Cathelicidin Antimicrobial Peptides with Reduced Activation of Toll-Like Receptor Signaling Have Potent Bactericidal Activity against Colistin-Resistant Bacteria.

abstract：:Viral 2',5'-phosphodiesterases (2',5'-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2',5'-oligoadenylate (2-5A) activators of RNase L. A kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) to localize and organize cyclic AMP (cAMP) s...

journal_title：mBio

authors： Gusho E,Zhang R,Jha BK,Thornbrough JM,Dong B,Gaughan C,Elliott R,Weiss SR,Silverman RH

更新日期：2014-07-01 00:00:00

abstract：:The acquisition and incorporation of genetic material between nonmating species, or horizontal gene transfer (HGT), has been frequently described for phylogenetically related organisms, but far less evidence exists for HGT between highly divergent organisms. Here we report the identification and characterization of a ...

journal_title：mBio

authors： Anderson MT,Seifert HS

更新日期：2011-02-15 00:00:00

abstract：:While Shiga toxins (Stx) are key determinants of enterohemorrhagic Escherichia coli (EHEC) pathophysiology in humans, their dissemination to target organs following gastrointestinal EHEC infection is still poorly understood. Most types of Stx target cells with globotriaosylceramide (Gb3) receptors, which are expressed...

journal_title：mBio

authors： Lengeling A,Mahajan A,Gally DL

更新日期：2013-11-12 00:00:00

abstract：:The appearance of Cryptococcus gattii in the North American Pacific Northwest (PNW) in 1999 was an unexpected and is still an unexplained event. Recent phylogenomic analyses strongly suggest that this pathogenic fungus arrived in the PNW approximately 7 to 9 decades ago. In this paper, we theorize that the ancestors o...

journal_title：mBio

authors： Engelthaler DM,Casadevall A

更新日期：2019-10-01 00:00:00

abstract：UNLABELLED:Viruses of the Enterovirus genus of picornaviruses, including poliovirus, coxsackievirus B3 (CVB3), and human rhinovirus, commandeer the functions of host cell proteins to aid in the replication of their small viral genomic RNAs during infection. One of these host proteins is a cellular DNA repair enzyme kno...

journal_title：mBio

authors： Maciejewski S,Nguyen JH,Gómez-Herreros F,Cortés-Ledesma F,Caldecott KW,Semler BL

更新日期：2015-12-29 00:00:00

abstract：UNLABELLED:Methicillin-resistant Staphylococcus aureus (MRSA) strains are leading causes of hospital-acquired infections in the United States, and clonal cluster 5 (CC5) is the predominant lineage responsible for these infections. Since 2002, there have been 12 cases of vancomycin-resistant S. aureus (VRSA) infection i...

journal_title：mBio

authors： Kos VN,Desjardins CA,Griggs A,Cerqueira G,Van Tonder A,Holden MT,Godfrey P,Palmer KL,Bodi K,Mongodin EF,Wortman J,Feldgarden M,Lawley T,Gill SR,Haas BJ,Birren B,Gilmore MS

更新日期：2012-05-22 00:00:00

abstract：UNLABELLED:Enterococcus faecium, natively a gut commensal organism, emerged as a leading cause of multidrug-resistant hospital-acquired infection in the 1980s. As the living record of its adaptation to changes in habitat, we sequenced the genomes of 51 strains, isolated from various ecological environments, to understa...

journal_title：mBio

authors： Lebreton F,van Schaik W,McGuire AM,Godfrey P,Griggs A,Mazumdar V,Corander J,Cheng L,Saif S,Young S,Zeng Q,Wortman J,Birren B,Willems RJ,Earl AM,Gilmore MS

更新日期：2013-08-20 00:00:00

abstract：:Host-associated microbial communities are shaped by extrinsic and intrinsic factors to the holobiont organism. Environmental factors and microbe-microbe interactions act simultaneously on the microbial community structure, making the microbiome dynamics challenging to predict. The coral microbiome is essential to the ...

journal_title：mBio

authors： Lima LFO,Weissman M,Reed M,Papudeshi B,Alker AT,Morris MM,Edwards RA,de Putron SJ,Vaidya NK,Dinsdale EA

