Abstract:
:The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown mechanisms. Here we show that bacterial delivery or ectopic expression of SipA, a T3SS-1-translocated protein, led to the activation of the NOD1/NOD2 signaling pathway and consequent RIP2-mediated induction of NF-κB-dependent inflammatory responses. SipA-mediated activation of NOD1/NOD2 signaling was independent of bacterial invasion in vitro but required an intact T3SS-1. In the mouse colitis model, SipA triggered mucosal inflammation in wild-type mice but not in NOD1/NOD2-deficient mice. These findings implicate SipA-driven activation of the NOD1/NOD2 signaling pathway as a mechanism by which the T3SS-1 induces inflammatory responses in vitro and in vivo.
journal_name
mBiojournal_title
mBioauthors
Keestra AM,Winter MG,Klein-Douwel D,Xavier MN,Winter SE,Kim A,Tsolis RM,Bäumler AJdoi
10.1128/mBio.00266-11subject
Has Abstractpub_date
2011-12-20 00:00:00issue
6issn
2150-7511pii
mBio.00266-11journal_volume
2pub_type
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