Staphylococcus aureus Impairs the Function of and Kills Human Dendritic Cells via the LukAB Toxin.

abstract：UNLABELLED:Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extrac...

journal_title：mBio

authors： Singh B,Alvarado-Kristensson M,Johansson M,Hallgren O,Westergren-Thorsson G,Mörgelin M,Riesbeck K

更新日期：2016-03-22 00:00:00

abstract：:Herpesvirus latency has been difficult to understand molecularly due to low levels of viral genomes and gene expression. In the case of the betaherpesvirus human cytomegalovirus (HCMV), this is further complicated by the heterogeneity inherent to hematopoietic subpopulations harboring genomes and, as a consequence, th...

journal_title：mBio

authors： Goodrum F,McWeeney S

更新日期：2018-06-12 00:00:00

abstract：UNLABELLED:While research has identified an important contribution for metals, such as iron, in microbial pathogenesis, the roles of other transition metals, such as copper, remain mostly unknown. Recent evidence points to a requirement for copper homeostasis in the virulence of Cryptococcus neoformans based on a role ...

journal_title：mBio

authors： Waterman SR,Park YD,Raja M,Qiu J,Hammoud DA,O'Halloran TV,Williamson PR

更新日期：2012-10-02 00:00:00

abstract：:Since the discovery of symbioses between sulfur-oxidizing (thiotrophic) bacteria and invertebrates at hydrothermal vents over 40 years ago, it has been assumed that autotrophic fixation of CO2 by the symbionts drives these nutritional associations. In this study, we investigated "Candidatus Kentron," the clade of symb...

journal_title：mBio

authors： Seah BKB,Antony CP,Huettel B,Zarzycki J,Schada von Borzyskowski L,Erb TJ,Kouris A,Kleiner M,Liebeke M,Dubilier N,Gruber-Vodicka HR

更新日期：2019-06-25 00:00:00

abstract：:The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics. Despite intensive studies since (p)ppGpp was discovered over 4 decades ago, (p)ppGpp binding proteins have not been systematically identi...

journal_title：mBio

authors： Zhang Y,Zborníková E,Rejman D,Gerdes K

更新日期：2018-03-06 00:00:00

abstract：:The blast fungus initiates infection using a heavily melanized, dome-shaped infection structure known as the appressorium, which forcibly ruptures the cuticle to enter the rice leaf tissue. How this process takes place remains not fully understood. Here, we used untargeted metabolomics analyses to profile the metabolo...

journal_title：mBio

authors： Liu XH,Liang S,Wei YY,Zhu XM,Li L,Liu PP,Zheng QX,Zhou HN,Zhang Y,Mao LJ,Fernandes CM,Del Poeta M,Naqvi NI,Lin FC

更新日期：2019-08-20 00:00:00

abstract：UNLABELLED:In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P. jirovecii) were compared among themselves and with the free-living, phylogenetically related fission yeast (Schizosaccharomyces pombe)...

journal_title：mBio

authors： Porollo A,Sesterhenn TM,Collins MS,Welge JA,Cushion MT

更新日期：2014-11-04 00:00:00

abstract：:Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy. They can also use poised electrodes as their electron donor via phototrophic extracellular electron uptake (phototrophic EEU). The e...

journal_title：mBio

authors： Gupta D,Sutherland MC,Rengasamy K,Meacham JM,Kranz RG,Bose A

更新日期：2019-11-05 00:00:00

abstract：UNLABELLED:Particular types of hormonal contraceptives (HCs) and genital tract infections have been independently associated with risk of HIV-1 acquisition. We examined whether immunity in women using injectable depot medroxyprogesterone acetate (DMPA), combined oral contraceptives (COC), or no HCs differs by the prese...

journal_title：mBio

authors： Fichorova RN,Chen PL,Morrison CS,Doncel GF,Mendonca K,Kwok C,Chipato T,Salata R,Mauck C

更新日期：2015-09-01 00:00:00

abstract：:Simian virus 40 (SV40) is a nonenveloped DNA virus that traffics through the endoplasmic reticulum (ER) en route to the nucleus, but the mechanisms of capsid disassembly and ER exit are poorly understood. We conducted an unbiased RNA interference screen to identify cellular genes required for SV40 infection. SV40 infe...

journal_title：mBio

authors： Goodwin EC,Lipovsky A,Inoue T,Magaldi TG,Edwards AP,Van Goor KE,Paton AW,Paton JC,Atwood WJ,Tsai B,DiMaio D