更新日期：2020-03-03 00:00:00

abstract：UNLABELLED:Small RNAs play a critical role in host-pathogen interaction. Indeed, small RNA-mediated silencing or RNA interference (RNAi) is one of the earliest forms of antiviral immunity. Although it represents the main defense system against viruses in many organisms, the antiviral role of RNAi has not been clearly p...

journal_title：mBio

authors： Girardi E,Chane-Woon-Ming B,Messmer M,Kaukinen P,Pfeffer S

更新日期：2013-11-19 00:00:00

abstract：:Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobact...

journal_title：mBio

authors： Hagan AK,Tripathi A,Berger D,Sherman DH,Hanna PC

更新日期：2017-09-12 00:00:00

abstract：:Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages an...

journal_title：mBio

authors： Frazão SO,Sousa HR,Silva LGD,Folha JDS,Gorgonha KCM,Oliveira GP Jr,Felipe MSS,Silva-Pereira I,Casadevall A,Nicola AM,Albuquerque P

更新日期：2020-09-08 00:00:00

abstract：:The chemistry underpinning microbial interactions provides an integrative framework for linking the activities of individual microbes, microbial communities, plants, and their environments. Currently, we know very little about the functions of genes and metabolites within these communities because genome annotations a...

journal_title：mBio

authors： Zhalnina K,Zengler K,Newman D,Northen TR

更新日期：2018-07-17 00:00:00

abstract：:The major oxidative stress response in Streptomyces is controlled by the sigma factor SigR and its cognate antisigma factor RsrA, and SigR activity is tightly controlled through multiple mechanisms at both the transcriptional and posttranslational levels. Here we show that sigR has a highly unusual GTC start codon and...

journal_title：mBio

authors： Feeney MA,Chandra G,Findlay KC,Paget MSB,Buttner MJ

更新日期：2017-06-13 00:00:00

abstract：UNLABELLED:Kaposi sarcoma (KS) herpesvirus (KSHV) infection of endothelial cells (EC) is associated with strong induction of heme oxygenase-1 (HO-1), a stress-inducible host gene that encodes the rate-limiting enzyme responsible for heme catabolism. KS is an angioproliferative tumor characterized by the proliferation o...

journal_title：mBio

authors： Botto S,Totonchy JE,Gustin JK,Moses AV

更新日期：2015-06-04 00:00:00

abstract：UNLABELLED:Recent studies have established the fact that multiple members of the Rgg family of transcriptional regulators serve as key components of quorum sensing (QS) pathways that utilize peptides as intercellular signaling molecules. We previously described a novel QS system in Streptococcus pyogenes which utilizes...

journal_title：mBio

authors： Lasarre B,Aggarwal C,Federle MJ

更新日期：2013-01-02 00:00:00

abstract：:The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the potential of modulating the...

journal_title：mBio

authors： Domínguez-Andrés J,van Crevel R,Divangahi M,Netea MG

更新日期：2020-12-22 00:00:00

abstract：:Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados)...

journal_title：mBio

authors： Wurster S,Tatara AM,Albert ND,Ibrahim AS,Heitman J,Lee SC,Shetty AC,McCracken C,Graf KT,Mikos AG,Bruno VM,Kontoyiannis DP

更新日期：2020-06-30 00:00:00

abstract：UNLABELLED:Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations. In a long-term evolution experiment, twelve Escherichia coli populations have been propagated in a glucose-limited environment for over 25 ...

journal_title：mBio

authors： Raeside C,Gaffé J,Deatherage DE,Tenaillon O,Briska AM,Ptashkin RN,Cruveiller S,Médigue C,Lenski RE,Barrick JE,Schneider D

更新日期：2014-09-09 00:00:00

abstract：:All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for ...

journal_title：mBio

authors： Guerardel Y,Sadovskaya I,Maes E,Furlan S,Chapot-Chartier MP,Mesnage S,Rigottier-Gois L,Serror P

