Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine.

abstract：UNLABELLED:As diet is considered the major regulator of the gut ecosystem, the overall objective of this work was to demonstrate that a detailed knowledge of the phytochemical composition of food could add to our understanding of observed changes in functionality and activity of the gut microbiota. We used metatranscri...

journal_title：mBio

authors： Ni Y,Li J,Panagiotou G

更新日期：2015-10-27 00:00:00

abstract：:The apparent mislocalization or excretion of cytoplasmic proteins is a commonly observed phenomenon in both bacteria and eukaryotes. However, reports on the mechanistic basis and the cellular function of this so-called "nonclassical protein secretion" are limited. Here we report that protein overexpression in recombin...

journal_title：mBio

authors： Morra R,Del Carratore F,Muhamadali H,Horga LG,Halliwell S,Goodacre R,Breitling R,Dixon N

更新日期：2018-01-30 00:00:00

abstract：:Nicotine, a toxic and addictive alkaloid from tobacco, is an environmental pollutant in areas near cigarette production facilities. Over the last decade, our group has studied, in depth, the pyrrolidine pathway of nicotine degradation in Pseudomonas putida S16. However, little is known regarding whole mechanism(s) reg...

journal_title：mBio

authors： Hu H,Wang L,Wang W,Wu G,Tao F,Xu P,Deng Z,Tang H

更新日期：2019-06-04 00:00:00

abstract：UNLABELLED:Kaposi sarcoma (KS) herpesvirus (KSHV) infection of endothelial cells (EC) is associated with strong induction of heme oxygenase-1 (HO-1), a stress-inducible host gene that encodes the rate-limiting enzyme responsible for heme catabolism. KS is an angioproliferative tumor characterized by the proliferation o...

journal_title：mBio

authors： Botto S,Totonchy JE,Gustin JK,Moses AV

更新日期：2015-06-04 00:00:00

abstract：UNLABELLED:Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems. However, the structural specificity of these systems for sugar substrates has hindered their appl...

journal_title：mBio

authors： Pan C,Sun P,Liu B,Liang H,Peng Z,Dong Y,Wang D,Liu X,Wang B,Zeng M,Wu J,Zhu L,Wang H

更新日期：2016-04-26 00:00:00

abstract：UNLABELLED:Pneumococcal pili have been shown to influence pneumococcal colonization, disease development, and the inflammatory response in mice. The role of the pilus-associated RrgA adhesin in pneumococcal interactions with murine and human macrophages was investigated. Expression of pili with RrgA enhanced the uptake...

journal_title：mBio

authors： Orrskog S,Rounioja S,Spadafina T,Gallotta M,Norman M,Hentrich K,Fälker S,Ygberg-Eriksson S,Hasenberg M,Johansson B,Uotila LM,Gahmberg CG,Barocchi M,Gunzer M,Normark S,Henriques-Normark B

更新日期：2012-12-26 00:00:00

abstract：:Long noncoding RNA (lncRNA) plays important roles in sexual development in eukaryotes. In filamentous fungi, however, little is known about the expression and roles of lncRNAs during fruiting body formation. By profiling developmental transcriptomes during the life cycle of the plant-pathogenic fungus Fusarium gramine...

journal_title：mBio

authors： Kim W,Miguel-Rojas C,Wang J,Townsend JP,Trail F

更新日期：2018-08-14 00:00:00

abstract：UNLABELLED:The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens that protect mice from sepsis. In this study, we characterized one of ...

journal_title：mBio

authors： Nesta B,Spraggon G,Alteri C,Moriel DG,Rosini R,Veggi D,Smith S,Bertoldi I,Pastorello I,Ferlenghi I,Fontana MR,Frankel G,Mobley HL,Rappuoli R,Pizza M,Serino L,Soriani M

更新日期：2012-04-10 00:00:00

abstract：:Mycoviruses infect fungi, and while most persist asymptomatically, there are examples of mycoviruses having both beneficial and detrimental effects on their host. Virus-infected Saccharomyces and Ustilago strains exhibit a killer phenotype conferring a growth advantage over uninfected strains and other competing yeast...

