Nitrite Derived from Endogenous Bacterial Nitric Oxide Synthase Activity Promotes Aerobic Respiration.

abstract：:With great apprehension, the world is now watching the birth of a novel pandemic already causing tremendous suffering, death, and disruption of normal life. Uncertainty and dread are exacerbated by the belief that what we are experiencing is new and mysterious. However, deadly pandemics and disease emergences are not ...

journal_title：mBio

authors： Morens DM,Daszak P,Markel H,Taubenberger JK

更新日期：2020-05-29 00:00:00

abstract：:Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynt...

journal_title：mBio

authors： Shrivastava-Ranjan P,Bergeron É,Chakrabarti AK,Albariño CG,Flint M,Nichol ST,Spiropoulou CF

更新日期：2016-12-20 00:00:00

abstract：:Binding of Staphylococcus aureus to the large plasma glycoprotein von Willebrand factor (vWF) is controlled by hydrodynamic flow conditions. Currently, we know little about the molecular details of this shear-stress-dependent interaction. Using single-molecule atomic force microscopy, we demonstrate that vWF binds to ...

journal_title：mBio

authors： Viela F,Prystopiuk V,Leprince A,Mahillon J,Speziale P,Pietrocola G,Dufrêne YF

更新日期：2019-04-30 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral...

journal_title：mBio

authors： Hosseinipour MC,Sweet KM,Xiong J,Namarika D,Mwafongo A,Nyirenda M,Chiwoko L,Kamwendo D,Hoffman I,Lee J,Phiri S,Vahrson W,Damania B,Dittmer DP

更新日期：2014-09-23 00:00:00

abstract：:SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Streptococcus pyogenes,...

journal_title：mBio

authors： Port GC,Cusumano ZT,Tumminello PR,Caparon MG

更新日期：2017-03-28 00:00:00

abstract：:Coordination between chromosome replication and segregation is essential for equal partitioning of genetic material between daughter cells. In bacteria, this is achieved through the proximity of the origin of replication, oriC, and the chromosome partitioning site, parS We report here that in Pseudomonas aeruginosa, s...

journal_title：mBio

authors： Bhowmik BK,Clevenger AL,Zhao H,Rybenkov VV

更新日期：2018-10-23 00:00:00

abstract：:Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely unknown owing to the complexity of the process. Here, using a represen...

journal_title：mBio

authors： Zhang L,Liu Y,Zhao R,Zhang C,Jiang W,Gu Y

更新日期：2020-08-18 00:00:00

abstract：UNLABELLED:Cholera continues to be a global threat, with high rates of morbidity and mortality. In 2011, a cholera outbreak occurred in Palawan, Philippines, affecting more than 500 people, and 20 individuals died. Vibrio cholerae O1 was confirmed as the etiological agent. Source attribution is critical in cholera outb...

journal_title：mBio

authors： Klinzing DC,Choi SY,Hasan NA,Matias RR,Tayag E,Geronimo J,Skowronski E,Rashed SM,Kawashima K,Rosenzweig CN,Gibbons HS,Torres BC,Liles V,Alfon AC,Juan ML,Natividad FF,Cebula TA,Colwell RR

更新日期：2015-04-21 00:00:00

abstract：UNLABELLED:Investigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial inhabitant, Propionibacterium acnes, which is thought to contribute to th...

journal_title：mBio

authors： Marinelli LJ,Fitz-Gibbon S,Hayes C,Bowman C,Inkeles M,Loncaric A,Russell DA,Jacobs-Sera D,Cokus S,Pellegrini M,Kim J,Miller JF,Hatfull GF,Modlin RL

更新日期：2012-09-25 00:00:00

abstract：UNLABELLED:Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts. The underlying molecular mechanism of PMT was defined as a persistent activation of he...

journal_title：mBio

authors： Strack J,Heni H,Gilsbach R,Hein L,Aktories K,Orth JH

更新日期：2014-11-11 00:00:00

abstract：UNLABELLED:We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and affinities, which are determined by the compactness o...

journal_title：mBio

authors： Goossens KV,Ielasi FS,Nookaew I,Stals I,Alonso-Sarduy L,Daenen L,Van Mulders SE,Stassen C,van Eijsden RG,Siewers V,Delvaux FR,Kasas S,Nielsen J,Devreese B,Willaert RG

