Tol-Pal System and Rgs Proteins Interact to Promote Unipolar Growth and Cell Division in Sinorhizobium meliloti.

abstract：:The hospital environment is a potential reservoir of bacteria with plasmids conferring carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive sampling of high-touch surfaces, sinks, and other locations in the hospital. Over a 2-year period, additional sampling was conducted at a broader ...

journal_title：mBio

authors： Weingarten RA,Johnson RC,Conlan S,Ramsburg AM,Dekker JP,Lau AF,Khil P,Odom RT,Deming C,Park M,Thomas PJ,NISC Comparative Sequencing Program.,Henderson DK,Palmore TN,Segre JA,Frank KM

更新日期：2018-02-06 00:00:00

abstract：UNLABELLED:Elevated intracellular levels of the bacterial second messenger c-di-GMP are known to suppress motility and promote sessility. Bacterial chemotaxis guides motile cells in gradients of attractants and repellents over broad concentration ranges, thus allowing bacteria to quickly adapt to changes in their surro...

journal_title：mBio

authors： Russell MH,Bible AN,Fang X,Gooding JR,Campagna SR,Gomelsky M,Alexandre G

更新日期：2013-03-19 00:00:00

abstract：UNLABELLED:The genus Cyanothece comprises unicellular cyanobacteria that are morphologically diverse and ecologically versatile. Studies over the last decade have established members of this genus to be important components of the marine ecosystem, contributing significantly to the nitrogen and carbon cycle. System-lev...

journal_title：mBio

authors： Bandyopadhyay A,Elvitigala T,Welsh E,Stöckel J,Liberton M,Min H,Sherman LA,Pakrasi HB

更新日期：2011-10-04 00:00:00

abstract：:Mobile elements-plasmids and phages-are important components of microbial function and evolution via traits that they encode and their capacity to shuttle genetic material between species. We here report the unusually rich array of mobile elements within the genome of Arsenophonus nasoniae, the son-killer symbiont of ...

journal_title：mBio

authors： Frost CL,Siozios S,Nadal-Jimenez P,Brockhurst MA,King KC,Darby AC,Hurst GDD

更新日期：2020-03-24 00:00:00

abstract：UNLABELLED:Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited. Of the two major antifungal drug classes, azoles are active against C. neoformans but exert a fungistatic effect, necessitating long tr...

journal_title：mBio

authors： Huang W,Liao G,Baker GM,Wang Y,Lau R,Paderu P,Perlin DS,Xue C

更新日期：2016-05-10 00:00:00

abstract：:Fungal cell wall mannans are complex carbohydrate polysaccharides with different structures in yeasts and molds. In contrast to yeasts, their biosynthetic pathway has been poorly investigated in filamentous fungi. In Aspergillus fumigatus, the major mannan structure is a galactomannan that is cross-linked to the β-1,3...

journal_title：mBio

authors： Henry C,Li J,Danion F,Alcazar-Fuoli L,Mellado E,Beau R,Jouvion G,Latgé JP,Fontaine T

更新日期：2019-02-12 00:00:00

abstract：:SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as the primary receptor to enter host cells and initiate the infection. The critical binding region of ACE2 is an ∼30-amino-acid (aa)-long helix. Here, we report the design of four stapled peptides based on the ACE2 helix, which is expected to bind to SARS-C...

journal_title：mBio

authors： Curreli F,Victor SMB,Ahmed S,Drelich A,Tong X,Tseng CK,Hillyer CD,Debnath AK

更新日期：2020-12-11 00:00:00

abstract：:Paramyxoviruses are negative-sense single-stranded RNA viruses that comprise many important human and animal pathogens, including human parainfluenza viruses. These viruses bud from the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is transported from the cytoplasm to the cell memb...

journal_title：mBio

authors： Genoyer E,Kulej K,Hung CT,Thibault PA,Azarm K,Takimoto T,Garcia BA,Lee B,Lakdawala S,Weitzman MD,López CB

更新日期：2020-08-25 00:00:00

abstract：:Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which concentrate all the proteins of the polymerase complex as well as some cellular proteins, were initially considered aggresomes formed by viral dead...

journal_title：mBio

authors： Galloux M,Risso-Ballester J,Richard CA,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2020-09-22 00:00:00

abstract：UNLABELLED:DNA lesions in the template strand block synthesis by replicative DNA polymerases (Pols). Eukaryotic cells possess a number of specialized translesion synthesis (TLS) Pols with the ability to replicate through DNA lesions. The Epstein-Barr virus (EBV), a member of the herpesvirus family, infects human B cell...

