Candida albicans hypha formation and mannan masking of β-glucan inhibit macrophage phagosome maturation.

abstract：:Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved am...

journal_title：mBio

authors： Schubert K,Sieger B,Meyer F,Giacomelli G,Böhm K,Rieblinger A,Lindenthal L,Sachs N,Wanner G,Bramkamp M

更新日期：2017-02-07 00:00:00

abstract：:1-Butanol is a large-volume, intermediate chemical with favorable physical and chemical properties for blending with or directly substituting for gasoline. The per-volume value of butanol, as a chemical, is sufficient for investing into the recommercialization of the classical acetone-butanol-ethanol (ABE) (E. M. Gree...

journal_title：mBio

authors： Tracy BP

更新日期：2012-12-11 00:00:00

abstract：:Microbial carbon degradation and methanogenesis in wetland soils generate a large proportion of atmospheric methane, a highly potent greenhouse gas. Despite their potential to mitigate greenhouse gas emissions, knowledge about methane-consuming methanotrophs is often limited to lower-resolution single-gene surveys tha...

journal_title：mBio

authors： Smith GJ,Angle JC,Solden LM,Borton MA,Morin TH,Daly RA,Johnston MD,Stefanik KC,Wolfe R,Gil B,Wrighton KC

更新日期：2018-11-06 00:00:00

abstract：:Uncultured and therefore uncharacterized Bacteroidetes lineages are ubiquitous in many natural ecosystems which specialize in lignocellulose degradation. However, their metabolic contribution remains mysterious, as well-studied cultured Bacteroidetes have been shown to degrade only soluble polysaccharides within the h...

journal_title：mBio

authors： Naas AE,Mackenzie AK,Mravec J,Schückel J,Willats WG,Eijsink VG,Pope PB

更新日期：2014-08-05 00:00:00

abstract：UNLABELLED:Honeybees harbor well-defined bacterial communities in their guts. The major members of these communities appear to benefit the host, but little is known about how they interact with the host and specifically how they interface with the host immune system. In the pylorus, a short region between the midgut an...

journal_title：mBio

authors： Engel P,Bartlett KD,Moran NA

更新日期：2015-05-19 00:00:00

abstract：:Plant-infecting viruses utilize various strategies involving multiple viral and host factors to achieve successful systemic infections of their compatible hosts. Lettuce infectious yellows virus (LIYV), genus Crinivirus, family Closteroviridae, has long, filamentous flexuous virions and causes phloem-limited infection...

journal_title：mBio

authors： Qiao W,Medina V,Kuo YW,Falk BW

更新日期：2018-11-20 00:00:00

abstract：UNLABELLED:West Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune responses to WNV infection have been well studied in C57BL/6J inbred mice, but this model lacks the variations in susceptibility, immunity, and outcome t...

journal_title：mBio

authors： Graham JB,Thomas S,Swarts J,McMillan AA,Ferris MT,Suthar MS,Treuting PM,Ireton R,Gale M Jr,Lund JM

更新日期：2015-05-05 00:00:00

abstract：:Diet influences health in multiple ways. One important effect of diet is on the gut microbiota. The effects of diet are often related to an individual's specific microbiota composition. The close links between health, diet, and gut microbiota are illustrated in a new mouse model of sepsis where the combination of a hi...

journal_title：mBio

authors： Bassis CM

更新日期：2019-10-08 00:00:00

abstract：:Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resistance in S. aureus, we screened the Nebraska Transpo...

journal_title：mBio

authors： Vestergaard M,Nøhr-Meldgaard K,Bojer MS,Krogsgård Nielsen C,Meyer RL,Slavetinsky C,Peschel A,Ingmer H

更新日期：2017-09-05 00:00:00

abstract：:The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which...

journal_title：mBio

authors： Antunes LC,McDonald JA,Schroeter K,Carlucci C,Ferreira RB,Wang M,Yurist-Doutsch S,Hira G,Jacobson K,Davies J,Allen-Vercoe E,Finlay BB

更新日期：2014-07-29 00:00:00

abstract：:Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic understanding of how bacteria evolve resistance against multiple phages is lacking, ...

journal_title：mBio

authors： Wright RCT,Friman VP,Smith MCM,Brockhurst MA

更新日期：2019-09-24 00:00:00

abstract：:Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of ...

