Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus.

abstract：UNLABELLED:Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations. In a long-term evolution experiment, twelve Escherichia coli populations have been propagated in a glucose-limited environment for over 25 ...

journal_title：mBio

authors： Raeside C,Gaffé J,Deatherage DE,Tenaillon O,Briska AM,Ptashkin RN,Cruveiller S,Médigue C,Lenski RE,Barrick JE,Schneider D

更新日期：2014-09-09 00:00:00

abstract：:Sinorhizobium meliloti is an alphaproteobacterium belonging to the Rhizobiales Bacteria from this order elongate their cell wall at the new cell pole, generated by cell division. Screening for protein interaction partners of the previously characterized polar growth factors RgsP and RgsM, we identified the inner membr...

journal_title：mBio

authors： Krol E,Yau HCL,Lechner M,Schäper S,Bange G,Vollmer W,Becker A

更新日期：2020-06-30 00:00:00

abstract：:We have previously identified Vibrio cholerae mutants in which the stress response to subinhibitory concentrations of aminoglycoside is altered. One gene identified, VC1636, encodes a putative DNA/RNA helicase, recently named RadD in Escherichia coli Here we combined extensive genetic characterization and high-through...

journal_title：mBio

authors： Negro V,Krin E,Aguilar Pierlé S,Chaze T,Giai Gianetto Q,Kennedy SP,Matondo M,Mazel D,Baharoglu Z

更新日期：2019-07-02 00:00:00

abstract：:Microbial establishment within the gastrointestinal (GI) tract requires surveillance of the gut biogeography. The gut microbiota coordinates behaviors by sensing host- or microbiota-derived signals. Here we show for the first time that microbiota-derived indole is highly prevalent in the lumen compared to the intestin...

journal_title：mBio

authors： Kumar A,Sperandio V

更新日期：2019-06-04 00:00:00

abstract：UNLABELLED:Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had an increased risk of HIV transmission, raised concerns about endpoints used to evaluate microbicide safety. A possible explanation for the increased ...

journal_title：mBio

authors： Ravel J,Gajer P,Fu L,Mauck CK,Koenig SS,Sakamoto J,Motsinger-Reif AA,Doncel GF,Zeichner SL

更新日期：2012-12-18 00:00:00

abstract：:Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference (RNAi) response are poorly understood. Here, we characterized antiviral RN...

journal_title：mBio

authors： Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW

更新日期：2020-08-04 00:00:00

abstract：:In celebrating the 125th anniversary of the National Institutes of Health (NIH) in August 2012, NIH has been examining its origins, its history, and the visionary men and women whose research have contributed to the saving and/or improving the quality of life of millions of people throughout the world. This minireview...

journal_title：mBio

authors： Morens DM,Fauci AS

更新日期：2012-06-26 00:00:00

abstract：:Formation of multispecies communities allows nearly every niche on earth to be colonized, and the exchange of molecular information among neighboring bacteria in such communities is key for bacterial success. To clarify the principles controlling interspecies interactions, we previously developed a coculture model wit...

journal_title：mBio

authors： Ranava D,Backes C,Karthikeyan G,Ouari O,Soric A,Guiral M,Cárdenas ML,Giudici-Orticoni MT

更新日期：2021-01-19 00:00:00

abstract：:Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in the mammalian adaptation of AIVs. The H7N9 AIVs that emerged in 2013 in China easily acquired the PB2 E627K mutation u...

journal_title：mBio

authors： Liang L,Jiang L,Li J,Zhao Q,Wang J,He X,Huang S,Wang Q,Zhao Y,Wang G,Sun N,Deng G,Shi J,Tian G,Zeng X,Jiang Y,Liu L,Liu J,Chen P,Bu Z,Kawaoka Y,Chen H,Li C

更新日期：2019-06-18 00:00:00

abstract：:Hepatitis E virus (HEV), a single-strand positive-sense RNA virus, is an understudied but important human pathogen. The virus can establish infection at a number of host tissues, including the small intestine and liver, causing acute and chronic hepatitis E as well as certain neurological disorders. The retinoic acid-...

