Male circumcision significantly reduces prevalence and load of genital anaerobic bacteria.

abstract：UNLABELLED:Recent studies strongly suggest that the gene expression sustaining both normal and pathogenic bacterial growth is governed by the structural dynamics of the chromosome. However, the mechanistic device coordinating the chromosomal configuration with selective expression of the adaptive traits remains largely...

journal_title：mBio

authors： Jiang X,Sobetzko P,Nasser W,Reverchon S,Muskhelishvili G

更新日期：2015-04-28 00:00:00

abstract：:5-Aminosalicylic acid (5-ASA), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is a widely used first-line medication for the treatment of ulcerative colitis, but its anti-inflammatory mechanism is not fully resolved. Here, we show that 5-ASA ameliorates colitis in dextran sulfate sodium (DSS)-tre...

journal_title：mBio

authors： Cevallos SA,Lee JY,Velazquez EM,Foegeding NJ,Shelton CD,Tiffany CR,Parry BH,Stull-Lane AR,Olsan EE,Savage HP,Nguyen H,Ghanaat SS,Byndloss AJ,Agu IO,Tsolis RM,Byndloss MX,Bäumler AJ

更新日期：2021-01-19 00:00:00

abstract：UNLABELLED:Nap1 has long been identified as a potential septin regulator in yeasts. However, its function and regulation remain poorly defined. Here, we report functional characterization of Nap1 in the human-pathogenic fungus Candida albicans. We find that deletion of NAP1 causes constitutive filamentous growth and ch...

journal_title：mBio

authors： Huang ZX,Zhao P,Zeng GS,Wang YM,Sudbery I,Wang Y

更新日期：2014-02-04 00:00:00

abstract：:Acute flaccid myelitis (AFM) is a rare but serious illness of the nervous system, specifically affecting the gray matter of the spinal cord, motor-controlling regions of the brain, and cranial nerves. Most cases of AFM are pathogen associated, typically with poliovirus and enterovirus infections, and occur in children...

journal_title：mBio

authors： Rosenfeld AB,Warren AL,Racaniello VR

更新日期：2019-10-22 00:00:00

abstract：:Two Shigella species, Shigella flexneri and Shigella sonnei, cause approximately 90% of bacterial dysentery worldwide. While S. flexneri is the dominant species in low-income countries, S. sonnei causes the majority of infections in middle- and high-income countries. S. flexneri is a prototypic cytosolic bacterium; on...

journal_title：mBio

authors： Watson JL,Sanchez-Garrido J,Goddard PJ,Torraca V,Mostowy S,Shenoy AR,Clements A

更新日期：2019-12-17 00:00:00

abstract：UNLABELLED:The outer membrane (OM) of Gram-negative bacteria provides protection against toxic molecules, including reactive oxygen species (ROS). Decreased OM permeability can promote bacterial survival under harsh circumstances and protects against antibiotics. To better understand the regulation of OM permeability, ...

journal_title：mBio

authors： van der Heijden J,Reynolds LA,Deng W,Mills A,Scholz R,Imami K,Foster LJ,Duong F,Finlay BB

更新日期：2016-08-09 00:00:00

abstract：UNLABELLED:The protein YfeX from Escherichia coli has been proposed to be essential for the process of iron removal from heme by carrying out a dechelation of heme without cleavage of the porphyrin macrocycle. Since this proposed reaction is unique and would represent the first instance of the biological dechelation of...

journal_title：mBio

authors： Dailey HA,Septer AN,Daugherty L,Thames D,Gerdes S,Stabb EV,Dunn AK,Dailey TA,Phillips JD

更新日期：2011-11-08 00:00:00

abstract：:A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying permeabilized retrovirus parti...

journal_title：mBio

authors： Jennings J,Shi J,Varadarajan J,Jamieson PJ,Aiken C

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:Viruses of the Enterovirus genus of picornaviruses, including poliovirus, coxsackievirus B3 (CVB3), and human rhinovirus, commandeer the functions of host cell proteins to aid in the replication of their small viral genomic RNAs during infection. One of these host proteins is a cellular DNA repair enzyme kno...

journal_title：mBio

authors： Maciejewski S,Nguyen JH,Gómez-Herreros F,Cortés-Ledesma F,Caldecott KW,Semler BL

更新日期：2015-12-29 00:00:00

abstract：UNLABELLED:Significant gut microbiota heterogeneity exists among ulcerative colitis (UC) patients, though the clinical implications of this variance are unknown. We hypothesized that ethnically distinct UC patients exhibit discrete gut microbiotas with unique metabolic programming that differentially influence immune a...

