A new player at the flagellar motor: FliL controls both motor output and bias.

abstract：:The major oxidative stress response in Streptomyces is controlled by the sigma factor SigR and its cognate antisigma factor RsrA, and SigR activity is tightly controlled through multiple mechanisms at both the transcriptional and posttranslational levels. Here we show that sigR has a highly unusual GTC start codon and...

journal_title：mBio

authors： Feeney MA,Chandra G,Findlay KC,Paget MSB,Buttner MJ

更新日期：2017-06-13 00:00:00

abstract：UNLABELLED:Enoyl-acyl carrier protein (enoyl-ACP) reductase catalyzes the last step of the elongation cycle in the synthesis of bacterial fatty acids. The Enterococcus faecalis genome contains two genes annotated as enoyl-ACP reductases, a FabI-type enoyl-ACP reductase and a FabK-type enoyl-ACP reductase. We report tha...

journal_title：mBio

authors： Zhu L,Bi H,Ma J,Hu Z,Zhang W,Cronan JE,Wang H

更新日期：2013-10-01 00:00:00

abstract：:The human antibody repertoire has an exceptionally large capacity to recognize new or changing antigens through combinatorial and junctional diversity established at the time of V(D)J recombination and through somatic hypermutation. Influenza viruses exhibit a relentless capacity to escape the human antibody response ...

journal_title：mBio

authors： Crowe JE Jr

更新日期：2012-07-31 00:00:00

abstract：:Formation of multispecies communities allows nearly every niche on earth to be colonized, and the exchange of molecular information among neighboring bacteria in such communities is key for bacterial success. To clarify the principles controlling interspecies interactions, we previously developed a coculture model wit...

journal_title：mBio

authors： Ranava D,Backes C,Karthikeyan G,Ouari O,Soric A,Guiral M,Cárdenas ML,Giudici-Orticoni MT

更新日期：2021-01-19 00:00:00

abstract：:Escherichia coli mazEF is an extensively studied stress-induced toxin-antitoxin (TA) system. The toxin MazF is an endoribonuclease that cleaves RNAs at ACA sites. Thereby, under stress, the induced MazF generates a stress-induced translation machinery (STM), composed of MazF-processed mRNAs and selective ribosomes tha...

journal_title：mBio

authors： Oron-Gottesman A,Sauert M,Moll I,Engelberg-Kulka H

更新日期：2016-11-15 00:00:00

abstract：:Aspergillosis associated with azole-resistant Aspergillus fumigatus has a mortality rate that can approach 90% in certain patient populations. The best-understood avenue for azole resistance involves changes in the cyp51A gene that encodes the target of azole drugs, lanosterol α-14 demethylase. The most common azole r...

journal_title：mBio

authors： Paul S,Stamnes M,Thomas GH,Liu H,Hagiwara D,Gomi K,Filler SG,Moye-Rowley WS

更新日期：2019-03-12 00:00:00

abstract：:Mucormycosis, caused by Rhizopus species, is a life-threatening fungal infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy, immunosuppressive therapy, hematologic malignancies, or severe trauma. Inhaled Rhizopus spores cause pulmonary infections in patients with h...

journal_title：mBio

authors： Alqarihi A,Gebremariam T,Gu Y,Swidergall M,Alkhazraji S,Soliman SSM,Bruno VM,Edwards JE Jr,Filler SG,Uppuluri P,Ibrahim AS

更新日期：2020-06-02 00:00:00

abstract：UNLABELLED:Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE surface membrane. To investigate the relationship between ...

journal_title：mBio

authors： Subramani R,Quadt K,Jeppesen AE,Hempel C,Petersen JE,Hassenkam T,Hviid L,Barfod L

更新日期：2015-10-06 00:00:00

abstract：:The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...

journal_title：mBio

authors： Ausiello CM,Cassone A

更新日期：2014-06-10 00:00:00

abstract：UNLABELLED:Carbonate chimneys at the Lost City hydrothermal field are coated in biofilms dominated by a single phylotype of archaea known as Lost City Methanosarcinales. In this study, we have detected surprising physiological complexity in single-species biofilms, which is typically indicative of multispecies biofilm ...

