Sharing of prey: coinfection of a bacterium by a virus and a prokaryotic predator.

abstract：:Catabolite control protein A (CcpA) is the master regulator in Gram-positive bacteria that mediates carbon catabolite repression (CCR) and carbon catabolite activation (CCA), two fundamental regulatory mechanisms that enable competitive advantages in carbon catabolism. It is generally regarded that CcpA exerts its reg...

journal_title：mBio

authors： Yang Y,Zhang L,Huang H,Yang C,Yang S,Gu Y,Jiang W

更新日期：2017-01-24 00:00:00

abstract：UNLABELLED:In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P. jirovecii) were compared among themselves and with the free-living, phylogenetically related fission yeast (Schizosaccharomyces pombe)...

journal_title：mBio

authors： Porollo A,Sesterhenn TM,Collins MS,Welge JA,Cushion MT

更新日期：2014-11-04 00:00:00

abstract：:Most bacteria and archaea use the tubulin homologue FtsZ as its central organizer of cell division. In Gram-negative Escherichia coli bacteria, FtsZ recruits cytosolic, transmembrane, periplasmic, and outer membrane proteins, assembling the divisome that facilitates bacterial cell division. One such divisome component...

journal_title：mBio

authors： Kureisaite-Ciziene D,Varadajan A,McLaughlin SH,Glas M,Montón Silva A,Luirink R,Mueller C,den Blaauwen T,Grossmann TN,Luirink J,Löwe J

更新日期：2018-09-11 00:00:00

abstract：:Most bacteria can generate ATP by respiratory metabolism, in which electrons are shuttled from reduced substrates to terminal electron acceptors, via quinone molecules like ubiquinone. Dioxygen (O2) is the terminal electron acceptor of aerobic respiration and serves as a co-substrate in the biosynthesis of ubiquinone....

journal_title：mBio

authors： Pelosi L,Vo CD,Abby SS,Loiseau L,Rascalou B,Hajj Chehade M,Faivre B,Goussé M,Chenal C,Touati N,Binet L,Cornu D,Fyfe CD,Fontecave M,Barras F,Lombard M,Pierrel F

更新日期：2019-07-09 00:00:00

abstract：:Hepatitis E virus (HEV), a single-strand positive-sense RNA virus, is an understudied but important human pathogen. The virus can establish infection at a number of host tissues, including the small intestine and liver, causing acute and chronic hepatitis E as well as certain neurological disorders. The retinoic acid-...

journal_title：mBio

authors： Sooryanarain H,Heffron CL,Meng XJ

更新日期：2020-01-14 00:00:00

abstract：:SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Streptococcus pyogenes,...

journal_title：mBio

authors： Port GC,Cusumano ZT,Tumminello PR,Caparon MG

更新日期：2017-03-28 00:00:00

abstract：:Pseudomonas aeruginosa, known as one of the leading causes of disease in cystic fibrosis (CF) patients, secretes a variety of proteases. These enzymes contribute significantly to P. aeruginosa pathogenesis and biofilm formation in the chronic colonization of CF patient lungs, as well as playing a role in infections of...

journal_title：mBio

authors： Esoda CN,Kuehn MJ

更新日期：2019-11-19 00:00:00

abstract：:1-Butanol is a large-volume, intermediate chemical with favorable physical and chemical properties for blending with or directly substituting for gasoline. The per-volume value of butanol, as a chemical, is sufficient for investing into the recommercialization of the classical acetone-butanol-ethanol (ABE) (E. M. Gree...

journal_title：mBio

authors： Tracy BP

更新日期：2012-12-11 00:00:00

abstract：:ABSTRACT The major clonal lineages of the human pathogen Staphylococcus aureus produce cell wall-anchored anionic poly-ribitol-phosphate (RboP) wall teichoic acids (WTA) substituted with d-Alanine and N-acetyl-d-glucosamine. The phylogenetically isolated S. aureus ST395 lineage has recently been found to produce a uni...

journal_title：mBio

authors： Winstel V,Sanchez-Carballo P,Holst O,Xia G,Peschel A

更新日期：2014-04-08 00:00:00

abstract：UNLABELLED:Significant gut microbiota heterogeneity exists among ulcerative colitis (UC) patients, though the clinical implications of this variance are unknown. We hypothesized that ethnically distinct UC patients exhibit discrete gut microbiotas with unique metabolic programming that differentially influence immune a...