更新日期：2015-04-14 00:00:00

abstract：:5-Aminosalicylic acid (5-ASA), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is a widely used first-line medication for the treatment of ulcerative colitis, but its anti-inflammatory mechanism is not fully resolved. Here, we show that 5-ASA ameliorates colitis in dextran sulfate sodium (DSS)-tre...

journal_title：mBio

authors： Cevallos SA,Lee JY,Velazquez EM,Foegeding NJ,Shelton CD,Tiffany CR,Parry BH,Stull-Lane AR,Olsan EE,Savage HP,Nguyen H,Ghanaat SS,Byndloss AJ,Agu IO,Tsolis RM,Byndloss MX,Bäumler AJ

更新日期：2021-01-19 00:00:00

abstract：UNLABELLED:Rapidly fatal cases of invasive fungal infections due to a fungus later identified as Saprochaete clavata were reported in France in May 2012. The objectives of this study were to determine the clonal relatedness of the isolates and to investigate possible sources of contamination. A nationwide alert was lau...

journal_title：mBio

authors： Vaux S,Criscuolo A,Desnos-Ollivier M,Diancourt L,Tarnaud C,Vandenbogaert M,Brisse S,Coignard B,Dromer F,Geotrichum Investigation Group.

更新日期：2014-12-16 00:00:00

abstract：:The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where t...

journal_title：mBio

authors： Alagaili AN,Briese T,Mishra N,Kapoor V,Sameroff SC,Burbelo PD,de Wit E,Munster VJ,Hensley LE,Zalmout IS,Kapoor A,Epstein JH,Karesh WB,Daszak P,Mohammed OB,Lipkin WI

更新日期：2014-02-25 00:00:00

abstract：:Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available to probe its biology. However, S. cerevisiae has proven difficult ...

journal_title：mBio

authors： Cernak P,Estrela R,Poddar S,Skerker JM,Cheng YF,Carlson AK,Chen B,Glynn VM,Furlan M,Ryan OW,Donnelly MK,Arkin AP,Taylor JW,Cate JHD

更新日期：2018-09-25 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：UNLABELLED:The human pathogen Streptococcus pneumoniae (pneumococcus) exhibits a high degree of genomic diversity and plasticity. Isolates with high genomic similarity are grouped into lineages that undergo homologous recombination at variable rates. PMEN1 is a pandemic, multidrug-resistant lineage. Heterologous gene e...

journal_title：mBio

authors： Eutsey RA,Powell E,Dordel J,Salter SJ,Clark TA,Korlach J,Ehrlich GD,Hiller NL

更新日期：2015-06-16 00:00:00

abstract：UNLABELLED:Mammalian lipopolysaccharide (LPS) binding proteins (LBPs) occur mainly in extracellular fluids and promote LPS delivery to specific host cell receptors. The function of LBPs has been studied principally in the context of host defense; the possible role of LBPs in nonpathogenic host-microbe interactions has ...

journal_title：mBio

authors： Krasity BC,Troll JV,Lehnert EM,Hackett KT,Dillard JP,Apicella MA,Goldman WE,Weiss JP,McFall-Ngai MJ

更新日期：2015-10-13 00:00:00

abstract：:EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) o...

journal_title：mBio

authors： McCarthy KR,Timpona JL,Jenni S,Bloyet LM,Brusic V,Johnson WE,Whelan SPJ,Robinson-McCarthy LR

更新日期：2020-11-17 00:00:00

abstract：UNLABELLED:The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface for interactions between these pathogens and the respi...

journal_title：mBio

authors： Heyl KA,Klassert TE,Heinrich A,Müller MM,Klaile E,Dienemann H,Grünewald C,Bals R,Singer BB,Slevogt H

更新日期：2014-08-26 00:00:00

abstract：UNLABELLED:Methicillin-resistant Staphylococcus aureus (MRSA) is a global human health problem causing infections in both hospitals and the community. Companion animals, such as cats, dogs, and horses, are also frequently colonized by MRSA and can become infected. We sequenced the genomes of 46 multilocus sequence type...

