Simple sari cloth filtration of water is sustainable and continues to protect villagers from cholera in Matlab, Bangladesh.

abstract：:Epidemiological studies on Streptococcus pneumoniae show that rates of carriage are highest in early childhood and that the major benefit of the pneumococcal conjugate vaccine (PCV) is a reduction in the incidence of nasopharyngeal colonization through decreased transmission within a population. In this study, we soug...

journal_title：mBio

authors： Zangari T,Wang Y,Weiser JN

更新日期：2017-03-14 00:00:00

abstract：UNLABELLED:Carbonate chimneys at the Lost City hydrothermal field are coated in biofilms dominated by a single phylotype of archaea known as Lost City Methanosarcinales. In this study, we have detected surprising physiological complexity in single-species biofilms, which is typically indicative of multispecies biofilm ...

journal_title：mBio

authors： Brazelton WJ,Mehta MP,Kelley DS,Baross JA

更新日期：2011-09-01 00:00:00

abstract：UNLABELLED:Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a variety of environmental stimuli and play a critical r...

journal_title：mBio

authors： Agostoni M,Koestler BJ,Waters CM,Williams BL,Montgomery BL

更新日期：2013-08-13 00:00:00

abstract：:Low doses of antibiotics can trigger secondary metabolite biosynthesis in bacteria, but the underlying mechanisms are generally unknown. We sought to better understand this phenomenon by studying how the antibiotic trimethoprim activates the synthesis of the virulence factor malleilactone in Burkholderia thailandensis...

journal_title：mBio

authors： Li A,Mao D,Yoshimura A,Rosen PC,Martin WL,Gallant É,Wühr M,Seyedsayamdost MR

更新日期：2020-02-25 00:00:00

abstract：:Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life. Recent application of deep-sequencing technologies has revealed that the transcription of asRNAs occurs genome-wide in bacter...

journal_title：mBio

authors： Raghavan R,Sloan DB,Ochman H

更新日期：2012-08-07 00:00:00

abstract：:Japanese encephalitis virus (JEV) remains a leading cause of viral encephalitis worldwide. Although JEV-specific antibodies have been described, an assessment of their ability to neutralize multiple genotypes of JEV has been limited. Here, we describe the development of a panel of mouse and human neutralizing monoclon...

journal_title：mBio

authors： Fernandez E,Kose N,Edeling MA,Adhikari J,Sapparapu G,Lazarte SM,Nelson CA,Govero J,Gross ML,Fremont DH,Crowe JE Jr,Diamond MS

更新日期：2018-02-27 00:00:00

abstract：:In bacteria, elongation factor Tu is a translational cofactor that forms ternary complexes with aminoacyl-tRNA (aa-tRNA) and GTP. Binding of a ternary complex to one of four flexible L7/L12 units on the ribosome tethers a charged tRNA in close proximity to the ribosomal A site. Two sequential tests for a match between...

journal_title：mBio

authors： Mustafi M,Weisshaar JC

更新日期：2018-01-16 00:00:00

abstract：:Flavor compound metabolism is one of the last areas in metabolism where multiple genes encoding biosynthetic enzymes are still unknown. A major challenge is the involvement of side activities of enzymes having their main function in other areas of metabolism. We have applied pooled-segregant whole-genome sequence anal...

journal_title：mBio

authors： Trindade de Carvalho B,Holt S,Souffriau B,Lopes Brandão R,Foulquié-Moreno MR,Thevelein JM

更新日期：2017-11-07 00:00:00

abstract：:Malaria parasite ookinetes must traverse the vector mosquito midgut epithelium to transform into sporozoite-producing oocysts. The Anopheles innate immune system is a key regulator of this process, thereby determining vector competence and disease transmission. The role of Anopheles innate immunity factors as agonists...

journal_title：mBio

authors： Simões ML,Mlambo G,Tripathi A,Dong Y,Dimopoulos G

更新日期：2017-10-17 00:00:00

abstract：:Our knowledge of cell cycle regulatory mechanisms in apicomplexan parasites is very limited. In this study, we describe a novel Toxoplasma gondii factor that has a vital role in chromosome replication and the regulation of cytoplasmic and nuclear mitotic structures, and we named this factor ECR1 for essential for chro...

