On the Emergence of Cryptococcus gattii in the Pacific Northwest: Ballast Tanks, Tsunamis, and Black Swans.

abstract：UNLABELLED:Human cathepsin W (CtsW) is a cysteine protease, which was identified in a genome-wide RNA interference (RNAi) screen to be required for influenza A virus (IAV) replication. In this study, we show that reducing the levels of expression of CtsW reduces viral titers for different subtypes of IAV, and we map th...

journal_title：mBio

authors： Edinger TO,Pohl MO,Yángüez E,Stertz S

更新日期：2015-06-09 00:00:00

abstract：:Fission yeast phosphate homeostasis entails transcriptional induction of genes encoding phosphate-mobilizing proteins under conditions of phosphate starvation. Transcription factor Pho7, a member of the Zn2Cys6 family of fungal transcription regulators, is the central player in the starvation response. The DNA binding...

journal_title：mBio

authors： Schwer B,Sanchez AM,Garg A,Chatterjee D,Shuman S

更新日期：2017-08-15 00:00:00

abstract：UNLABELLED:Clostridium perfringens enterotoxin (CPE) contributes to several important human gastrointestinal (GI) diseases. This toxin and its derivatives are also being explored for translational applications, i.e., cancer therapy or drug delivery. Some, but not all, members of the 24-member claudin (Cldn) family of m...

journal_title：mBio

authors： Shrestha A,McClane BA

更新日期：2013-01-15 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral...

journal_title：mBio

authors： Hosseinipour MC,Sweet KM,Xiong J,Namarika D,Mwafongo A,Nyirenda M,Chiwoko L,Kamwendo D,Hoffman I,Lee J,Phiri S,Vahrson W,Damania B,Dittmer DP

更新日期：2014-09-23 00:00:00

abstract：UNLABELLED:Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persisted in the health care setting for decades, but the basis of its success has not...

journal_title：mBio

authors： Baines SL,Holt KE,Schultz MB,Seemann T,Howden BO,Jensen SO,van Hal SJ,Coombs GW,Firth N,Powell DR,Stinear TP,Howden BP

更新日期：2015-03-03 00:00:00

abstract：UNLABELLED:This study demonstrates the prevalence, phylogenetic diversity, and physiology of nitrate-reducing microorganisms capable of utilizing reduced humic acids (HA) as electron donors in agricultural soils. Most probable number (MPN) enumeration of agricultural soils revealed large populations (10(4) to 10(6) cel...

journal_title：mBio

authors： Van Trump JI,Wrighton KC,Thrash JC,Weber KA,Andersen GL,Coates JD

更新日期：2011-07-12 00:00:00

abstract：UNLABELLED:The genus Cyanothece comprises unicellular cyanobacteria that are morphologically diverse and ecologically versatile. Studies over the last decade have established members of this genus to be important components of the marine ecosystem, contributing significantly to the nitrogen and carbon cycle. System-lev...

journal_title：mBio

authors： Bandyopadhyay A,Elvitigala T,Welsh E,Stöckel J,Liberton M,Min H,Sherman LA,Pakrasi HB

更新日期：2011-10-04 00:00:00

abstract：UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...

journal_title：mBio

authors： Memoli MJ,Shaw PA,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Fargis S,Risos K,Powers JH,Davey RT Jr,Taubenberger JK

更新日期：2016-04-19 00:00:00

abstract：:The USA300 North American epidemic (USA300-NAE) clone of methicillin-resistant Staphylococcus aureus has caused a wave of severe skin and soft tissue infections in the United States since it emerged in the early 2000s, but its geographic origin is obscure. Here we use the population genomic signatures expected from th...

journal_title：mBio

authors： Challagundla L,Luo X,Tickler IA,Didelot X,Coleman DC,Shore AC,Coombs GW,Sordelli DO,Brown EL,Skov R,Larsen AR,Reyes J,Robledo IE,Vazquez GJ,Rivera R,Fey PD,Stevenson K,Wang SH,Kreiswirth BN,Mediavilla JR,Arias CA

