H,Douglas LM,Konopka JB,Vogel J,Whiteway M

更新日期：2013-08-27 00:00:00

abstract：:Cell surface expression of sialic acid has been reported to decrease during immune cell activation, but the significance and regulation of this phenomenon are still being investigated. The major human bacterial pathogen Streptococcus pneumoniae causes pneumonia, sepsis and meningitis, often accompanied by strong infla...

journal_title：mBio

authors： Chang YC,Uchiyama S,Varki A,Nizet V

更新日期：2012-01-03 00:00:00

abstract：:Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response. Deletion of NS1 (DelNS1) would create a safer and more extensively immunogenic live attenuated influenza virus (LAIV) vaccine. However, DelNS1 vir...

journal_title：mBio

authors： Wang P,Zheng M,Lau SY,Chen P,Mok BW,Liu S,Liu H,Huang X,Cremin CJ,Song W,Chen Y,Wong YC,Huang H,To KK,Chen Z,Xia N,Yuen KY,Chen H

更新日期：2019-09-17 00:00:00

abstract：:Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference (RNAi) response are poorly understood. Here, we characterized antiviral RN...

journal_title：mBio

authors： Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW

更新日期：2020-08-04 00:00:00

abstract：:The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence. In this study, we identified a novel mitochondrial co-chaperone, Mrj1 (mitochondrial re...

journal_title：mBio

authors： Horianopoulos LC,Hu G,Caza M,Schmitt K,Overby P,Johnson JD,Valerius O,Braus GH,Kronstad JW

更新日期：2020-06-09 00:00:00

abstract：:Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease. During enterotoxemia, the nearly inactive ETX prototoxin is produced in the intestines but then must be activated by proteolytic ...

journal_title：mBio

authors： Freedman JC,Li J,Uzal FA,McClane BA

更新日期：2014-10-21 00:00:00

abstract：UNLABELLED:While research has identified an important contribution for metals, such as iron, in microbial pathogenesis, the roles of other transition metals, such as copper, remain mostly unknown. Recent evidence points to a requirement for copper homeostasis in the virulence of Cryptococcus neoformans based on a role ...

journal_title：mBio

authors： Waterman SR,Park YD,Raja M,Qiu J,Hammoud DA,O'Halloran TV,Williamson PR

更新日期：2012-10-02 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the CFTR gene and is associated with progressive and ultimately fatal infectious lung disease. There can be considerable variability in disease severity among individuals with the same CFTR mutations, and recent genome-wide association studies have identified secondary ge...

journal_title：mBio

authors： Di Paola M,Park AJ,Ahmadi S,Roach EJ,Wu YS,Struder-Kypke M,Lam JS,Bear CE,Khursigara CM

更新日期：2017-12-19 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：:The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels an...

journal_title：mBio

authors： Andrade DV,Katzelnick LC,Widman DG,Balmaseda A,de Silva AM,Baric RS,Harris E

更新日期：2017-09-19 00:00:00

abstract：:UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar moiety is incorporated into glycosylphosphatidylinositol (GPI) glycolipids and N- and O-linked glycans. Apicomplexan parasites have a hexosamine pathway compa...

journal_title：mBio

authors： Chi J,Cova M,de Las Rivas M,Medina A,Borges RJ,Leivar P,Planas A,Usón I,Hurtado-Guerrero R,Izquierdo L

更新日期：2020-10-20 00:00:00

abstract：:The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell wall-acting antibiotics. In rich medium, c-di-AMP is essential; however, muta...

journal_title：mBio

authors： Peterson BN,Young MKM,Luo S,Wang J,Whiteley AT,Woodward JJ,Tong L,Wang JD,Portnoy DA

更新日期：2020-08-25 00:00:00

abstract：:The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the potential of modulating the...

journal_title：mBio

authors： Domínguez-Andrés J,van Crevel R,Divangahi M,Netea MG

更新日期：2020-12-22 00:00:00

abstract：:Malaria parasites increase their host erythrocyte's permeability to various nutrients, fueling intracellular pathogen development and replication. The plasmodial surface anion channel (PSAC) mediates this uptake and is linked to the parasite-encoded RhopH complex, consisting of CLAG3, RhopH2, and RhopH3. While interac...

