Monoassociation with Lactobacillus plantarum Disrupts Intestinal Homeostasis in Adult Drosophila melanogaster.

abstract：:Sodium-translocating NADH:quinone oxidoreductase (Na+-NQR) functions as a unique redox-driven sodium pump, generating membrane potential, which is related to aminoglycoside antibiotic resistance. However, whether it modulates other metabolisms to confer antibiotic resistance is unknown. The present study showed that l...

journal_title：mBio

authors： Jiang M,Kuang SF,Lai SS,Zhang S,Yang J,Peng B,Peng XX,Chen ZG,Li H

更新日期：2020-11-17 00:00:00

abstract：:The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an immunoproteasome (iProteasome). iProteasome-degraded products are...

journal_title：mBio

authors： Yang Y,Liu W,Hu D,Su R,Ji M,Huang Y,Shereen MA,Xu X,Luo Z,Zhang Q,Liu F,Wu K,Liu Y,Wu J

更新日期：2020-10-27 00:00:00

abstract：UNLABELLED:Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense mole...

journal_title：mBio

authors： Warren TK,Whitehouse CA,Wells J,Welch L,Heald AE,Charleston JS,Sazani P,Reid SP,Iversen PL,Bavari S

更新日期：2015-02-10 00:00:00

abstract：UNLABELLED:Pneumococcal pili have been shown to influence pneumococcal colonization, disease development, and the inflammatory response in mice. The role of the pilus-associated RrgA adhesin in pneumococcal interactions with murine and human macrophages was investigated. Expression of pili with RrgA enhanced the uptake...

journal_title：mBio

authors： Orrskog S,Rounioja S,Spadafina T,Gallotta M,Norman M,Hentrich K,Fälker S,Ygberg-Eriksson S,Hasenberg M,Johansson B,Uotila LM,Gahmberg CG,Barocchi M,Gunzer M,Normark S,Henriques-Normark B

更新日期：2012-12-26 00:00:00

abstract：:Host-associated microbial communities are shaped by extrinsic and intrinsic factors to the holobiont organism. Environmental factors and microbe-microbe interactions act simultaneously on the microbial community structure, making the microbiome dynamics challenging to predict. The coral microbiome is essential to the ...

journal_title：mBio

authors： Lima LFO,Weissman M,Reed M,Papudeshi B,Alker AT,Morris MM,Edwards RA,de Putron SJ,Vaidya NK,Dinsdale EA

更新日期：2020-03-03 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic of chlamydial infection is the propensity to cause persistent in...

journal_title：mBio

authors： Yang C,Kari L,Lei L,Carlson JH,Ma L,Couch CE,Whitmire WM,Bock K,Moore I,Bonner C,McClarty G,Caldwell HD

更新日期：2020-08-18 00:00:00

abstract：UNLABELLED:Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a variety of environmental stimuli and play a critical r...

journal_title：mBio

authors： Agostoni M,Koestler BJ,Waters CM,Williams BL,Montgomery BL

更新日期：2013-08-13 00:00:00

abstract：:ABSTRACT The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the virulence of pathogenic mycobacteria and conjugation in the model organism Mycobacterium smegmatis, Esx-3 contributes to mycobactin-media...

journal_title：mBio

authors： Siegrist MS,Steigedal M,Ahmad R,Mehra A,Dragset MS,Schuster BM,Philips JA,Carr SA,Rubin EJ

更新日期：2014-05-06 00:00:00

abstract：UNLABELLED:A 32-nucleotide (nt) RNA motif located at the 3' end of the transmissible gastroenteritis coronavirus (TGEV) genome was found to specifically interact with the host proteins glutamyl-prolyl-tRNA synthetase (EPRS) and arginyl-tRNA synthetase (RRS). This RNA motif has high homology in sequence and secondary st...

journal_title：mBio

authors： Marquez-Jurado S,Nogales A,Zuñiga S,Enjuanes L,Almazán F

更新日期：2015-03-10 00:00:00

abstract：:A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying permeabilized retrovirus parti...