journal_title：mBio

authors： Cobián Güemes AG,Lim YW,Quinn RA,Conrad DJ,Benler S,Maughan H,Edwards R,Brettin T,Cantú VA,Cuevas D,Hamidi R,Dorrestein P,Rohwer F

更新日期：2019-04-16 00:00:00

abstract：UNLABELLED:We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and affinities, which are determined by the compactness o...

journal_title：mBio

authors： Goossens KV,Ielasi FS,Nookaew I,Stals I,Alonso-Sarduy L,Daenen L,Van Mulders SE,Stassen C,van Eijsden RG,Siewers V,Delvaux FR,Kasas S,Nielsen J,Devreese B,Willaert RG

更新日期：2015-04-14 00:00:00

abstract：UNLABELLED:Enterococcus faecium, natively a gut commensal organism, emerged as a leading cause of multidrug-resistant hospital-acquired infection in the 1980s. As the living record of its adaptation to changes in habitat, we sequenced the genomes of 51 strains, isolated from various ecological environments, to understa...

journal_title：mBio

authors： Lebreton F,van Schaik W,McGuire AM,Godfrey P,Griggs A,Mazumdar V,Corander J,Cheng L,Saif S,Young S,Zeng Q,Wortman J,Birren B,Willems RJ,Earl AM,Gilmore MS

更新日期：2013-08-20 00:00:00

abstract：:The hospital environment is a potential reservoir of bacteria with plasmids conferring carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive sampling of high-touch surfaces, sinks, and other locations in the hospital. Over a 2-year period, additional sampling was conducted at a broader ...

journal_title：mBio

authors： Weingarten RA,Johnson RC,Conlan S,Ramsburg AM,Dekker JP,Lau AF,Khil P,Odom RT,Deming C,Park M,Thomas PJ,NISC Comparative Sequencing Program.,Henderson DK,Palmore TN,Segre JA,Frank KM

更新日期：2018-02-06 00:00:00

abstract：:The PCNA (proliferating cell nuclear antigen) ring plays central roles during DNA replication and repair. The yeast Elg1 RFC-like complex (RLC) is the principal unloader of chromatin-bound PCNA and thus plays a central role in maintaining genome stability. Here we identify a role for Elg1 in the unloading of PCNA duri...

journal_title：mBio

authors： Sau S,Liefshitz B,Kupiec M

更新日期：2019-06-11 00:00:00

abstract：UNLABELLED:The Pseudomonas aeruginosa type III secretion system has been associated with poor outcomes in both animal models and human patients. Despite a large number of studies exploring the regulation of type III secretion in vitro, little is known about the timing of secretion during mammalian infection. Here we de...

journal_title：mBio

authors： Howell HA,Logan LK,Hauser AR

更新日期：2013-03-12 00:00:00

abstract：UNLABELLED:Osteomyelitis is a difficult-to-eradicate bone infection typically caused by Staphylococcus aureus. In this study, we investigated the in vivo transcriptional adaptation of S. aureus during bone infection. To this end, we determined the transcriptome of S. aureus during the acute (day 7) and chronic (day 28)...

journal_title：mBio

authors： Szafranska AK,Oxley AP,Chaves-Moreno D,Horst SA,Roßlenbroich S,Peters G,Goldmann O,Rohde M,Sinha B,Pieper DH,Löffler B,Jauregui R,Wos-Oxley ML,Medina E

更新日期：2014-12-23 00:00:00

abstract：:Yellow fever virus (YFV) is an arthropod-borne flavivirus, infecting ~200,000 people worldwide annually and causing about 30,000 deaths. The live attenuated vaccine strain, YFV-17D, has significantly contributed in controlling the global burden of yellow fever worldwide. However, the viral and host contributions to YF...

journal_title：mBio

authors： Douam F,Soto Albrecht YE,Hrebikova G,Sadimin E,Davidson C,Kotenko SV,Ploss A

更新日期：2017-08-15 00:00:00

abstract：UNLABELLED:Male circumcision reduces female-to-male HIV transmission. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. We compared the coronal sulcus microbiota of men from a group of uncircumcised controls (n = 77) a...

