Decreased, Deformed, Defective-How HIV-1 Vpu Targets Peroxisomes.

abstract：:Vibrio cholerae is an estuarine bacterium and an intestinal pathogen of humans that causes severe epidemic diarrhea. In the absence of adequate mammalian models in which to study the interaction of V. cholerae with the host intestinal innate immune system, we have implemented Drosophila melanogaster as a surrogate hos...

journal_title：mBio

authors： Wang Z,Hang S,Purdy AE,Watnick PI

更新日期：2013-06-18 00:00:00

abstract：:Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised immune systems. The absence of a continuous in vitro culture system for any species of Pneumocystis has led to limited understanding of these fungi, especially f...

journal_title：mBio

authors： Cushion MT,Collins MS,Sesterhenn T,Porollo A,Vadukoot AK,Merino EJ

更新日期：2016-12-13 00:00:00

abstract：:Mucormycosis, caused by Rhizopus species, is a life-threatening fungal infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy, immunosuppressive therapy, hematologic malignancies, or severe trauma. Inhaled Rhizopus spores cause pulmonary infections in patients with h...

journal_title：mBio

authors： Alqarihi A,Gebremariam T,Gu Y,Swidergall M,Alkhazraji S,Soliman SSM,Bruno VM,Edwards JE Jr,Filler SG,Uppuluri P,Ibrahim AS

更新日期：2020-06-02 00:00:00

abstract：UNLABELLED:Salmonella enterica serovar Typhimurium is one of the most common S. enterica serovars associated with U.S. foodborne outbreaks. S. Typhimurium bacteria isolated from humans exhibit wide-ranging virulence phenotypes in inbred mice, leading to speculation that some strains are more virulent in nature. However...

journal_title：mBio

authors： Hayden HS,Matamouros S,Hager KR,Brittnacher MJ,Rohmer L,Radey MC,Weiss EJ,Kim KB,Jacobs MA,Sims-Day EH,Yue M,Zaidi MB,Schifferli DM,Manning SD,Walson JL,Miller SI

更新日期：2016-03-08 00:00:00

abstract：UNLABELLED:The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is req...

journal_title：mBio

authors： Ekici S,Yang H,Koch HG,Daldal F

更新日期：2012-01-31 00:00:00

abstract：UNLABELLED:Rarely, if ever, has a single bacterial cell been confirmed to simultaneously host two fundamentally different predators. Two such predators are viruses and the predatory prokaryotes known as Bdellovibrio and like organisms. Viruses or bacteriophage are particles requiring prey cells in an active metabolic s...

journal_title：mBio

authors： Chen H,Williams HN

更新日期：2012-04-17 00:00:00

abstract：:Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002) is in advanced clinical trials and shows promise for improved v...

journal_title：mBio

authors： Fletcher HA

更新日期：2016-08-30 00:00:00

abstract：:In immunocompromised hosts, latent infection with Toxoplasma gondii can reactivate from tissue cysts, leading to encephalitis. A characteristic of T. gondii bradyzoites in tissue cysts is the presence of amylopectin granules. The regulatory mechanisms and role of amylopectin accumulation in this organism are not fully...

journal_title：mBio

authors： Sugi T,Tu V,Ma Y,Tomita T,Weiss LM

更新日期：2017-08-29 00:00:00

abstract：:Antimicrobial resistance is a major health threat as it limits treatment options for infection. At the forefront of this serious issue is Acinetobacter baumannii, a Gram-negative opportunistic pathogen that exhibits the remarkable ability to resist antibiotics through multiple mechanisms. As bacterial ribosomes repres...

journal_title：mBio

authors： Morgan CE,Huang W,Rudin SD,Taylor DJ,Kirby JE,Bonomo RA,Yu EW

更新日期：2020-01-21 00:00:00

abstract：:Forested ecosystems throughout the world are experiencing increases in the incidence and magnitude of insect-induced tree mortality with large ecologic ramifications. Interestingly, correlations between water quality and the extent of tree mortality in Colorado montane ecosystems suggest compensatory effects from adja...

journal_title：mBio

authors： Mikkelson KM,Brouillard BM,Bokman CM,Sharp JO

更新日期：2017-12-05 00:00:00

abstract：UNLABELLED:The bacterial flagellum is driven by a bidirectional rotary motor, which propels bacteria to swim through liquids or swarm over surfaces. While the functions of the major structural and regulatory components of the flagellum are known, the function of the well-conserved FliL protein is not. In Salmonella and...

