BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection.

abstract：:Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing a...

journal_title：mBio

authors： Hopfensperger K,Sauter D

更新日期：2020-05-26 00:00:00

abstract：:Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of ...

journal_title：mBio

authors： Cobián Güemes AG,Lim YW,Quinn RA,Conrad DJ,Benler S,Maughan H,Edwards R,Brettin T,Cantú VA,Cuevas D,Hamidi R,Dorrestein P,Rohwer F

更新日期：2019-04-16 00:00:00

abstract：:Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel vaccine development. These antibodies have been observed in humans after natura...

journal_title：mBio

authors： Park JK,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Rosas LA,Cervantes-Medina A,Taubenberger JK,Memoli MJ

更新日期：2018-01-23 00:00:00

abstract：:The genomes of actinomycetes contain numerous gene clusters potentially able to encode the production of many antibiotics and other specialized metabolites that are not expressed during growth under typical laboratory conditions. Undoubtedly, this reflects the soil habitat of these organisms, which is highly complex p...

journal_title：mBio

authors： Hopwood DA

更新日期：2013-09-03 00:00:00

abstract：:Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference (RNAi) response are poorly understood. Here, we characterized antiviral RN...

journal_title：mBio

authors： Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW

更新日期：2020-08-04 00:00:00

abstract：:Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the natural evolution of ...

journal_title：mBio

authors： Broset E,Martín C,Gonzalo-Asensio J

更新日期：2015-10-20 00:00:00

abstract：UNLABELLED:Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors durin...

journal_title：mBio

authors： Serapio-Palacios A,Navarro-Garcia F

更新日期：2016-06-21 00:00:00

abstract：:Nicotine, a toxic and addictive alkaloid from tobacco, is an environmental pollutant in areas near cigarette production facilities. Over the last decade, our group has studied, in depth, the pyrrolidine pathway of nicotine degradation in Pseudomonas putida S16. However, little is known regarding whole mechanism(s) reg...

journal_title：mBio

authors： Hu H,Wang L,Wang W,Wu G,Tao F,Xu P,Deng Z,Tang H

更新日期：2019-06-04 00:00:00

abstract：:A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A to...

journal_title：mBio

authors： Huq A,Yunus M,Sohel SS,Bhuiya A,Emch M,Luby SP,Russek-Cohen E,Nair GB,Sack RB,Colwell RR

更新日期：2010-05-18 00:00:00

abstract：:Motility is an important virulence trait for many bacterial pathogens, allowing them to position themselves in appropriate locations at appropriate times. The motility structures type IV pili and flagella are also involved in sensing surface contact, which modulates pathogenicity. In Pseudomonas aeruginosa, the PilS-P...

journal_title：mBio

authors： Kilmury SLN,Burrows LL

更新日期：2018-07-24 00:00:00

abstract：:Zika virus is a mosquito-borne flavivirus which can cause severe disease in humans, including microcephaly and other congenital malformations in newborns and Guillain-Barré syndrome in adults. There are currently no approved prophylactics or therapeutics for Zika virus; the development of a safe and effective vaccine ...

journal_title：mBio

authors： Bailey MJ,Broecker F,Duehr J,Arumemi F,Krammer F,Palese P,Tan GS

更新日期：2019-04-02 00:00:00

abstract：:The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which...

journal_title：mBio

authors： Antunes LC,McDonald JA,Schroeter K,Carlucci C,Ferreira RB,Wang M,Yurist-Doutsch S,Hira G,Jacobson K,Davies J,Allen-Vercoe E,Finlay BB

更新日期：2014-07-29 00:00:00

abstract：UNLABELLED:The group of proteins known as serine protease autotransporters of Enterobacteriaceae (SPATE) is a growing family of serine proteases secreted to the external milieu by the type V secretion system. Pet toxin and some other SPATE belong to the class 1 cytotoxic SPATE, which have comparable protease strength o...

journal_title：mBio

authors： Nava-Acosta R,Navarro-Garcia F

更新日期：2013-12-10 00:00:00

abstract：:Antimicrobial resistance is a major health threat as it limits treatment options for infection. At the forefront of this serious issue is Acinetobacter baumannii, a Gram-negative opportunistic pathogen that exhibits the remarkable ability to resist antibiotics through multiple mechanisms. As bacterial ribosomes repres...

journal_title：mBio

authors： Morgan CE,Huang W,Rudin SD,Taylor DJ,Kirby JE,Bonomo RA,Yu EW

更新日期：2020-01-21 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00

abstract：UNLABELLED:In vivo transcriptional analyses of microbial pathogens are often hampered by low proportions of pathogen biomass in host organs, hindering the coverage of full pathogen transcriptome. We aimed to address the transcriptome profiles of Candida albicans, the most prevalent fungal pathogen in systemically infec...

journal_title：mBio

authors： Amorim-Vaz S,Tran Vdu T,Pradervand S,Pagni M,Coste AT,Sanglard D

更新日期：2015-09-22 00:00:00

abstract：:Resistance-nodulation-division (RND) superfamily efflux systems have been widely studied for their role in antibiotic resistance, but their native biological functions remain poorly understood. We previously showed that loss of RND-mediated efflux in Vibrio cholerae resulted in activation of the Cpx two-component regu...

journal_title：mBio

authors： Kunkle DE,Bina XR,Bina JE

更新日期：2017-05-16 00:00:00

abstract：UNLABELLED:As diet is considered the major regulator of the gut ecosystem, the overall objective of this work was to demonstrate that a detailed knowledge of the phytochemical composition of food could add to our understanding of observed changes in functionality and activity of the gut microbiota. We used metatranscri...

