A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection.

abstract：:Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical fo...

journal_title：mBio

authors： Johnson CJ,Davis JM,Huttenlocher A,Kernien JF,Nett JE

更新日期：2018-08-21 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent report in mBio (E. A. Cameron, M...

journal_title：mBio

authors： Palmer LD,Skaar EP

更新日期：2019-02-26 00:00:00

abstract：:Mannitol-1-phosphate dehydrogenase (M1PDH) is a key enzyme in Staphylococcus aureus mannitol metabolism, but its roles in pathophysiological settings have not been established. We performed comprehensive structure-function analysis of M1PDH from S. aureus USA300, a strain of community-associated methicillin-resistant ...

journal_title：mBio

authors： Nguyen T,Kim T,Ta HM,Yeo WS,Choi J,Mizar P,Lee SS,Bae T,Chaurasia AK,Kim KK

更新日期：2019-07-09 00:00:00

abstract：:Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated ...

journal_title：mBio

authors： Alves R,Sousa-Silva M,Vieira D,Soares P,Chebaro Y,Lorenz MC,Casal M,Soares-Silva I,Paiva S

更新日期：2020-05-12 00:00:00

abstract：UNLABELLED:Enterococcus faecium, natively a gut commensal organism, emerged as a leading cause of multidrug-resistant hospital-acquired infection in the 1980s. As the living record of its adaptation to changes in habitat, we sequenced the genomes of 51 strains, isolated from various ecological environments, to understa...

journal_title：mBio

authors： Lebreton F,van Schaik W,McGuire AM,Godfrey P,Griggs A,Mazumdar V,Corander J,Cheng L,Saif S,Young S,Zeng Q,Wortman J,Birren B,Willems RJ,Earl AM,Gilmore MS

更新日期：2013-08-20 00:00:00

abstract：:In bacteria, elongation factor Tu is a translational cofactor that forms ternary complexes with aminoacyl-tRNA (aa-tRNA) and GTP. Binding of a ternary complex to one of four flexible L7/L12 units on the ribosome tethers a charged tRNA in close proximity to the ribosomal A site. Two sequential tests for a match between...

journal_title：mBio

authors： Mustafi M,Weisshaar JC

更新日期：2018-01-16 00:00:00

abstract：UNLABELLED:Pseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are major problems that can complicate antibiotic therapy. We evaluated the efficacy of using bacteriophages to kill the pathogen i...

journal_title：mBio

authors： Alemayehu D,Casey PG,McAuliffe O,Guinane CM,Martin JG,Shanahan F,Coffey A,Ross RP,Hill C

更新日期：2012-03-06 00:00:00

abstract：:Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with M. tuberculosis, and about 15 million people with latent tuberculosis infection (LTBI) reside in the United States. An estimated 10% of indiv...

journal_title：mBio

authors： Ayyappan JP,Ganapathi U,Lizardo K,Vinnard C,Subbian S,Perlin DS,Nagajyothi JF

更新日期：2019-04-16 00:00:00

abstract：:Photosynthetic bacteria are capable of producing their own food via photosynthesis. Unsurprisingly, they evolved the ability to move toward better light conditions (i.e., phototaxis). In a recent article in mBio, Chau et al. tuned the wavelength, flux, direction, and timing of light input and characterized the motilit...

journal_title：mBio

authors： Kim M

更新日期：2017-04-11 00:00:00

abstract：:The human fungal pathogen Candida albicans causes lethal systemic infections because of its ability to grow and disseminate in a host. The C. albicans plasma membrane is essential for virulence by acting as a protective barrier and through its key roles in interfacing with the environment, secretion of virulence facto...

journal_title：mBio

authors： Douglas LM,Wang HX,Keppler-Ross S,Dean N,Konopka JB

更新日期：2011-12-27 00:00:00

abstract：:Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely unknown owing to the complexity of the process. Here, using a represen...

