The CpxQ sRNA Negatively Regulates Skp To Prevent Mistargeting of β-Barrel Outer Membrane Proteins into the Cytoplasmic Membrane.

abstract：UNLABELLED:Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems. However, the structural specificity of these systems for sugar substrates has hindered their appl...

journal_title：mBio

authors： Pan C,Sun P,Liu B,Liang H,Peng Z,Dong Y,Wang D,Liu X,Wang B,Zeng M,Wu J,Zhu L,Wang H

更新日期：2016-04-26 00:00:00

abstract：:Two Shigella species, Shigella flexneri and Shigella sonnei, cause approximately 90% of bacterial dysentery worldwide. While S. flexneri is the dominant species in low-income countries, S. sonnei causes the majority of infections in middle- and high-income countries. S. flexneri is a prototypic cytosolic bacterium; on...

journal_title：mBio

authors： Watson JL,Sanchez-Garrido J,Goddard PJ,Torraca V,Mostowy S,Shenoy AR,Clements A

更新日期：2019-12-17 00:00:00

abstract：UNLABELLED:The human pathogen Streptococcus pneumoniae (pneumococcus) exhibits a high degree of genomic diversity and plasticity. Isolates with high genomic similarity are grouped into lineages that undergo homologous recombination at variable rates. PMEN1 is a pandemic, multidrug-resistant lineage. Heterologous gene e...

journal_title：mBio

authors： Eutsey RA,Powell E,Dordel J,Salter SJ,Clark TA,Korlach J,Ehrlich GD,Hiller NL

更新日期：2015-06-16 00:00:00

abstract：UNLABELLED:Members of the genus Vibrio include many pathogens of humans and marine animals that share genetic information via horizontal gene transfer. Hence, the Vibrio pan-genome carries the potential to establish new pathogenic strains by sharing virulence determinants, many of which have yet to be characterized. He...

journal_title：mBio

authors： Ray A,Kinch LN,de Souza Santos M,Grishin NV,Orth K,Salomon D

更新日期：2016-07-26 00:00:00

abstract：:Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical fo...

journal_title：mBio

authors： Johnson CJ,Davis JM,Huttenlocher A,Kernien JF,Nett JE

更新日期：2018-08-21 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the most common etiologic agent of uncomplicated urinary tract infection (UTI). An important mechanism of gene regulation in UPEC is phase variation that involves inversion of a promoter-containing DNA element via enzymatic activity of tyrosine recombinases, resulting in biphas...

journal_title：mBio

authors： Battaglioli EJ,Goh KGK,Atruktsang TS,Schwartz K,Schembri MA,Welch RA

更新日期：2018-08-07 00:00:00

abstract：:The deep-sea tubeworm Riftia pachyptila lacks a digestive system but completely relies on bacterial endosymbionts for nutrition. Although the symbiont has been studied in detail on the molecular level, such analyses were unavailable for the animal host, because sequence information was lacking. To identify host-symbio...

journal_title：mBio

authors： Hinzke T,Kleiner M,Breusing C,Felbeck H,Häsler R,Sievert SM,Schlüter R,Rosenstiel P,Reusch TBH,Schweder T,Markert S

更新日期：2019-12-17 00:00:00

abstract：:Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with M. tuberculosis, and about 15 million people with latent tuberculosis infection (LTBI) reside in the United States. An estimated 10% of indiv...

journal_title：mBio

authors： Ayyappan JP,Ganapathi U,Lizardo K,Vinnard C,Subbian S,Perlin DS,Nagajyothi JF

更新日期：2019-04-16 00:00:00

abstract：:Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo We hypothesized that we could improve the specificity of LV targeting by coupling (i) reduction of their binding to off-target cells with (ii) redirection of the vect...

journal_title：mBio

authors： Parker CL,Jacobs TM,Huckaby JT,Harit D,Lai SK

更新日期：2020-01-21 00:00:00

abstract：UNLABELLED:The world is at the precipice of a postantibiotic era in which medical procedures and minor injuries can result in bacterial infections that are no longer effectively treated by antibiotics. Cathelicidins are peptides produced by animals to combat bacterial infections and to regulate innate immune responses....

