Live and Diet by Your Gut Microbiota.

abstract：:The disease mechanisms associated with the onset of astrovirus diarrhea are unknown. Unlike other enteric virus infections, astrovirus infection is not associated with an inflammatory response or cellular damage. In vitro studies in differentiated Caco-2 cells demonstrated that human astrovirus serotype 1 (HAstV-1) ca...

journal_title：mBio

authors： Meliopoulos VA,Marvin SA,Freiden P,Moser LA,Nighot P,Ali R,Blikslager A,Reddivari M,Heath RJ,Koci MD,Schultz-Cherry S

更新日期：2016-11-01 00:00:00

abstract：:Neisseria meningitidis (the meningococcus) is primarily a commensal of the human oropharynx that sporadically causes septicemia and meningitis. Meningococci adapt to diverse local host conditions differing in nutrient supply, like the nasopharynx, blood, and cerebrospinal fluid, by changing metabolism and protein repe...

journal_title：mBio

authors： Pannekoek Y,Huis In 't Veld RA,Schipper K,Bovenkerk S,Kramer G,Brouwer MC,van de Beek D,Speijer D,van der Ende A

更新日期：2017-03-21 00:00:00

abstract：:Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution K432E. This substitution exists in 99.25% of seasonal influenza ...

journal_title：mBio

authors： Jiang H,Peng W,Qi J,Chai Y,Song H,Bi Y,Rijal P,Wang H,Oladejo BO,Liu J,Shi Y,Gao GF,Townsend AR,Wu Y

更新日期：2020-10-06 00:00:00

abstract：:Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers...

journal_title：mBio

authors： Fedson DS,Jacobson JR,Rordam OM,Opal SM

更新日期：2015-06-23 00:00:00

abstract：UNLABELLED:Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts. The underlying molecular mechanism of PMT was defined as a persistent activation of he...

journal_title：mBio

authors： Strack J,Heni H,Gilsbach R,Hein L,Aktories K,Orth JH

更新日期：2014-11-11 00:00:00

abstract：:Once HIV-1 enters a cell, the viral core is uncoated by a poorly understood mechanism and the HIV-1 genomic RNA is reverse transcribed into DNA. Host cell factors are essential for these processes, although very few reverse transcription complex binding host cell factors have been convincingly shown to affect uncoatin...

journal_title：mBio

authors： Rawle DJ,Li D,Swedberg JE,Wang L,Soares DC,Harrich D

更新日期：2018-03-27 00:00:00

abstract：:The saw-toothed grain beetle, Oryzaephilus surinamensis (Silvanidae), is a cosmopolitan stored-product pest. Early studies on O. surinamensis in the 1930s described the presence of peculiar bacteriomes harboring endosymbiotic bacteria in the abdomen. Since then, however, the microbiological nature of the symbiont has ...

journal_title：mBio

authors： Hirota B,Okude G,Anbutsu H,Futahashi R,Moriyama M,Meng XY,Nikoh N,Koga R,Fukatsu T

更新日期：2017-09-26 00:00:00

abstract：:Paramyxoviruses are negative-sense single-stranded RNA viruses that comprise many important human and animal pathogens, including human parainfluenza viruses. These viruses bud from the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is transported from the cytoplasm to the cell memb...

journal_title：mBio

authors： Genoyer E,Kulej K,Hung CT,Thibault PA,Azarm K,Takimoto T,Garcia BA,Lee B,Lakdawala S,Weitzman MD,López CB

更新日期：2020-08-25 00:00:00

abstract：:The chemistry underpinning microbial interactions provides an integrative framework for linking the activities of individual microbes, microbial communities, plants, and their environments. Currently, we know very little about the functions of genes and metabolites within these communities because genome annotations a...

journal_title：mBio

authors： Zhalnina K,Zengler K,Newman D,Northen TR

更新日期：2018-07-17 00:00:00

abstract：UNLABELLED:Members of the genus Vibrio include many pathogens of humans and marine animals that share genetic information via horizontal gene transfer. Hence, the Vibrio pan-genome carries the potential to establish new pathogenic strains by sharing virulence determinants, many of which have yet to be characterized. He...

