Abstract:
:Symbiotic microorganisms can have a profound impact on the host physiology and behavior, and novel relationships between symbionts and their hosts are continually discovered. A colony of social ants consists of various castes that exhibit distinct lifestyles and is, thus, a unique model for investigating how symbionts may be involved in host eusociality. Yet our knowledge of social ant-symbiont dynamics has remained rudimentary. Through 16S rRNA gene deep sequencing of the carpenter ant Camponotus japonicus symbiont community across various castes, we here report caste-dependent diversity of commensal gut microbiota and lineage divergence of "Candidatus Blochmannia," an obligate endosymbiont. While most prevalent gut-associated bacterial populations are found across all castes (Alphaproteobacteria, Gammaproteobacteria, Bacteroidetes, and Cyanobacteria), we also discovered uncultured populations that are found only in males (belonging to Corynebacteriales, Alkanindiges, and Burkholderia). Most of those populations are not detected in laboratory-maintained queens and workers, suggesting that they are facultative gut symbionts introduced via environmental acquisition. Further inspection of "Ca. Blochmannia" endosymbionts reveals that two populations are dominant in all individuals across all castes but that males preferentially contain two different sublineages that are diversified from others. Clearly, each caste has distinct symbiont communities, suggesting an overlooked biological aspect of host-symbiont interaction in social insects.IMPORTANCE Social animals, such as primates and some insects, have been shown to exchange symbiotic microbes among individuals through sharing diet or habitats, resulting in increased consistency of microbiota among social partners. The ant is a representative of social insects exhibiting various castes within a colony; queens, males, and nonreproductive females (so-called workers) show distinct morphologies, physiologies, and behaviors but tightly interact with each other in the nest. However, how this social context affects their gut microbiota has remained unclear. In this study, we deeply sequenced the gut symbiont community across various castes of the carpenter ant Camponotus japonicus We report caste-dependent diversity of commensal gut microbial community and lineage divergence of the mutualistic endosymbiont "Candidatus Blochmannia." This report sheds light on the hidden diversity in microbial populations and community structure associated with guts of males in social ants.
journal_name
mBiojournal_title
mBioauthors
Koto A,Nobu MK,Miyazaki Rdoi
10.1128/mBio.00408-20subject
Has Abstractpub_date
2020-04-21 00:00:00issue
2issn
2150-7511pii
mBio.00408-20journal_volume
11pub_type
杂志文章相关文献
mBio文献大全abstract:UNLABELLED:Curing HIV-1 infection will require elimination of persistent cellular reservoirs that harbor latent virus in the face of combination antiretroviral therapy (cART). Proposed immunotherapeutic strategies to cure HIV-1 infection include enhancing lysis of these infected cells by cytotoxic T lymphocytes (CTL). ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00473-16
更新日期:2016-05-31 00:00:00
abstract:UNLABELLED:Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems. However, the structural specificity of these systems for sugar substrates has hindered their appl...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00443-16
更新日期:2016-04-26 00:00:00
abstract::The members of the OM43 clade of Betaproteobacteria are abundant coastal methylotrophs with a range of carbon-utilizing capabilities. However, their underlying transcriptional and metabolic responses to shifting conditions or different carbon substrates remain poorly understood. We examined the transcriptional dynamic...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01279-16
更新日期:2016-11-22 00:00:00
abstract::Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ), and acyl carrier protein (ACP), are utilized to elongate the p...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01334-20
更新日期:2020-09-15 00:00:00
abstract:UNLABELLED:Type III secretion systems (T3SS) translocate effector proteins into target cells in order to disrupt or modulate host cell signaling pathways and establish replicative niches. However, recognition of T3SS activity by cytosolic pattern recognition receptors (PRRs) of the nucleotide-binding domain leucine ric...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02095-14
更新日期:2015-02-17 00:00:00
abstract::To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we constructed a genome encyclopedia describing the core supragingival plaque microb...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01631-18
更新日期:2018-11-27 00:00:00
abstract::Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment of a type IV secretion system (T4SS). However, the mechanism by which the T4SS elicits inflammation remains unknown. Here we show that translocation of the T4SS substrate VceC into host cells induces proinflammatory resp...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00418-12
更新日期:2013-02-19 00:00:00
abstract::Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy. They can also use poised electrodes as their electron donor via phototrophic extracellular electron uptake (phototrophic EEU). The e...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02668-19
更新日期:2019-11-05 00:00:00
abstract::Most bacteria and archaea use the tubulin homologue FtsZ as its central organizer of cell division. In Gram-negative Escherichia coli bacteria, FtsZ recruits cytosolic, transmembrane, periplasmic, and outer membrane proteins, assembling the divisome that facilitates bacterial cell division. One such divisome component...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01346-18
更新日期:2018-09-11 00:00:00
abstract::Bats are reservoirs for many RNA viruses that are highly pathogenic in humans yet relatively apathogenic in the natural host. It has been suggested that differences in innate immunity are responsible. The antiviral OAS-RNase L pathway is well characterized in humans, but there is little known about its activation and ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02414-19
更新日期:2019-11-12 00:00:00
abstract::Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural origin, discovering new natural products is challenging, and there is a need to expand the chemical ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01474-17