journal_title：mBio

authors： Kao C,Lin X,Yi G,Zhang Y,Rowe-Magnus DA,Bush K

更新日期：2016-09-20 00:00:00

abstract：UNLABELLED:Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level. Here, we present an analysis of CME in the human fungal pathogen Candida albicans that shows the same modular structure as those in other fungi and mammalian cells. Intriguingly, C. albic...

journal_title：mBio

authors： Epp E,Nazarova E,Regan H,Douglas LM,Konopka JB,Vogel J,Whiteway M

更新日期：2013-08-27 00:00:00

abstract：:The ability to withstand UV damage shapes the ecology of microbes. While mechanisms of UV tolerance were extensively investigated in microorganisms regularly exposed to the sun, far less is known about UV repair of soilborne microorganisms. Fusarium oxysporum is a soilborne fungal plant pathogen that is resistant to U...

journal_title：mBio

authors： Milo-Cochavi S,Adar S,Covo S

更新日期：2019-12-03 00:00:00

abstract：:The epidemiology of methicillin-resistant Staphylococcus aureus has changed considerably over the last 3 decades, including the recognition of lineages associated with the community and with livestock exposure, in addition to nosocomial strains. A recent study by R. N. Sieber, R. L. Skov, J. Nielsen, J. Schulz, et al....

journal_title：mBio

authors： Smith TC,Davis MF,Heaney CD

更新日期：2018-12-11 00:00:00

abstract：UNLABELLED:Bacterial transporter proteins are involved in the translocation of many essential nutrients and metabolites. However, many of these key bacterial transport systems remain to be identified, including those involved in the transport of riboflavin (vitamin B(2)). Pathogenic spirochetes lack riboflavin biosynth...

journal_title：mBio

authors： Deka RK,Brautigam CA,Biddy BA,Liu WZ,Norgard MV

更新日期：2013-02-12 00:00:00

abstract：:Nineteen Thermococcus kodakarensis strains have been constructed, each of which synthesizes a different His(6)-tagged protein known or predicted to be a component of the archaeal DNA replication machinery. Using the His(6)-tagged proteins, stable complexes assembled in vivo have been isolated directly from clarified c...

journal_title：mBio

authors： Li Z,Santangelo TJ,Cuboňová L,Reeve JN,Kelman Z

更新日期：2010-10-26 00:00:00

abstract：:Like their cellular hosts, herpesviruses are subject to the regulatory impacts of chromatin assembled on their genomes. Upon infection, these viruses are assembled into domains of chromatin with heterochromatic signatures that suppress viral gene expression or euchromatic characteristics that promote gene expression. ...

journal_title：mBio

authors： Kristie TM

更新日期：2016-02-16 00:00:00

abstract：:Biological nitrogen fixation is catalyzed by nitrogenase, a complex metalloenzyme found only in prokaryotes. N2 fixation is energetically highly expensive, and an energy-generating process such as photosynthesis can meet the energy demand of N2 fixation. However, synthesis and expression of nitrogenase are exquisitely...

journal_title：mBio

authors： Liu D,Liberton M,Yu J,Pakrasi HB,Bhattacharyya-Pakrasi M

更新日期：2018-06-05 00:00:00

abstract：:The 1977-1978 influenza epidemic was probably not a natural event, as the genetic sequence of the virus was nearly identical to the sequences of decades-old strains. While there are several hypotheses that could explain its origin, the possibility that the 1977 epidemic resulted from a laboratory accident has recently...

journal_title：mBio

authors： Rozo M,Gronvall GK

更新日期：2015-08-18 00:00:00

abstract：UNLABELLED:Infection by alphaherpesviruses, including herpes simplex virus (HSV) and pseudorabies virus (PRV), typically begins at epithelial surfaces and continues into the peripheral nervous system (PNS). Inflammatory responses are induced at the infected peripheral site prior to invasion of the PNS. When the periphe...

journal_title：mBio

authors： Song R,Koyuncu OO,Greco TM,Diner BA,Cristea IM,Enquist LW

更新日期：2016-02-02 00:00:00

abstract：:Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing a...