journal_title：mBio

authors： Ahmad M,Manzella-Lapeira J,Saggu G,Ito D,Brzostowski JA,Desai SA

更新日期：2020-09-08 00:00:00

abstract：:Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the natural evolution of ...

journal_title：mBio

authors： Broset E,Martín C,Gonzalo-Asensio J

更新日期：2015-10-20 00:00:00

abstract：UNLABELLED:Pseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are major problems that can complicate antibiotic therapy. We evaluated the efficacy of using bacteriophages to kill the pathogen i...

journal_title：mBio

authors： Alemayehu D,Casey PG,McAuliffe O,Guinane CM,Martin JG,Shanahan F,Coffey A,Ross RP,Hill C

更新日期：2012-03-06 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131), a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC) infections, has been known widely for its contribution to the worldwide dissemination of multidrug resistance. Although other ExPEC-associated and extended-spectrum-β-lactamase ...

journal_title：mBio

authors： Shaik S,Ranjan A,Tiwari SK,Hussain A,Nandanwar N,Kumar N,Jadhav S,Semmler T,Baddam R,Islam MA,Alam M,Wieler LH,Watanabe H,Ahmed N

更新日期：2017-10-24 00:00:00

abstract：UNLABELLED:Cholera continues to be a global threat, with high rates of morbidity and mortality. In 2011, a cholera outbreak occurred in Palawan, Philippines, affecting more than 500 people, and 20 individuals died. Vibrio cholerae O1 was confirmed as the etiological agent. Source attribution is critical in cholera outb...

journal_title：mBio

authors： Klinzing DC,Choi SY,Hasan NA,Matias RR,Tayag E,Geronimo J,Skowronski E,Rashed SM,Kawashima K,Rosenzweig CN,Gibbons HS,Torres BC,Liles V,Alfon AC,Juan ML,Natividad FF,Cebula TA,Colwell RR

更新日期：2015-04-21 00:00:00

abstract：:While Shiga toxins (Stx) are key determinants of enterohemorrhagic Escherichia coli (EHEC) pathophysiology in humans, their dissemination to target organs following gastrointestinal EHEC infection is still poorly understood. Most types of Stx target cells with globotriaosylceramide (Gb3) receptors, which are expressed...

journal_title：mBio

authors： Lengeling A,Mahajan A,Gally DL

更新日期：2013-11-12 00:00:00

abstract：:Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynt...

journal_title：mBio

authors： Shrivastava-Ranjan P,Bergeron É,Chakrabarti AK,Albariño CG,Flint M,Nichol ST,Spiropoulou CF

更新日期：2016-12-20 00:00:00

abstract：:To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we constructed a genome encyclopedia describing the core supragingival plaque microb...

journal_title：mBio

authors： Espinoza JL,Harkins DM,Torralba M,Gomez A,Highlander SK,Jones MB,Leong P,Saffery R,Bockmann M,Kuelbs C,Inman JM,Hughes T,Craig JM,Nelson KE,Dupont CL

更新日期：2018-11-27 00:00:00

abstract：:Pseudomonas aeruginosa produces an extracellular biofilm matrix that consists of nucleic acids, exopolysaccharides, lipid vesicles, and proteins. In general, the protein component of the biofilm matrix is poorly defined and understudied relative to the other major matrix constituents. While matrix proteins have been s...

journal_title：mBio

authors： Tseng BS,Reichhardt C,Merrihew GE,Araujo-Hernandez SA,Harrison JJ,MacCoss MJ,Parsek MR

更新日期：2018-04-10 00:00:00

abstract：:Enteroaggregative Escherichia coli (EAEC) is an important diarrheal pathogen and a cause of both acute and chronic diarrhea. It is a common cause of pediatric bacterial diarrhea in developing countries. Despite its discovery in 1987, the intestinal tropism of the pathogen remains unknown. Cell lines used to study EAEC...

journal_title：mBio

authors： Rajan A,Vela L,Zeng XL,Yu X,Shroyer N,Blutt SE,Poole NM,Carlin LG,Nataro JP,Estes MK,Okhuysen PC,Maresso AW

更新日期：2018-02-20 00:00:00