Abstract:
:Uncultured and therefore uncharacterized Bacteroidetes lineages are ubiquitous in many natural ecosystems which specialize in lignocellulose degradation. However, their metabolic contribution remains mysterious, as well-studied cultured Bacteroidetes have been shown to degrade only soluble polysaccharides within the human distal gut and herbivore rumen. We have interrogated a reconstructed genome from an uncultured Bacteroidetes phylotype that dominates a switchgrass-associated community within the cow rumen. Importantly, this characterization effort has revealed the first preliminary evidence for polysaccharide utilization locus (PUL)-catalyzed conversion of cellulose. Based on these findings, we propose a further expansion of the PUL paradigm and the saccharolytic capacity of rumen Bacteroidetes species to include cellulose, the most abundant terrestrial polysaccharide on Earth. Moreover, the perspective of a cellulolytic PUL lays the foundation for PULs to be considered an alternative mechanism for cellulose degradation, next to cellulosomes and free-enzyme systems.
journal_name
mBiojournal_title
mBioauthors
Naas AE,Mackenzie AK,Mravec J,Schückel J,Willats WG,Eijsink VG,Pope PBdoi
10.1128/mBio.01401-14subject
Has Abstractpub_date
2014-08-05 00:00:00pages
e01401-14issue
4issn
2150-7511pii
mBio.01401-14journal_volume
5pub_type
杂志文章相关文献
mBio文献大全abstract:UNLABELLED:Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors durin...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00479-16
更新日期:2016-06-21 00:00:00
abstract:UNLABELLED:The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems. We have probed the systemic metabolic adaptation to gut colonization for 20 days following exposure of axenic mice (n = 35) to a typical...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00271-10
更新日期:2011-03-01 00:00:00
abstract:UNLABELLED:Pseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are major problems that can complicate antibiotic therapy. We evaluated the efficacy of using bacteriophages to kill the pathogen i...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00029-12
更新日期:2012-03-06 00:00:00
abstract::The microbiome of wild Mus musculus (house mouse), a globally distributed invasive pest that resides in close contact with humans in urban centers, is largely unexplored. Here, we report analysis of the fecal virome of house mice in residential buildings in New York City, NY. Mice were collected at seven sites in Manh...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01354-17
更新日期:2018-04-17 00:00:00
abstract::Host-associated microbial communities are shaped by extrinsic and intrinsic factors to the holobiont organism. Environmental factors and microbe-microbe interactions act simultaneously on the microbial community structure, making the microbiome dynamics challenging to predict. The coral microbiome is essential to the ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02691-19
更新日期:2020-03-03 00:00:00
abstract::Our knowledge of cell cycle regulatory mechanisms in apicomplexan parasites is very limited. In this study, we describe a novel Toxoplasma gondii factor that has a vital role in chromosome replication and the regulation of cytoplasmic and nuclear mitotic structures, and we named this factor ECR1 for essential for chro...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00579-17
更新日期:2017-08-22 00:00:00
abstract::The gut microbiota contributes to nutrients absorption and metabolism by enterocytes, but the molecular mechanisms involved remain poorly understood, and most conclusions are inferred from studies comparing germfree and conventional animals colonized with diverse bacterial species. We selected two model commensal micr...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01493-18
更新日期:2018-09-04 00:00:00
abstract:UNLABELLED:Rarely, if ever, has a single bacterial cell been confirmed to simultaneously host two fundamentally different predators. Two such predators are viruses and the predatory prokaryotes known as Bdellovibrio and like organisms. Viruses or bacteriophage are particles requiring prey cells in an active metabolic s...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00051-12
更新日期:2012-04-17 00:00:00
abstract::Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy. They can also use poised electrodes as their electron donor via phototrophic extracellular electron uptake (phototrophic EEU). The e...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02668-19
更新日期:2019-11-05 00:00:00
abstract::Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00716-15
更新日期:2015-06-23 00:00:00
abstract:UNLABELLED:The world is at the precipice of a postantibiotic era in which medical procedures and minor injuries can result in bacterial infections that are no longer effectively treated by antibiotics. Cathelicidins are peptides produced by animals to combat bacterial infections and to regulate innate immune responses....
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01418-16
更新日期:2016-09-20 00:00:00
abstract::Vibrio vulnificus, an opportunistic pathogen, is the causative agent of a life-threatening septicemia and a rising problem for aquaculture worldwide. The genetic factors that differentiate its clinical and environmental strains remain enigmatic. Furthermore, clinical strains have emerged from every clade of V. vulnifi...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02852-18
更新日期:2019-02-19 00:00:00
abstract:UNLABELLED:Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but h...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02451-14
更新日期:2015-01-20 00:00:00
abstract:UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00417-16
更新日期:2016-04-19 00:00:00
abstract::The saw-toothed grain beetle, Oryzaephilus surinamensis (Silvanidae), is a cosmopolitan stored-product pest. Early studies on O. surinamensis in the 1930s described the presence of peculiar bacteriomes harboring endosymbiotic bacteria in the abdomen. Since then, however, the microbiological nature of the symbiont has ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01482-17
更新日期:2017-09-26 00:00:00
abstract::Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing a...