journal_title：mBio

authors： Harrison EM,Weinert LA,Holden MT,Welch JJ,Wilson K,Morgan FJ,Harris SR,Loeffler A,Boag AK,Peacock SJ,Paterson GK,Waller AS,Parkhill J,Holmes MA

更新日期：2014-05-13 00:00:00

abstract：:E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the African swine fever virus (ASFV) genome, is required for productive replication of ASFV in swine macrophages. Here, we solved the high-resolution crystal structures of E165R in its apo state and in complex with its product dUMP. Structural anal...

journal_title：mBio

authors： Li C,Chai Y,Song H,Weng C,Qi J,Sun Y,Gao GF

更新日期：2019-10-29 00:00:00

abstract：:Escherichia colimazEF is an extensively studied stress-induced toxin-antitoxin (TA) system. The toxin MazF is an endoribonuclease that cleaves RNAs at ACA sites. By that means, under stress, the induced MazF generates a stress-induced translation machinery (STM) composed of MazF-processed mRNAs and selective ribosomes...

journal_title：mBio

authors： Nigam A,Ziv T,Oron-Gottesman A,Engelberg-Kulka H

更新日期：2019-03-26 00:00:00

abstract：:In Escherichia coli, FtsEX coordinates peptidoglycan (PG) synthesis and hydrolysis at the septum. It acts on FtsA in the cytoplasm to promote recruitment of septal PG synthetases and recruits EnvC, an activator of septal PG hydrolases, in the periplasm. Following recruitment, ATP hydrolysis by FtsEX is thought to regu...

journal_title：mBio

authors： Du S,Pichoff S,Lutkenhaus J

更新日期：2020-07-07 00:00:00

abstract：:Cerebral malaria is a severe neurological complication associated with sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the specific binding interactions remain under debate. Here, we have generated an engineered three-dimensional (3D) human brain endothelial microve...

journal_title：mBio

authors： Bernabeu M,Gunnarsson C,Vishnyakova M,Howard CC,Nagao RJ,Avril M,Taylor TE,Seydel KB,Zheng Y,Smith JD

更新日期：2019-05-28 00:00:00

abstract：:In immunocompromised hosts, latent infection with Toxoplasma gondii can reactivate from tissue cysts, leading to encephalitis. A characteristic of T. gondii bradyzoites in tissue cysts is the presence of amylopectin granules. The regulatory mechanisms and role of amylopectin accumulation in this organism are not fully...

journal_title：mBio

authors： Sugi T,Tu V,Ma Y,Tomita T,Weiss LM

更新日期：2017-08-29 00:00:00

abstract：:Fission yeast phosphate homeostasis entails transcriptional induction of genes encoding phosphate-mobilizing proteins under conditions of phosphate starvation. Transcription factor Pho7, a member of the Zn2Cys6 family of fungal transcription regulators, is the central player in the starvation response. The DNA binding...

journal_title：mBio

authors： Schwer B,Sanchez AM,Garg A,Chatterjee D,Shuman S

更新日期：2017-08-15 00:00:00

abstract：:History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic reassortment. Going back to the...

journal_title：mBio

authors： Morens DM,Taubenberger JK,Fauci AS

更新日期：2010-09-28 00:00:00

abstract：UNLABELLED:The urinary tract is one of the most frequent sites of bacterial infection in humans. Uropathogenic Escherichia coli (UPEC) strains are the leading cause of urinary tract infections (UTIs) and are responsible for greater than 80% of uncomplicated cases in adults. Infection of the urinary tract occurs in an a...

journal_title：mBio

authors： Walters MS,Lane MC,Vigil PD,Smith SN,Walk ST,Mobley HL

更新日期：2012-02-07 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the CFTR gene and is associated with progressive and ultimately fatal infectious lung disease. There can be considerable variability in disease severity among individuals with the same CFTR mutations, and recent genome-wide association studies have identified secondary ge...

journal_title：mBio

authors： Di Paola M,Park AJ,Ahmadi S,Roach EJ,Wu YS,Struder-Kypke M,Lam JS,Bear CE,Khursigara CM

更新日期：2017-12-19 00:00:00