journal_title：mBio

authors： Partridge JD,Nieto V,Harshey RM

更新日期：2015-02-24 00:00:00

abstract：:The gut microbiota contributes to nutrients absorption and metabolism by enterocytes, but the molecular mechanisms involved remain poorly understood, and most conclusions are inferred from studies comparing germfree and conventional animals colonized with diverse bacterial species. We selected two model commensal micr...

journal_title：mBio

authors： Tazi A,Araujo JR,Mulet C,Arena ET,Nigro G,Pédron T,Sansonetti PJ

更新日期：2018-09-04 00:00:00

abstract：:Escherichia colimazEF is an extensively studied stress-induced toxin-antitoxin (TA) system. The toxin MazF is an endoribonuclease that cleaves RNAs at ACA sites. By that means, under stress, the induced MazF generates a stress-induced translation machinery (STM) composed of MazF-processed mRNAs and selective ribosomes...

journal_title：mBio

authors： Nigam A,Ziv T,Oron-Gottesman A,Engelberg-Kulka H

更新日期：2019-03-26 00:00:00

abstract：UNLABELLED:The promoter most strongly induced upon activation of the Cpx two-component envelope stress response is the cpxP promoter. The 3' untranscribed region (UTR) of the cpxP transcript is shown to produce a small RNA (sRNA), CpxQ. We investigated the role of CpxQ in combating envelope stress. Remarkably, the two ...

journal_title：mBio

authors： Grabowicz M,Koren D,Silhavy TJ

更新日期：2016-04-05 00:00:00

abstract：:Herpesvirus latency has been difficult to understand molecularly due to low levels of viral genomes and gene expression. In the case of the betaherpesvirus human cytomegalovirus (HCMV), this is further complicated by the heterogeneity inherent to hematopoietic subpopulations harboring genomes and, as a consequence, th...

journal_title：mBio

authors： Goodrum F,McWeeney S

更新日期：2018-06-12 00:00:00

abstract：:The PCNA (proliferating cell nuclear antigen) ring plays central roles during DNA replication and repair. The yeast Elg1 RFC-like complex (RLC) is the principal unloader of chromatin-bound PCNA and thus plays a central role in maintaining genome stability. Here we identify a role for Elg1 in the unloading of PCNA duri...

journal_title：mBio

authors： Sau S,Liefshitz B,Kupiec M

更新日期：2019-06-11 00:00:00

abstract：:Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved am...

journal_title：mBio

authors： Schubert K,Sieger B,Meyer F,Giacomelli G,Böhm K,Rieblinger A,Lindenthal L,Sachs N,Wanner G,Bramkamp M

更新日期：2017-02-07 00:00:00

abstract：:Formation of multispecies communities allows nearly every niche on earth to be colonized, and the exchange of molecular information among neighboring bacteria in such communities is key for bacterial success. To clarify the principles controlling interspecies interactions, we previously developed a coculture model wit...

journal_title：mBio

authors： Ranava D,Backes C,Karthikeyan G,Ouari O,Soric A,Guiral M,Cárdenas ML,Giudici-Orticoni MT

更新日期：2021-01-19 00:00:00

abstract：:Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy. They can also use poised electrodes as their electron donor via phototrophic extracellular electron uptake (phototrophic EEU). The e...

journal_title：mBio

authors： Gupta D,Sutherland MC,Rengasamy K,Meacham JM,Kranz RG,Bose A

更新日期：2019-11-05 00:00:00

abstract：:The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown mechanisms. Here we show that bacterial delivery or ectopic expres...

journal_title：mBio

authors： Keestra AM,Winter MG,Klein-Douwel D,Xavier MN,Winter SE,Kim A,Tsolis RM,Bäumler AJ

更新日期：2011-12-20 00:00:00

abstract：UNLABELLED:Methicillin-resistant Staphylococcus aureus (MRSA) is a global human health problem causing infections in both hospitals and the community. Companion animals, such as cats, dogs, and horses, are also frequently colonized by MRSA and can become infected. We sequenced the genomes of 46 multilocus sequence type...

journal_title：mBio

authors： Harrison EM,Weinert LA,Holden MT,Welch JJ,Wilson K,Morgan FJ,Harris SR,Loeffler A,Boag AK,Peacock SJ,Paterson GK,Waller AS,Parkhill J,Holmes MA

