Affinity purification of an archaeal DNA replication protein network.

abstract：:The ability to withstand UV damage shapes the ecology of microbes. While mechanisms of UV tolerance were extensively investigated in microorganisms regularly exposed to the sun, far less is known about UV repair of soilborne microorganisms. Fusarium oxysporum is a soilborne fungal plant pathogen that is resistant to U...

journal_title：mBio

authors： Milo-Cochavi S,Adar S,Covo S

更新日期：2019-12-03 00:00:00

abstract：:Typhoid fever, caused by Salmonella enterica serovar Typhi, is a global public health concern due to increasing antimicrobial resistance (AMR). Characterization of S Typhi genomes for AMR and the evolution of different lineages, especially in countries where typhoid fever is endemic such as Bangladesh, will help publi...

journal_title：mBio

authors： Tanmoy AM,Westeel E,De Bruyne K,Goris J,Rajoharison A,Sajib MSI,van Belkum A,Saha SK,Komurian-Pradel F,Endtz HP

更新日期：2018-11-13 00:00:00

abstract：:Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughput purposes. Here, we made a...

journal_title：mBio

authors： Moudjou M,Sibille P,Fichet G,Reine F,Chapuis J,Herzog L,Jaumain E,Laferrière F,Richard CA,Laude H,Andréoletti O,Rezaei H,Béringue V

更新日期：2013-12-31 00:00:00

abstract：UNLABELLED:Elevated intracellular levels of the bacterial second messenger c-di-GMP are known to suppress motility and promote sessility. Bacterial chemotaxis guides motile cells in gradients of attractants and repellents over broad concentration ranges, thus allowing bacteria to quickly adapt to changes in their surro...

journal_title：mBio

authors： Russell MH,Bible AN,Fang X,Gooding JR,Campagna SR,Gomelsky M,Alexandre G

更新日期：2013-03-19 00:00:00

abstract：UNLABELLED:The route taken by papillomaviruses from the cell surface to the nucleus during infection is incompletely understood. Here, we developed a novel human papillomavirus 16 (HPV16) pseudovirus in which the carboxy terminus of the minor capsid protein L2 is exposed on the exterior of the intact capsid prior to ce...

journal_title：mBio

authors： Zhang W,Kazakov T,Popa A,DiMaio D

更新日期：2014-09-16 00:00:00

abstract：UNLABELLED:Type III secretion systems (T3SS) translocate effector proteins into target cells in order to disrupt or modulate host cell signaling pathways and establish replicative niches. However, recognition of T3SS activity by cytosolic pattern recognition receptors (PRRs) of the nucleotide-binding domain leucine ric...

journal_title：mBio

authors： Zwack EE,Snyder AG,Wynosky-Dolfi MA,Ruthel G,Philip NH,Marketon MM,Francis MS,Bliska JB,Brodsky IE

更新日期：2015-02-17 00:00:00

abstract：:RNA-binding proteins (RBPs) play a major role during control of mRNA localization, stability, and translation and are central to most cellular processes. In the fission yeast Schizosaccharomyces pombe, the multiple K homology (KH) domain RBP Rnc1 downregulates the activity of the cell integrity pathway (CIP) via stabi...

journal_title：mBio

authors： Prieto-Ruiz F,Vicente-Soler J,Franco A,Gómez-Gil E,Sánchez-Marinas M,Vázquez-Marín B,Aligué R,Madrid M,Moreno S,Soto T,Cansado J

更新日期：2020-01-07 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significant...

journal_title：mBio

authors： Vaillancourt M,Jorth P

更新日期：2020-08-07 00:00:00

abstract：:The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an immunoproteasome (iProteasome). iProteasome-degraded products are...

journal_title：mBio

authors： Yang Y,Liu W,Hu D,Su R,Ji M,Huang Y,Shereen MA,Xu X,Luo Z,Zhang Q,Liu F,Wu K,Liu Y,Wu J

更新日期：2020-10-27 00:00:00

abstract：:Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated ...