journal_title：mBio

authors： Jennings J,Shi J,Varadarajan J,Jamieson PJ,Aiken C

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:Helicobacter pylori chronically infects the gastric mucosa in more than half of the human population; in a subset of this population, its presence is associated with development of severe disease, such as gastric cancer. Genomic analysis of several strains has revealed an extensive H. pylori pan-genome, like...

journal_title：mBio

authors： Lehours P,Vale FF,Bjursell MK,Melefors O,Advani R,Glavas S,Guegueniat J,Gontier E,Lacomme S,Alves Matos A,Menard A,Mégraud F,Engstrand L,Andersson AF

更新日期：2011-11-15 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. Septins are a group of 13 GTP-binding proteins that assemble into oligomeric complexes and that can form higher-order filaments. We report here that the septins SEPT2, -9, -11, and p...

journal_title：mBio

authors： Volceanov L,Herbst K,Biniossek M,Schilling O,Haller D,Nölke T,Subbarayal P,Rudel T,Zieger B,Häcker G

更新日期：2014-10-07 00:00:00

abstract：:Diet influences health in multiple ways. One important effect of diet is on the gut microbiota. The effects of diet are often related to an individual's specific microbiota composition. The close links between health, diet, and gut microbiota are illustrated in a new mouse model of sepsis where the combination of a hi...

journal_title：mBio

authors： Bassis CM

更新日期：2019-10-08 00:00:00

abstract：:Biological nitrogen fixation is catalyzed by nitrogenase, a complex metalloenzyme found only in prokaryotes. N2 fixation is energetically highly expensive, and an energy-generating process such as photosynthesis can meet the energy demand of N2 fixation. However, synthesis and expression of nitrogenase are exquisitely...

journal_title：mBio

authors： Liu D,Liberton M,Yu J,Pakrasi HB,Bhattacharyya-Pakrasi M

更新日期：2018-06-05 00:00:00

abstract：:The gut microbiota contributes to nutrients absorption and metabolism by enterocytes, but the molecular mechanisms involved remain poorly understood, and most conclusions are inferred from studies comparing germfree and conventional animals colonized with diverse bacterial species. We selected two model commensal micr...

journal_title：mBio

authors： Tazi A,Araujo JR,Mulet C,Arena ET,Nigro G,Pédron T,Sansonetti PJ

更新日期：2018-09-04 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral...

journal_title：mBio

authors： Hosseinipour MC,Sweet KM,Xiong J,Namarika D,Mwafongo A,Nyirenda M,Chiwoko L,Kamwendo D,Hoffman I,Lee J,Phiri S,Vahrson W,Damania B,Dittmer DP

更新日期：2014-09-23 00:00:00

abstract：:Photosynthetic bacteria are capable of producing their own food via photosynthesis. Unsurprisingly, they evolved the ability to move toward better light conditions (i.e., phototaxis). In a recent article in mBio, Chau et al. tuned the wavelength, flux, direction, and timing of light input and characterized the motilit...

journal_title：mBio

authors： Kim M

更新日期：2017-04-11 00:00:00

abstract：:The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which...

journal_title：mBio

authors： Antunes LC,McDonald JA,Schroeter K,Carlucci C,Ferreira RB,Wang M,Yurist-Doutsch S,Hira G,Jacobson K,Davies J,Allen-Vercoe E,Finlay BB

更新日期：2014-07-29 00:00:00

abstract：:Bacteriophages are numerically the most abundant DNA-containing entities in the oligotrophic ocean, yet how specific phage populations vary over time and space remains to be fully explored. Here, we conducted a metagenomic time-series survey of double-stranded DNA phages throughout the water column in the North Pacifi...