journal_title：mBio

authors： Mar JS,LaMere BJ,Lin DL,Levan S,Nazareth M,Mahadevan U,Lynch SV

更新日期：2016-08-16 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:Methylglyoxal (MG) is a detrimental metabolic by-product that threatens most organisms (in humans MG causes diabetes). MG is predominantly detoxified by the glyoxalase pathway. This process begins with the conjugation of MG with glutathione (GSH), yielding a hemithioacetal product that is subsequently transformed by t...

journal_title：mBio

authors： Kammerscheit X,Hecker A,Rouhier N,Chauvat F,Cassier-Chauvat C

更新日期：2020-08-04 00:00:00

abstract：:The pathogenic species of Cryptococcus are a major cause of mortality owing to severe infections in immunocompromised as well as immunocompetent individuals. Although antifungal treatment is usually effective, many patients relapse after treatment, and in such cases, comparative analyses of the genomes of incident and...

journal_title：mBio

authors： Chen Y,Farrer RA,Giamberardino C,Sakthikumar S,Jones A,Yang T,Tenor JL,Wagih O,Van Wyk M,Govender NP,Mitchell TG,Litvintseva AP,Cuomo CA,Perfect JR

更新日期：2017-03-07 00:00:00

abstract：:Enteroaggregative Escherichia coli (EAEC) is an important diarrheal pathogen and a cause of both acute and chronic diarrhea. It is a common cause of pediatric bacterial diarrhea in developing countries. Despite its discovery in 1987, the intestinal tropism of the pathogen remains unknown. Cell lines used to study EAEC...

journal_title：mBio

authors： Rajan A,Vela L,Zeng XL,Yu X,Shroyer N,Blutt SE,Poole NM,Carlin LG,Nataro JP,Estes MK,Okhuysen PC,Maresso AW

更新日期：2018-02-20 00:00:00

abstract：:Escherichia colimazEF is an extensively studied stress-induced toxin-antitoxin (TA) system. The toxin MazF is an endoribonuclease that cleaves RNAs at ACA sites. By that means, under stress, the induced MazF generates a stress-induced translation machinery (STM) composed of MazF-processed mRNAs and selective ribosomes...

journal_title：mBio

authors： Nigam A,Ziv T,Oron-Gottesman A,Engelberg-Kulka H

更新日期：2019-03-26 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Tat binds the viral RNA structure transactivation-responsive element (TAR) and recruits transcriptional cofactors, amplifying viral mRNA expression. The Tat inhibitor didehydro-cortistatin A (dCA) promotes a state of persistent latency, refractory to viral reactivation. Here...

journal_title：mBio

authors： Mousseau G,Aneja R,Clementz MA,Mediouni S,Lima NS,Haregot A,Kessing CF,Jablonski JA,Thenin-Houssier S,Nagarsheth N,Trautmann L,Valente ST

更新日期：2019-07-02 00:00:00

abstract：:Formation of multispecies communities allows nearly every niche on earth to be colonized, and the exchange of molecular information among neighboring bacteria in such communities is key for bacterial success. To clarify the principles controlling interspecies interactions, we previously developed a coculture model wit...

journal_title：mBio

authors： Ranava D,Backes C,Karthikeyan G,Ouari O,Soric A,Guiral M,Cárdenas ML,Giudici-Orticoni MT

更新日期：2021-01-19 00:00:00

abstract：:Candida albicans has developmental programs that govern transitions between yeast and filamentous morphologies and between unattached and biofilm lifestyles. Here, we report that filamentation, intercellular adherence, and biofilm development were inhibited during interactions between Candida albicans and Pseudomonas ...

journal_title：mBio

authors： Morales DK,Grahl N,Okegbe C,Dietrich LE,Jacobs NJ,Hogan DA

更新日期：2013-01-29 00:00:00

abstract：:Butanol production by Clostridium acetobutylicum is accompanied by coproduction of acetone and ethanol, which reduces the yield of butanol and increases the production cost. Here, we report development of several clostridial aldehyde/alcohol dehydrogenase (AAD) variants showing increased butanol selectivity by a serie...

journal_title：mBio

authors： Cho C,Hong S,Moon HG,Jang YS,Kim D,Lee SY

更新日期：2019-01-22 00:00:00

abstract：:A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A to...