journal_title：mBio

authors： Mar JS,LaMere BJ,Lin DL,Levan S,Nazareth M,Mahadevan U,Lynch SV

更新日期：2016-08-16 00:00:00

abstract：:The flagellar motor can spin in both counterclockwise (CCW) and clockwise (CW) directions. The flagellar motor consists of a rotor and multiple stator units, which act as a proton channel. The rotor is composed of the transmembrane MS ring made of FliF and the cytoplasmic C ring consisting of FliG, FliM, and FliN. The...

journal_title：mBio

authors： Sakai T,Miyata T,Terahara N,Mori K,Inoue Y,Morimoto YV,Kato T,Namba K,Minamino T

更新日期：2019-04-02 00:00:00

abstract：:With great apprehension, the world is now watching the birth of a novel pandemic already causing tremendous suffering, death, and disruption of normal life. Uncertainty and dread are exacerbated by the belief that what we are experiencing is new and mysterious. However, deadly pandemics and disease emergences are not ...

journal_title：mBio

authors： Morens DM,Daszak P,Markel H,Taubenberger JK

更新日期：2020-05-29 00:00:00

abstract：:Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available to probe its biology. However, S. cerevisiae has proven difficult ...

journal_title：mBio

authors： Cernak P,Estrela R,Poddar S,Skerker JM,Cheng YF,Carlson AK,Chen B,Glynn VM,Furlan M,Ryan OW,Donnelly MK,Arkin AP,Taylor JW,Cate JHD

更新日期：2018-09-25 00:00:00

abstract：:The Bacillus cereus group comprises numerous closely related species, including bioterrorism agent B. anthracis, foodborne pathogen B. cereus, and biopesticide B. thuringiensis Differentiating organisms capable of causing illness or death from those used in industry is essential for risk assessment and outbreak prepar...

journal_title：mBio

authors： Carroll LM,Wiedmann M,Kovac J

更新日期：2020-02-25 00:00:00

abstract：UNLABELLED:The prominent host muramidase lysozyme cleaves bacterial peptidoglycan (PG), and the enzyme is abundant in mucosal secretions. The lytic enzyme susceptibility of Gram-negative bacteria and mechanisms they use to thwart lytic enzyme activity are poorly studied. We previously characterized a Helicobacter pylor...

journal_title：mBio

authors： Wang G,Lo LF,Forsberg LS,Maier RJ

更新日期：2012-12-04 00:00:00

abstract：:The PCNA (proliferating cell nuclear antigen) ring plays central roles during DNA replication and repair. The yeast Elg1 RFC-like complex (RLC) is the principal unloader of chromatin-bound PCNA and thus plays a central role in maintaining genome stability. Here we identify a role for Elg1 in the unloading of PCNA duri...

journal_title：mBio

authors： Sau S,Liefshitz B,Kupiec M

更新日期：2019-06-11 00:00:00

abstract：:Uncultured and therefore uncharacterized Bacteroidetes lineages are ubiquitous in many natural ecosystems which specialize in lignocellulose degradation. However, their metabolic contribution remains mysterious, as well-studied cultured Bacteroidetes have been shown to degrade only soluble polysaccharides within the h...

journal_title：mBio

authors： Naas AE,Mackenzie AK,Mravec J,Schückel J,Willats WG,Eijsink VG,Pope PB

更新日期：2014-08-05 00:00:00

abstract：UNLABELLED:In infection experiments with genetically distinct Mycobacterium tuberculosis complex (MTBC) strains, we identified clade-specific virulence patterns in human primary macrophages and in mice infected by the aerosol route, both reflecting relevant model systems. Exclusively human-adapted M. tuberculosis linea...

journal_title：mBio

authors： Reiling N,Homolka S,Walter K,Brandenburg J,Niwinski L,Ernst M,Herzmann C,Lange C,Diel R,Ehlers S,Niemann S

更新日期：2013-07-30 00:00:00

abstract：:The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics. Despite intensive studies since (p)ppGpp was discovered over 4 decades ago, (p)ppGpp binding proteins have not been systematically identi...

journal_title：mBio

authors： Zhang Y,Zborníková E,Rejman D,Gerdes K

更新日期：2018-03-06 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent report in mBio (E. A. Cameron, M...

journal_title：mBio

authors： Palmer LD,Skaar EP

更新日期：2019-02-26 00:00:00

abstract：:Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo We hypothesized that we could improve the specificity of LV targeting by coupling (i) reduction of their binding to off-target cells with (ii) redirection of the vect...

