FtsZ-Dependent Elongation of a Coccoid Bacterium.

abstract：:Gammaherpesviruses (γHVs) are generally considered host specific and to have codiverged with their hosts over millions of years. This tenet is challenged here by broad-scale phylogenetic analysis of two viral genes using the largest sample of mammalian γHVs to date, integrating for the first time bat γHV sequences ava...

journal_title：mBio

authors： Escalera-Zamudio M,Rojas-Anaya E,Kolokotronis SO,Taboada B,Loza-Rubio E,Méndez-Ojeda ML,Arias CF,Osterrieder N,Greenwood AD

更新日期：2016-11-08 00:00:00

abstract：:Mucormycosis, caused by Rhizopus species, is a life-threatening fungal infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy, immunosuppressive therapy, hematologic malignancies, or severe trauma. Inhaled Rhizopus spores cause pulmonary infections in patients with h...

journal_title：mBio

authors： Alqarihi A,Gebremariam T,Gu Y,Swidergall M,Alkhazraji S,Soliman SSM,Bruno VM,Edwards JE Jr,Filler SG,Uppuluri P,Ibrahim AS

更新日期：2020-06-02 00:00:00

abstract：:As the GroES/GroEL chaperonin system is the only bacterial chaperone that is essential under all conditions, we have been interested in the development of GroES/GroEL inhibitors as potential antibiotics. Using Escherichia coli GroES/GroEL as a surrogate, we have discovered several classes of GroES/GroEL inhibitors tha...

journal_title：mBio

authors： Sivinski J,Ambrose AJ,Panfilenko I,Zerio CJ,Machulis JM,Mollasalehi N,Kaneko LK,Stevens M,Ray AM,Park Y,Wu C,Hoang QQ,Johnson SM,Chapman E

更新日期：2021-01-12 00:00:00

abstract：UNLABELLED:Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level. Here, we present an analysis of CME in the human fungal pathogen Candida albicans that shows the same modular structure as those in other fungi and mammalian cells. Intriguingly, C. albic...

journal_title：mBio

authors： Epp E,Nazarova E,Regan H,Douglas LM,Konopka JB,Vogel J,Whiteway M

更新日期：2013-08-27 00:00:00

abstract：:All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for ...

journal_title：mBio

authors： Guerardel Y,Sadovskaya I,Maes E,Furlan S,Chapot-Chartier MP,Mesnage S,Rigottier-Gois L,Serror P

更新日期：2020-04-28 00:00:00

abstract：UNLABELLED:β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients. Systematically tracking β-lactam resistance could benefit disease surveillance. Here we developed a classification syst...

journal_title：mBio

authors： Li Y,Metcalf BJ,Chochua S,Li Z,Gertz RE Jr,Walker H,Hawkins PA,Tran T,Whitney CG,McGee L,Beall BW

更新日期：2016-06-14 00:00:00

abstract：UNLABELLED:The human pathogen Streptococcus pneumoniae (pneumococcus) exhibits a high degree of genomic diversity and plasticity. Isolates with high genomic similarity are grouped into lineages that undergo homologous recombination at variable rates. PMEN1 is a pandemic, multidrug-resistant lineage. Heterologous gene e...

journal_title：mBio

authors： Eutsey RA,Powell E,Dordel J,Salter SJ,Clark TA,Korlach J,Ehrlich GD,Hiller NL

更新日期：2015-06-16 00:00:00

abstract：:Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated ...

journal_title：mBio

authors： Alves R,Sousa-Silva M,Vieira D,Soares P,Chebaro Y,Lorenz MC,Casal M,Soares-Silva I,Paiva S

更新日期：2020-05-12 00:00:00

abstract：:Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel vaccine development. These antibodies have been observed in humans after natura...

journal_title：mBio

authors： Park JK,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Rosas LA,Cervantes-Medina A,Taubenberger JK,Memoli MJ

更新日期：2018-01-23 00:00:00

abstract：UNLABELLED:Toll-like receptor 4 is thought to have a primary role in host defense against Escherichia coli bladder colonization, based on mouse models of urinary tract infection using C3H/HeJ female mice. This strain carries a point mutation in the Tlr4 gene, which renders the mice unresponsive to lipopolysaccharide (L...

