Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens.

abstract：:Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response. Deletion of NS1 (DelNS1) would create a safer and more extensively immunogenic live attenuated influenza virus (LAIV) vaccine. However, DelNS1 vir...

journal_title：mBio

authors： Wang P,Zheng M,Lau SY,Chen P,Mok BW,Liu S,Liu H,Huang X,Cremin CJ,Song W,Chen Y,Wong YC,Huang H,To KK,Chen Z,Xia N,Yuen KY,Chen H

更新日期：2019-09-17 00:00:00

abstract：:Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with M. tuberculosis, and about 15 million people with latent tuberculosis infection (LTBI) reside in the United States. An estimated 10% of indiv...

journal_title：mBio

authors： Ayyappan JP,Ganapathi U,Lizardo K,Vinnard C,Subbian S,Perlin DS,Nagajyothi JF

更新日期：2019-04-16 00:00:00

abstract：:In contrast to usual laboratory conditions, most bacteria in the human body grow in biofilms. Encased in a structured matrix, many pathogens display heightened resistance to antibiotics. Pseudomonas aeruginosa lung infections in cystic fibrosis patients represent a prime example of the clinical challenges that antibio...

journal_title：mBio

authors： Brüssow H

更新日期：2012-04-03 00:00:00

abstract：UNLABELLED:The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens that protect mice from sepsis. In this study, we characterized one of ...

journal_title：mBio

authors： Nesta B,Spraggon G,Alteri C,Moriel DG,Rosini R,Veggi D,Smith S,Bertoldi I,Pastorello I,Ferlenghi I,Fontana MR,Frankel G,Mobley HL,Rappuoli R,Pizza M,Serino L,Soriani M

更新日期：2012-04-10 00:00:00

abstract：:A voluntary 60-day pause on avian H5N1 influenza virus transmission research was announced in January 2012 by the international community of influenza scientists engaged in this work to provide time to explain the benefits of such work and the risk mitigation measures in place. Subsequently, the pause was extended to ...

journal_title：mBio

authors： Fouchier RA,García-Sastre A,Kawaoka Y

更新日期：2012-11-01 00:00:00

abstract：:Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35 IFN-antagonist function, ide...

journal_title：mBio

authors： Luthra P,Aguirre S,Yen BC,Pietzsch CA,Sanchez-Aparicio MT,Tigabu B,Morlock LK,García-Sastre A,Leung DW,Williams NS,Fernandez-Sesma A,Bukreyev A,Basler CF

更新日期：2017-04-04 00:00:00

abstract：:Paramyxoviruses are negative-sense single-stranded RNA viruses that comprise many important human and animal pathogens, including human parainfluenza viruses. These viruses bud from the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is transported from the cytoplasm to the cell memb...

journal_title：mBio

authors： Genoyer E,Kulej K,Hung CT,Thibault PA,Azarm K,Takimoto T,Garcia BA,Lee B,Lakdawala S,Weitzman MD,López CB

更新日期：2020-08-25 00:00:00

abstract：:In bacteria and eukaryotes alike, proper cellular physiology relies on robust subcellular organization. For the phototrophic purple nonsulfur bacteria (PNSB), this organization entails the use of a light-harvesting, membrane-bound compartment known as the intracytoplasmic membrane (ICM). Here we show that ICMs are spa...

journal_title：mBio

authors： LaSarre B,Kysela DT,Stein BD,Ducret A,Brun YV,McKinlay JB

更新日期：2018-07-03 00:00:00

abstract：:Escherichia colimazEF is an extensively studied stress-induced toxin-antitoxin (TA) system. The toxin MazF is an endoribonuclease that cleaves RNAs at ACA sites. By that means, under stress, the induced MazF generates a stress-induced translation machinery (STM) composed of MazF-processed mRNAs and selective ribosomes...

journal_title：mBio

authors： Nigam A,Ziv T,Oron-Gottesman A,Engelberg-Kulka H

更新日期：2019-03-26 00:00:00

abstract：UNLABELLED:Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but h...