journal_title：mBio

authors： Ni Y,Li J,Panagiotou G

更新日期：2015-10-27 00:00:00

abstract：UNLABELLED:Mycoplasma pneumoniae, a pathogenic bacterium, glides on host surfaces using a unique mechanism. It forms an attachment organelle at a cell pole as a protrusion comprised of knoblike surface structures and an internal core. Here, we analyzed the three-dimensional structure of the organelle in detail by elect...

journal_title：mBio

authors： Kawamoto A,Matsuo L,Kato T,Yamamoto H,Namba K,Miyata M

更新日期：2016-04-12 00:00:00

abstract：UNLABELLED:The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe respiratory infection with a high mortality rate (~35%). MERS-CoV has been a global threat due to continuous outbreaks in the Arabian peninsula and international spread by infected travelers since 2012. From May to Jul...

journal_title：mBio

authors： Kim Y,Cheon S,Min CK,Sohn KM,Kang YJ,Cha YJ,Kang JI,Han SK,Ha NY,Kim G,Aigerim A,Shin HM,Choi MS,Kim S,Cho HS,Kim YS,Cho NH

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Many filamentous cyanobacteria produce specialized nitrogen-fixing cells called heterocysts, which are located at semiregular intervals along the filament with about 10 to 20 photosynthetic vegetative cells in between. Nitrogen fixation in these complex multicellular bacteria depends on metabolite exchange b...

journal_title：mBio

authors： Nürnberg DJ,Mariscal V,Bornikoel J,Nieves-Morión M,Krauß N,Herrero A,Maldener I,Flores E,Mullineaux CW

更新日期：2015-03-17 00:00:00

abstract：:Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers...

journal_title：mBio

authors： Fedson DS,Jacobson JR,Rordam OM,Opal SM

更新日期：2015-06-23 00:00:00

abstract：:Uncultured and therefore uncharacterized Bacteroidetes lineages are ubiquitous in many natural ecosystems which specialize in lignocellulose degradation. However, their metabolic contribution remains mysterious, as well-studied cultured Bacteroidetes have been shown to degrade only soluble polysaccharides within the h...

journal_title：mBio

authors： Naas AE,Mackenzie AK,Mravec J,Schückel J,Willats WG,Eijsink VG,Pope PB

更新日期：2014-08-05 00:00:00

abstract：:The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA) contribute independently to protection against disease, antigen...

journal_title：mBio

authors： Gao J,Couzens L,Burke DF,Wan H,Wilson P,Memoli MJ,Xu X,Harvey R,Wrammert J,Ahmed R,Taubenberger JK,Smith DJ,Fouchier RAM,Eichelberger MC

更新日期：2019-04-09 00:00:00

abstract：:Cell surface expression of sialic acid has been reported to decrease during immune cell activation, but the significance and regulation of this phenomenon are still being investigated. The major human bacterial pathogen Streptococcus pneumoniae causes pneumonia, sepsis and meningitis, often accompanied by strong infla...

journal_title：mBio

authors： Chang YC,Uchiyama S,Varki A,Nizet V

更新日期：2012-01-03 00:00:00

abstract：UNLABELLED:The world is at the precipice of a postantibiotic era in which medical procedures and minor injuries can result in bacterial infections that are no longer effectively treated by antibiotics. Cathelicidins are peptides produced by animals to combat bacterial infections and to regulate innate immune responses....

journal_title：mBio

authors： Kao C,Lin X,Yi G,Zhang Y,Rowe-Magnus DA,Bush K

更新日期：2016-09-20 00:00:00

abstract：UNLABELLED:Diverse colony morphologies are a hallmark of Burkholderia pseudomallei recovered from infected patients. We observed that stresses that inhibit aerobic respiration shifted populations of B. pseudomallei from the canonical white colony morphotype toward two distinct, reversible, yet relatively stable yellow ...

journal_title：mBio

authors： Austin CR,Goodyear AW,Bartek IL,Stewart A,Sutherland MD,Silva EB,Zweifel A,Vitko NP,Tuanyok A,Highnam G,Mittelman D,Keim P,Schweizer HP,Vázquez-Torres A,Dow SW,Voskuil MI

更新日期：2015-02-03 00:00:00

abstract：:Cholera continues to be an important cause of human infections, and outbreaks are often observed after natural disasters, such as the one following the 2010 earthquake in Haiti. Once the cholera outbreak was confirmed, rumors spread that the disease was brought to Haiti by a battalion of Nepalese soldiers serving as U...

journal_title：mBio

authors： Hendriksen RS,Price LB,Schupp JM,Gillece JD,Kaas RS,Engelthaler DM,Bortolaia V,Pearson T,Waters AE,Upadhyay BP,Shrestha SD,Adhikari S,Shakya G,Keim PS,Aarestrup FM

更新日期：2011-09-01 00:00:00

abstract：:Enterococcus faecalis strains resistant to penicillin and ampicillin are rare and have been associated with increases in quantities of low-affinity penicillin-binding protein 4 (PBP4) or with amino acid substitutions in PBP4. We report an E. faecalis strain (LS4828) isolated from a prosthetic knee joint that was subje...

journal_title：mBio

authors： Rice LB,Desbonnet C,Tait-Kamradt A,Garcia-Solache M,Lonks J,Moon TM,D'Andréa ÉD,Page R,Peti W

更新日期：2018-04-03 00:00:00

abstract：:Cerebral malaria is a severe neurological complication associated with sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the specific binding interactions remain under debate. Here, we have generated an engineered three-dimensional (3D) human brain endothelial microve...

journal_title：mBio

authors： Bernabeu M,Gunnarsson C,Vishnyakova M,Howard CC,Nagao RJ,Avril M,Taylor TE,Seydel KB,Zheng Y,Smith JD

更新日期：2019-05-28 00:00:00