journal_title：mBio

authors： Parker CL,Jacobs TM,Huckaby JT,Harit D,Lai SK

更新日期：2020-01-21 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Tat binds the viral RNA structure transactivation-responsive element (TAR) and recruits transcriptional cofactors, amplifying viral mRNA expression. The Tat inhibitor didehydro-cortistatin A (dCA) promotes a state of persistent latency, refractory to viral reactivation. Here...

journal_title：mBio

authors： Mousseau G,Aneja R,Clementz MA,Mediouni S,Lima NS,Haregot A,Kessing CF,Jablonski JA,Thenin-Houssier S,Nagarsheth N,Trautmann L,Valente ST

更新日期：2019-07-02 00:00:00

abstract：:The saw-toothed grain beetle, Oryzaephilus surinamensis (Silvanidae), is a cosmopolitan stored-product pest. Early studies on O. surinamensis in the 1930s described the presence of peculiar bacteriomes harboring endosymbiotic bacteria in the abdomen. Since then, however, the microbiological nature of the symbiont has ...

journal_title：mBio

authors： Hirota B,Okude G,Anbutsu H,Futahashi R,Moriyama M,Meng XY,Nikoh N,Koga R,Fukatsu T

更新日期：2017-09-26 00:00:00

abstract：UNLABELLED:Glycoside hydrolases (GHs) are key enzymes in the depolymerization of plant-derived cellulose, a process central to the global carbon cycle and the conversion of plant biomass to fuels and chemicals. A limited number of GH families hydrolyze crystalline cellulose, often by a processive mechanism along the ce...

journal_title：mBio

authors： Hiras J,Wu YW,Deng K,Nicora CD,Aldrich JT,Frey D,Kolinko S,Robinson EW,Jacobs JM,Adams PD,Northen TR,Simmons BA,Singer SW

更新日期：2016-08-23 00:00:00

abstract：:The human malaria parasite Plasmodium falciparum replicates within circulating red blood cells, where it is subjected to conditions that frequently cause DNA damage. The repair of DNA double-stranded breaks (DSBs) is thought to rely almost exclusively on homologous recombination (HR), due to a lack of efficient nonhom...

journal_title：mBio

authors： Calhoun SF,Reed J,Alexander N,Mason CE,Deitsch KW,Kirkman LA

更新日期：2017-08-08 00:00:00

abstract：:Chlamydiales species are obligate intracellular bacteria lacking a classical peptidoglycan sacculus but relying on peptidoglycan synthesis for cytokinesis. While septal peptidoglycan biosynthesis seems to be regulated by MreB actin and its membrane anchor RodZ rather than FtsZ tubulin in Chlamydiales, the mechanism of...

journal_title：mBio

authors： Jacquier N,Yadav AK,Pillonel T,Viollier PH,Cava F,Greub G

更新日期：2019-07-16 00:00:00

abstract：UNLABELLED:Honeybees harbor well-defined bacterial communities in their guts. The major members of these communities appear to benefit the host, but little is known about how they interact with the host and specifically how they interface with the host immune system. In the pylorus, a short region between the midgut an...

journal_title：mBio

authors： Engel P,Bartlett KD,Moran NA

更新日期：2015-05-19 00:00:00

abstract：UNLABELLED:The ExPortal of Streptococcus pyogenes is a focal microdomain of the cytoplasmic membrane that clusters the translocons of the general secretory pathway with accessory factors to facilitate the maturation of secreted polypeptides. While it is known that the ExPortal is enriched in anionic lipids, the mechani...

journal_title：mBio

authors： Vega LA,Port GC,Caparon MG

更新日期：2013-09-24 00:00:00

abstract：:Dephospho-coenzyme A (dephospho-CoA) kinase (DPCK) catalyzes the ATP-dependent phosphorylation of dephospho-CoA, the final step in coenzyme A (CoA) biosynthesis. DPCK has been identified and characterized in bacteria and eukaryotes but not in archaea. The hyperthermophilic archaeon Thermococcus kodakarensis encodes tw...

journal_title：mBio

authors： Shimosaka T,Makarova KS,Koonin EV,Atomi H

更新日期：2019-07-23 00:00:00

abstract：:Cerebral malaria is a severe neurological complication associated with sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the specific binding interactions remain under debate. Here, we have generated an engineered three-dimensional (3D) human brain endothelial microve...

journal_title：mBio

authors： Bernabeu M,Gunnarsson C,Vishnyakova M,Howard CC,Nagao RJ,Avril M,Taylor TE,Seydel KB,Zheng Y,Smith JD

更新日期：2019-05-28 00:00:00