journal_title：mBio

authors： Alves R,Sousa-Silva M,Vieira D,Soares P,Chebaro Y,Lorenz MC,Casal M,Soares-Silva I,Paiva S

更新日期：2020-05-12 00:00:00

abstract：:Murein lipoprotein (Lpp) and peptidoglycan-associated lipoprotein (Pal) are major outer membrane lipoproteins in Escherichia coli Their roles in cell-envelope integrity have been documented in E. coli laboratory strains, and while Lpp has been linked to serum resistance in vitro, the underlying mechanism has not been ...

journal_title：mBio

authors： Diao J,Bouwman C,Yan D,Kang J,Katakam AK,Liu P,Pantua H,Abbas AR,Nickerson NN,Austin C,Reichelt M,Sandoval W,Xu M,Whitfield C,Kapadia SB

更新日期：2017-05-23 00:00:00

abstract：UNLABELLED:Human cathepsin W (CtsW) is a cysteine protease, which was identified in a genome-wide RNA interference (RNAi) screen to be required for influenza A virus (IAV) replication. In this study, we show that reducing the levels of expression of CtsW reduces viral titers for different subtypes of IAV, and we map th...

journal_title：mBio

authors： Edinger TO,Pohl MO,Yángüez E,Stertz S

更新日期：2015-06-09 00:00:00

abstract：UNLABELLED:In infection experiments with genetically distinct Mycobacterium tuberculosis complex (MTBC) strains, we identified clade-specific virulence patterns in human primary macrophages and in mice infected by the aerosol route, both reflecting relevant model systems. Exclusively human-adapted M. tuberculosis linea...

journal_title：mBio

authors： Reiling N,Homolka S,Walter K,Brandenburg J,Niwinski L,Ernst M,Herzmann C,Lange C,Diel R,Ehlers S,Niemann S

更新日期：2013-07-30 00:00:00

abstract：:Interferons (IFNs) and autophagy are critical neuronal defenses against viral infection. IFNs alter neuronal autophagy by promoting the accumulation of IFN-dependent LC3-decorated autophagic structures, termed LC3 clusters. Here, we analyzed LC3 clusters in sensory ganglia following herpes simplex virus 1 (HSV-1) infe...

journal_title：mBio

authors： Cabrera JR,Manivanh R,North BJ,Leib DA

更新日期：2019-03-05 00:00:00

abstract：:The clonal population structure of Candida albicans suggests that (para)sexual recombination does not play an important role in the lifestyle of this opportunistic fungal pathogen, an assumption that is strengthened by the fact that most C. albicans strains are heterozygous at the mating type locus (MTL) and therefore...

journal_title：mBio

authors： Popp C,Ramírez-Zavala B,Schwanfelder S,Krüger I,Morschhäuser J

更新日期：2019-02-05 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00

abstract：:Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the natural evolution of ...

journal_title：mBio

authors： Broset E,Martín C,Gonzalo-Asensio J

更新日期：2015-10-20 00:00:00

abstract：:The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...

journal_title：mBio

authors： Ausiello CM,Cassone A

更新日期：2014-06-10 00:00:00

abstract：UNLABELLED:Sensing of and responding to environmental changes are of vital importance for microbial cells. Consequently, bacteria have evolved a plethora of signaling systems that usually sense biochemical cues either via direct ligand binding, thereby acting as "concentration sensors," or by responding to downstream e...

journal_title：mBio

authors： Fritz G,Dintner S,Treichel NS,Radeck J,Gerland U,Mascher T,Gebhard S

更新日期：2015-07-21 00:00:00

abstract：:Symbiotic microorganisms can have a profound impact on the host physiology and behavior, and novel relationships between symbionts and their hosts are continually discovered. A colony of social ants consists of various castes that exhibit distinct lifestyles and is, thus, a unique model for investigating how symbionts...

journal_title：mBio

authors： Koto A,Nobu MK,Miyazaki R

更新日期：2020-04-21 00:00:00

abstract：:Motility is an important virulence trait for many bacterial pathogens, allowing them to position themselves in appropriate locations at appropriate times. The motility structures type IV pili and flagella are also involved in sensing surface contact, which modulates pathogenicity. In Pseudomonas aeruginosa, the PilS-P...

