Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions.

abstract：UNLABELLED:Diverse colony morphologies are a hallmark of Burkholderia pseudomallei recovered from infected patients. We observed that stresses that inhibit aerobic respiration shifted populations of B. pseudomallei from the canonical white colony morphotype toward two distinct, reversible, yet relatively stable yellow ...

journal_title：mBio

authors： Austin CR,Goodyear AW,Bartek IL,Stewart A,Sutherland MD,Silva EB,Zweifel A,Vitko NP,Tuanyok A,Highnam G,Mittelman D,Keim P,Schweizer HP,Vázquez-Torres A,Dow SW,Voskuil MI

更新日期：2015-02-03 00:00:00

abstract：:The microbiome of wild Mus musculus (house mouse), a globally distributed invasive pest that resides in close contact with humans in urban centers, is largely unexplored. Here, we report analysis of the fecal virome of house mice in residential buildings in New York City, NY. Mice were collected at seven sites in Manh...

journal_title：mBio

authors： Williams SH,Che X,Garcia JA,Klena JD,Lee B,Muller D,Ulrich W,Corrigan RM,Nichol S,Jain K,Lipkin WI

更新日期：2018-04-17 00:00:00

abstract：:Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ), and acyl carrier protein (ACP), are utilized to elongate the p...

journal_title：mBio

authors： Hua K,Liu X,Zhao Y,Gao Y,Pan L,Zhang H,Deng Z,Jiang M

更新日期：2020-09-15 00:00:00

abstract：:The appearance of Cryptococcus gattii in the North American Pacific Northwest (PNW) in 1999 was an unexpected and is still an unexplained event. Recent phylogenomic analyses strongly suggest that this pathogenic fungus arrived in the PNW approximately 7 to 9 decades ago. In this paper, we theorize that the ancestors o...

journal_title：mBio

authors： Engelthaler DM,Casadevall A

更新日期：2019-10-01 00:00:00

abstract：UNLABELLED:The world is at the precipice of a postantibiotic era in which medical procedures and minor injuries can result in bacterial infections that are no longer effectively treated by antibiotics. Cathelicidins are peptides produced by animals to combat bacterial infections and to regulate innate immune responses....

journal_title：mBio

authors： Kao C,Lin X,Yi G,Zhang Y,Rowe-Magnus DA,Bush K

更新日期：2016-09-20 00:00:00

abstract：:The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which...

journal_title：mBio

authors： Antunes LC,McDonald JA,Schroeter K,Carlucci C,Ferreira RB,Wang M,Yurist-Doutsch S,Hira G,Jacobson K,Davies J,Allen-Vercoe E,Finlay BB

更新日期：2014-07-29 00:00:00

abstract：:The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell wall-acting antibiotics. In rich medium, c-di-AMP is essential; however, muta...

journal_title：mBio

authors： Peterson BN,Young MKM,Luo S,Wang J,Whiteley AT,Woodward JJ,Tong L,Wang JD,Portnoy DA

更新日期：2020-08-25 00:00:00

abstract：UNLABELLED:The Pseudomonas aeruginosa type III secretion system has been associated with poor outcomes in both animal models and human patients. Despite a large number of studies exploring the regulation of type III secretion in vitro, little is known about the timing of secretion during mammalian infection. Here we de...

journal_title：mBio

authors： Howell HA,Logan LK,Hauser AR

更新日期：2013-03-12 00:00:00

abstract：:EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) o...

journal_title：mBio

authors： McCarthy KR,Timpona JL,Jenni S,Bloyet LM,Brusic V,Johnson WE,Whelan SPJ,Robinson-McCarthy LR

更新日期：2020-11-17 00:00:00

abstract：:Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with M. tuberculosis, and about 15 million people with latent tuberculosis infection (LTBI) reside in the United States. An estimated 10% of indiv...

journal_title：mBio

authors： Ayyappan JP,Ganapathi U,Lizardo K,Vinnard C,Subbian S,Perlin DS,Nagajyothi JF