journal_title：mBio

authors： Orrú CD,Groveman BR,Hughson AG,Zanusso G,Coulthart MB,Caughey B

更新日期：2015-01-20 00:00:00

abstract：:Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4+ cells expressing a Nullbasi...

journal_title：mBio

authors： Jin H,Sun Y,Li D,Lin MH,Lor M,Rustanti L,Harrich D

更新日期：2019-08-27 00:00:00

abstract：UNLABELLED:Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral load) variance that occurs between resistant BALB/c and susceptible SJL...

journal_title：mBio

authors： Hsu TH,Althaus IW,Foreman O,Spindler KR

更新日期：2012-05-29 00:00:00

abstract：:Bacillus anthracis is a Gram-positive bacillus that under conditions of environmental stress, such as low nutrients, can convert from a vegetative bacillus to a highly durable spore that enables long-term survival. The sporulation process is regulated by a sequential cascade of dedicated transcription factors but requ...

journal_title：mBio

authors： Hagan AK,Plotnick YM,Dingle RE,Mendel ZI,Cendrowski SR,Sherman DH,Tripathi A,Hanna PC

更新日期：2018-11-06 00:00:00

abstract：UNLABELLED:Elongins B and C are members of complexes that increase the efficiency of transcriptional elongation by RNA polymerase II (RNAPII) and enhance the monoubiquitination of histone H2B, an epigenetic mark of actively transcribed genes. Here we show that, in addition to its role in facilitating transcription of t...

journal_title：mBio

authors： Hwang J,Saffert RT,Kalejta RF

更新日期：2011-03-29 00:00:00

abstract：:Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughput purposes. Here, we made a...

journal_title：mBio

authors： Moudjou M,Sibille P,Fichet G,Reine F,Chapuis J,Herzog L,Jaumain E,Laferrière F,Richard CA,Laude H,Andréoletti O,Rezaei H,Béringue V

更新日期：2013-12-31 00:00:00

abstract：:Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal a conserved role for bacter...

journal_title：mBio

authors： Chaudhari SS,Kim M,Lei S,Razvi F,Alqarzaee AA,Hutfless EH,Powers R,Zimmerman MC,Fey PD,Thomas VC

更新日期：2017-08-01 00:00:00

abstract：:Estrogen, a major female sex steroid hormone, has been shown to promote the selection of mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases, including cystic fibrosis. This results in long-term persistence, poorer clinical outcomes, and limited therapeutic options. In this study...

journal_title：mBio

authors： Vidaillac C,Yong VFL,Aschtgen MS,Qu J,Yang S,Xu G,Seng ZJ,Brown AC,Ali MK,Jaggi TK,Sankaran J,Foo YH,Righetti F,Nedumaran AM,Mac Aogáin M,Roizman D,Richard JA,Rogers TR,Toyofuku M,Luo D,Loh E,Wohland T,Czarny

更新日期：2020-09-29 00:00:00

abstract：:Our current understanding of lipoprotein synthesis and localization in Gram-negative bacteria is based primarily on studies of Escherichia coli Newly synthesized E. coli prolipoproteins undergo posttranslational modifications catalyzed by three essential enzymes (Lgt, LspA, and Lnt). The mature lipoproteins are then s...

journal_title：mBio

authors： McClain MS,Voss BJ,Cover TL

更新日期：2020-05-19 00:00:00

abstract：:Unlike all other archaeal lineages, ammonia-oxidizing archaea (AOA) of the phylum Thaumarchaeota are widespread and abundant in all moderate and oxic environments on Earth. The evolutionary adaptations that led to such unprecedented ecological success of a microbial clade characterized by highly conserved energy and c...

journal_title：mBio

authors： Abby SS,Kerou M,Schleper C

更新日期：2020-10-13 00:00:00

abstract：UNLABELLED:The route taken by papillomaviruses from the cell surface to the nucleus during infection is incompletely understood. Here, we developed a novel human papillomavirus 16 (HPV16) pseudovirus in which the carboxy terminus of the minor capsid protein L2 is exposed on the exterior of the intact capsid prior to ce...

