Phototaxis of Cyanobacteria under Complex Light Environments.

abstract：:Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel vaccine development. These antibodies have been observed in humans after natura...

journal_title：mBio

authors： Park JK,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Rosas LA,Cervantes-Medina A,Taubenberger JK,Memoli MJ

更新日期：2018-01-23 00:00:00

abstract：:The growing ubiquity of electronic devices is increasingly consuming substantial energy and rare resources for materials fabrication, as well as creating expansive volumes of toxic waste. This is not sustainable. Electronic biological materials (e-biologics) that are produced with microbes, or designed with microbial ...

journal_title：mBio

authors： Lovley DR

更新日期：2017-06-27 00:00:00

abstract：UNLABELLED:Clostridium perfringens enterotoxin (CPE) contributes to several important human gastrointestinal (GI) diseases. This toxin and its derivatives are also being explored for translational applications, i.e., cancer therapy or drug delivery. Some, but not all, members of the 24-member claudin (Cldn) family of m...

journal_title：mBio

authors： Shrestha A,McClane BA

更新日期：2013-01-15 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. P. aeruginosa infections are difficult to treat due to a number of antibiotic resistance mechanisms and the organism's propensity to form multicellular biofilms. Epidemic strains of P....

journal_title：mBio

authors： Oluyombo O,Penfold CN,Diggle SP

更新日期：2019-01-29 00:00:00

abstract：:Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny. In contrast, adhesion and biofilm formation, which are potentially involved in gut colonization...

journal_title：mBio

authors： Béchon N,Mihajlovic J,Vendrell-Fernández S,Chain F,Langella P,Beloin C,Ghigo JM

更新日期：2020-06-23 00:00:00

abstract：UNLABELLED:Investigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial inhabitant, Propionibacterium acnes, which is thought to contribute to th...

journal_title：mBio

authors： Marinelli LJ,Fitz-Gibbon S,Hayes C,Bowman C,Inkeles M,Loncaric A,Russell DA,Jacobs-Sera D,Cokus S,Pellegrini M,Kim J,Miller JF,Hatfull GF,Modlin RL

更新日期：2012-09-25 00:00:00

abstract：:The alphaproteobacterial general stress response is governed by a conserved partner-switching mechanism that is triggered by phosphorylation of the response regulator PhyR. In the model organism Caulobacter crescentus, PhyR was proposed to be phosphorylated by the histidine kinase PhyK, but biochemical evidence in sup...

journal_title：mBio

authors： Lori C,Kaczmarczyk A,de Jong I,Jenal U

更新日期：2018-05-22 00:00:00

abstract：:The ability to withstand UV damage shapes the ecology of microbes. While mechanisms of UV tolerance were extensively investigated in microorganisms regularly exposed to the sun, far less is known about UV repair of soilborne microorganisms. Fusarium oxysporum is a soilborne fungal plant pathogen that is resistant to U...

journal_title：mBio

authors： Milo-Cochavi S,Adar S,Covo S

更新日期：2019-12-03 00:00:00

abstract：:Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved am...

journal_title：mBio

authors： Schubert K,Sieger B,Meyer F,Giacomelli G,Böhm K,Rieblinger A,Lindenthal L,Sachs N,Wanner G,Bramkamp M

更新日期：2017-02-07 00:00:00

abstract：:To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we constructed a genome encyclopedia describing the core supragingival plaque microb...

journal_title：mBio

authors： Espinoza JL,Harkins DM,Torralba M,Gomez A,Highlander SK,Jones MB,Leong P,Saffery R,Bockmann M,Kuelbs C,Inman JM,Hughes T,Craig JM,Nelson KE,Dupont CL

更新日期：2018-11-27 00:00:00

abstract：:Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural origin, discovering new natural products is challenging, and there is a need to expand the chemical ...

journal_title：mBio

authors： Cleto S,Lu TK

更新日期：2017-10-10 00:00:00

abstract：UNLABELLED:Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had an increased risk of HIV transmission, raised concerns about endpoints used to evaluate microbicide safety. A possible explanation for the increased ...