更新日期：2011-06-14 00:00:00

abstract：:Microbial establishment within the gastrointestinal (GI) tract requires surveillance of the gut biogeography. The gut microbiota coordinates behaviors by sensing host- or microbiota-derived signals. Here we show for the first time that microbiota-derived indole is highly prevalent in the lumen compared to the intestin...

journal_title：mBio

authors： Kumar A,Sperandio V

更新日期：2019-06-04 00:00:00

abstract：:Colicins are toxins produced and released by Enterobacteriaceae to kill competitors in the gut. While group A colicins employ a division of labor strategy to liberate the toxin into the environment via colicin-specific lysis, group B colicin systems lack cognate lysis genes. In Salmonella enterica serovar Typhimurium ...

journal_title：mBio

authors： Spriewald S,Stadler E,Hense BA,Münch PC,McHardy AC,Weiss AS,Obeng N,Müller J,Stecher B

更新日期：2020-07-21 00:00:00

abstract：:The pharmacopeia used by physicians and laypeople in medieval Europe has largely been dismissed as placebo or superstition. While we now recognize that some of the materia medica used by medieval physicians could have had useful biological properties, research in this area is limited by the labor-intensive process of ...

journal_title：mBio

authors： Connelly E,Del Genio CI,Harrison F

更新日期：2020-02-11 00:00:00

abstract：:The major oxidative stress response in Streptomyces is controlled by the sigma factor SigR and its cognate antisigma factor RsrA, and SigR activity is tightly controlled through multiple mechanisms at both the transcriptional and posttranslational levels. Here we show that sigR has a highly unusual GTC start codon and...

journal_title：mBio

authors： Feeney MA,Chandra G,Findlay KC,Paget MSB,Buttner MJ

更新日期：2017-06-13 00:00:00

abstract：:The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...

journal_title：mBio

authors： Ausiello CM,Cassone A

更新日期：2014-06-10 00:00:00

abstract：:Pseudomonas aeruginosa produces an extracellular biofilm matrix that consists of nucleic acids, exopolysaccharides, lipid vesicles, and proteins. In general, the protein component of the biofilm matrix is poorly defined and understudied relative to the other major matrix constituents. While matrix proteins have been s...

journal_title：mBio

authors： Tseng BS,Reichhardt C,Merrihew GE,Araujo-Hernandez SA,Harrison JJ,MacCoss MJ,Parsek MR

更新日期：2018-04-10 00:00:00

abstract：:1-Butanol is a large-volume, intermediate chemical with favorable physical and chemical properties for blending with or directly substituting for gasoline. The per-volume value of butanol, as a chemical, is sufficient for investing into the recommercialization of the classical acetone-butanol-ethanol (ABE) (E. M. Gree...

journal_title：mBio

authors： Tracy BP

更新日期：2012-12-11 00:00:00

abstract：UNLABELLED:Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but h...

journal_title：mBio

authors： Orrú CD,Groveman BR,Hughson AG,Zanusso G,Coulthart MB,Caughey B

更新日期：2015-01-20 00:00:00

abstract：:UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar moiety is incorporated into glycosylphosphatidylinositol (GPI) glycolipids and N- and O-linked glycans. Apicomplexan parasites have a hexosamine pathway compa...

journal_title：mBio

authors： Chi J,Cova M,de Las Rivas M,Medina A,Borges RJ,Leivar P,Planas A,Usón I,Hurtado-Guerrero R,Izquierdo L

更新日期：2020-10-20 00:00:00

abstract：UNLABELLED:Methicillin-resistant Staphylococcus aureus (MRSA) strains are leading causes of hospital-acquired infections in the United States, and clonal cluster 5 (CC5) is the predominant lineage responsible for these infections. Since 2002, there have been 12 cases of vancomycin-resistant S. aureus (VRSA) infection i...

journal_title：mBio

authors： Kos VN,Desjardins CA,Griggs A,Cerqueira G,Van Tonder A,Holden MT,Godfrey P,Palmer KL,Bodi K,Mongodin EF,Wortman J,Feldgarden M,Lawley T,Gill SR,Haas BJ,Birren B,Gilmore MS

更新日期：2012-05-22 00:00:00

abstract：UNLABELLED:The promoter most strongly induced upon activation of the Cpx two-component envelope stress response is the cpxP promoter. The 3' untranscribed region (UTR) of the cpxP transcript is shown to produce a small RNA (sRNA), CpxQ. We investigated the role of CpxQ in combating envelope stress. Remarkably, the two ...

journal_title：mBio

authors： Grabowicz M,Koren D,Silhavy TJ

更新日期：2016-04-05 00:00:00

abstract：:Estrogen, a major female sex steroid hormone, has been shown to promote the selection of mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases, including cystic fibrosis. This results in long-term persistence, poorer clinical outcomes, and limited therapeutic options. In this study...

