Restricted Localization of Photosynthetic Intracytoplasmic Membranes (ICMs) in Multiple Genera of Purple Nonsulfur Bacteria.

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restrict T lymphocyte responses to chemokine stimulation and T cell recept...

journal_title：mBio

authors： Imle A,Abraham L,Tsopoulidis N,Hoflack B,Saksela K,Fackler OT

更新日期：2015-09-08 00:00:00

abstract：:Zika virus is a mosquito-borne flavivirus which can cause severe disease in humans, including microcephaly and other congenital malformations in newborns and Guillain-Barré syndrome in adults. There are currently no approved prophylactics or therapeutics for Zika virus; the development of a safe and effective vaccine ...

journal_title：mBio

authors： Bailey MJ,Broecker F,Duehr J,Arumemi F,Krammer F,Palese P,Tan GS

更新日期：2019-04-02 00:00:00

abstract：:Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely unknown owing to the complexity of the process. Here, using a represen...

journal_title：mBio

authors： Zhang L,Liu Y,Zhao R,Zhang C,Jiang W,Gu Y

更新日期：2020-08-18 00:00:00

abstract：:Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny. In contrast, adhesion and biofilm formation, which are potentially involved in gut colonization...

journal_title：mBio

authors： Béchon N,Mihajlovic J,Vendrell-Fernández S,Chain F,Langella P,Beloin C,Ghigo JM

更新日期：2020-06-23 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：UNLABELLED:Cholera continues to be a global threat, with high rates of morbidity and mortality. In 2011, a cholera outbreak occurred in Palawan, Philippines, affecting more than 500 people, and 20 individuals died. Vibrio cholerae O1 was confirmed as the etiological agent. Source attribution is critical in cholera outb...

journal_title：mBio

authors： Klinzing DC,Choi SY,Hasan NA,Matias RR,Tayag E,Geronimo J,Skowronski E,Rashed SM,Kawashima K,Rosenzweig CN,Gibbons HS,Torres BC,Liles V,Alfon AC,Juan ML,Natividad FF,Cebula TA,Colwell RR

更新日期：2015-04-21 00:00:00

abstract：:Ocean viruses are ubiquitous and abundant and play important roles in global biogeochemical cycles by means of their mortality, horizontal gene transfer, and manipulation of host metabolism. However, the obstacles involved in linking viruses to their hosts in a high-throughput manner bottlenecks our ability to underst...

journal_title：mBio

authors： Deng L,Gregory A,Yilmaz S,Poulos BT,Hugenholtz P,Sullivan MB

更新日期：2012-10-30 00:00:00

abstract：:Increasing evidence has indicated that single nucleotide polymorphisms (SNPs) are related to the susceptibility of sepsis and might provide potential evidence for the mechanisms of sepsis. Our recent preliminary study showed that the ADAM10 genetic polymorphism was clinically associated with the development of sepsis,...

journal_title：mBio

authors： Chen F,Wang Y,Zhang W,Cai Y,Zhao T,Mai H,Tao S,Wei W,Li J,Chen X,Li X,Tang P,Fan W,Yang J,Ou M,Lu F,Lai Z,Chen H,Zou T,Sun F,Shao Y,Cui L

更新日期：2019-08-06 00:00:00

abstract：:The availability of energy has significant impact on cell physiology. However, the role of cellular metabolism in bacterial pathogenesis is not understood. We investigated the dynamics of central metabolism during virulence induction by surface sensing and quorum sensing in early-stage biofilms of the multidrug-resist...

journal_title：mBio

authors： Perinbam K,Chacko JV,Kannan A,Digman MA,Siryaporn A

更新日期：2020-03-10 00:00:00

abstract：:This research analyzed six Aspergillus fumigatus genes encoding putative efflux proteins for their roles as transporters. TheA. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI were cloned into plasmids and overexpressed in a Saccharomyces cerevisiae strain in which the highly active endogenous ABC transporter g...

journal_title：mBio

authors： Esquivel BD,Rybak JM,Barker KS,Fortwendel JR,Rogers PD,White TC

更新日期：2020-03-24 00:00:00

abstract：:Our current understanding of lipoprotein synthesis and localization in Gram-negative bacteria is based primarily on studies of Escherichia coli Newly synthesized E. coli prolipoproteins undergo posttranslational modifications catalyzed by three essential enzymes (Lgt, LspA, and Lnt). The mature lipoproteins are then s...

journal_title：mBio

authors： McClain MS,Voss BJ,Cover TL

更新日期：2020-05-19 00:00:00

abstract：UNLABELLED:The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is req...

journal_title：mBio

authors： Ekici S,Yang H,Koch HG,Daldal F

更新日期：2012-01-31 00:00:00

abstract：UNLABELLED:Diverse colony morphologies are a hallmark of Burkholderia pseudomallei recovered from infected patients. We observed that stresses that inhibit aerobic respiration shifted populations of B. pseudomallei from the canonical white colony morphotype toward two distinct, reversible, yet relatively stable yellow ...

journal_title：mBio

authors： Austin CR,Goodyear AW,Bartek IL,Stewart A,Sutherland MD,Silva EB,Zweifel A,Vitko NP,Tuanyok A,Highnam G,Mittelman D,Keim P,Schweizer HP,Vázquez-Torres A,Dow SW,Voskuil MI

更新日期：2015-02-03 00:00:00

abstract：:Once HIV-1 enters a cell, the viral core is uncoated by a poorly understood mechanism and the HIV-1 genomic RNA is reverse transcribed into DNA. Host cell factors are essential for these processes, although very few reverse transcription complex binding host cell factors have been convincingly shown to affect uncoatin...

