Nile red detection of bacterial hydrocarbons and ketones in a high-throughput format.

abstract：UNLABELLED:Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral load) variance that occurs between resistant BALB/c and susceptible SJL...

journal_title：mBio

authors： Hsu TH,Althaus IW,Foreman O,Spindler KR

更新日期：2012-05-29 00:00:00

abstract：:Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynt...

journal_title：mBio

authors： Shrivastava-Ranjan P,Bergeron É,Chakrabarti AK,Albariño CG,Flint M,Nichol ST,Spiropoulou CF

更新日期：2016-12-20 00:00:00

abstract：UNLABELLED:In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P. jirovecii) were compared among themselves and with the free-living, phylogenetically related fission yeast (Schizosaccharomyces pombe)...

journal_title：mBio

authors： Porollo A,Sesterhenn TM,Collins MS,Welge JA,Cushion MT

更新日期：2014-11-04 00:00:00

abstract：:Enterococci are important human commensals and significant opportunistic pathogens. Biofilm-related enterococcal infections, such as endocarditis, urinary tract infections, wound and surgical site infections, and medical device-associated infections, often become chronic upon the formation of biofilm. The biofilm matr...

journal_title：mBio

authors： Keogh D,Lam LN,Doyle LE,Matysik A,Pavagadhi S,Umashankar S,Low PM,Dale JL,Song Y,Ng SP,Boothroyd CB,Dunny GM,Swarup S,Williams RBH,Marsili E,Kline KA

更新日期：2018-04-10 00:00:00

abstract：:Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002) is in advanced clinical trials and shows promise for improved v...

journal_title：mBio

authors： Fletcher HA

更新日期：2016-08-30 00:00:00

abstract：:Aspergillus fumigatus is the leading cause of pulmonary fungal diseases. Azoles have been used for many years as the main antifungal agents to treat and prevent invasive aspergillosis. However, in the last 10 years there have been several reports of azole resistance in A. fumigatus and new strategies are needed to com...

journal_title：mBio

authors： Valero C,Colabardini AC,Chiaratto J,Pardeshi L,de Castro PA,Ferreira Filho JA,Silva LP,Rocha MC,Malavazi I,Costa JH,Fill T,Barros MH,Wong SSW,Aimanianda V,Wong KH,Goldman GH

更新日期：2020-06-16 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00

abstract：:In immunocompromised hosts, latent infection with Toxoplasma gondii can reactivate from tissue cysts, leading to encephalitis. A characteristic of T. gondii bradyzoites in tissue cysts is the presence of amylopectin granules. The regulatory mechanisms and role of amylopectin accumulation in this organism are not fully...

journal_title：mBio

authors： Sugi T,Tu V,Ma Y,Tomita T,Weiss LM

更新日期：2017-08-29 00:00:00

abstract：:Since the original report that Halomonas sp. strain GFAJ-1 was capable of using arsenic instead of phosphorus to sustain growth, additional studies have been conducted, and GFAJ-1 is now considered a highly arsenic-resistant but phosphorus-dependent bacterium. However, the mechanisms supporting the extreme arsenic res...

journal_title：mBio

authors： Wu S,Wang L,Gan R,Tong T,Bian H,Li Z,Du S,Deng Z,Chen S

更新日期：2018-05-01 00:00:00

abstract：:The fungus Paracoccidioides is a prevalent human pathogen endemic to South America. The genus is composed of five species. In this report, we use 37 whole-genome sequences to study the allocation of genetic variation in Paracoccidioides We tested three genome-wide predictions of advanced speciation, namely, that all s...

journal_title：mBio

authors： Mavengere H,Mattox K,Teixeira MM,Sepúlveda VE,Gomez OM,Hernandez O,McEwen J,Matute DR

更新日期：2020-12-22 00:00:00

abstract：UNLABELLED:In Staphylococcus aureus, hundreds of small regulatory or small RNAs (sRNAs) have been identified, yet this class of molecule remains poorly understood and severely understudied. sRNA genes are typically absent from genome annotation files, and as a consequence, their existence is often overlooked, particula...

journal_title：mBio

authors： Carroll RK,Weiss A,Broach WH,Wiemels RE,Mogen AB,Rice KC,Shaw LN

更新日期：2016-02-09 00:00:00

abstract：:EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) o...

journal_title：mBio

authors： McCarthy KR,Timpona JL,Jenni S,Bloyet LM,Brusic V,Johnson WE,Whelan SPJ,Robinson-McCarthy LR

更新日期：2020-11-17 00:00:00

abstract：:Stenotrophomonas maltophilia is a Gram-negative, nonfermenting, environmental bacillus that is an important cause of nosocomial infections, primarily associated with the respiratory tract in the immunocompromised population. Aiming to understand the population structure, microbiological characteristics and impact of a...

journal_title：mBio

authors： Mojica MF,Rutter JD,Taracila M,Abriata LA,Fouts DE,Papp-Wallace KM,Walsh TJ,LiPuma JJ,Vila AJ,Bonomo RA

更新日期：2019-07-02 00:00:00

abstract：:Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados)...

journal_title：mBio

authors： Wurster S,Tatara AM,Albert ND,Ibrahim AS,Heitman J,Lee SC,Shetty AC,McCracken C,Graf KT,Mikos AG,Bruno VM,Kontoyiannis DP

更新日期：2020-06-30 00:00:00

abstract：:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), also known as A20, is a ubiquitin-editing enzyme capable of ubiquitination or deubiquitination of its target proteins. In this study, we show that hepatitis C virus (HCV) infection could induce the expression of A20 via the activation of the A20 promoter. The in...