journal_title：mBio

authors： Kilmury SLN,Burrows LL

更新日期：2018-07-24 00:00:00

abstract：UNLABELLED:Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had an increased risk of HIV transmission, raised concerns about endpoints used to evaluate microbicide safety. A possible explanation for the increased ...

journal_title：mBio

authors： Ravel J,Gajer P,Fu L,Mauck CK,Koenig SS,Sakamoto J,Motsinger-Reif AA,Doncel GF,Zeichner SL

更新日期：2012-12-18 00:00:00

abstract：UNLABELLED:Staphylococcus aureus is a human commensal that at times turns into a serious bacterial pathogen causing life-threatening infections. For the delicate control of virulence, S. aureus employs the agr quorum-sensing system that, via the intracellular effector molecule RNAIII, regulates virulence gene expressio...

journal_title：mBio

authors： Paulander W,Nissen Varming A,Bæk KT,Haaber J,Frees D,Ingmer H

更新日期：2013-01-02 00:00:00

abstract：UNLABELLED:Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations. In a long-term evolution experiment, twelve Escherichia coli populations have been propagated in a glucose-limited environment for over 25 ...

journal_title：mBio

authors： Raeside C,Gaffé J,Deatherage DE,Tenaillon O,Briska AM,Ptashkin RN,Cruveiller S,Médigue C,Lenski RE,Barrick JE,Schneider D

更新日期：2014-09-09 00:00:00

abstract：:The 1977-1978 influenza epidemic was probably not a natural event, as the genetic sequence of the virus was nearly identical to the sequences of decades-old strains. While there are several hypotheses that could explain its origin, the possibility that the 1977 epidemic resulted from a laboratory accident has recently...

journal_title：mBio

authors： Rozo M,Gronvall GK

更新日期：2015-08-18 00:00:00

abstract：UNLABELLED:The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe respiratory infection with a high mortality rate (~35%). MERS-CoV has been a global threat due to continuous outbreaks in the Arabian peninsula and international spread by infected travelers since 2012. From May to Jul...

journal_title：mBio

authors： Kim Y,Cheon S,Min CK,Sohn KM,Kang YJ,Cha YJ,Kang JI,Han SK,Ha NY,Kim G,Aigerim A,Shin HM,Choi MS,Kim S,Cho HS,Kim YS,Cho NH

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:The ExPortal of Streptococcus pyogenes is a focal microdomain of the cytoplasmic membrane that clusters the translocons of the general secretory pathway with accessory factors to facilitate the maturation of secreted polypeptides. While it is known that the ExPortal is enriched in anionic lipids, the mechani...

journal_title：mBio

authors： Vega LA,Port GC,Caparon MG

更新日期：2013-09-24 00:00:00

abstract：:Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease. During enterotoxemia, the nearly inactive ETX prototoxin is produced in the intestines but then must be activated by proteolytic ...

journal_title：mBio

authors： Freedman JC,Li J,Uzal FA,McClane BA

更新日期：2014-10-21 00:00:00

abstract：:Cerebral malaria is a severe neurological complication associated with sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the specific binding interactions remain under debate. Here, we have generated an engineered three-dimensional (3D) human brain endothelial microve...

journal_title：mBio

authors： Bernabeu M,Gunnarsson C,Vishnyakova M,Howard CC,Nagao RJ,Avril M,Taylor TE,Seydel KB,Zheng Y,Smith JD

更新日期：2019-05-28 00:00:00

abstract：:Microbial establishment within the gastrointestinal (GI) tract requires surveillance of the gut biogeography. The gut microbiota coordinates behaviors by sensing host- or microbiota-derived signals. Here we show for the first time that microbiota-derived indole is highly prevalent in the lumen compared to the intestin...

journal_title：mBio

authors： Kumar A,Sperandio V

更新日期：2019-06-04 00:00:00