journal_title：mBio

authors： Yoon JH,Prakash S,Prakash L

更新日期：2012-09-11 00:00:00

abstract：:An operon comprising two genes, CA_P0037 and CA_P0036, that encode proteins of unknown function that were previously shown to be highly expressed in acidogenic cells and repressed in solventogenic and alcohologenic cells is located on the pSOL1 megaplasmid of Clostridium acetobutylicum upstream of adhE2 A CA_P0037::in...

journal_title：mBio

authors： Nguyen NP,Linder S,Flitsch SK,Schiel-Bengelsdorf B,Dürre P,Soucaille P

更新日期：2016-10-04 00:00:00

abstract：:ZipA is an essential cell division protein in Escherichia coli Together with FtsA, ZipA tethers dynamic polymers of FtsZ to the cytoplasmic membrane, and these polymers are required to guide synthesis of the cell division septum. This dynamic behavior of FtsZ has been reconstituted on planar lipid surfaces in vitro, v...

journal_title：mBio

authors： Krupka M,Sobrinos-Sanguino M,Jiménez M,Rivas G,Margolin W

更新日期：2018-06-19 00:00:00

abstract：:The concept that anaerobic microorganisms can directly accept electrons from Fe(0) has been controversial because direct metal-microbe electron transfer has previously only been indirectly inferred. Fe(0) oxidation was studied with Geobacter sulfurreducens strain ACL, an autotrophic strain that was previously shown to...

journal_title：mBio

authors： Tang HY,Holmes DE,Ueki T,Palacios PA,Lovley DR

更新日期：2019-05-14 00:00:00

abstract：:Herpesvirus latency has been difficult to understand molecularly due to low levels of viral genomes and gene expression. In the case of the betaherpesvirus human cytomegalovirus (HCMV), this is further complicated by the heterogeneity inherent to hematopoietic subpopulations harboring genomes and, as a consequence, th...

journal_title：mBio

authors： Goodrum F,McWeeney S

更新日期：2018-06-12 00:00:00

abstract：:During DNA replication, stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances, the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage tolerance (DDT) mechanisms that can bypass lesions encountered during DNA rep...

journal_title：mBio

authors： Arbel M,Bronstein A,Sau S,Liefshitz B,Kupiec M

更新日期：2020-05-05 00:00:00

abstract：:UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar moiety is incorporated into glycosylphosphatidylinositol (GPI) glycolipids and N- and O-linked glycans. Apicomplexan parasites have a hexosamine pathway compa...

journal_title：mBio

authors： Chi J,Cova M,de Las Rivas M,Medina A,Borges RJ,Leivar P,Planas A,Usón I,Hurtado-Guerrero R,Izquierdo L

更新日期：2020-10-20 00:00:00

abstract：:Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny. In contrast, adhesion and biofilm formation, which are potentially involved in gut colonization...

journal_title：mBio

authors： Béchon N,Mihajlovic J,Vendrell-Fernández S,Chain F,Langella P,Beloin C,Ghigo JM

更新日期：2020-06-23 00:00:00

abstract：:Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity and mortality and tend to be challenging to treat. Candida albicans and Staphylococcus aureus specifically are considered leading opportunistic fungal and bacterial pathogens, respect...

journal_title：mBio

authors： Kong EF,Tsui C,Kucharíková S,Andes D,Van Dijck P,Jabra-Rizk MA

更新日期：2016-10-11 00:00:00

abstract：:Motility is an important virulence trait for many bacterial pathogens, allowing them to position themselves in appropriate locations at appropriate times. The motility structures type IV pili and flagella are also involved in sensing surface contact, which modulates pathogenicity. In Pseudomonas aeruginosa, the PilS-P...

journal_title：mBio

authors： Kilmury SLN,Burrows LL

更新日期：2018-07-24 00:00:00

abstract：UNLABELLED:The aerial surfaces of plants, or phyllosphere, are microbial habitats important to plant and human health. In order to accurately investigate microbial interactions in the phyllosphere under laboratory conditions, the composition of the phyllosphere microbiota should be representative of the diversity of mi...

journal_title：mBio

authors： Williams TR,Marco ML

更新日期：2014-08-12 00:00:00

abstract：UNLABELLED:Despite their high genomic diversity, all known viruses are structurally constrained to a limited number of virion morphotypes. One morphotype of viruses infecting bacteria, archaea, and eukaryotes is the tailless icosahedral morphotype with an internal membrane. Although it is considered an abundant morphot...