journal_title：mBio

authors： Brazelton WJ,Mehta MP,Kelley DS,Baross JA

更新日期：2011-09-01 00:00:00

abstract：:Protein ubiquitylation regulates not only endocellular trafficking and proteasomal degradation but also the catalytic activity of enzymes. In Saccharomyces cerevisiae, we analyzed the composition of the ubiquitylated proteomes in strains lacking acetyltransferase Gcn5p, Ub-protease Ubp8p, or both to understand their i...

journal_title：mBio

authors： De Palma A,Fanelli G,Cretella E,De Luca V,Palladino RA,Panzeri V,Roffia V,Saliola M,Mauri P,Filetici P

更新日期：2020-08-11 00:00:00

abstract：:New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antitubercular agents in vitro All five compounds showed good activity against M. tu...

journal_title：mBio

authors： Foo CS,Lupien A,Kienle M,Vocat A,Benjak A,Sommer R,Lamprecht DA,Steyn AJC,Pethe K,Piton J,Altmann KH,Cole ST

更新日期：2018-10-09 00:00:00

abstract：:Yellow fever virus (YFV) is an arthropod-borne flavivirus, infecting ~200,000 people worldwide annually and causing about 30,000 deaths. The live attenuated vaccine strain, YFV-17D, has significantly contributed in controlling the global burden of yellow fever worldwide. However, the viral and host contributions to YF...

journal_title：mBio

authors： Douam F,Soto Albrecht YE,Hrebikova G,Sadimin E,Davidson C,Kotenko SV,Ploss A

更新日期：2017-08-15 00:00:00

abstract：:Listeria monocytogenes is a bacterial pathogen causing severe foodborne infections in humans and animals. Listeria can enter into host cells and survive and multiply therein, due to an arsenal of virulence determinants encoded in different loci on the chromosome. Several key Listeria virulence genes are clustered in L...

journal_title：mBio

authors： Prokop A,Gouin E,Villiers V,Nahori MA,Vincentelli R,Duval M,Cossart P,Dussurget O

更新日期：2017-10-31 00:00:00

abstract：:Bacillus anthracis is a Gram-positive bacillus that under conditions of environmental stress, such as low nutrients, can convert from a vegetative bacillus to a highly durable spore that enables long-term survival. The sporulation process is regulated by a sequential cascade of dedicated transcription factors but requ...

journal_title：mBio

authors： Hagan AK,Plotnick YM,Dingle RE,Mendel ZI,Cendrowski SR,Sherman DH,Tripathi A,Hanna PC

更新日期：2018-11-06 00:00:00

abstract：:Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny. In contrast, adhesion and biofilm formation, which are potentially involved in gut colonization...

journal_title：mBio

authors： Béchon N,Mihajlovic J,Vendrell-Fernández S,Chain F,Langella P,Beloin C,Ghigo JM

更新日期：2020-06-23 00:00:00

abstract：:In immunocompromised hosts, latent infection with Toxoplasma gondii can reactivate from tissue cysts, leading to encephalitis. A characteristic of T. gondii bradyzoites in tissue cysts is the presence of amylopectin granules. The regulatory mechanisms and role of amylopectin accumulation in this organism are not fully...

journal_title：mBio

authors： Sugi T,Tu V,Ma Y,Tomita T,Weiss LM

更新日期：2017-08-29 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the CFTR gene and is associated with progressive and ultimately fatal infectious lung disease. There can be considerable variability in disease severity among individuals with the same CFTR mutations, and recent genome-wide association studies have identified secondary ge...

journal_title：mBio

authors： Di Paola M,Park AJ,Ahmadi S,Roach EJ,Wu YS,Struder-Kypke M,Lam JS,Bear CE,Khursigara CM

更新日期：2017-12-19 00:00:00

abstract：:Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved am...

journal_title：mBio

authors： Schubert K,Sieger B,Meyer F,Giacomelli G,Böhm K,Rieblinger A,Lindenthal L,Sachs N,Wanner G,Bramkamp M