journal_title：mBio

authors： Sooryanarain H,Heffron CL,Meng XJ

更新日期：2020-01-14 00:00:00

abstract：:Forested ecosystems throughout the world are experiencing increases in the incidence and magnitude of insect-induced tree mortality with large ecologic ramifications. Interestingly, correlations between water quality and the extent of tree mortality in Colorado montane ecosystems suggest compensatory effects from adja...

journal_title：mBio

authors： Mikkelson KM,Brouillard BM,Bokman CM,Sharp JO

更新日期：2017-12-05 00:00:00

abstract：:Unlike all other archaeal lineages, ammonia-oxidizing archaea (AOA) of the phylum Thaumarchaeota are widespread and abundant in all moderate and oxic environments on Earth. The evolutionary adaptations that led to such unprecedented ecological success of a microbial clade characterized by highly conserved energy and c...

journal_title：mBio

authors： Abby SS,Kerou M,Schleper C

更新日期：2020-10-13 00:00:00

abstract：:EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) o...

journal_title：mBio

authors： McCarthy KR,Timpona JL,Jenni S,Bloyet LM,Brusic V,Johnson WE,Whelan SPJ,Robinson-McCarthy LR

更新日期：2020-11-17 00:00:00

abstract：:Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo We hypothesized that we could improve the specificity of LV targeting by coupling (i) reduction of their binding to off-target cells with (ii) redirection of the vect...

journal_title：mBio

authors： Parker CL,Jacobs TM,Huckaby JT,Harit D,Lai SK

更新日期：2020-01-21 00:00:00

abstract：UNLABELLED:The aerial surfaces of plants, or phyllosphere, are microbial habitats important to plant and human health. In order to accurately investigate microbial interactions in the phyllosphere under laboratory conditions, the composition of the phyllosphere microbiota should be representative of the diversity of mi...

journal_title：mBio

authors： Williams TR,Marco ML

更新日期：2014-08-12 00:00:00

abstract：:The ability to withstand UV damage shapes the ecology of microbes. While mechanisms of UV tolerance were extensively investigated in microorganisms regularly exposed to the sun, far less is known about UV repair of soilborne microorganisms. Fusarium oxysporum is a soilborne fungal plant pathogen that is resistant to U...

journal_title：mBio

authors： Milo-Cochavi S,Adar S,Covo S

更新日期：2019-12-03 00:00:00

abstract：:Bacillus anthracis is a Gram-positive bacillus that under conditions of environmental stress, such as low nutrients, can convert from a vegetative bacillus to a highly durable spore that enables long-term survival. The sporulation process is regulated by a sequential cascade of dedicated transcription factors but requ...

journal_title：mBio

authors： Hagan AK,Plotnick YM,Dingle RE,Mendel ZI,Cendrowski SR,Sherman DH,Tripathi A,Hanna PC

更新日期：2018-11-06 00:00:00

abstract：:The β-barrel assembly machinery, the Bam complex, is central to the biogenesis of integral outer membrane proteins (OMPs) as well as OMP-dependent surface-exposed lipoproteins, such as regulator of capsule synthesis protein F (RcsF). Previous genetic analysis established the model that nonessential components BamE and...

journal_title：mBio

authors： Tata M,Konovalova A

更新日期：2019-05-21 00:00:00

abstract：:1-Butanol is a large-volume, intermediate chemical with favorable physical and chemical properties for blending with or directly substituting for gasoline. The per-volume value of butanol, as a chemical, is sufficient for investing into the recommercialization of the classical acetone-butanol-ethanol (ABE) (E. M. Gree...

journal_title：mBio

authors： Tracy BP

更新日期：2012-12-11 00:00:00

abstract：:A central question in mechanobiology is how cellular-scale structures are established and regulated. In bacteria, the cell envelope is essential for mechanical integrity, protecting against environmental stresses and bearing the load from high turgor pressures. Trivedi et al. (mBio 9:e01340-18, 2018, https://doi.org/1...

journal_title：mBio

authors： Odermatt PD,Arjes HA,Chang F,Huang KC

更新日期：2018-10-23 00:00:00

abstract：:The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics. Despite intensive studies since (p)ppGpp was discovered over 4 decades ago, (p)ppGpp binding proteins have not been systematically identi...