journal_title：mBio

authors： Lee J,Chan ST,Kim JY,Ou JJ

更新日期：2019-07-23 00:00:00

abstract：:Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference (RNAi) response are poorly understood. Here, we characterized antiviral RN...

journal_title：mBio

authors： Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW

更新日期：2020-08-04 00:00:00

abstract：:Motility is an important virulence trait for many bacterial pathogens, allowing them to position themselves in appropriate locations at appropriate times. The motility structures type IV pili and flagella are also involved in sensing surface contact, which modulates pathogenicity. In Pseudomonas aeruginosa, the PilS-P...

journal_title：mBio

authors： Kilmury SLN,Burrows LL

更新日期：2018-07-24 00:00:00

abstract：:ZipA is an essential cell division protein in Escherichia coli Together with FtsA, ZipA tethers dynamic polymers of FtsZ to the cytoplasmic membrane, and these polymers are required to guide synthesis of the cell division septum. This dynamic behavior of FtsZ has been reconstituted on planar lipid surfaces in vitro, v...

journal_title：mBio

authors： Krupka M,Sobrinos-Sanguino M,Jiménez M,Rivas G,Margolin W

更新日期：2018-06-19 00:00:00

abstract：:Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughput purposes. Here, we made a...

journal_title：mBio

authors： Moudjou M,Sibille P,Fichet G,Reine F,Chapuis J,Herzog L,Jaumain E,Laferrière F,Richard CA,Laude H,Andréoletti O,Rezaei H,Béringue V

更新日期：2013-12-31 00:00:00

abstract：:Two Shigella species, Shigella flexneri and Shigella sonnei, cause approximately 90% of bacterial dysentery worldwide. While S. flexneri is the dominant species in low-income countries, S. sonnei causes the majority of infections in middle- and high-income countries. S. flexneri is a prototypic cytosolic bacterium; on...

journal_title：mBio

authors： Watson JL,Sanchez-Garrido J,Goddard PJ,Torraca V,Mostowy S,Shenoy AR,Clements A

更新日期：2019-12-17 00:00:00

abstract：UNLABELLED:Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extrac...

journal_title：mBio

authors： Singh B,Alvarado-Kristensson M,Johansson M,Hallgren O,Westergren-Thorsson G,Mörgelin M,Riesbeck K

更新日期：2016-03-22 00:00:00

abstract：:Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an important phase in their development. Here, we present a systemati...

journal_title：mBio

authors： Obaldia N 3rd,Meibalan E,Sa JM,Ma S,Clark MA,Mejia P,Moraes Barros RR,Otero W,Ferreira MU,Mitchell JR,Milner DA,Huttenhower C,Wirth DF,Duraisingh MT,Wellems TE,Marti M

更新日期：2018-05-08 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and interconnected quorum sensing (QS) regulatory circuits to produce a battery of virulence factors such as elastase, phenazines, and rhamnol...

journal_title：mBio

authors： Cruz RL,Asfahl KL,Van den Bossche S,Coenye T,Crabbé A,Dandekar AA

更新日期：2020-04-07 00:00:00

abstract：:The appearance of Cryptococcus gattii in the North American Pacific Northwest (PNW) in 1999 was an unexpected and is still an unexplained event. Recent phylogenomic analyses strongly suggest that this pathogenic fungus arrived in the PNW approximately 7 to 9 decades ago. In this paper, we theorize that the ancestors o...

journal_title：mBio

authors： Engelthaler DM,Casadevall A

更新日期：2019-10-01 00:00:00

abstract：:A voluntary 60-day pause on avian H5N1 influenza virus transmission research was announced in January 2012 by the international community of influenza scientists engaged in this work to provide time to explain the benefits of such work and the risk mitigation measures in place. Subsequently, the pause was extended to ...

journal_title：mBio

authors： Fouchier RA,García-Sastre A,Kawaoka Y

更新日期：2012-11-01 00:00:00

abstract：:Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resista...

journal_title：mBio

authors： Somprasong N,Hall CM,Webb JR,Sahl JW,Wagner DM,Keim P,Currie BJ,Schweizer HP

更新日期：2020-04-14 00:00:00

abstract：:Protein kinase R (PKR) plays a major role in activating host immunity during infection by sensing double-stranded RNA (dsRNA) produced by viruses. Once activated by dsRNA, PKR phosphorylates the translation factor eukaryotic initiation factor 2α (eIF2α), halting cellular translation. Many viruses have methods of inhib...

journal_title：mBio

authors： Goodman DE,Pretto CD,Krepostman TA,Carnahan KE,Spindler KR

更新日期：2019-04-23 00:00:00

abstract：:Plant-infecting viruses utilize various strategies involving multiple viral and host factors to achieve successful systemic infections of their compatible hosts. Lettuce infectious yellows virus (LIYV), genus Crinivirus, family Closteroviridae, has long, filamentous flexuous virions and causes phloem-limited infection...

journal_title：mBio

authors： Qiao W,Medina V,Kuo YW,Falk BW

更新日期：2018-11-20 00:00:00

abstract：:Interindividual variation in the composition of the human gut microbiome was examined in relation to demographic and anthropometric traits, and to changes in dietary saturated fat intake and protein source. One hundred nine healthy men and women aged 21 to 65, with BMIs of 18 to 36, were randomized, after a two-week b...

journal_title：mBio

authors： Lang JM,Pan C,Cantor RM,Tang WHW,Garcia-Garcia JC,Kurtz I,Hazen SL,Bergeron N,Krauss RM,Lusis AJ

更新日期：2018-12-11 00:00:00

abstract：UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...

journal_title：mBio

authors： Memoli MJ,Shaw PA,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Fargis S,Risos K,Powers JH,Davey RT Jr,Taubenberger JK

更新日期：2016-04-19 00:00:00