journal_title：mBio

authors： Huq A,Yunus M,Sohel SS,Bhuiya A,Emch M,Luby SP,Russek-Cohen E,Nair GB,Sack RB,Colwell RR

更新日期：2010-05-18 00:00:00

abstract：:A voluntary 60-day pause on avian H5N1 influenza virus transmission research was announced in January 2012 by the international community of influenza scientists engaged in this work to provide time to explain the benefits of such work and the risk mitigation measures in place. Subsequently, the pause was extended to ...

journal_title：mBio

authors： Fouchier RA,García-Sastre A,Kawaoka Y

更新日期：2012-11-01 00:00:00

abstract：UNLABELLED:We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and affinities, which are determined by the compactness o...

journal_title：mBio

authors： Goossens KV,Ielasi FS,Nookaew I,Stals I,Alonso-Sarduy L,Daenen L,Van Mulders SE,Stassen C,van Eijsden RG,Siewers V,Delvaux FR,Kasas S,Nielsen J,Devreese B,Willaert RG

更新日期：2015-04-14 00:00:00

abstract：:We have previously identified Vibrio cholerae mutants in which the stress response to subinhibitory concentrations of aminoglycoside is altered. One gene identified, VC1636, encodes a putative DNA/RNA helicase, recently named RadD in Escherichia coli Here we combined extensive genetic characterization and high-through...

journal_title：mBio

authors： Negro V,Krin E,Aguilar Pierlé S,Chaze T,Giai Gianetto Q,Kennedy SP,Matondo M,Mazel D,Baharoglu Z

更新日期：2019-07-02 00:00:00

abstract：:Staphylococcus aureus is a human pathogen responsible for high morbidity and mortality worldwide. Recurrent infections with this bacterium are common, suggesting that S. aureus thwarts the development of sterilizing immunity. S. aureus strains that cause disease in humans produce up to five different bicomponent toxin...

journal_title：mBio

authors： Berends ETM,Zheng X,Zwack EE,Ménager MM,Cammer M,Shopsin B,Torres VJ

更新日期：2019-01-02 00:00:00

abstract：UNLABELLED:Candida albicans is a major life-threatening human fungal pathogen in the immunocompromised host. Host defense against systemic Candida infection relies heavily on the capacity of professional phagocytes of the innate immune system to ingest and destroy fungal cells. A number of pathogens, including C. albic...

journal_title：mBio

authors： Bain JM,Louw J,Lewis LE,Okai B,Walls CA,Ballou ER,Walker LA,Reid D,Munro CA,Brown AJ,Brown GD,Gow NA,Erwig LP

更新日期：2014-12-02 00:00:00

abstract：:Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras...

journal_title：mBio

authors： Teixeira MM,Alvarado P,Roe CC,Thompson GR 3rd,Patané JSL,Sahl JW,Keim P,Galgiani JN,Litvintseva AP,Matute DR,Barker BM

更新日期：2019-11-26 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral...

journal_title：mBio

authors： Hosseinipour MC,Sweet KM,Xiong J,Namarika D,Mwafongo A,Nyirenda M,Chiwoko L,Kamwendo D,Hoffman I,Lee J,Phiri S,Vahrson W,Damania B,Dittmer DP

更新日期：2014-09-23 00:00:00

abstract：:The acquisition and incorporation of genetic material between nonmating species, or horizontal gene transfer (HGT), has been frequently described for phylogenetically related organisms, but far less evidence exists for HGT between highly divergent organisms. Here we report the identification and characterization of a ...

journal_title：mBio

authors： Anderson MT,Seifert HS

更新日期：2011-02-15 00:00:00

abstract：:The Pseudomonas quinolone signal (PQS) is an important quorum-sensing molecule in Pseudomonas aeruginosa that also mediates its own packaging and transport by stimulating outer membrane vesicle (OMV) formation. Because OMVs have been implicated in many virulence-associated behaviors, it is critical that we understand ...

journal_title：mBio

authors： Florez C,Raab JE,Cooke AC,Schertzer JW

更新日期：2017-08-08 00:00:00

abstract：:Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughput purposes. Here, we made a...

journal_title：mBio

authors： Moudjou M,Sibille P,Fichet G,Reine F,Chapuis J,Herzog L,Jaumain E,Laferrière F,Richard CA,Laude H,Andréoletti O,Rezaei H,Béringue V

更新日期：2013-12-31 00:00:00