journal_title：mBio

authors： Zhang Y,Zborníková E,Rejman D,Gerdes K

更新日期：2018-03-06 00:00:00

abstract：:The microbiome of wild Mus musculus (house mouse), a globally distributed invasive pest that resides in close contact with humans in urban centers, is largely unexplored. Here, we report analysis of the fecal virome of house mice in residential buildings in New York City, NY. Mice were collected at seven sites in Manh...

journal_title：mBio

authors： Williams SH,Che X,Garcia JA,Klena JD,Lee B,Muller D,Ulrich W,Corrigan RM,Nichol S,Jain K,Lipkin WI

更新日期：2018-04-17 00:00:00

abstract：:The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell wall-acting antibiotics. In rich medium, c-di-AMP is essential; however, muta...

journal_title：mBio

authors： Peterson BN,Young MKM,Luo S,Wang J,Whiteley AT,Woodward JJ,Tong L,Wang JD,Portnoy DA

更新日期：2020-08-25 00:00:00

abstract：:To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we constructed a genome encyclopedia describing the core supragingival plaque microb...

journal_title：mBio

authors： Espinoza JL,Harkins DM,Torralba M,Gomez A,Highlander SK,Jones MB,Leong P,Saffery R,Bockmann M,Kuelbs C,Inman JM,Hughes T,Craig JM,Nelson KE,Dupont CL

更新日期：2018-11-27 00:00:00

abstract：:Yellow fever virus (YFV) is an arthropod-borne flavivirus, infecting ~200,000 people worldwide annually and causing about 30,000 deaths. The live attenuated vaccine strain, YFV-17D, has significantly contributed in controlling the global burden of yellow fever worldwide. However, the viral and host contributions to YF...

journal_title：mBio

authors： Douam F,Soto Albrecht YE,Hrebikova G,Sadimin E,Davidson C,Kotenko SV,Ploss A

更新日期：2017-08-15 00:00:00

abstract：UNLABELLED:A 32-nucleotide (nt) RNA motif located at the 3' end of the transmissible gastroenteritis coronavirus (TGEV) genome was found to specifically interact with the host proteins glutamyl-prolyl-tRNA synthetase (EPRS) and arginyl-tRNA synthetase (RRS). This RNA motif has high homology in sequence and secondary st...

journal_title：mBio

authors： Marquez-Jurado S,Nogales A,Zuñiga S,Enjuanes L,Almazán F

更新日期：2015-03-10 00:00:00

abstract：:Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many bacteria, the pneumococcus can import DNA from other strains or even species by transformation and homologous recombination, which has allowed the pneumococcus to...

journal_title：mBio

authors： Chaguza C,Andam CP,Harris SR,Cornick JE,Yang M,Bricio-Moreno L,Kamng'ona AW,Parkhill J,French N,Heyderman RS,Kadioglu A,Everett DB,Bentley SD,Hanage WP

更新日期：2016-09-27 00:00:00

abstract：:Adult Drosophila melanogaster raised in the absence of symbiotic bacteria have fewer intestinal stem cell divisions and a longer life span than their conventionally reared counterparts. However, we do not know if increased stem cell divisions are essential for symbiont-dependent regulation of longevity. To determine i...

journal_title：mBio

authors： Fast D,Duggal A,Foley E

更新日期：2018-07-31 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that can cause life-threatening invasive lung infections in immunodeficient patients. The cellular and molecular processes of infection during onset, establishment, and progression of A. fumigatus infections are highly complex and depend on both fungal attribut...

journal_title：mBio

authors： Amich J,Mokhtari Z,Strobel M,Vialetto E,Sheta D,Yu Y,Hartweg J,Kalleda N,Jarick KJ,Brede C,Jordán-Garrote AL,Thusek S,Schmiedgen K,Arslan B,Pinnecker J,Thornton CR,Gunzer M,Krappmann S,Einsele H,Heinze KG,Beilhack

更新日期：2020-02-04 00:00:00

abstract：UNLABELLED:Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited. Of the two major antifungal drug classes, azoles are active against C. neoformans but exert a fungistatic effect, necessitating long tr...

journal_title：mBio

authors： Huang W,Liao G,Baker GM,Wang Y,Lau R,Paderu P,Perlin DS,Xue C

更新日期：2016-05-10 00:00:00