journal_title：mBio

authors： Zhang L,Liu Y,Zhao R,Zhang C,Jiang W,Gu Y

更新日期：2020-08-18 00:00:00

abstract：:Sinorhizobium meliloti is an alphaproteobacterium belonging to the Rhizobiales Bacteria from this order elongate their cell wall at the new cell pole, generated by cell division. Screening for protein interaction partners of the previously characterized polar growth factors RgsP and RgsM, we identified the inner membr...

journal_title：mBio

authors： Krol E,Yau HCL,Lechner M,Schäper S,Bange G,Vollmer W,Becker A

更新日期：2020-06-30 00:00:00

abstract：:The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mechanism is how completion of the prepore is sensed to initiate its conversion to the pore. We identified a motif that is conserved between the CDCs and a diverse family of nearly 300 unchara...

journal_title：mBio

authors： Evans JC,Johnstone BA,Lawrence SL,Morton CJ,Christie MP,Parker MW,Tweten RK

更新日期：2020-09-29 00:00:00

abstract：:Bats are reservoirs for many RNA viruses that are highly pathogenic in humans yet relatively apathogenic in the natural host. It has been suggested that differences in innate immunity are responsible. The antiviral OAS-RNase L pathway is well characterized in humans, but there is little known about its activation and ...

journal_title：mBio

authors： Li Y,Dong B,Wei Z,Silverman RH,Weiss SR

更新日期：2019-11-12 00:00:00

abstract：UNLABELLED:The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens that protect mice from sepsis. In this study, we characterized one of ...

journal_title：mBio

authors： Nesta B,Spraggon G,Alteri C,Moriel DG,Rosini R,Veggi D,Smith S,Bertoldi I,Pastorello I,Ferlenghi I,Fontana MR,Frankel G,Mobley HL,Rappuoli R,Pizza M,Serino L,Soriani M

更新日期：2012-04-10 00:00:00

abstract：UNLABELLED:Viruses of the Enterovirus genus of picornaviruses, including poliovirus, coxsackievirus B3 (CVB3), and human rhinovirus, commandeer the functions of host cell proteins to aid in the replication of their small viral genomic RNAs during infection. One of these host proteins is a cellular DNA repair enzyme kno...

journal_title：mBio

authors： Maciejewski S,Nguyen JH,Gómez-Herreros F,Cortés-Ledesma F,Caldecott KW,Semler BL

更新日期：2015-12-29 00:00:00

abstract：:Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spectrum antibacterial activity....

journal_title：mBio

authors： Reithuber E,Nannapaneni P,Rzhepishevska O,Lindgren AEG,Ilchenko O,Normark S,Almqvist F,Henriques-Normark B,Mellroth P

更新日期：2020-12-15 00:00:00

abstract：UNLABELLED:The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening meningitis in immunocompromised individuals. The expression of virulence factors, including capsule and melanin, is in part regulated by the cyclic-AMP/protein kinase A (cAMP/PKA) signal transduction pathway. In this study, we ...

journal_title：mBio

authors： Geddes JM,Caza M,Croll D,Stoynov N,Foster LJ,Kronstad JW

更新日期：2016-01-12 00:00:00

abstract：:Emerging zoonotic viral diseases remain a challenge to global public health. Recent surveillance studies have implicated bats as potential reservoirs for a number of viral pathogens, including coronaviruses and Ebola viruses. Caliciviridae represent a major viral family contributing to emerging diseases in both human ...

journal_title：mBio

authors： Kocher JF,Lindesmith LC,Debbink K,Beall A,Mallory ML,Yount BL,Graham RL,Huynh J,Gates JE,Donaldson EF,Baric RS

更新日期：2018-05-22 00:00:00

abstract：UNLABELLED:We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and affinities, which are determined by the compactness o...

journal_title：mBio

authors： Goossens KV,Ielasi FS,Nookaew I,Stals I,Alonso-Sarduy L,Daenen L,Van Mulders SE,Stassen C,van Eijsden RG,Siewers V,Delvaux FR,Kasas S,Nielsen J,Devreese B,Willaert RG

更新日期：2015-04-14 00:00:00

abstract：:Bacteria of the phylum Bacteroidetes, including commensal organisms and opportunistic pathogens, harbor abundant surface-exposed multiprotein membrane complexes (Sus-like systems) involved in carbohydrate acquisition. These complexes have been mostly linked to commensalism, and in some instances, they have also been s...