journal_title:mBio
pub_type: 评论,杂志文章
doi:10.1128/mBio.00967-20
更新日期:2020-05-26 00:00:00
abstract::We have previously identified Vibrio cholerae mutants in which the stress response to subinhibitory concentrations of aminoglycoside is altered. One gene identified, VC1636, encodes a putative DNA/RNA helicase, recently named RadD in Escherichia coli Here we combined extensive genetic characterization and high-through...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01173-19
更新日期:2019-07-02 00:00:00
abstract::Posttranslational modification of a protein, either alone or in combination with other modifications, can control properties of that protein, such as enzymatic activity, localization, stability, or interactions with other molecules. N-ε-Lysine acetylation is one such modification that has gained attention in recent ye...
journal_title:mBio
pub_type: 杂志文章,评审
doi:10.1128/mBio.02708-18
更新日期:2019-04-09 00:00:00
abstract::The biosynthesis of antioxidant pigments, namely, betalains, was believed to be restricted to Caryophyllales plants. This paper changes this paradigm, and enzyme mining from bacterial hosts promoted the discovery of bacterial cultures producing betalains. The spectrum of possible sources of betalain pigments in nature...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00345-19
更新日期:2019-03-19 00:00:00
abstract::Increasing evidence has indicated that single nucleotide polymorphisms (SNPs) are related to the susceptibility of sepsis and might provide potential evidence for the mechanisms of sepsis. Our recent preliminary study showed that the ADAM10 genetic polymorphism was clinically associated with the development of sepsis,...
journal_title:mBio
pub_type: 杂志文章,多中心研究
doi:10.1128/mBio.01663-19
更新日期:2019-08-06 00:00:00
abstract:UNLABELLED:A change in viral hemagglutinin (HA) receptor binding specificity from α2,3- to α2,6-linked sialic acid is necessary for highly pathogenic avian influenza (AI) virus subtype H5N1 to become pandemic. However, details of the human-adaptive change in the H5N1 virus remain unknown. Our database search of H5N1 cl...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00081-15
更新日期:2015-04-07 00:00:00
abstract:UNLABELLED:Sensing of and responding to environmental changes are of vital importance for microbial cells. Consequently, bacteria have evolved a plethora of signaling systems that usually sense biochemical cues either via direct ligand binding, thereby acting as "concentration sensors," or by responding to downstream e...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00975-15
更新日期:2015-07-21 00:00:00
abstract:UNLABELLED:Type III secretion systems (T3SS) translocate effector proteins into target cells in order to disrupt or modulate host cell signaling pathways and establish replicative niches. However, recognition of T3SS activity by cytosolic pattern recognition receptors (PRRs) of the nucleotide-binding domain leucine ric...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02095-14
更新日期:2015-02-17 00:00:00
abstract::Dephospho-coenzyme A (dephospho-CoA) kinase (DPCK) catalyzes the ATP-dependent phosphorylation of dephospho-CoA, the final step in coenzyme A (CoA) biosynthesis. DPCK has been identified and characterized in bacteria and eukaryotes but not in archaea. The hyperthermophilic archaeon Thermococcus kodakarensis encodes tw...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01146-19
更新日期:2019-07-23 00:00:00
abstract::EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) o...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02772-20
更新日期:2020-11-17 00:00:00
abstract::Helicobacter pylori colonizes about half of humans worldwide, and its presence in the gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric lymphoma, and peptic ulcer disease. H. pylori strains carrying the cag pathogenicity island (cagPAI) are associated with increased risk of disease...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00849-19
更新日期:2019-05-14 00:00:00
abstract::Flavor production in yeast fermentation is of paramount importance for industrial production of alcoholic beverages. Although major enzymes of flavor compound biosynthesis have been identified, few specific mutations responsible for strain diversity in flavor production are known. The ATF1-encoded alcohol acetyl coenz...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01279-18
更新日期:2018-08-28 00:00:00
abstract::A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying permeabilized retrovirus parti...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02820-20
更新日期:2020-12-01 00:00:00
abstract::Bordetella pertussis controls the expression of its virulence regulon through the two-component system BvgAS. BvgS is a prototype for a family of multidomain sensor kinases. In BvgS, helical linkers connect periplasmic Venus flytrap (VFT) perception domains to a cytoplasmic Per-Arnt-Sim (PAS) domain and the PAS domain...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02052-17
更新日期:2018-02-27 00:00:00
abstract::The epidemiology of methicillin-resistant Staphylococcus aureus has changed considerably over the last 3 decades, including the recognition of lineages associated with the community and with livestock exposure, in addition to nosocomial strains. A recent study by R. N. Sieber, R. L. Skov, J. Nielsen, J. Schulz, et al....
journal_title:mBio
pub_type: 评论,杂志文章
doi:10.1128/mBio.02459-18
更新日期:2018-12-11 00:00:00