journal_title：mBio

authors： Suhs KA,Marthaler BR,Welch RA,Hopkins WJ

更新日期：2011-05-31 00:00:00

abstract：:Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral dUTPase (vDUT), each with enzymatic and nonenzymatic functions. However, the coordinated roles of these enzymatic activities in gammaherpesvirus pat...

journal_title：mBio

authors： Dong Q,Smith KR,Oldenburg DG,Shapiro M,Schutt WR,Malik L,Plummer JB,Mu Y,MacCarthy T,White DW,McBride KM,Krug LT

更新日期：2018-10-30 00:00:00

abstract：:The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown mechanisms. Here we show that bacterial delivery or ectopic expres...

journal_title：mBio

authors： Keestra AM,Winter MG,Klein-Douwel D,Xavier MN,Winter SE,Kim A,Tsolis RM,Bäumler AJ

更新日期：2011-12-20 00:00:00

abstract：:Aspergillus fumigatus is the leading cause of pulmonary fungal diseases. Azoles have been used for many years as the main antifungal agents to treat and prevent invasive aspergillosis. However, in the last 10 years there have been several reports of azole resistance in A. fumigatus and new strategies are needed to com...

journal_title：mBio

authors： Valero C,Colabardini AC,Chiaratto J,Pardeshi L,de Castro PA,Ferreira Filho JA,Silva LP,Rocha MC,Malavazi I,Costa JH,Fill T,Barros MH,Wong SSW,Aimanianda V,Wong KH,Goldman GH

更新日期：2020-06-16 00:00:00

abstract：:The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriaceae serves as an important indicator that the golden era of antibiotics is unde...

journal_title：mBio

authors： Bulman ZP,Chen L,Walsh TJ,Satlin MJ,Qian Y,Bulitta JB,Peloquin CA,Holden PN,Nation RL,Li J,Kreiswirth BN,Tsuji BT

更新日期：2017-07-25 00:00:00

abstract：:Many viruses produce protein-coding and noncoding subgenomic RNAs (sgRNAs) that are critical for infection. A recently discovered pathway for viral sgRNA production uses exoribonuclease-resistant RNAs (xrRNAs), discrete folded RNA elements that block the processive exoribonucleolytic degradation of RNA. xrRNAs are wid...

journal_title：mBio

authors： Steckelberg AL,Vicens Q,Kieft JS

更新日期：2018-12-18 00:00:00

abstract：UNLABELLED:Sensing of and responding to environmental changes are of vital importance for microbial cells. Consequently, bacteria have evolved a plethora of signaling systems that usually sense biochemical cues either via direct ligand binding, thereby acting as "concentration sensors," or by responding to downstream e...

journal_title：mBio

authors： Fritz G,Dintner S,Treichel NS,Radeck J,Gerland U,Mascher T,Gebhard S

更新日期：2015-07-21 00:00:00

abstract：:Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobact...

journal_title：mBio

authors： Hagan AK,Tripathi A,Berger D,Sherman DH,Hanna PC

更新日期：2017-09-12 00:00:00

abstract：:Nutritional immunity is an elegant host mechanism used to starve invading pathogens of necessary nutrient metals. Calprotectin, a metal-binding protein, is produced abundantly by neutrophils and is found in high concentrations within inflammatory sites during infection. Group B Streptococcus (GBS) colonizes the gastro...

journal_title：mBio

authors： Burcham LR,Le Breton Y,Radin JN,Spencer BL,Deng L,Hiron A,Ransom MR,Mendonça JDC,Belew AT,El-Sayed NM,McIver KS,Kehl-Fie TE,Doran KS

更新日期：2020-11-10 00:00:00

abstract：:Systemic infections of Candida species pose a significant threat to public health. Toxicity associated with current therapies and emergence of resistant strains present major therapeutic challenges. Here, we report exploitation of the probiotic properties of two novel, food-derived yeasts, Saccharomyces cerevisiae (st...

journal_title：mBio

authors： Kunyeit L,Kurrey NK,Anu-Appaiah KA,Rao RP

更新日期：2019-10-15 00:00:00

abstract：UNLABELLED:Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. Like many coronaviruses, MERS-CoV carries genes that encode multiple accessory proteins that are not required for replicat...

journal_title：mBio

authors： Thornbrough JM,Jha BK,Yount B,Goldstein SA,Li Y,Elliott R,Sims AC,Baric RS,Silverman RH,Weiss SR