journal_title：mBio

authors： Lauber F,Cornelis GR,Renzi F

更新日期：2016-10-25 00:00:00

abstract：UNLABELLED:The human pathogen Streptococcus pneumoniae (pneumococcus) exhibits a high degree of genomic diversity and plasticity. Isolates with high genomic similarity are grouped into lineages that undergo homologous recombination at variable rates. PMEN1 is a pandemic, multidrug-resistant lineage. Heterologous gene e...

journal_title：mBio

authors： Eutsey RA,Powell E,Dordel J,Salter SJ,Clark TA,Korlach J,Ehrlich GD,Hiller NL

更新日期：2015-06-16 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii employs a vast array of effector proteins from the rhoptry and dense granule organelles to modulate host cell biology; these effectors are known as ROPs and GRAs, respectively. To examine the individual impacts of ROPs and GRAs on host gene expression, we developed a robust...

journal_title：mBio

authors： Rastogi S,Xue Y,Quake SR,Boothroyd JC

更新日期：2020-06-09 00:00:00

abstract：UNLABELLED:In the model eukaryote Saccharomyces cerevisiae, the transcription factor Cst6p has been reported to play important roles in several biological processes. However, the genome-wide targets of Cst6p and its physiological functions remain unknown. Here, we mapped the genome-wide binding sites of Cst6p at high r...

journal_title：mBio

authors： Liu G,Bergenholm D,Nielsen J

更新日期：2016-05-03 00:00:00

abstract：UNLABELLED:The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is req...

journal_title：mBio

authors： Ekici S,Yang H,Koch HG,Daldal F

更新日期：2012-01-31 00:00:00

abstract：UNLABELLED:Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses. Complement, an important arm of innate immunity, plays a significant role in fungal pathogenesis, especially the...

journal_title：mBio

authors： Agarwal S,Specht CA,Haibin H,Ostroff GR,Ram S,Rice PA,Levitz SM

更新日期：2011-08-30 00:00:00

abstract：UNLABELLED:Recent studies have established the fact that multiple members of the Rgg family of transcriptional regulators serve as key components of quorum sensing (QS) pathways that utilize peptides as intercellular signaling molecules. We previously described a novel QS system in Streptococcus pyogenes which utilizes...

journal_title：mBio

authors： Lasarre B,Aggarwal C,Federle MJ

更新日期：2013-01-02 00:00:00

abstract：:Nutritional immunity is an elegant host mechanism used to starve invading pathogens of necessary nutrient metals. Calprotectin, a metal-binding protein, is produced abundantly by neutrophils and is found in high concentrations within inflammatory sites during infection. Group B Streptococcus (GBS) colonizes the gastro...

journal_title：mBio

authors： Burcham LR,Le Breton Y,Radin JN,Spencer BL,Deng L,Hiron A,Ransom MR,Mendonça JDC,Belew AT,El-Sayed NM,McIver KS,Kehl-Fie TE,Doran KS

更新日期：2020-11-10 00:00:00

abstract：UNLABELLED:The outer membrane (OM) of Gram-negative bacteria provides protection against toxic molecules, including reactive oxygen species (ROS). Decreased OM permeability can promote bacterial survival under harsh circumstances and protects against antibiotics. To better understand the regulation of OM permeability, ...

journal_title：mBio

authors： van der Heijden J,Reynolds LA,Deng W,Mills A,Scholz R,Imami K,Foster LJ,Duong F,Finlay BB

更新日期：2016-08-09 00:00:00

abstract：:Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks. How host immune responses are orchestrated after alphaviral infections and lead to musculoskeletal inflammation remains poorly understood. Her...

journal_title：mBio

authors： Zaid A,Tharmarajah K,Mostafavi H,Freitas JR,Sheng KC,Foo SS,Chen W,Vider J,Liu X,West NP,Herrero LJ,Taylor A,Mackay LK,Getts DR,King NJC,Mahalingam S

更新日期：2020-03-03 00:00:00