更新日期：2019-04-16 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent report in mBio (E. A. Cameron, M...

journal_title：mBio

authors： Palmer LD,Skaar EP

更新日期：2019-02-26 00:00:00

abstract：:Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved am...

journal_title：mBio

authors： Schubert K,Sieger B,Meyer F,Giacomelli G,Böhm K,Rieblinger A,Lindenthal L,Sachs N,Wanner G,Bramkamp M

更新日期：2017-02-07 00:00:00

abstract：:Bacteria of the phylum Bacteroidetes, including commensal organisms and opportunistic pathogens, harbor abundant surface-exposed multiprotein membrane complexes (Sus-like systems) involved in carbohydrate acquisition. These complexes have been mostly linked to commensalism, and in some instances, they have also been s...

journal_title：mBio

authors： Lauber F,Cornelis GR,Renzi F

更新日期：2016-10-25 00:00:00

abstract：UNLABELLED:Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors durin...

journal_title：mBio

authors： Serapio-Palacios A,Navarro-Garcia F

更新日期：2016-06-21 00:00:00

abstract：:Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks. How host immune responses are orchestrated after alphaviral infections and lead to musculoskeletal inflammation remains poorly understood. Her...

journal_title：mBio

authors： Zaid A,Tharmarajah K,Mostafavi H,Freitas JR,Sheng KC,Foo SS,Chen W,Vider J,Liu X,West NP,Herrero LJ,Taylor A,Mackay LK,Getts DR,King NJC,Mahalingam S

更新日期：2020-03-03 00:00:00

abstract：UNLABELLED:In Staphylococcus aureus, hundreds of small regulatory or small RNAs (sRNAs) have been identified, yet this class of molecule remains poorly understood and severely understudied. sRNA genes are typically absent from genome annotation files, and as a consequence, their existence is often overlooked, particula...

journal_title：mBio

authors： Carroll RK,Weiss A,Broach WH,Wiemels RE,Mogen AB,Rice KC,Shaw LN

更新日期：2016-02-09 00:00:00

abstract：UNLABELLED:Rapidly fatal cases of invasive fungal infections due to a fungus later identified as Saprochaete clavata were reported in France in May 2012. The objectives of this study were to determine the clonal relatedness of the isolates and to investigate possible sources of contamination. A nationwide alert was lau...

journal_title：mBio

authors： Vaux S,Criscuolo A,Desnos-Ollivier M,Diancourt L,Tarnaud C,Vandenbogaert M,Brisse S,Coignard B,Dromer F,Geotrichum Investigation Group.

更新日期：2014-12-16 00:00:00

abstract：UNLABELLED:Heteroresistance refers to phenotypic heterogeneity of microbial clonal populations under antibiotic stress, and it has been thought to be an allocation of a subset of "resistant" cells for surviving in higher concentrations of antibiotic. The assumption fits the so-called bet-hedging strategy, where a bacte...

journal_title：mBio

authors： Wang X,Kang Y,Luo C,Zhao T,Liu L,Jiang X,Fu R,An S,Chen J,Jiang N,Ren L,Wang Q,Baillie JK,Gao Z,Yu J

更新日期：2014-02-11 00:00:00

abstract：:The USA300 North American epidemic (USA300-NAE) clone of methicillin-resistant Staphylococcus aureus has caused a wave of severe skin and soft tissue infections in the United States since it emerged in the early 2000s, but its geographic origin is obscure. Here we use the population genomic signatures expected from th...

journal_title：mBio

authors： Challagundla L,Luo X,Tickler IA,Didelot X,Coleman DC,Shore AC,Coombs GW,Sordelli DO,Brown EL,Skov R,Larsen AR,Reyes J,Robledo IE,Vazquez GJ,Rivera R,Fey PD,Stevenson K,Wang SH,Kreiswirth BN,Mediavilla JR,Arias CA

更新日期：2018-01-02 00:00:00

abstract：:Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resistance in S. aureus, we screened the Nebraska Transpo...