journal_title：mBio

authors： Zhang W,Kazakov T,Popa A,DiMaio D

更新日期：2014-09-16 00:00:00

abstract：:Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resista...

journal_title：mBio

authors： Somprasong N,Hall CM,Webb JR,Sahl JW,Wagner DM,Keim P,Currie BJ,Schweizer HP

更新日期：2020-04-14 00:00:00

abstract：UNLABELLED:Glycoside hydrolases (GHs) are key enzymes in the depolymerization of plant-derived cellulose, a process central to the global carbon cycle and the conversion of plant biomass to fuels and chemicals. A limited number of GH families hydrolyze crystalline cellulose, often by a processive mechanism along the ce...

journal_title：mBio

authors： Hiras J,Wu YW,Deng K,Nicora CD,Aldrich JT,Frey D,Kolinko S,Robinson EW,Jacobs JM,Adams PD,Northen TR,Simmons BA,Singer SW

更新日期：2016-08-23 00:00:00

abstract：:Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados)...

journal_title：mBio

authors： Wurster S,Tatara AM,Albert ND,Ibrahim AS,Heitman J,Lee SC,Shetty AC,McCracken C,Graf KT,Mikos AG,Bruno VM,Kontoyiannis DP

更新日期：2020-06-30 00:00:00

abstract：UNLABELLED:Kaposi sarcoma (KS) herpesvirus (KSHV) infection of endothelial cells (EC) is associated with strong induction of heme oxygenase-1 (HO-1), a stress-inducible host gene that encodes the rate-limiting enzyme responsible for heme catabolism. KS is an angioproliferative tumor characterized by the proliferation o...

journal_title：mBio

authors： Botto S,Totonchy JE,Gustin JK,Moses AV

更新日期：2015-06-04 00:00:00

abstract：:Microbial photoautotroph-heterotroph interactions underlie marine food webs and shape ecosystem diversity and structure in upper ocean environments. Here, bacterial community composition, lifestyle preference, and genomic- and proteomic-level metabolic characteristics were investigated for an open ocean Synechococcus ...

journal_title：mBio

authors： Zheng Q,Wang Y,Lu J,Lin W,Chen F,Jiao N

更新日期：2020-02-18 00:00:00

abstract：UNLABELLED:Small colony variants (SCVs) are naturally occurring subpopulations of bacteria. The clinical characteristics and treatment outcomes of patients with prosthetic joint infection (PJI) caused by staphylococcal SCVs are unknown. This study was a retrospective series of 113 patients with staphylococcal PJI, with...

journal_title：mBio

authors： Tande AJ,Osmon DR,Greenwood-Quaintance KE,Mabry TM,Hanssen AD,Patel R

更新日期：2014-09-30 00:00:00

abstract：UNLABELLED:Rarely, if ever, has a single bacterial cell been confirmed to simultaneously host two fundamentally different predators. Two such predators are viruses and the predatory prokaryotes known as Bdellovibrio and like organisms. Viruses or bacteriophage are particles requiring prey cells in an active metabolic s...

journal_title：mBio

authors： Chen H,Williams HN

更新日期：2012-04-17 00:00:00

abstract：:The concept that anaerobic microorganisms can directly accept electrons from Fe(0) has been controversial because direct metal-microbe electron transfer has previously only been indirectly inferred. Fe(0) oxidation was studied with Geobacter sulfurreducens strain ACL, an autotrophic strain that was previously shown to...

journal_title：mBio

authors： Tang HY,Holmes DE,Ueki T,Palacios PA,Lovley DR

更新日期：2019-05-14 00:00:00

abstract：:Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the natural evolution of ...

journal_title：mBio

authors： Broset E,Martín C,Gonzalo-Asensio J

更新日期：2015-10-20 00:00:00

abstract：:The human antibody repertoire has an exceptionally large capacity to recognize new or changing antigens through combinatorial and junctional diversity established at the time of V(D)J recombination and through somatic hypermutation. Influenza viruses exhibit a relentless capacity to escape the human antibody response ...

journal_title：mBio

authors： Crowe JE Jr

更新日期：2012-07-31 00:00:00