journal_title：mBio

authors： Ray A,Kinch LN,de Souza Santos M,Grishin NV,Orth K,Salomon D

更新日期：2016-07-26 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restrict T lymphocyte responses to chemokine stimulation and T cell recept...

journal_title：mBio

authors： Imle A,Abraham L,Tsopoulidis N,Hoflack B,Saksela K,Fackler OT

更新日期：2015-09-08 00:00:00

abstract：:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), also known as A20, is a ubiquitin-editing enzyme capable of ubiquitination or deubiquitination of its target proteins. In this study, we show that hepatitis C virus (HCV) infection could induce the expression of A20 via the activation of the A20 promoter. The in...

journal_title：mBio

authors： Lee J,Chan ST,Kim JY,Ou JJ

更新日期：2019-07-23 00:00:00

abstract：:Resistance-nodulation-division (RND) superfamily efflux systems have been widely studied for their role in antibiotic resistance, but their native biological functions remain poorly understood. We previously showed that loss of RND-mediated efflux in Vibrio cholerae resulted in activation of the Cpx two-component regu...

journal_title：mBio

authors： Kunkle DE,Bina XR,Bina JE

更新日期：2017-05-16 00:00:00

abstract：UNLABELLED:Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-stage para...

journal_title：mBio

authors： LaMonte G,Lim MY,Wree M,Reimer C,Nachon M,Corey V,Gedeck P,Plouffe D,Du A,Figueroa N,Yeung B,Bifani P,Winzeler EA

更新日期：2016-07-05 00:00:00

abstract：:Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causat...

journal_title：mBio

authors： Idnurm A

更新日期：2013-04-30 00:00:00

abstract：:Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny. In contrast, adhesion and biofilm formation, which are potentially involved in gut colonization...

journal_title：mBio

authors： Béchon N,Mihajlovic J,Vendrell-Fernández S,Chain F,Langella P,Beloin C,Ghigo JM

更新日期：2020-06-23 00:00:00

abstract：UNLABELLED:Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral load) variance that occurs between resistant BALB/c and susceptible SJL...

journal_title：mBio

authors： Hsu TH,Althaus IW,Foreman O,Spindler KR

更新日期：2012-05-29 00:00:00

abstract：:Flavor production in yeast fermentation is of paramount importance for industrial production of alcoholic beverages. Although major enzymes of flavor compound biosynthesis have been identified, few specific mutations responsible for strain diversity in flavor production are known. The ATF1-encoded alcohol acetyl coenz...

journal_title：mBio

authors： Holt S,Trindade de Carvalho B,Foulquié-Moreno MR,Thevelein JM

更新日期：2018-08-28 00:00:00

abstract：UNLABELLED:The nucleus has emerged as a key target for nucleomodulins, a family of effectors produced by bacterial pathogens to control host transcription or other nuclear processes. The virulence factor LntA from Listeria monocytogenes stimulates interferon responses during infection by inhibiting BAHD1, a nuclear pro...

journal_title：mBio

authors： Lebreton A,Job V,Ragon M,Le Monnier A,Dessen A,Cossart P,Bierne H

更新日期：2014-01-21 00:00:00

abstract：:Ocean viruses are ubiquitous and abundant and play important roles in global biogeochemical cycles by means of their mortality, horizontal gene transfer, and manipulation of host metabolism. However, the obstacles involved in linking viruses to their hosts in a high-throughput manner bottlenecks our ability to underst...

journal_title：mBio

authors： Deng L,Gregory A,Yilmaz S,Poulos BT,Hugenholtz P,Sullivan MB

更新日期：2012-10-30 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the most common etiologic agent of uncomplicated urinary tract infection (UTI). An important mechanism of gene regulation in UPEC is phase variation that involves inversion of a promoter-containing DNA element via enzymatic activity of tyrosine recombinases, resulting in biphas...

journal_title：mBio

authors： Battaglioli EJ,Goh KGK,Atruktsang TS,Schwartz K,Schembri MA,Welch RA

更新日期：2018-08-07 00:00:00

abstract：:Epstein-Barr virus (EBV) infects and activates resting human B lymphocytes, reprograms them, induces their proliferation, and establishes a latent infection in them. In established EBV-infected cell lines, many viral latent genes are expressed. Their roles in supporting the continuous proliferation of EBV-infected B c...