更新日期：2016-03-29 00:00:00

abstract：UNLABELLED:Rarely, if ever, has a single bacterial cell been confirmed to simultaneously host two fundamentally different predators. Two such predators are viruses and the predatory prokaryotes known as Bdellovibrio and like organisms. Viruses or bacteriophage are particles requiring prey cells in an active metabolic s...

journal_title：mBio

authors： Chen H,Williams HN

更新日期：2012-04-17 00:00:00

abstract：:The diversity of the genetic code systems used by microbes on earth is yet to be elucidated. It is known that certain methanogenic archaea employ an alternative system for cysteine (Cys) biosynthesis and encoding; tRNACys is first acylated with phosphoserine (Sep) by O-phosphoseryl-tRNA synthetase (SepRS) and then con...

journal_title：mBio

authors： Mukai T,Crnković A,Umehara T,Ivanova NN,Kyrpides NC,Söll D

更新日期：2017-05-09 00:00:00

abstract：UNLABELLED:Acinetobacter baumannii is a nosocomial pathogen of increasing importance due to its multiple resistance to antibiotics and ability to survive in the hospital environment linked to its capacity to form biofilms. To fully characterize the contribution of AdeABC, AdeFGH, and AdeIJK resistance-nodulation-cell d...

journal_title：mBio

authors： Yoon EJ,Chabane YN,Goussard S,Snesrud E,Courvalin P,Dé E,Grillot-Courvalin C

更新日期：2015-03-24 00:00:00

abstract：UNLABELLED:Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE surface membrane. To investigate the relationship between ...

journal_title：mBio

authors： Subramani R,Quadt K,Jeppesen AE,Hempel C,Petersen JE,Hassenkam T,Hviid L,Barfod L

更新日期：2015-10-06 00:00:00

abstract：UNLABELLED:A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal dr...

journal_title：mBio

authors： Abdolrasouli A,Rhodes J,Beale MA,Hagen F,Rogers TR,Chowdhary A,Meis JF,Armstrong-James D,Fisher MC

更新日期：2015-06-02 00:00:00

abstract：UNLABELLED:The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we have taken advantage of a zebrafish model to investigate host-pathogen interactions of Cryptococcus w...

journal_title：mBio

authors： Tenor JL,Oehlers SH,Yang JL,Tobin DM,Perfect JR

更新日期：2015-09-29 00:00:00

abstract：:The ability to withstand UV damage shapes the ecology of microbes. While mechanisms of UV tolerance were extensively investigated in microorganisms regularly exposed to the sun, far less is known about UV repair of soilborne microorganisms. Fusarium oxysporum is a soilborne fungal plant pathogen that is resistant to U...

journal_title：mBio

authors： Milo-Cochavi S,Adar S,Covo S

更新日期：2019-12-03 00:00:00

abstract：:Japanese encephalitis virus (JEV) remains a leading cause of viral encephalitis worldwide. Although JEV-specific antibodies have been described, an assessment of their ability to neutralize multiple genotypes of JEV has been limited. Here, we describe the development of a panel of mouse and human neutralizing monoclon...

journal_title：mBio

authors： Fernandez E,Kose N,Edeling MA,Adhikari J,Sapparapu G,Lazarte SM,Nelson CA,Govero J,Gross ML,Fremont DH,Crowe JE Jr,Diamond MS

更新日期：2018-02-27 00:00:00

abstract：:The PCNA (proliferating cell nuclear antigen) ring plays central roles during DNA replication and repair. The yeast Elg1 RFC-like complex (RLC) is the principal unloader of chromatin-bound PCNA and thus plays a central role in maintaining genome stability. Here we identify a role for Elg1 in the unloading of PCNA duri...

journal_title：mBio

authors： Sau S,Liefshitz B,Kupiec M

更新日期：2019-06-11 00:00:00

abstract：:E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the African swine fever virus (ASFV) genome, is required for productive replication of ASFV in swine macrophages. Here, we solved the high-resolution crystal structures of E165R in its apo state and in complex with its product dUMP. Structural anal...

journal_title：mBio

authors： Li C,Chai Y,Song H,Weng C,Qi J,Sun Y,Gao GF

更新日期：2019-10-29 00:00:00