journal_title：mBio

authors： Ravel J,Gajer P,Fu L,Mauck CK,Koenig SS,Sakamoto J,Motsinger-Reif AA,Doncel GF,Zeichner SL

更新日期：2012-12-18 00:00:00

abstract：:Murein lipoprotein (Lpp) and peptidoglycan-associated lipoprotein (Pal) are major outer membrane lipoproteins in Escherichia coli Their roles in cell-envelope integrity have been documented in E. coli laboratory strains, and while Lpp has been linked to serum resistance in vitro, the underlying mechanism has not been ...

journal_title：mBio

authors： Diao J,Bouwman C,Yan D,Kang J,Katakam AK,Liu P,Pantua H,Abbas AR,Nickerson NN,Austin C,Reichelt M,Sandoval W,Xu M,Whitfield C,Kapadia SB

更新日期：2017-05-23 00:00:00

abstract：UNLABELLED:Significant gut microbiota heterogeneity exists among ulcerative colitis (UC) patients, though the clinical implications of this variance are unknown. We hypothesized that ethnically distinct UC patients exhibit discrete gut microbiotas with unique metabolic programming that differentially influence immune a...

journal_title：mBio

authors： Mar JS,LaMere BJ,Lin DL,Levan S,Nazareth M,Mahadevan U,Lynch SV

更新日期：2016-08-16 00:00:00

abstract：:Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment of a type IV secretion system (T4SS). However, the mechanism by which the T4SS elicits inflammation remains unknown. Here we show that translocation of the T4SS substrate VceC into host cells induces proinflammatory resp...

journal_title：mBio

authors： de Jong MF,Starr T,Winter MG,den Hartigh AB,Child R,Knodler LA,van Dijl JM,Celli J,Tsolis RM

更新日期：2013-02-19 00:00:00

abstract：:Typhoid fever, caused by Salmonella enterica serovar Typhi, is a global public health concern due to increasing antimicrobial resistance (AMR). Characterization of S Typhi genomes for AMR and the evolution of different lineages, especially in countries where typhoid fever is endemic such as Bangladesh, will help publi...

journal_title：mBio

authors： Tanmoy AM,Westeel E,De Bruyne K,Goris J,Rajoharison A,Sajib MSI,van Belkum A,Saha SK,Komurian-Pradel F,Endtz HP

更新日期：2018-11-13 00:00:00

abstract：:Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life. Recent application of deep-sequencing technologies has revealed that the transcription of asRNAs occurs genome-wide in bacter...

journal_title：mBio

authors： Raghavan R,Sloan DB,Ochman H

更新日期：2012-08-07 00:00:00

abstract：:A method for use in high-throughput screening of bacteria for the production of long-chain hydrocarbons and ketones by monitoring fluorescent light emission in the presence of Nile red is described. Nile red has previously been used to screen for polyhydroxybutyrate (PHB) and fatty acid esters, but this is the first r...

journal_title：mBio

authors： Pinzon NM,Aukema KG,Gralnick JA,Wackett LP

更新日期：2011-06-28 00:00:00

abstract：:Enterococci are important human commensals and significant opportunistic pathogens. Biofilm-related enterococcal infections, such as endocarditis, urinary tract infections, wound and surgical site infections, and medical device-associated infections, often become chronic upon the formation of biofilm. The biofilm matr...

journal_title：mBio

authors： Keogh D,Lam LN,Doyle LE,Matysik A,Pavagadhi S,Umashankar S,Low PM,Dale JL,Song Y,Ng SP,Boothroyd CB,Dunny GM,Swarup S,Williams RBH,Marsili E,Kline KA

更新日期：2018-04-10 00:00:00

abstract：:Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by the enzyme UDP-4-keto-6-deo...

journal_title：mBio

authors： Ma L,Salas O,Bowler K,Bar-Peled M,Sharon A

更新日期：2017-11-21 00:00:00

abstract：:The USA300 North American epidemic (USA300-NAE) clone of methicillin-resistant Staphylococcus aureus has caused a wave of severe skin and soft tissue infections in the United States since it emerged in the early 2000s, but its geographic origin is obscure. Here we use the population genomic signatures expected from th...