journal_title：mBio

authors： Applen Clancey S,Ruchti F,LeibundGut-Landmann S,Heitman J,Ianiri G

更新日期：2020-09-01 00:00:00

abstract：UNLABELLED:The bacterial flagellum is driven by a bidirectional rotary motor, which propels bacteria to swim through liquids or swarm over surfaces. While the functions of the major structural and regulatory components of the flagellum are known, the function of the well-conserved FliL protein is not. In Salmonella and...

journal_title：mBio

authors： Partridge JD,Nieto V,Harshey RM

更新日期：2015-02-24 00:00:00

abstract：:Two recently submitted (but as yet unpublished) studies describe success in creating mutant isolates of H5N1 influenza A virus that can be transmitted via the respiratory route between ferrets; concern has been raised regarding human-to-human transmissibility of these or similar laboratory-generated influenza viruses....

journal_title：mBio

authors： Osterholm MT,Kelley NS

更新日期：2012-02-24 00:00:00

abstract：:Transposon insertion sequencing (TIS) is a powerful high-throughput genetic technique that is transforming functional genomics in prokaryotes, because it enables genome-wide mapping of the determinants of fitness. However, current approaches for analyzing TIS data assume that selective pressures are constant over time...

journal_title：mBio

authors： Yang G,Billings G,Hubbard TP,Park JS,Yin Leung K,Liu Q,Davis BM,Zhang Y,Wang Q,Waldor MK

更新日期：2017-10-03 00:00:00

abstract：UNLABELLED:Coagulase (Coa) and Efb, secreted Staphylococcus aureus proteins, are important virulence factors in staphylococcal infections. Coa interacts with fibrinogen (Fg) and induces the formation of fibrin(ogen) clots through activation of prothrombin. Efb attracts Fg to the bacterial surface and forms a shield to ...

journal_title：mBio

authors： Ko YP,Kang M,Ganesh VK,Ravirajan D,Li B,Höök M

更新日期：2016-01-05 00:00:00

abstract：:E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the African swine fever virus (ASFV) genome, is required for productive replication of ASFV in swine macrophages. Here, we solved the high-resolution crystal structures of E165R in its apo state and in complex with its product dUMP. Structural anal...

journal_title：mBio

authors： Li C,Chai Y,Song H,Weng C,Qi J,Sun Y,Gao GF

更新日期：2019-10-29 00:00:00

abstract：:Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease. During enterotoxemia, the nearly inactive ETX prototoxin is produced in the intestines but then must be activated by proteolytic ...

journal_title：mBio

authors： Freedman JC,Li J,Uzal FA,McClane BA

更新日期：2014-10-21 00:00:00

abstract：:The availability of energy has significant impact on cell physiology. However, the role of cellular metabolism in bacterial pathogenesis is not understood. We investigated the dynamics of central metabolism during virulence induction by surface sensing and quorum sensing in early-stage biofilms of the multidrug-resist...

journal_title：mBio

authors： Perinbam K,Chacko JV,Kannan A,Digman MA,Siryaporn A

更新日期：2020-03-10 00:00:00

abstract：:Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference (RNAi) response are poorly understood. Here, we characterized antiviral RN...

journal_title：mBio

authors： Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW

更新日期：2020-08-04 00:00:00

abstract：UNLABELLED:Toxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into the nascent parasitophorous vacuole. These GRAs are believed to pl...

journal_title：mBio

authors： Nadipuram SM,Kim EW,Vashisht AA,Lin AH,Bell HN,Coppens I,Wohlschlegel JA,Bradley PJ

更新日期：2016-08-02 00:00:00

abstract：:Pathogens frequently employ eukaryotic linear motif (ELM)-rich intrinsically disordered proteins (IDPs) to perturb and hijack host cell networks for a productive infection. Mycobacterium tuberculosis has a relatively high percentage of IDPs in its proteome, the significance of which is not known. The Mycobacterium-spe...

journal_title：mBio

authors： Ahmad J,Farhana A,Pancsa R,Arora SK,Srinivasan A,Tyagi AK,Babu MM,Ehtesham NZ,Hasnain SE

更新日期：2018-01-23 00:00:00

abstract：:Typhoid fever, caused by Salmonella enterica serovar Typhi, is a global public health concern due to increasing antimicrobial resistance (AMR). Characterization of S Typhi genomes for AMR and the evolution of different lineages, especially in countries where typhoid fever is endemic such as Bangladesh, will help publi...