更新日期:2017-10-10 00:00:00
abstract:UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00417-16
更新日期:2016-04-19 00:00:00
abstract::E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the African swine fever virus (ASFV) genome, is required for productive replication of ASFV in swine macrophages. Here, we solved the high-resolution crystal structures of E165R in its apo state and in complex with its product dUMP. Structural anal...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02483-19
更新日期:2019-10-29 00:00:00
abstract::The blast fungus initiates infection using a heavily melanized, dome-shaped infection structure known as the appressorium, which forcibly ruptures the cuticle to enter the rice leaf tissue. How this process takes place remains not fully understood. Here, we used untargeted metabolomics analyses to profile the metabolo...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01467-19
更新日期:2019-08-20 00:00:00
abstract:UNLABELLED:In Staphylococcus aureus, hundreds of small regulatory or small RNAs (sRNAs) have been identified, yet this class of molecule remains poorly understood and severely understudied. sRNA genes are typically absent from genome annotation files, and as a consequence, their existence is often overlooked, particula...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01990-15
更新日期:2016-02-09 00:00:00
abstract::Antimicrobial resistance is a major health threat as it limits treatment options for infection. At the forefront of this serious issue is Acinetobacter baumannii, a Gram-negative opportunistic pathogen that exhibits the remarkable ability to resist antibiotics through multiple mechanisms. As bacterial ribosomes repres...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.03117-19
更新日期:2020-01-21 00:00:00
abstract::The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics. Despite intensive studies since (p)ppGpp was discovered over 4 decades ago, (p)ppGpp binding proteins have not been systematically identi...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02188-17
更新日期:2018-03-06 00:00:00
abstract:UNLABELLED:Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts. The underlying molecular mechanism of PMT was defined as a persistent activation of he...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02190-14
更新日期:2014-11-11 00:00:00
abstract::Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resista...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00592-20
更新日期:2020-04-14 00:00:00
abstract::The biosynthesis of antioxidant pigments, namely, betalains, was believed to be restricted to Caryophyllales plants. This paper changes this paradigm, and enzyme mining from bacterial hosts promoted the discovery of bacterial cultures producing betalains. The spectrum of possible sources of betalain pigments in nature...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00345-19
更新日期:2019-03-19 00:00:00
abstract::The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02507-20
更新日期:2020-12-08 00:00:00
abstract::Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity and mortality and tend to be challenging to treat. Candida albicans and Staphylococcus aureus specifically are considered leading opportunistic fungal and bacterial pathogens, respect...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01365-16
更新日期:2016-10-11 00:00:00
abstract::Mannitol-1-phosphate dehydrogenase (M1PDH) is a key enzyme in Staphylococcus aureus mannitol metabolism, but its roles in pathophysiological settings have not been established. We performed comprehensive structure-function analysis of M1PDH from S. aureus USA300, a strain of community-associated methicillin-resistant ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02660-18
更新日期:2019-07-09 00:00:00
abstract::Acute flaccid myelitis (AFM) is a rare but serious illness of the nervous system, specifically affecting the gray matter of the spinal cord, motor-controlling regions of the brain, and cranial nerves. Most cases of AFM are pathogen associated, typically with poliovirus and enterovirus infections, and occur in children...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02370-19
更新日期:2019-10-22 00:00:00
abstract::Fission yeast phosphate homeostasis entails transcriptional induction of genes encoding phosphate-mobilizing proteins under conditions of phosphate starvation. Transcription factor Pho7, a member of the Zn2Cys6 family of fungal transcription regulators, is the central player in the starvation response. The DNA binding...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01218-17
更新日期:2017-08-15 00:00:00
abstract:UNLABELLED:Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE surface membrane. To investigate the relationship between ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01456-15
更新日期:2015-10-06 00:00:00
abstract::Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic understanding of how bacteria evolve resistance against multiple phages is lacking, ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01652-19
更新日期:2019-09-24 00:00:00
abstract::Biofilms play a critical role in the colonization, persistence, and pathogenesis of many human pathogens. Multiple mucosa-associated pathogens have evolved a mechanism of rapid adaptation, termed the phasevarion, which facilitates a coordinated regulation of numerous genes throughout the bacterial genome. This epigene...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01682-18
更新日期:2018-09-18 00:00:00
abstract::Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor composed of three subunits, namely, NF-YA, NF-YB, and NF-YC, which are conserved throughout evolution. In higher eukaryotes, NF-Y plays important roles in several cellular processes (development, cell cycle regulation, apoptosis, and response to growth, ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00737-19
更新日期:2019-06-18 00:00:00
abstract:UNLABELLED:Honeybees harbor well-defined bacterial communities in their guts. The major members of these communities appear to benefit the host, but little is known about how they interact with the host and specifically how they interface with the host immune system. In the pylorus, a short region between the midgut an...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00193-15
更新日期:2015-05-19 00:00:00