journal_title：mBio

authors： Challagundla L,Luo X,Tickler IA,Didelot X,Coleman DC,Shore AC,Coombs GW,Sordelli DO,Brown EL,Skov R,Larsen AR,Reyes J,Robledo IE,Vazquez GJ,Rivera R,Fey PD,Stevenson K,Wang SH,Kreiswirth BN,Mediavilla JR,Arias CA

更新日期：2018-01-02 00:00:00

abstract：:Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages an...

journal_title：mBio

authors： Frazão SO,Sousa HR,Silva LGD,Folha JDS,Gorgonha KCM,Oliveira GP Jr,Felipe MSS,Silva-Pereira I,Casadevall A,Nicola AM,Albuquerque P

更新日期：2020-09-08 00:00:00

abstract：:In bacteria and eukaryotes alike, proper cellular physiology relies on robust subcellular organization. For the phototrophic purple nonsulfur bacteria (PNSB), this organization entails the use of a light-harvesting, membrane-bound compartment known as the intracytoplasmic membrane (ICM). Here we show that ICMs are spa...

journal_title：mBio

authors： LaSarre B,Kysela DT,Stein BD,Ducret A,Brun YV,McKinlay JB

更新日期：2018-07-03 00:00:00

abstract：UNLABELLED:The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens cause an increasing number of nosocomial infections worldwide since they escape the inhibitory effect of the available antibiotics and the immun...

journal_title：mBio

authors： Behroozian S,Svensson SL,Davies J

更新日期：2016-01-26 00:00:00

abstract：:Posttranslational modification of a protein, either alone or in combination with other modifications, can control properties of that protein, such as enzymatic activity, localization, stability, or interactions with other molecules. N-ε-Lysine acetylation is one such modification that has gained attention in recent ye...

journal_title：mBio

authors： Christensen DG,Baumgartner JT,Xie X,Jew KM,Basisty N,Schilling B,Kuhn ML,Wolfe AJ

更新日期：2019-04-09 00:00:00

abstract：:Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic understanding of how bacteria evolve resistance against multiple phages is lacking, ...

journal_title：mBio

authors： Wright RCT,Friman VP,Smith MCM,Brockhurst MA

更新日期：2019-09-24 00:00:00

abstract：:Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of ...

journal_title：mBio

authors： Cobián Güemes AG,Lim YW,Quinn RA,Conrad DJ,Benler S,Maughan H,Edwards R,Brettin T,Cantú VA,Cuevas D,Hamidi R,Dorrestein P,Rohwer F

更新日期：2019-04-16 00:00:00

abstract：UNLABELLED:The ability to cultivate food is an innovation that has produced some of the most successful ecological strategies on the planet. Although most well recognized in humans, where agriculture represents a defining feature of civilization, species of ants, beetles, and termites have also independently evolved sy...

journal_title：mBio

authors： Aylward FO,Suen G,Biedermann PH,Adams AS,Scott JJ,Malfatti SA,Glavina del Rio T,Tringe SG,Poulsen M,Raffa KF,Klepzig KD,Currie CR

更新日期：2014-11-18 00:00:00

abstract：:Chlamydiales species are obligate intracellular bacteria lacking a classical peptidoglycan sacculus but relying on peptidoglycan synthesis for cytokinesis. While septal peptidoglycan biosynthesis seems to be regulated by MreB actin and its membrane anchor RodZ rather than FtsZ tubulin in Chlamydiales, the mechanism of...

journal_title：mBio

authors： Jacquier N,Yadav AK,Pillonel T,Viollier PH,Cava F,Greub G

更新日期：2019-07-16 00:00:00

abstract：UNLABELLED:Sensing of and responding to environmental changes are of vital importance for microbial cells. Consequently, bacteria have evolved a plethora of signaling systems that usually sense biochemical cues either via direct ligand binding, thereby acting as "concentration sensors," or by responding to downstream e...

journal_title：mBio

authors： Fritz G,Dintner S,Treichel NS,Radeck J,Gerland U,Mascher T,Gebhard S

更新日期：2015-07-21 00:00:00