journal_title：mBio

authors： Naumov A,Kratzer S,Ting LM,Kim K,Suvorova ES,White MW

更新日期：2017-08-22 00:00:00

abstract：UNLABELLED:Methicillin-resistant Staphylococcus aureus (MRSA) is a global human health problem causing infections in both hospitals and the community. Companion animals, such as cats, dogs, and horses, are also frequently colonized by MRSA and can become infected. We sequenced the genomes of 46 multilocus sequence type...

journal_title：mBio

authors： Harrison EM,Weinert LA,Holden MT,Welch JJ,Wilson K,Morgan FJ,Harris SR,Loeffler A,Boag AK,Peacock SJ,Paterson GK,Waller AS,Parkhill J,Holmes MA

更新日期：2014-05-13 00:00:00

abstract：UNLABELLED:Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral load) variance that occurs between resistant BALB/c and susceptible SJL...

journal_title：mBio

authors： Hsu TH,Althaus IW,Foreman O,Spindler KR

更新日期：2012-05-29 00:00:00

abstract：UNLABELLED:The world is at the precipice of a postantibiotic era in which medical procedures and minor injuries can result in bacterial infections that are no longer effectively treated by antibiotics. Cathelicidins are peptides produced by animals to combat bacterial infections and to regulate innate immune responses....

journal_title：mBio

authors： Kao C,Lin X,Yi G,Zhang Y,Rowe-Magnus DA,Bush K

更新日期：2016-09-20 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that can cause life-threatening invasive lung infections in immunodeficient patients. The cellular and molecular processes of infection during onset, establishment, and progression of A. fumigatus infections are highly complex and depend on both fungal attribut...

journal_title：mBio

authors： Amich J,Mokhtari Z,Strobel M,Vialetto E,Sheta D,Yu Y,Hartweg J,Kalleda N,Jarick KJ,Brede C,Jordán-Garrote AL,Thusek S,Schmiedgen K,Arslan B,Pinnecker J,Thornton CR,Gunzer M,Krappmann S,Einsele H,Heinze KG,Beilhack

更新日期：2020-02-04 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：UNLABELLED:Curing HIV-1 infection will require elimination of persistent cellular reservoirs that harbor latent virus in the face of combination antiretroviral therapy (cART). Proposed immunotherapeutic strategies to cure HIV-1 infection include enhancing lysis of these infected cells by cytotoxic T lymphocytes (CTL). ...

journal_title：mBio

authors： Smith KN,Mailliard RB,Piazza PA,Fischer W,Korber BT,Fecek RJ,Ratner D,Gupta P,Mullins JI,Rinaldo CR

更新日期：2016-05-31 00:00:00

abstract：:Cryptococcus gattii, the sister species of Cryptococcus neoformans, is an emerging pathogen which gained importance in connection with the ongoing cryptococcosis outbreak on Vancouver Island. Many molecular studies have divided this species into for major lineages: VGI, VGII, VGIII, and VGIV. This commentary summarize...

journal_title：mBio

authors： Meyer W

更新日期：2015-11-17 00:00:00

abstract：:Mitochondrial function adapts to cellular demands and is affected by the ability of the organelle to undergo fusion and fission in response to physiological and nonphysiological cues. We previously showed that infection with the human bacterial pathogen Listeria monocytogenes elicits transient mitochondrial fission an...

journal_title：mBio

authors： Carvalho F,Spier A,Chaze T,Matondo M,Cossart P,Stavru F

更新日期：2020-02-04 00:00:00

abstract：UNLABELLED:Filamentous, heterocyst-forming cyanobacteria exchange nutrients and regulators between cells for diazotrophic growth. Two alternative modes of exchange have been discussed involving transport either through the periplasm or through septal junctions linking adjacent cells. Septal junctions and channels in th...

journal_title：mBio

authors： Rudolf M,Tetik N,Ramos-León F,Flinner N,Ngo G,Stevanovic M,Burnat M,Pernil R,Flores E,Schleiff E

更新日期：2015-06-30 00:00:00

abstract：:Mucormycosis is an emerging lethal fungal infection in immunocompromised patients. Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to understand genetics in Mucorales. Calcineurin is a conserved virulence factor in many pathogenic fungi, and calcineurin inhibition or deletion of the...