更新日期：2020-04-28 00:00:00

abstract：UNLABELLED:The ExPortal of Streptococcus pyogenes is a focal microdomain of the cytoplasmic membrane that clusters the translocons of the general secretory pathway with accessory factors to facilitate the maturation of secreted polypeptides. While it is known that the ExPortal is enriched in anionic lipids, the mechani...

journal_title：mBio

authors： Vega LA,Port GC,Caparon MG

更新日期：2013-09-24 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significant...

journal_title：mBio

authors： Vaillancourt M,Jorth P

更新日期：2020-08-07 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the most common etiologic agent of uncomplicated urinary tract infection (UTI). An important mechanism of gene regulation in UPEC is phase variation that involves inversion of a promoter-containing DNA element via enzymatic activity of tyrosine recombinases, resulting in biphas...

journal_title：mBio

authors： Battaglioli EJ,Goh KGK,Atruktsang TS,Schwartz K,Schembri MA,Welch RA

更新日期：2018-08-07 00:00:00

abstract：:Nicotine, a toxic and addictive alkaloid from tobacco, is an environmental pollutant in areas near cigarette production facilities. Over the last decade, our group has studied, in depth, the pyrrolidine pathway of nicotine degradation in Pseudomonas putida S16. However, little is known regarding whole mechanism(s) reg...

journal_title：mBio

authors： Hu H,Wang L,Wang W,Wu G,Tao F,Xu P,Deng Z,Tang H

更新日期：2019-06-04 00:00:00

abstract：:Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised immune systems. The absence of a continuous in vitro culture system for any species of Pneumocystis has led to limited understanding of these fungi, especially f...

journal_title：mBio

authors： Cushion MT,Collins MS,Sesterhenn T,Porollo A,Vadukoot AK,Merino EJ

更新日期：2016-12-13 00:00:00

abstract：UNLABELLED:The group of proteins known as serine protease autotransporters of Enterobacteriaceae (SPATE) is a growing family of serine proteases secreted to the external milieu by the type V secretion system. Pet toxin and some other SPATE belong to the class 1 cytotoxic SPATE, which have comparable protease strength o...

journal_title：mBio

authors： Nava-Acosta R,Navarro-Garcia F

更新日期：2013-12-10 00:00:00

abstract：:1-Butanol is a large-volume, intermediate chemical with favorable physical and chemical properties for blending with or directly substituting for gasoline. The per-volume value of butanol, as a chemical, is sufficient for investing into the recommercialization of the classical acetone-butanol-ethanol (ABE) (E. M. Gree...

journal_title：mBio

authors： Tracy BP

更新日期：2012-12-11 00:00:00

abstract：UNLABELLED:Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extrac...

journal_title：mBio

authors： Singh B,Alvarado-Kristensson M,Johansson M,Hallgren O,Westergren-Thorsson G,Mörgelin M,Riesbeck K

更新日期：2016-03-22 00:00:00

abstract：:Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ), and acyl carrier protein (ACP), are utilized to elongate the p...

journal_title：mBio

authors： Hua K,Liu X,Zhao Y,Gao Y,Pan L,Zhang H,Deng Z,Jiang M

更新日期：2020-09-15 00:00:00

abstract：:The pathogenic species of Cryptococcus are a major cause of mortality owing to severe infections in immunocompromised as well as immunocompetent individuals. Although antifungal treatment is usually effective, many patients relapse after treatment, and in such cases, comparative analyses of the genomes of incident and...

journal_title：mBio

authors： Chen Y,Farrer RA,Giamberardino C,Sakthikumar S,Jones A,Yang T,Tenor JL,Wagih O,Van Wyk M,Govender NP,Mitchell TG,Litvintseva AP,Cuomo CA,Perfect JR

更新日期：2017-03-07 00:00:00

abstract：UNLABELLED:Rarely, if ever, has a single bacterial cell been confirmed to simultaneously host two fundamentally different predators. Two such predators are viruses and the predatory prokaryotes known as Bdellovibrio and like organisms. Viruses or bacteriophage are particles requiring prey cells in an active metabolic s...

journal_title：mBio

authors： Chen H,Williams HN

更新日期：2012-04-17 00:00:00