更新日期：2018-01-02 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00

abstract：:Posttranslational modification of a protein, either alone or in combination with other modifications, can control properties of that protein, such as enzymatic activity, localization, stability, or interactions with other molecules. N-ε-Lysine acetylation is one such modification that has gained attention in recent ye...

journal_title：mBio

authors： Christensen DG,Baumgartner JT,Xie X,Jew KM,Basisty N,Schilling B,Kuhn ML,Wolfe AJ

更新日期：2019-04-09 00:00:00

abstract：:Legionella pneumophila grows within cells ranging from environmental amoebae to human macrophages. In spite of this conserved strategy of pathogenesis, identification of host factors that restrict L. pneumophila intracellular replication has not been extended outside components of the mammalian innate immune response....

journal_title：mBio

authors： de Jesús-Díaz DA,Murphy C,Sol A,Dorer M,Isberg RR

更新日期：2017-08-22 00:00:00

abstract：:The human antibody repertoire has an exceptionally large capacity to recognize new or changing antigens through combinatorial and junctional diversity established at the time of V(D)J recombination and through somatic hypermutation. Influenza viruses exhibit a relentless capacity to escape the human antibody response ...

journal_title：mBio

authors： Crowe JE Jr

更新日期：2012-07-31 00:00:00

abstract：:Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical fo...

journal_title：mBio

authors： Johnson CJ,Davis JM,Huttenlocher A,Kernien JF,Nett JE

更新日期：2018-08-21 00:00:00

abstract：:The blast fungus initiates infection using a heavily melanized, dome-shaped infection structure known as the appressorium, which forcibly ruptures the cuticle to enter the rice leaf tissue. How this process takes place remains not fully understood. Here, we used untargeted metabolomics analyses to profile the metabolo...

journal_title：mBio

authors： Liu XH,Liang S,Wei YY,Zhu XM,Li L,Liu PP,Zheng QX,Zhou HN,Zhang Y,Mao LJ,Fernandes CM,Del Poeta M,Naqvi NI,Lin FC

更新日期：2019-08-20 00:00:00

abstract：:Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002) is in advanced clinical trials and shows promise for improved v...

journal_title：mBio

authors： Fletcher HA

更新日期：2016-08-30 00:00:00

abstract：UNLABELLED:Small RNAs play a critical role in host-pathogen interaction. Indeed, small RNA-mediated silencing or RNA interference (RNAi) is one of the earliest forms of antiviral immunity. Although it represents the main defense system against viruses in many organisms, the antiviral role of RNAi has not been clearly p...

journal_title：mBio

authors： Girardi E,Chane-Woon-Ming B,Messmer M,Kaukinen P,Pfeffer S

更新日期：2013-11-19 00:00:00

abstract：UNLABELLED:Marine methane seeps are globally distributed geologic features in which reduced fluids, including methane, are advected upward from the subsurface. As a result of alkalinity generation during sulfate-coupled methane oxidation, authigenic carbonates form slabs, nodules, and extensive pavements. These carbona...

journal_title：mBio

authors： Case DH,Pasulka AL,Marlow JJ,Grupe BM,Levin LA,Orphan VJ

更新日期：2015-12-22 00:00:00

abstract：UNLABELLED:The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is req...

journal_title：mBio

authors： Ekici S,Yang H,Koch HG,Daldal F

更新日期：2012-01-31 00:00:00

abstract：UNLABELLED:Toll-like receptors (TLRs) are sensors that recognize molecular patterns from viruses, bacteria, and fungi to initiate innate immune responses to invading pathogens. The emergence of highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome ...

journal_title：mBio

authors： Totura AL,Whitmore A,Agnihothram S,Schäfer A,Katze MG,Heise MT,Baric RS

更新日期：2015-05-26 00:00:00

abstract：:The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...