journal_title：mBio

authors： Vellanki S,Billmyre RB,Lorenzen A,Campbell M,Turner B,Huh EY,Heitman J,Lee SC

更新日期：2020-01-28 00:00:00

abstract：:Reactive oxygen species (ROS) are produced by host phagocytes and exert antimicrobial actions against a broad range of pathogens. The observable antimicrobial actions of ROS are highly dependent on experimental conditions. This perspective reviews recent controversies regarding ROS in Salmonella-phagocyte interactions...

journal_title：mBio

authors： Fang FC

更新日期：2011-09-06 00:00:00

abstract：UNLABELLED:Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and outcome. As in many infectious diseases, this variability is commonly assigned to host factors. To investigate whether the diversity of Cryptococcus neoformans clinical (ClinCn) isolates influences the interaction with ...

journal_title：mBio

authors： Alanio A,Desnos-Ollivier M,Dromer F

更新日期：2011-08-09 00:00:00

abstract：:Influenza A viruses cause an annual contagious respiratory disease in humans and are responsible for periodic high-mortality human pandemics. Pandemic influenza A viruses usually result from the reassortment of gene segments between human and avian influenza viruses. These avian influenza virus gene segments need to a...

journal_title：mBio

authors： Smith BL,Chen G,Wilke CO,Krug RM

更新日期：2018-07-03 00:00:00

abstract：UNLABELLED:The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems. We have probed the systemic metabolic adaptation to gut colonization for 20 days following exposure of axenic mice (n = 35) to a typical...

journal_title：mBio

authors： Claus SP,Ellero SL,Berger B,Krause L,Bruttin A,Molina J,Paris A,Want EJ,de Waziers I,Cloarec O,Richards SE,Wang Y,Dumas ME,Ross A,Rezzi S,Kochhar S,Van Bladeren P,Lindon JC,Holmes E,Nicholson JK

更新日期：2011-03-01 00:00:00

abstract：:The genomes of actinomycetes contain numerous gene clusters potentially able to encode the production of many antibiotics and other specialized metabolites that are not expressed during growth under typical laboratory conditions. Undoubtedly, this reflects the soil habitat of these organisms, which is highly complex p...

journal_title：mBio

authors： Hopwood DA

更新日期：2013-09-03 00:00:00

abstract：UNLABELLED:Despite their high genomic diversity, all known viruses are structurally constrained to a limited number of virion morphotypes. One morphotype of viruses infecting bacteria, archaea, and eukaryotes is the tailless icosahedral morphotype with an internal membrane. Although it is considered an abundant morphot...

journal_title：mBio

authors： Demina TA,Pietilä MK,Svirskaitė J,Ravantti JJ,Atanasova NS,Bamford DH,Oksanen HM

更新日期：2016-07-19 00:00:00

abstract：:A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying permeabilized retrovirus parti...

journal_title：mBio

authors： Jennings J,Shi J,Varadarajan J,Jamieson PJ,Aiken C

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level. Here, we present an analysis of CME in the human fungal pathogen Candida albicans that shows the same modular structure as those in other fungi and mammalian cells. Intriguingly, C. albic...

journal_title：mBio

authors： Epp E,Nazarova E,Regan H,Douglas LM,Konopka JB,Vogel J,Whiteway M

更新日期：2013-08-27 00:00:00

abstract：UNLABELLED:The promoter most strongly induced upon activation of the Cpx two-component envelope stress response is the cpxP promoter. The 3' untranscribed region (UTR) of the cpxP transcript is shown to produce a small RNA (sRNA), CpxQ. We investigated the role of CpxQ in combating envelope stress. Remarkably, the two ...

journal_title：mBio

authors： Grabowicz M,Koren D,Silhavy TJ

更新日期：2016-04-05 00:00:00

abstract：:Typhoid fever, caused by Salmonella enterica serovar Typhi, is a global public health concern due to increasing antimicrobial resistance (AMR). Characterization of S Typhi genomes for AMR and the evolution of different lineages, especially in countries where typhoid fever is endemic such as Bangladesh, will help publi...

journal_title：mBio

authors： Tanmoy AM,Westeel E,De Bruyne K,Goris J,Rajoharison A,Sajib MSI,van Belkum A,Saha SK,Komurian-Pradel F,Endtz HP

更新日期：2018-11-13 00:00:00