journal_title：mBio

authors： Tanmoy AM,Westeel E,De Bruyne K,Goris J,Rajoharison A,Sajib MSI,van Belkum A,Saha SK,Komurian-Pradel F,Endtz HP

更新日期：2018-11-13 00:00:00

abstract：:The deep-sea tubeworm Riftia pachyptila lacks a digestive system but completely relies on bacterial endosymbionts for nutrition. Although the symbiont has been studied in detail on the molecular level, such analyses were unavailable for the animal host, because sequence information was lacking. To identify host-symbio...

journal_title：mBio

authors： Hinzke T,Kleiner M,Breusing C,Felbeck H,Häsler R,Sievert SM,Schlüter R,Rosenstiel P,Reusch TBH,Schweder T,Markert S

更新日期：2019-12-17 00:00:00

abstract：:Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing a...

journal_title：mBio

authors： Hopfensperger K,Sauter D

更新日期：2020-05-26 00:00:00

abstract：:Vibrio vulnificus, an opportunistic pathogen, is the causative agent of a life-threatening septicemia and a rising problem for aquaculture worldwide. The genetic factors that differentiate its clinical and environmental strains remain enigmatic. Furthermore, clinical strains have emerged from every clade of V. vulnifi...

journal_title：mBio

authors： López-Pérez M,Jayakumar JM,Haro-Moreno JM,Zaragoza-Solas A,Reddi G,Rodriguez-Valera F,Shapiro OH,Alam M,Almagro-Moreno S

更新日期：2019-02-19 00:00:00

abstract：UNLABELLED:Competence for genetic transformation in Streptococcus pneumoniae develops in response to accumulation of a secreted peptide pheromone and was one of the initial examples of bacterial quorum sensing. Activation of this signaling system induces not only expression of the proteins required for transformation b...

journal_title：mBio

authors： Stevens KE,Chang D,Zwack EE,Sebert ME

更新日期：2011-09-20 00:00:00

abstract：:Since the original report that Halomonas sp. strain GFAJ-1 was capable of using arsenic instead of phosphorus to sustain growth, additional studies have been conducted, and GFAJ-1 is now considered a highly arsenic-resistant but phosphorus-dependent bacterium. However, the mechanisms supporting the extreme arsenic res...

journal_title：mBio

authors： Wu S,Wang L,Gan R,Tong T,Bian H,Li Z,Du S,Deng Z,Chen S

更新日期：2018-05-01 00:00:00

abstract：:Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved am...

journal_title：mBio

authors： Schubert K,Sieger B,Meyer F,Giacomelli G,Böhm K,Rieblinger A,Lindenthal L,Sachs N,Wanner G,Bramkamp M

更新日期：2017-02-07 00:00:00

abstract：:Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados)...

journal_title：mBio

authors： Wurster S,Tatara AM,Albert ND,Ibrahim AS,Heitman J,Lee SC,Shetty AC,McCracken C,Graf KT,Mikos AG,Bruno VM,Kontoyiannis DP

更新日期：2020-06-30 00:00:00

abstract：UNLABELLED:The ability to cultivate food is an innovation that has produced some of the most successful ecological strategies on the planet. Although most well recognized in humans, where agriculture represents a defining feature of civilization, species of ants, beetles, and termites have also independently evolved sy...

journal_title：mBio

authors： Aylward FO,Suen G,Biedermann PH,Adams AS,Scott JJ,Malfatti SA,Glavina del Rio T,Tringe SG,Poulsen M,Raffa KF,Klepzig KD,Currie CR

更新日期：2014-11-18 00:00:00

abstract：:The acquisition and incorporation of genetic material between nonmating species, or horizontal gene transfer (HGT), has been frequently described for phylogenetically related organisms, but far less evidence exists for HGT between highly divergent organisms. Here we report the identification and characterization of a ...

journal_title：mBio

authors： Anderson MT,Seifert HS

更新日期：2011-02-15 00:00:00

abstract：:Plant roots support complex microbial communities that can influence plant growth, nutrition, and health. While extensive characterizations of the composition and spatial compartmentalization of these communities have been performed in different plant species, there is relatively little known about the impact of abiot...

journal_title：mBio

authors： Santos-Medellín C,Edwards J,Liechty Z,Nguyen B,Sundaresan V

更新日期：2017-07-18 00:00:00