journal_title：mBio

authors： Ausiello CM,Cassone A

更新日期：2014-06-10 00:00:00

abstract：:Many viruses produce protein-coding and noncoding subgenomic RNAs (sgRNAs) that are critical for infection. A recently discovered pathway for viral sgRNA production uses exoribonuclease-resistant RNAs (xrRNAs), discrete folded RNA elements that block the processive exoribonucleolytic degradation of RNA. xrRNAs are wid...

journal_title：mBio

authors： Steckelberg AL,Vicens Q,Kieft JS

更新日期：2018-12-18 00:00:00

abstract：:Estrogen, a major female sex steroid hormone, has been shown to promote the selection of mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases, including cystic fibrosis. This results in long-term persistence, poorer clinical outcomes, and limited therapeutic options. In this study...

journal_title：mBio

authors： Vidaillac C,Yong VFL,Aschtgen MS,Qu J,Yang S,Xu G,Seng ZJ,Brown AC,Ali MK,Jaggi TK,Sankaran J,Foo YH,Righetti F,Nedumaran AM,Mac Aogáin M,Roizman D,Richard JA,Rogers TR,Toyofuku M,Luo D,Loh E,Wohland T,Czarny

更新日期：2020-09-29 00:00:00

abstract：UNLABELLED:Antibiotics are a cost-effective tool for improving feed efficiency and preventing disease in agricultural animals, but the full scope of their collateral effects is not understood. Antibiotics have been shown to mediate gene transfer by inducing prophages in certain bacterial strains; therefore, one collate...

journal_title：mBio

authors： Allen HK,Looft T,Bayles DO,Humphrey S,Levine UY,Alt D,Stanton TB

更新日期：2011-11-29 00:00:00

abstract：UNLABELLED:The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we have taken advantage of a zebrafish model to investigate host-pathogen interactions of Cryptococcus w...

journal_title：mBio

authors： Tenor JL,Oehlers SH,Yang JL,Tobin DM,Perfect JR

更新日期：2015-09-29 00:00:00

abstract：UNLABELLED:Enterococcus faecium, natively a gut commensal organism, emerged as a leading cause of multidrug-resistant hospital-acquired infection in the 1980s. As the living record of its adaptation to changes in habitat, we sequenced the genomes of 51 strains, isolated from various ecological environments, to understa...

journal_title：mBio

authors： Lebreton F,van Schaik W,McGuire AM,Godfrey P,Griggs A,Mazumdar V,Corander J,Cheng L,Saif S,Young S,Zeng Q,Wortman J,Birren B,Willems RJ,Earl AM,Gilmore MS

更新日期：2013-08-20 00:00:00

abstract：:Production of metallo-β-lactamases (MBLs), which hydrolyze carbapenems, is a cause of carbapenem resistance in Enterobacteriaceae Development of effective inhibitors for MBLs is one approach to restore carbapenem efficacy in carbapenem-resistant Enterobacteriaceae (CRE). We report here that sulfamoyl heteroarylcarboxy...

journal_title：mBio

authors： Wachino JI,Jin W,Kimura K,Kurosaki H,Sato A,Arakawa Y

更新日期：2020-03-17 00:00:00

abstract：:Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causat...

journal_title：mBio

authors： Idnurm A

更新日期：2013-04-30 00:00:00

abstract：:Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing a...

journal_title：mBio

authors： Hopfensperger K,Sauter D

更新日期：2020-05-26 00:00:00

abstract：:To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we constructed a genome encyclopedia describing the core supragingival plaque microb...

journal_title：mBio

authors： Espinoza JL,Harkins DM,Torralba M,Gomez A,Highlander SK,Jones MB,Leong P,Saffery R,Bockmann M,Kuelbs C,Inman JM,Hughes T,Craig JM,Nelson KE,Dupont CL

更新日期：2018-11-27 00:00:00