更新日期：2017-02-07 00:00:00

abstract：:Since the discovery of symbioses between sulfur-oxidizing (thiotrophic) bacteria and invertebrates at hydrothermal vents over 40 years ago, it has been assumed that autotrophic fixation of CO2 by the symbionts drives these nutritional associations. In this study, we investigated "Candidatus Kentron," the clade of symb...

journal_title：mBio

authors： Seah BKB,Antony CP,Huettel B,Zarzycki J,Schada von Borzyskowski L,Erb TJ,Kouris A,Kleiner M,Liebeke M,Dubilier N,Gruber-Vodicka HR

更新日期：2019-06-25 00:00:00

abstract：:Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a genome-wide CRISPR-Cas9 screening approach to identify host fact...

journal_title：mBio

authors： Ma H,Qian W,Bambouskova M,Collins PL,Porter SI,Byrum AK,Zhang R,Artyomov M,Oltz EM,Mosammaparast N,Miner JJ,Diamond MS

更新日期：2020-03-10 00:00:00

abstract：:Binding of Staphylococcus aureus to the large plasma glycoprotein von Willebrand factor (vWF) is controlled by hydrodynamic flow conditions. Currently, we know little about the molecular details of this shear-stress-dependent interaction. Using single-molecule atomic force microscopy, we demonstrate that vWF binds to ...

journal_title：mBio

authors： Viela F,Prystopiuk V,Leprince A,Mahillon J,Speziale P,Pietrocola G,Dufrêne YF

更新日期：2019-04-30 00:00:00

abstract：:Innate immune response plays a critical role in controlling invading pathogens, but such an immune response must be tightly regulated. Insufficient or overactivated immune responses may lead to harmful or even fatal consequences. To dissect the complex host-parasite interactions and the molecular mechanisms underlying...

journal_title：mBio

authors： Cai B,Wu J,Yu X,Su XZ,Wang RF

更新日期：2017-01-03 00:00:00

abstract：UNLABELLED:Antibiotics are a cost-effective tool for improving feed efficiency and preventing disease in agricultural animals, but the full scope of their collateral effects is not understood. Antibiotics have been shown to mediate gene transfer by inducing prophages in certain bacterial strains; therefore, one collate...

journal_title：mBio

authors： Allen HK,Looft T,Bayles DO,Humphrey S,Levine UY,Alt D,Stanton TB

更新日期：2011-11-29 00:00:00

abstract：:Plant roots support complex microbial communities that can influence plant growth, nutrition, and health. While extensive characterizations of the composition and spatial compartmentalization of these communities have been performed in different plant species, there is relatively little known about the impact of abiot...

journal_title：mBio

authors： Santos-Medellín C,Edwards J,Liechty Z,Nguyen B,Sundaresan V

更新日期：2017-07-18 00:00:00

abstract：UNLABELLED:The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is req...

journal_title：mBio

authors： Ekici S,Yang H,Koch HG,Daldal F

更新日期：2012-01-31 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:Our current understanding of lipoprotein synthesis and localization in Gram-negative bacteria is based primarily on studies of Escherichia coli Newly synthesized E. coli prolipoproteins undergo posttranslational modifications catalyzed by three essential enzymes (Lgt, LspA, and Lnt). The mature lipoproteins are then s...

journal_title：mBio

authors： McClain MS,Voss BJ,Cover TL

更新日期：2020-05-19 00:00:00

abstract：:Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spectrum antibacterial activity....

journal_title：mBio

authors： Reithuber E,Nannapaneni P,Rzhepishevska O,Lindgren AEG,Ilchenko O,Normark S,Almqvist F,Henriques-Normark B,Mellroth P

更新日期：2020-12-15 00:00:00

abstract：UNLABELLED:West Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune responses to WNV infection have been well studied in C57BL/6J inbred mice, but this model lacks the variations in susceptibility, immunity, and outcome t...

journal_title：mBio

authors： Graham JB,Thomas S,Swarts J,McMillan AA,Ferris MT,Suthar MS,Treuting PM,Ireton R,Gale M Jr,Lund JM

更新日期：2015-05-05 00:00:00