journal_title：mBio

authors： Pich D,Mrozek-Gorska P,Bouvet M,Sugimoto A,Akidil E,Grundhoff A,Hamperl S,Ling PD,Hammerschmidt W

更新日期：2019-09-17 00:00:00

abstract：:Emerging zoonotic viral diseases remain a challenge to global public health. Recent surveillance studies have implicated bats as potential reservoirs for a number of viral pathogens, including coronaviruses and Ebola viruses. Caliciviridae represent a major viral family contributing to emerging diseases in both human ...

journal_title：mBio

authors： Kocher JF,Lindesmith LC,Debbink K,Beall A,Mallory ML,Yount BL,Graham RL,Huynh J,Gates JE,Donaldson EF,Baric RS

更新日期：2018-05-22 00:00:00

abstract：:Adult Drosophila melanogaster raised in the absence of symbiotic bacteria have fewer intestinal stem cell divisions and a longer life span than their conventionally reared counterparts. However, we do not know if increased stem cell divisions are essential for symbiont-dependent regulation of longevity. To determine i...

journal_title：mBio

authors： Fast D,Duggal A,Foley E

更新日期：2018-07-31 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131), a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC) infections, has been known widely for its contribution to the worldwide dissemination of multidrug resistance. Although other ExPEC-associated and extended-spectrum-β-lactamase ...

journal_title：mBio

authors： Shaik S,Ranjan A,Tiwari SK,Hussain A,Nandanwar N,Kumar N,Jadhav S,Semmler T,Baddam R,Islam MA,Alam M,Wieler LH,Watanabe H,Ahmed N

更新日期：2017-10-24 00:00:00

abstract：UNLABELLED:Many filamentous cyanobacteria produce specialized nitrogen-fixing cells called heterocysts, which are located at semiregular intervals along the filament with about 10 to 20 photosynthetic vegetative cells in between. Nitrogen fixation in these complex multicellular bacteria depends on metabolite exchange b...

journal_title：mBio

authors： Nürnberg DJ,Mariscal V,Bornikoel J,Nieves-Morión M,Krauß N,Herrero A,Maldener I,Flores E,Mullineaux CW

更新日期：2015-03-17 00:00:00

abstract：UNLABELLED:Small RNAs play a critical role in host-pathogen interaction. Indeed, small RNA-mediated silencing or RNA interference (RNAi) is one of the earliest forms of antiviral immunity. Although it represents the main defense system against viruses in many organisms, the antiviral role of RNAi has not been clearly p...

journal_title：mBio

authors： Girardi E,Chane-Woon-Ming B,Messmer M,Kaukinen P,Pfeffer S

更新日期：2013-11-19 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and interconnected quorum sensing (QS) regulatory circuits to produce a battery of virulence factors such as elastase, phenazines, and rhamnol...

journal_title：mBio

authors： Cruz RL,Asfahl KL,Van den Bossche S,Coenye T,Crabbé A,Dandekar AA

更新日期：2020-04-07 00:00:00

abstract：:In Escherichia coli, FtsEX coordinates peptidoglycan (PG) synthesis and hydrolysis at the septum. It acts on FtsA in the cytoplasm to promote recruitment of septal PG synthetases and recruits EnvC, an activator of septal PG hydrolases, in the periplasm. Following recruitment, ATP hydrolysis by FtsEX is thought to regu...

journal_title：mBio

authors： Du S,Pichoff S,Lutkenhaus J

更新日期：2020-07-07 00:00:00

abstract：:The hospital environment is a potential reservoir of bacteria with plasmids conferring carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive sampling of high-touch surfaces, sinks, and other locations in the hospital. Over a 2-year period, additional sampling was conducted at a broader ...

journal_title：mBio

authors： Weingarten RA,Johnson RC,Conlan S,Ramsburg AM,Dekker JP,Lau AF,Khil P,Odom RT,Deming C,Park M,Thomas PJ,NISC Comparative Sequencing Program.,Henderson DK,Palmore TN,Segre JA,Frank KM

更新日期：2018-02-06 00:00:00