更新日期：2014-05-13 00:00:00

abstract：:Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynt...

journal_title：mBio

authors： Shrivastava-Ranjan P,Bergeron É,Chakrabarti AK,Albariño CG,Flint M,Nichol ST,Spiropoulou CF

更新日期：2016-12-20 00:00:00

abstract：:Transposon insertion sequencing (TIS) is a powerful high-throughput genetic technique that is transforming functional genomics in prokaryotes, because it enables genome-wide mapping of the determinants of fitness. However, current approaches for analyzing TIS data assume that selective pressures are constant over time...

journal_title：mBio

authors： Yang G,Billings G,Hubbard TP,Park JS,Yin Leung K,Liu Q,Davis BM,Zhang Y,Wang Q,Waldor MK

更新日期：2017-10-03 00:00:00

abstract：:Since the original report that Halomonas sp. strain GFAJ-1 was capable of using arsenic instead of phosphorus to sustain growth, additional studies have been conducted, and GFAJ-1 is now considered a highly arsenic-resistant but phosphorus-dependent bacterium. However, the mechanisms supporting the extreme arsenic res...

journal_title：mBio

authors： Wu S,Wang L,Gan R,Tong T,Bian H,Li Z,Du S,Deng Z,Chen S

更新日期：2018-05-01 00:00:00

abstract：UNLABELLED:Many filamentous cyanobacteria produce specialized nitrogen-fixing cells called heterocysts, which are located at semiregular intervals along the filament with about 10 to 20 photosynthetic vegetative cells in between. Nitrogen fixation in these complex multicellular bacteria depends on metabolite exchange b...

journal_title：mBio

authors： Nürnberg DJ,Mariscal V,Bornikoel J,Nieves-Morión M,Krauß N,Herrero A,Maldener I,Flores E,Mullineaux CW

更新日期：2015-03-17 00:00:00

abstract：:Increasing evidence has indicated that single nucleotide polymorphisms (SNPs) are related to the susceptibility of sepsis and might provide potential evidence for the mechanisms of sepsis. Our recent preliminary study showed that the ADAM10 genetic polymorphism was clinically associated with the development of sepsis,...

journal_title：mBio

authors： Chen F,Wang Y,Zhang W,Cai Y,Zhao T,Mai H,Tao S,Wei W,Li J,Chen X,Li X,Tang P,Fan W,Yang J,Ou M,Lu F,Lai Z,Chen H,Zou T,Sun F,Shao Y,Cui L

更新日期：2019-08-06 00:00:00

abstract：UNLABELLED:Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral load) variance that occurs between resistant BALB/c and susceptible SJL...

journal_title：mBio

authors： Hsu TH,Althaus IW,Foreman O,Spindler KR

更新日期：2012-05-29 00:00:00

abstract：:The concept that anaerobic microorganisms can directly accept electrons from Fe(0) has been controversial because direct metal-microbe electron transfer has previously only been indirectly inferred. Fe(0) oxidation was studied with Geobacter sulfurreducens strain ACL, an autotrophic strain that was previously shown to...

journal_title：mBio

authors： Tang HY,Holmes DE,Ueki T,Palacios PA,Lovley DR

更新日期：2019-05-14 00:00:00

abstract：:Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral dUTPase (vDUT), each with enzymatic and nonenzymatic functions. However, the coordinated roles of these enzymatic activities in gammaherpesvirus pat...

journal_title：mBio

authors： Dong Q,Smith KR,Oldenburg DG,Shapiro M,Schutt WR,Malik L,Plummer JB,Mu Y,MacCarthy T,White DW,McBride KM,Krug LT

更新日期：2018-10-30 00:00:00

abstract：:Most bacteria can generate ATP by respiratory metabolism, in which electrons are shuttled from reduced substrates to terminal electron acceptors, via quinone molecules like ubiquinone. Dioxygen (O2) is the terminal electron acceptor of aerobic respiration and serves as a co-substrate in the biosynthesis of ubiquinone....

journal_title：mBio

authors： Pelosi L,Vo CD,Abby SS,Loiseau L,Rascalou B,Hajj Chehade M,Faivre B,Goussé M,Chenal C,Touati N,Binet L,Cornu D,Fyfe CD,Fontecave M,Barras F,Lombard M,Pierrel F

更新日期：2019-07-09 00:00:00