Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation.

abstract：:Photosynthetic bacteria are capable of producing their own food via photosynthesis. Unsurprisingly, they evolved the ability to move toward better light conditions (i.e., phototaxis). In a recent article in mBio, Chau et al. tuned the wavelength, flux, direction, and timing of light input and characterized the motilit...

journal_title：mBio

authors： Kim M

更新日期：2017-04-11 00:00:00

abstract：UNLABELLED:Carbonate chimneys at the Lost City hydrothermal field are coated in biofilms dominated by a single phylotype of archaea known as Lost City Methanosarcinales. In this study, we have detected surprising physiological complexity in single-species biofilms, which is typically indicative of multispecies biofilm ...

journal_title：mBio

authors： Brazelton WJ,Mehta MP,Kelley DS,Baross JA

更新日期：2011-09-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral...

journal_title：mBio

authors： Hosseinipour MC,Sweet KM,Xiong J,Namarika D,Mwafongo A,Nyirenda M,Chiwoko L,Kamwendo D,Hoffman I,Lee J,Phiri S,Vahrson W,Damania B,Dittmer DP

更新日期：2014-09-23 00:00:00

abstract：:The human fungal pathogen Candida albicans causes lethal systemic infections because of its ability to grow and disseminate in a host. The C. albicans plasma membrane is essential for virulence by acting as a protective barrier and through its key roles in interfacing with the environment, secretion of virulence facto...

journal_title：mBio

authors： Douglas LM,Wang HX,Keppler-Ross S,Dean N,Konopka JB

更新日期：2011-12-27 00:00:00

abstract：:The genomes of actinomycetes contain numerous gene clusters potentially able to encode the production of many antibiotics and other specialized metabolites that are not expressed during growth under typical laboratory conditions. Undoubtedly, this reflects the soil habitat of these organisms, which is highly complex p...

journal_title：mBio

authors： Hopwood DA

更新日期：2013-09-03 00:00:00

abstract：:Innate immune response plays a critical role in controlling invading pathogens, but such an immune response must be tightly regulated. Insufficient or overactivated immune responses may lead to harmful or even fatal consequences. To dissect the complex host-parasite interactions and the molecular mechanisms underlying...

journal_title：mBio

authors： Cai B,Wu J,Yu X,Su XZ,Wang RF

更新日期：2017-01-03 00:00:00

abstract：:Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of ...

journal_title：mBio

authors： Cobián Güemes AG,Lim YW,Quinn RA,Conrad DJ,Benler S,Maughan H,Edwards R,Brettin T,Cantú VA,Cuevas D,Hamidi R,Dorrestein P,Rohwer F

更新日期：2019-04-16 00:00:00

abstract：UNLABELLED:Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors durin...

journal_title：mBio

authors： Serapio-Palacios A,Navarro-Garcia F

更新日期：2016-06-21 00:00:00

abstract：:A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying permeabilized retrovirus parti...

journal_title：mBio

authors： Jennings J,Shi J,Varadarajan J,Jamieson PJ,Aiken C

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:Toxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into the nascent parasitophorous vacuole. These GRAs are believed to pl...

journal_title：mBio

authors： Nadipuram SM,Kim EW,Vashisht AA,Lin AH,Bell HN,Coppens I,Wohlschlegel JA,Bradley PJ

更新日期：2016-08-02 00:00:00

abstract：:Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence. The role of cyclic diguanylate signaling in the lifestyle of Legionella pne...

journal_title：mBio

authors： Levi A,Folcher M,Jenal U,Shuman HA

更新日期：2011-01-11 00:00:00

abstract：:Vibrio vulnificus, an opportunistic pathogen, is the causative agent of a life-threatening septicemia and a rising problem for aquaculture worldwide. The genetic factors that differentiate its clinical and environmental strains remain enigmatic. Furthermore, clinical strains have emerged from every clade of V. vulnifi...

journal_title：mBio

authors： López-Pérez M,Jayakumar JM,Haro-Moreno JM,Zaragoza-Solas A,Reddi G,Rodriguez-Valera F,Shapiro OH,Alam M,Almagro-Moreno S

更新日期：2019-02-19 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the enzyme plays a prote...

journal_title：mBio

authors： Costa DL,Namasivayam S,Amaral EP,Arora K,Chao A,Mittereder LR,Maiga M,Boshoff HI,Barry CE 3rd,Goulding CW,Andrade BB,Sher A

更新日期：2016-10-25 00:00:00

abstract：:Our knowledge of cell cycle regulatory mechanisms in apicomplexan parasites is very limited. In this study, we describe a novel Toxoplasma gondii factor that has a vital role in chromosome replication and the regulation of cytoplasmic and nuclear mitotic structures, and we named this factor ECR1 for essential for chro...

journal_title：mBio

authors： Naumov A,Kratzer S,Ting LM,Kim K,Suvorova ES,White MW

更新日期：2017-08-22 00:00:00

abstract：UNLABELLED:Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations. In a long-term evolution experiment, twelve Escherichia coli populations have been propagated in a glucose-limited environment for over 25 ...

journal_title：mBio

authors： Raeside C,Gaffé J,Deatherage DE,Tenaillon O,Briska AM,Ptashkin RN,Cruveiller S,Médigue C,Lenski RE,Barrick JE,Schneider D

更新日期：2014-09-09 00:00:00

abstract：:The human malaria parasite Plasmodium falciparum replicates within circulating red blood cells, where it is subjected to conditions that frequently cause DNA damage. The repair of DNA double-stranded breaks (DSBs) is thought to rely almost exclusively on homologous recombination (HR), due to a lack of efficient nonhom...