journal_title：mBio

authors： Rawle DJ,Li D,Swedberg JE,Wang L,Soares DC,Harrich D

更新日期：2018-03-27 00:00:00

abstract：:Methylglyoxal (MG) is a detrimental metabolic by-product that threatens most organisms (in humans MG causes diabetes). MG is predominantly detoxified by the glyoxalase pathway. This process begins with the conjugation of MG with glutathione (GSH), yielding a hemithioacetal product that is subsequently transformed by t...

journal_title：mBio

authors： Kammerscheit X,Hecker A,Rouhier N,Chauvat F,Cassier-Chauvat C

更新日期：2020-08-04 00:00:00

abstract：:As the GroES/GroEL chaperonin system is the only bacterial chaperone that is essential under all conditions, we have been interested in the development of GroES/GroEL inhibitors as potential antibiotics. Using Escherichia coli GroES/GroEL as a surrogate, we have discovered several classes of GroES/GroEL inhibitors tha...

journal_title：mBio

authors： Sivinski J,Ambrose AJ,Panfilenko I,Zerio CJ,Machulis JM,Mollasalehi N,Kaneko LK,Stevens M,Ray AM,Park Y,Wu C,Hoang QQ,Johnson SM,Chapman E

更新日期：2021-01-12 00:00:00

abstract：:The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell wall-acting antibiotics. In rich medium, c-di-AMP is essential; however, muta...

journal_title：mBio

authors： Peterson BN,Young MKM,Luo S,Wang J,Whiteley AT,Woodward JJ,Tong L,Wang JD,Portnoy DA

更新日期：2020-08-25 00:00:00

abstract：:Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life. Recent application of deep-sequencing technologies has revealed that the transcription of asRNAs occurs genome-wide in bacter...

journal_title：mBio

authors： Raghavan R,Sloan DB,Ochman H

更新日期：2012-08-07 00:00:00

abstract：:Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic understanding of how bacteria evolve resistance against multiple phages is lacking, ...

journal_title：mBio

authors： Wright RCT,Friman VP,Smith MCM,Brockhurst MA

更新日期：2019-09-24 00:00:00

abstract：:Microbial establishment within the gastrointestinal (GI) tract requires surveillance of the gut biogeography. The gut microbiota coordinates behaviors by sensing host- or microbiota-derived signals. Here we show for the first time that microbiota-derived indole is highly prevalent in the lumen compared to the intestin...

journal_title：mBio

authors： Kumar A,Sperandio V

更新日期：2019-06-04 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：UNLABELLED:Here we present an extensive genomic and genetic analysis of Escherichia coli strains of serotype O78 that represent the major cause of avian colisepticemia, an invasive infection caused by avian pathogenic Escherichia coli (APEC) strains. It is associated with high mortality and morbidity, resulting in sign...

journal_title：mBio

authors： Huja S,Oren Y,Trost E,Brzuszkiewicz E,Biran D,Blom J,Goesmann A,Gottschalk G,Hacker J,Ron EZ,Dobrindt U

更新日期：2015-01-13 00:00:00

abstract：:Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical fo...

journal_title：mBio

authors： Johnson CJ,Davis JM,Huttenlocher A,Kernien JF,Nett JE

更新日期：2018-08-21 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic of chlamydial infection is the propensity to cause persistent in...

journal_title：mBio

authors： Yang C,Kari L,Lei L,Carlson JH,Ma L,Couch CE,Whitmire WM,Bock K,Moore I,Bonner C,McClarty G,Caldwell HD

更新日期：2020-08-18 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131), a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC) infections, has been known widely for its contribution to the worldwide dissemination of multidrug resistance. Although other ExPEC-associated and extended-spectrum-β-lactamase ...

journal_title：mBio

authors： Shaik S,Ranjan A,Tiwari SK,Hussain A,Nandanwar N,Kumar N,Jadhav S,Semmler T,Baddam R,Islam MA,Alam M,Wieler LH,Watanabe H,Ahmed N

更新日期：2017-10-24 00:00:00

abstract：:Antimicrobial resistance is a major health threat as it limits treatment options for infection. At the forefront of this serious issue is Acinetobacter baumannii, a Gram-negative opportunistic pathogen that exhibits the remarkable ability to resist antibiotics through multiple mechanisms. As bacterial ribosomes repres...

journal_title：mBio

authors： Morgan CE,Huang W,Rudin SD,Taylor DJ,Kirby JE,Bonomo RA,Yu EW

更新日期：2020-01-21 00:00:00

abstract：:Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causat...

journal_title：mBio

authors： Idnurm A

更新日期：2013-04-30 00:00:00

abstract：:Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural origin, discovering new natural products is challenging, and there is a need to expand the chemical ...

journal_title：mBio

authors： Cleto S,Lu TK

更新日期：2017-10-10 00:00:00

abstract：UNLABELLED:Small RNAs play a critical role in host-pathogen interaction. Indeed, small RNA-mediated silencing or RNA interference (RNAi) is one of the earliest forms of antiviral immunity. Although it represents the main defense system against viruses in many organisms, the antiviral role of RNAi has not been clearly p...

journal_title：mBio

authors： Girardi E,Chane-Woon-Ming B,Messmer M,Kaukinen P,Pfeffer S

更新日期：2013-11-19 00:00:00

abstract：UNLABELLED:A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal dr...

journal_title：mBio

authors： Abdolrasouli A,Rhodes J,Beale MA,Hagen F,Rogers TR,Chowdhary A,Meis JF,Armstrong-James D,Fisher MC

更新日期：2015-06-02 00:00:00