journal_title：mBio

authors： Liu CM,Hungate BA,Tobian AA,Serwadda D,Ravel J,Lester R,Kigozi G,Aziz M,Galiwango RM,Nalugoda F,Contente-Cuomo TL,Wawer MJ,Keim P,Gray RH,Price LB

更新日期：2013-04-16 00:00:00

abstract：:Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life. Recent application of deep-sequencing technologies has revealed that the transcription of asRNAs occurs genome-wide in bacter...

journal_title：mBio

authors： Raghavan R,Sloan DB,Ochman H

更新日期：2012-08-07 00:00:00

abstract：:Protein kinase R (PKR) plays a major role in activating host immunity during infection by sensing double-stranded RNA (dsRNA) produced by viruses. Once activated by dsRNA, PKR phosphorylates the translation factor eukaryotic initiation factor 2α (eIF2α), halting cellular translation. Many viruses have methods of inhib...

journal_title：mBio

authors： Goodman DE,Pretto CD,Krepostman TA,Carnahan KE,Spindler KR

更新日期：2019-04-23 00:00:00

abstract：UNLABELLED:Pseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are major problems that can complicate antibiotic therapy. We evaluated the efficacy of using bacteriophages to kill the pathogen i...

journal_title：mBio

authors： Alemayehu D,Casey PG,McAuliffe O,Guinane CM,Martin JG,Shanahan F,Coffey A,Ross RP,Hill C

更新日期：2012-03-06 00:00:00

abstract：:Two Shigella species, Shigella flexneri and Shigella sonnei, cause approximately 90% of bacterial dysentery worldwide. While S. flexneri is the dominant species in low-income countries, S. sonnei causes the majority of infections in middle- and high-income countries. S. flexneri is a prototypic cytosolic bacterium; on...

journal_title：mBio

authors： Watson JL,Sanchez-Garrido J,Goddard PJ,Torraca V,Mostowy S,Shenoy AR,Clements A

更新日期：2019-12-17 00:00:00

abstract：:A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A to...

journal_title：mBio

authors： Huq A,Yunus M,Sohel SS,Bhuiya A,Emch M,Luby SP,Russek-Cohen E,Nair GB,Sack RB,Colwell RR

更新日期：2010-05-18 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restrict T lymphocyte responses to chemokine stimulation and T cell recept...

journal_title：mBio

authors： Imle A,Abraham L,Tsopoulidis N,Hoflack B,Saksela K,Fackler OT

更新日期：2015-09-08 00:00:00

abstract：:Since the original report that Halomonas sp. strain GFAJ-1 was capable of using arsenic instead of phosphorus to sustain growth, additional studies have been conducted, and GFAJ-1 is now considered a highly arsenic-resistant but phosphorus-dependent bacterium. However, the mechanisms supporting the extreme arsenic res...

journal_title：mBio

authors： Wu S,Wang L,Gan R,Tong T,Bian H,Li Z,Du S,Deng Z,Chen S

更新日期：2018-05-01 00:00:00

abstract：:HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4+ T cells by cytotoxic T lymphocytes (CTLs). To evade killing, many HIV-1 group M strains decrease HLA-C surface levels using their accessory protein Vpu. However, some HIV-1 group M isolates lack this activity, p...

journal_title：mBio

authors： Hopfensperger K,Richard J,Stürzel CM,Bibollet-Ruche F,Apps R,Leoz M,Plantier JC,Hahn BH,Finzi A,Kirchhoff F,Sauter D

更新日期：2020-07-14 00:00:00

abstract：:The Bacillus cereus group comprises numerous closely related species, including bioterrorism agent B. anthracis, foodborne pathogen B. cereus, and biopesticide B. thuringiensis Differentiating organisms capable of causing illness or death from those used in industry is essential for risk assessment and outbreak prepar...

journal_title：mBio

authors： Carroll LM,Wiedmann M,Kovac J

更新日期：2020-02-25 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii employs a vast array of effector proteins from the rhoptry and dense granule organelles to modulate host cell biology; these effectors are known as ROPs and GRAs, respectively. To examine the individual impacts of ROPs and GRAs on host gene expression, we developed a robust...

journal_title：mBio

authors： Rastogi S,Xue Y,Quake SR,Boothroyd JC

更新日期：2020-06-09 00:00:00