journal_title：mBio

authors： Calhoun SF,Reed J,Alexander N,Mason CE,Deitsch KW,Kirkman LA

更新日期：2017-08-08 00:00:00

abstract：UNLABELLED:Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extrac...

journal_title：mBio

authors： Singh B,Alvarado-Kristensson M,Johansson M,Hallgren O,Westergren-Thorsson G,Mörgelin M,Riesbeck K

更新日期：2016-03-22 00:00:00

abstract：UNLABELLED:The nucleus has emerged as a key target for nucleomodulins, a family of effectors produced by bacterial pathogens to control host transcription or other nuclear processes. The virulence factor LntA from Listeria monocytogenes stimulates interferon responses during infection by inhibiting BAHD1, a nuclear pro...

journal_title：mBio

authors： Lebreton A,Job V,Ragon M,Le Monnier A,Dessen A,Cossart P,Bierne H

更新日期：2014-01-21 00:00:00

abstract：UNLABELLED:Human cathepsin W (CtsW) is a cysteine protease, which was identified in a genome-wide RNA interference (RNAi) screen to be required for influenza A virus (IAV) replication. In this study, we show that reducing the levels of expression of CtsW reduces viral titers for different subtypes of IAV, and we map th...

journal_title：mBio

authors： Edinger TO,Pohl MO,Yángüez E,Stertz S

更新日期：2015-06-09 00:00:00

abstract：:ABSTRACT The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the virulence of pathogenic mycobacteria and conjugation in the model organism Mycobacterium smegmatis, Esx-3 contributes to mycobactin-media...

journal_title：mBio

authors： Siegrist MS,Steigedal M,Ahmad R,Mehra A,Dragset MS,Schuster BM,Philips JA,Carr SA,Rubin EJ

更新日期：2014-05-06 00:00:00

abstract：UNLABELLED:Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense mole...

journal_title：mBio

authors： Warren TK,Whitehouse CA,Wells J,Welch L,Heald AE,Charleston JS,Sazani P,Reid SP,Iversen PL,Bavari S

更新日期：2015-02-10 00:00:00

abstract：:Low doses of antibiotics can trigger secondary metabolite biosynthesis in bacteria, but the underlying mechanisms are generally unknown. We sought to better understand this phenomenon by studying how the antibiotic trimethoprim activates the synthesis of the virulence factor malleilactone in Burkholderia thailandensis...

journal_title：mBio

authors： Li A,Mao D,Yoshimura A,Rosen PC,Martin WL,Gallant É,Wühr M,Seyedsayamdost MR

更新日期：2020-02-25 00:00:00

abstract：:Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an important phase in their development. Here, we present a systemati...

journal_title：mBio

authors： Obaldia N 3rd,Meibalan E,Sa JM,Ma S,Clark MA,Mejia P,Moraes Barros RR,Otero W,Ferreira MU,Mitchell JR,Milner DA,Huttenhower C,Wirth DF,Duraisingh MT,Wellems TE,Marti M

更新日期：2018-05-08 00:00:00

abstract：:Enterococci are important human commensals and significant opportunistic pathogens. Biofilm-related enterococcal infections, such as endocarditis, urinary tract infections, wound and surgical site infections, and medical device-associated infections, often become chronic upon the formation of biofilm. The biofilm matr...

journal_title：mBio

authors： Keogh D,Lam LN,Doyle LE,Matysik A,Pavagadhi S,Umashankar S,Low PM,Dale JL,Song Y,Ng SP,Boothroyd CB,Dunny GM,Swarup S,Williams RBH,Marsili E,Kline KA

更新日期：2018-04-10 00:00:00

abstract：:Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised immune systems. The absence of a continuous in vitro culture system for any species of Pneumocystis has led to limited understanding of these fungi, especially f...

journal_title：mBio

authors： Cushion MT,Collins MS,Sesterhenn T,Porollo A,Vadukoot AK,Merino EJ

更新日期：2016-12-13 00:00:00

abstract：UNLABELLED:Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a variety of environmental stimuli and play a critical r...

journal_title：mBio

authors： Agostoni M,Koestler BJ,Waters CM,Williams BL,Montgomery BL

更新日期：2013-08-13 00:00:00

abstract：UNLABELLED:Male circumcision reduces female-to-male HIV transmission. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. We compared the coronal sulcus microbiota of men from a group of uncircumcised controls (n = 77) a...

journal_title：mBio

authors： Liu CM,Hungate BA,Tobian AA,Serwadda D,Ravel J,Lester R,Kigozi G,Aziz M,Galiwango RM,Nalugoda F,Contente-Cuomo TL,Wawer MJ,Keim P,Gray RH,Price LB

更新日期：2013-04-16 00:00:00

abstract：:Hepatitis E virus (HEV), a single-strand positive-sense RNA virus, is an understudied but important human pathogen. The virus can establish infection at a number of host tissues, including the small intestine and liver, causing acute and chronic hepatitis E as well as certain neurological disorders. The retinoic acid-...

journal_title：mBio

authors： Sooryanarain H,Heffron CL,Meng XJ

更新日期：2020-01-14 00:00:00

abstract：:Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4+ cells expressing a Nullbasi...

journal_title：mBio

authors： Jin H,Sun Y,Li D,Lin MH,Lor M,Rustanti L,Harrich D

更新日期：2019-08-27 00:00:00

abstract：:The 1977-1978 influenza epidemic was probably not a natural event, as the genetic sequence of the virus was nearly identical to the sequences of decades-old strains. While there are several hypotheses that could explain its origin, the possibility that the 1977 epidemic resulted from a laboratory accident has recently...

journal_title：mBio

authors： Rozo M,Gronvall GK

更新日期：2015-08-18 00:00:00