journal_title：mBio

authors： Vidaillac C,Yong VFL,Aschtgen MS,Qu J,Yang S,Xu G,Seng ZJ,Brown AC,Ali MK,Jaggi TK,Sankaran J,Foo YH,Righetti F,Nedumaran AM,Mac Aogáin M,Roizman D,Richard JA,Rogers TR,Toyofuku M,Luo D,Loh E,Wohland T,Czarny

更新日期：2020-09-29 00:00:00

abstract：:The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which...

journal_title：mBio

authors： Antunes LC,McDonald JA,Schroeter K,Carlucci C,Ferreira RB,Wang M,Yurist-Doutsch S,Hira G,Jacobson K,Davies J,Allen-Vercoe E,Finlay BB

更新日期：2014-07-29 00:00:00

abstract：:Protein ubiquitylation regulates not only endocellular trafficking and proteasomal degradation but also the catalytic activity of enzymes. In Saccharomyces cerevisiae, we analyzed the composition of the ubiquitylated proteomes in strains lacking acetyltransferase Gcn5p, Ub-protease Ubp8p, or both to understand their i...

journal_title：mBio

authors： De Palma A,Fanelli G,Cretella E,De Luca V,Palladino RA,Panzeri V,Roffia V,Saliola M,Mauri P,Filetici P

更新日期：2020-08-11 00:00:00

abstract：:The hospital environment is a potential reservoir of bacteria with plasmids conferring carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive sampling of high-touch surfaces, sinks, and other locations in the hospital. Over a 2-year period, additional sampling was conducted at a broader ...

journal_title：mBio

authors： Weingarten RA,Johnson RC,Conlan S,Ramsburg AM,Dekker JP,Lau AF,Khil P,Odom RT,Deming C,Park M,Thomas PJ,NISC Comparative Sequencing Program.,Henderson DK,Palmore TN,Segre JA,Frank KM

更新日期：2018-02-06 00:00:00

abstract：:The pathogenic species of Cryptococcus are a major cause of mortality owing to severe infections in immunocompromised as well as immunocompetent individuals. Although antifungal treatment is usually effective, many patients relapse after treatment, and in such cases, comparative analyses of the genomes of incident and...

journal_title：mBio

authors： Chen Y,Farrer RA,Giamberardino C,Sakthikumar S,Jones A,Yang T,Tenor JL,Wagih O,Van Wyk M,Govender NP,Mitchell TG,Litvintseva AP,Cuomo CA,Perfect JR

更新日期：2017-03-07 00:00:00

abstract：:Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny. In contrast, adhesion and biofilm formation, which are potentially involved in gut colonization...

journal_title：mBio

authors： Béchon N,Mihajlovic J,Vendrell-Fernández S,Chain F,Langella P,Beloin C,Ghigo JM

更新日期：2020-06-23 00:00:00

abstract：UNLABELLED:The intracellular parasite Toxoplasma gondii infects a wide variety of vertebrate species globally. Infection in most hosts causes a lifelong chronic infection and generates immunological memory responses that protect the host against new infections. In regions where the organism is endemic, multiple exposur...

journal_title：mBio

authors： Jensen KD,Camejo A,Melo MB,Cordeiro C,Julien L,Grotenbreg GM,Frickel EM,Ploegh HL,Young L,Saeij JP

更新日期：2015-02-24 00:00:00

abstract：:The human malaria parasite Plasmodium falciparum replicates within circulating red blood cells, where it is subjected to conditions that frequently cause DNA damage. The repair of DNA double-stranded breaks (DSBs) is thought to rely almost exclusively on homologous recombination (HR), due to a lack of efficient nonhom...

journal_title：mBio

authors： Calhoun SF,Reed J,Alexander N,Mason CE,Deitsch KW,Kirkman LA

更新日期：2017-08-08 00:00:00

abstract：:Enterococci are important human commensals and significant opportunistic pathogens. Biofilm-related enterococcal infections, such as endocarditis, urinary tract infections, wound and surgical site infections, and medical device-associated infections, often become chronic upon the formation of biofilm. The biofilm matr...

journal_title：mBio

authors： Keogh D,Lam LN,Doyle LE,Matysik A,Pavagadhi S,Umashankar S,Low PM,Dale JL,Song Y,Ng SP,Boothroyd CB,Dunny GM,Swarup S,Williams RBH,Marsili E,Kline KA

更新日期：2018-04-10 00:00:00