journal_title：mBio

authors： Demina TA,Pietilä MK,Svirskaitė J,Ravantti JJ,Atanasova NS,Bamford DH,Oksanen HM

更新日期：2016-07-19 00:00:00

abstract：:Membrane repair emerges as an innate defense protecting target cells against bacterial pore-forming toxins. Here, we report the first paradigm of Ca2+-dependent repair following attack by a small β-pore-forming toxin, namely, plasmid-encoded phobalysin of Photobacterium damselae subsp. damselae In striking contrast, V...

journal_title：mBio

authors： von Hoven G,Rivas AJ,Neukirch C,Meyenburg M,Qin Q,Parekh S,Hellmann N,Husmann M

更新日期：2017-02-14 00:00:00

abstract：:The biosynthesis of antioxidant pigments, namely, betalains, was believed to be restricted to Caryophyllales plants. This paper changes this paradigm, and enzyme mining from bacterial hosts promoted the discovery of bacterial cultures producing betalains. The spectrum of possible sources of betalain pigments in nature...

journal_title：mBio

authors： Contreras-Llano LE,Guerrero-Rubio MA,Lozada-Ramírez JD,García-Carmona F,Gandía-Herrero F

更新日期：2019-03-19 00:00:00

abstract：:The type III secretion system (T3SS) forms the functional core of injectisomes, protein transporters that allow bacteria to deliver virulence factors into their hosts for infection, and flagella, which are critical for many pathogens to reach the site of infection. In spite of intensive genetic and biochemical studies...

journal_title：mBio

authors： Terashima H,Kawamoto A,Tatsumi C,Namba K,Minamino T,Imada K

更新日期：2018-06-26 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：UNLABELLED:A change in viral hemagglutinin (HA) receptor binding specificity from α2,3- to α2,6-linked sialic acid is necessary for highly pathogenic avian influenza (AI) virus subtype H5N1 to become pandemic. However, details of the human-adaptive change in the H5N1 virus remain unknown. Our database search of H5N1 cl...

journal_title：mBio

authors： Watanabe Y,Arai Y,Daidoji T,Kawashita N,Ibrahim MS,El-Gendy Eel-D,Hiramatsu H,Kubota-Koketsu R,Takagi T,Murata T,Takahashi K,Okuno Y,Nakaya T,Suzuki Y,Ikuta K

更新日期：2015-04-07 00:00:00

abstract：UNLABELLED:Clostridium perfringens enterotoxin (CPE) contributes to several important human gastrointestinal (GI) diseases. This toxin and its derivatives are also being explored for translational applications, i.e., cancer therapy or drug delivery. Some, but not all, members of the 24-member claudin (Cldn) family of m...

journal_title：mBio

authors： Shrestha A,McClane BA

更新日期：2013-01-15 00:00:00

abstract：UNLABELLED:Cholera continues to be a global threat, with high rates of morbidity and mortality. In 2011, a cholera outbreak occurred in Palawan, Philippines, affecting more than 500 people, and 20 individuals died. Vibrio cholerae O1 was confirmed as the etiological agent. Source attribution is critical in cholera outb...

journal_title：mBio

authors： Klinzing DC,Choi SY,Hasan NA,Matias RR,Tayag E,Geronimo J,Skowronski E,Rashed SM,Kawashima K,Rosenzweig CN,Gibbons HS,Torres BC,Liles V,Alfon AC,Juan ML,Natividad FF,Cebula TA,Colwell RR

更新日期：2015-04-21 00:00:00

abstract：:Protein ubiquitylation regulates not only endocellular trafficking and proteasomal degradation but also the catalytic activity of enzymes. In Saccharomyces cerevisiae, we analyzed the composition of the ubiquitylated proteomes in strains lacking acetyltransferase Gcn5p, Ub-protease Ubp8p, or both to understand their i...

journal_title：mBio

authors： De Palma A,Fanelli G,Cretella E,De Luca V,Palladino RA,Panzeri V,Roffia V,Saliola M,Mauri P,Filetici P

更新日期：2020-08-11 00:00:00

abstract：:Catabolite control protein A (CcpA) is the master regulator in Gram-positive bacteria that mediates carbon catabolite repression (CCR) and carbon catabolite activation (CCA), two fundamental regulatory mechanisms that enable competitive advantages in carbon catabolism. It is generally regarded that CcpA exerts its reg...

journal_title：mBio

authors： Yang Y,Zhang L,Huang H,Yang C,Yang S,Gu Y,Jiang W

更新日期：2017-01-24 00:00:00