journal_title：mBio

authors： Luo E,Aylward FO,Mende DR,DeLong EF

更新日期：2017-11-28 00:00:00

abstract：:Vibrio vulnificus, an opportunistic pathogen, is the causative agent of a life-threatening septicemia and a rising problem for aquaculture worldwide. The genetic factors that differentiate its clinical and environmental strains remain enigmatic. Furthermore, clinical strains have emerged from every clade of V. vulnifi...

journal_title：mBio

authors： López-Pérez M,Jayakumar JM,Haro-Moreno JM,Zaragoza-Solas A,Reddi G,Rodriguez-Valera F,Shapiro OH,Alam M,Almagro-Moreno S

更新日期：2019-02-19 00:00:00

abstract：UNLABELLED:The bacterial flagellum is driven by a bidirectional rotary motor, which propels bacteria to swim through liquids or swarm over surfaces. While the functions of the major structural and regulatory components of the flagellum are known, the function of the well-conserved FliL protein is not. In Salmonella and...

journal_title：mBio

authors： Partridge JD,Nieto V,Harshey RM

更新日期：2015-02-24 00:00:00

abstract：UNLABELLED:Bacterial transporter proteins are involved in the translocation of many essential nutrients and metabolites. However, many of these key bacterial transport systems remain to be identified, including those involved in the transport of riboflavin (vitamin B(2)). Pathogenic spirochetes lack riboflavin biosynth...

journal_title：mBio

authors： Deka RK,Brautigam CA,Biddy BA,Liu WZ,Norgard MV

更新日期：2013-02-12 00:00:00

abstract：:This research analyzed six Aspergillus fumigatus genes encoding putative efflux proteins for their roles as transporters. TheA. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI were cloned into plasmids and overexpressed in a Saccharomyces cerevisiae strain in which the highly active endogenous ABC transporter g...

journal_title：mBio

authors： Esquivel BD,Rybak JM,Barker KS,Fortwendel JR,Rogers PD,White TC

更新日期：2020-03-24 00:00:00

abstract：:The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence of the CD4 receptor at the cell surface, primary Envs sample a "closed" conformation that occludes CD4-induced (CD4i) epitopes. The virus co...

journal_title：mBio

authors： Richard J,Prévost J,Baxter AE,von Bredow B,Ding S,Medjahed H,Delgado GG,Brassard N,Stürzel CM,Kirchhoff F,Hahn BH,Parsons MS,Kaufmann DE,Evans DT,Finzi A

更新日期：2018-03-20 00:00:00

abstract：:The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels an...

journal_title：mBio

authors： Andrade DV,Katzelnick LC,Widman DG,Balmaseda A,de Silva AM,Baric RS,Harris E

更新日期：2017-09-19 00:00:00

abstract：:The epidemiology of methicillin-resistant Staphylococcus aureus has changed considerably over the last 3 decades, including the recognition of lineages associated with the community and with livestock exposure, in addition to nosocomial strains. A recent study by R. N. Sieber, R. L. Skov, J. Nielsen, J. Schulz, et al....

journal_title：mBio

authors： Smith TC,Davis MF,Heaney CD

更新日期：2018-12-11 00:00:00

abstract：UNLABELLED:The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens cause an increasing number of nosocomial infections worldwide since they escape the inhibitory effect of the available antibiotics and the immun...

journal_title：mBio

authors： Behroozian S,Svensson SL,Davies J

更新日期：2016-01-26 00:00:00

abstract：:The alphaproteobacterial general stress response is governed by a conserved partner-switching mechanism that is triggered by phosphorylation of the response regulator PhyR. In the model organism Caulobacter crescentus, PhyR was proposed to be phosphorylated by the histidine kinase PhyK, but biochemical evidence in sup...

journal_title：mBio

authors： Lori C,Kaczmarczyk A,de Jong I,Jenal U

更新日期：2018-05-22 00:00:00

abstract：:Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by the enzyme UDP-4-keto-6-deo...

journal_title：mBio

authors： Ma L,Salas O,Bowler K,Bar-Peled M,Sharon A

更新日期：2017-11-21 00:00:00