journal_title：mBio

authors： Vestergaard M,Nøhr-Meldgaard K,Bojer MS,Krogsgård Nielsen C,Meyer RL,Slavetinsky C,Peschel A,Ingmer H

更新日期：2017-09-05 00:00:00

abstract：UNLABELLED:While research has identified an important contribution for metals, such as iron, in microbial pathogenesis, the roles of other transition metals, such as copper, remain mostly unknown. Recent evidence points to a requirement for copper homeostasis in the virulence of Cryptococcus neoformans based on a role ...

journal_title：mBio

authors： Waterman SR,Park YD,Raja M,Qiu J,Hammoud DA,O'Halloran TV,Williamson PR

更新日期：2012-10-02 00:00:00

abstract：UNLABELLED:The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is req...

journal_title：mBio

authors： Ekici S,Yang H,Koch HG,Daldal F

更新日期：2012-01-31 00:00:00

abstract：UNLABELLED:Many viruses induce acute T cell-independent (TI) B cell responses due to their repetitive epitopes and the induction of innate cytokines. Nevertheless, T cell help is thought necessary for the development of long-lasting antiviral antibody responses in the form of long-lived plasma cells and memory B cells....

journal_title：mBio

authors： Raval FM,Mishra R,Garcea RL,Welsh RM,Szomolanyi-Tsuda E

更新日期：2013-11-05 00:00:00

abstract：:Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical fo...

journal_title：mBio

authors： Johnson CJ,Davis JM,Huttenlocher A,Kernien JF,Nett JE

更新日期：2018-08-21 00:00:00

abstract：:The yeast Yarrowia lipolytica is a potent accumulator of lipids, and lipogenesis in this organism can be influenced by a variety of factors, such as genetics and environmental conditions. Using a multifactorial study, we elucidated the effects of both genetic and environmental factors on regulation of lipogenesis in Y...

journal_title：mBio

authors： Kerkhoven EJ,Kim YM,Wei S,Nicora CD,Fillmore TL,Purvine SO,Webb-Robertson BJ,Smith RD,Baker SE,Metz TO,Nielsen J

更新日期：2017-06-20 00:00:00

abstract：:Innate immune response plays a critical role in controlling invading pathogens, but such an immune response must be tightly regulated. Insufficient or overactivated immune responses may lead to harmful or even fatal consequences. To dissect the complex host-parasite interactions and the molecular mechanisms underlying...

journal_title：mBio

authors： Cai B,Wu J,Yu X,Su XZ,Wang RF

更新日期：2017-01-03 00:00:00

abstract：:Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution K432E. This substitution exists in 99.25% of seasonal influenza ...

journal_title：mBio

authors： Jiang H,Peng W,Qi J,Chai Y,Song H,Bi Y,Rijal P,Wang H,Oladejo BO,Liu J,Shi Y,Gao GF,Townsend AR,Wu Y

更新日期：2020-10-06 00:00:00

abstract：UNLABELLED:Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations. In a long-term evolution experiment, twelve Escherichia coli populations have been propagated in a glucose-limited environment for over 25 ...

journal_title：mBio

authors： Raeside C,Gaffé J,Deatherage DE,Tenaillon O,Briska AM,Ptashkin RN,Cruveiller S,Médigue C,Lenski RE,Barrick JE,Schneider D

更新日期：2014-09-09 00:00:00

abstract：:Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal a conserved role for bacter...

journal_title：mBio

authors： Chaudhari SS,Kim M,Lei S,Razvi F,Alqarzaee AA,Hutfless EH,Powers R,Zimmerman MC,Fey PD,Thomas VC

更新日期：2017-08-01 00:00:00

abstract：UNLABELLED:Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully used to study human-tropic pathogens in the past, we challenged BALB/c mice defici...

journal_title：mBio

authors： Taube S,Kolawole AO,Höhne M,Wilkinson JE,Handley SA,Perry JW,Thackray LB,Akkina R,Wobus CE

更新日期：2013-07-16 00:00:00