journal_title：mBio

authors： Hopfensperger K,Sauter D

更新日期：2020-05-26 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restrict T lymphocyte responses to chemokine stimulation and T cell recept...

journal_title：mBio

authors： Imle A,Abraham L,Tsopoulidis N,Hoflack B,Saksela K,Fackler OT

更新日期：2015-09-08 00:00:00

abstract：UNLABELLED:Recent studies strongly suggest that the gene expression sustaining both normal and pathogenic bacterial growth is governed by the structural dynamics of the chromosome. However, the mechanistic device coordinating the chromosomal configuration with selective expression of the adaptive traits remains largely...

journal_title：mBio

authors： Jiang X,Sobetzko P,Nasser W,Reverchon S,Muskhelishvili G

更新日期：2015-04-28 00:00:00

abstract：:Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causat...

journal_title：mBio

authors： Idnurm A

更新日期：2013-04-30 00:00:00

abstract：:Since the original report that Halomonas sp. strain GFAJ-1 was capable of using arsenic instead of phosphorus to sustain growth, additional studies have been conducted, and GFAJ-1 is now considered a highly arsenic-resistant but phosphorus-dependent bacterium. However, the mechanisms supporting the extreme arsenic res...

journal_title：mBio

authors： Wu S,Wang L,Gan R,Tong T,Bian H,Li Z,Du S,Deng Z,Chen S

更新日期：2018-05-01 00:00:00

abstract：:During DNA replication, stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances, the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage tolerance (DDT) mechanisms that can bypass lesions encountered during DNA rep...

journal_title：mBio

authors： Arbel M,Bronstein A,Sau S,Liefshitz B,Kupiec M

更新日期：2020-05-05 00:00:00

abstract：UNLABELLED:The genus Cyanothece comprises unicellular cyanobacteria that are morphologically diverse and ecologically versatile. Studies over the last decade have established members of this genus to be important components of the marine ecosystem, contributing significantly to the nitrogen and carbon cycle. System-lev...

journal_title：mBio

authors： Bandyopadhyay A,Elvitigala T,Welsh E,Stöckel J,Liberton M,Min H,Sherman LA,Pakrasi HB

更新日期：2011-10-04 00:00:00

abstract：:The human malaria parasite Plasmodium falciparum replicates within circulating red blood cells, where it is subjected to conditions that frequently cause DNA damage. The repair of DNA double-stranded breaks (DSBs) is thought to rely almost exclusively on homologous recombination (HR), due to a lack of efficient nonhom...

journal_title：mBio

authors： Calhoun SF,Reed J,Alexander N,Mason CE,Deitsch KW,Kirkman LA

更新日期：2017-08-08 00:00:00

abstract：:Butanol production by Clostridium acetobutylicum is accompanied by coproduction of acetone and ethanol, which reduces the yield of butanol and increases the production cost. Here, we report development of several clostridial aldehyde/alcohol dehydrogenase (AAD) variants showing increased butanol selectivity by a serie...

journal_title：mBio

authors： Cho C,Hong S,Moon HG,Jang YS,Kim D,Lee SY

更新日期：2019-01-22 00:00:00

abstract：:Cell surface expression of sialic acid has been reported to decrease during immune cell activation, but the significance and regulation of this phenomenon are still being investigated. The major human bacterial pathogen Streptococcus pneumoniae causes pneumonia, sepsis and meningitis, often accompanied by strong infla...

journal_title：mBio

authors： Chang YC,Uchiyama S,Varki A,Nizet V

更新日期：2012-01-03 00:00:00

abstract：:Since the discovery of symbioses between sulfur-oxidizing (thiotrophic) bacteria and invertebrates at hydrothermal vents over 40 years ago, it has been assumed that autotrophic fixation of CO2 by the symbionts drives these nutritional associations. In this study, we investigated "Candidatus Kentron," the clade of symb...

journal_title：mBio

authors： Seah BKB,Antony CP,Huettel B,Zarzycki J,Schada von Borzyskowski L,Erb TJ,Kouris A,Kleiner M,Liebeke M,Dubilier N,Gruber-Vodicka HR

更新日期：2019-06-25 00:00:00