Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target.

abstract：UNLABELLED:A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal dr...

journal_title：mBio

authors： Abdolrasouli A,Rhodes J,Beale MA,Hagen F,Rogers TR,Chowdhary A,Meis JF,Armstrong-James D,Fisher MC

更新日期：2015-06-02 00:00:00

abstract：:Dephospho-coenzyme A (dephospho-CoA) kinase (DPCK) catalyzes the ATP-dependent phosphorylation of dephospho-CoA, the final step in coenzyme A (CoA) biosynthesis. DPCK has been identified and characterized in bacteria and eukaryotes but not in archaea. The hyperthermophilic archaeon Thermococcus kodakarensis encodes tw...

journal_title：mBio

authors： Shimosaka T,Makarova KS,Koonin EV,Atomi H

更新日期：2019-07-23 00:00:00

abstract：:Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which concentrate all the proteins of the polymerase complex as well as some cellular proteins, were initially considered aggresomes formed by viral dead...

journal_title：mBio

authors： Galloux M,Risso-Ballester J,Richard CA,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2020-09-22 00:00:00

abstract：:Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor composed of three subunits, namely, NF-YA, NF-YB, and NF-YC, which are conserved throughout evolution. In higher eukaryotes, NF-Y plays important roles in several cellular processes (development, cell cycle regulation, apoptosis, and response to growth, ...

journal_title：mBio

authors： Manna D,Singh U

更新日期：2019-06-18 00:00:00

abstract：UNLABELLED:The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic predisposition synergizes with "environmental" factors, including viral infection, leading to disease. One elegant animal model used to study the pathogenesis of multiple sclerosis that perfectly bl...

journal_title：mBio

authors： Chastain EM,Getts DR,Miller SD

更新日期：2015-08-04 00:00:00

abstract：UNLABELLED:Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts. The underlying molecular mechanism of PMT was defined as a persistent activation of he...

journal_title：mBio

authors： Strack J,Heni H,Gilsbach R,Hein L,Aktories K,Orth JH

更新日期：2014-11-11 00:00:00

abstract：UNLABELLED:Staphylococcus aureus is a human commensal that at times turns into a serious bacterial pathogen causing life-threatening infections. For the delicate control of virulence, S. aureus employs the agr quorum-sensing system that, via the intracellular effector molecule RNAIII, regulates virulence gene expressio...

journal_title：mBio

authors： Paulander W,Nissen Varming A,Bæk KT,Haaber J,Frees D,Ingmer H

更新日期：2013-01-02 00:00:00

abstract：:Murein lipoprotein (Lpp) and peptidoglycan-associated lipoprotein (Pal) are major outer membrane lipoproteins in Escherichia coli Their roles in cell-envelope integrity have been documented in E. coli laboratory strains, and while Lpp has been linked to serum resistance in vitro, the underlying mechanism has not been ...

journal_title：mBio

authors： Diao J,Bouwman C,Yan D,Kang J,Katakam AK,Liu P,Pantua H,Abbas AR,Nickerson NN,Austin C,Reichelt M,Sandoval W,Xu M,Whitfield C,Kapadia SB

更新日期：2017-05-23 00:00:00

abstract：:Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many bacteria, the pneumococcus can import DNA from other strains or even species by transformation and homologous recombination, which has allowed the pneumococcus to...

journal_title：mBio

authors： Chaguza C,Andam CP,Harris SR,Cornick JE,Yang M,Bricio-Moreno L,Kamng'ona AW,Parkhill J,French N,Heyderman RS,Kadioglu A,Everett DB,Bentley SD,Hanage WP

更新日期：2016-09-27 00:00:00

abstract：:Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical fo...

journal_title：mBio

authors： Johnson CJ,Davis JM,Huttenlocher A,Kernien JF,Nett JE

更新日期：2018-08-21 00:00:00

abstract：:Nicotine, a toxic and addictive alkaloid from tobacco, is an environmental pollutant in areas near cigarette production facilities. Over the last decade, our group has studied, in depth, the pyrrolidine pathway of nicotine degradation in Pseudomonas putida S16. However, little is known regarding whole mechanism(s) reg...

journal_title：mBio

authors： Hu H,Wang L,Wang W,Wu G,Tao F,Xu P,Deng Z,Tang H

更新日期：2019-06-04 00:00:00

abstract：:The Pseudomonas quinolone signal (PQS) is an important quorum-sensing molecule in Pseudomonas aeruginosa that also mediates its own packaging and transport by stimulating outer membrane vesicle (OMV) formation. Because OMVs have been implicated in many virulence-associated behaviors, it is critical that we understand ...

journal_title：mBio

authors： Florez C,Raab JE,Cooke AC,Schertzer JW

更新日期：2017-08-08 00:00:00

abstract：:The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studi...

journal_title：mBio

authors： Alter HJ,Mikovits JA,Switzer WM,Ruscetti FW,Lo SC,Klimas N,Komaroff AL,Montoya JG,Bateman L,Levine S,Peterson D,Levin B,Hanson MR,Genfi A,Bhat M,Zheng H,Wang R,Li B,Hung GC,Lee LL,Sameroff S,Heneine W,Coffin J

更新日期：2012-09-18 00:00:00

abstract：:Like their cellular hosts, herpesviruses are subject to the regulatory impacts of chromatin assembled on their genomes. Upon infection, these viruses are assembled into domains of chromatin with heterochromatic signatures that suppress viral gene expression or euchromatic characteristics that promote gene expression. ...

journal_title：mBio

authors： Kristie TM

更新日期：2016-02-16 00:00:00

abstract：:Cellular sensing of bacterial RNA is increasingly recognized as a determinant of host-pathogen interactions. The intracellular pathogen Listeria monocytogenes induces high levels of type I interferons (alpha/beta interferons [IFN-α/β]) to create a growth-permissive microenvironment during infection. We previously demo...

journal_title：mBio

authors： Frantz R,Teubner L,Schultze T,La Pietra L,Müller C,Gwozdzinski K,Pillich H,Hain T,Weber-Gerlach M,Panagiotidis GD,Mostafa A,Weber F,Rohde M,Pleschka S,Chakraborty T,Abu Mraheil M

更新日期：2019-10-08 00:00:00

abstract：:Bacterial viruses, or bacteriophages, are highly abundant in the biosphere and have a major impact on microbial populations. Many examples of phage interactions with their hosts, including establishment of dormant lysogenic and active lytic states, have been characterized at the level of the individual cell. However, ...

journal_title：mBio

authors： Laganenka L,Sander T,Lagonenko A,Chen Y,Link H,Sourjik V

更新日期：2019-09-10 00:00:00

abstract：UNLABELLED:Elevated intracellular levels of the bacterial second messenger c-di-GMP are known to suppress motility and promote sessility. Bacterial chemotaxis guides motile cells in gradients of attractants and repellents over broad concentration ranges, thus allowing bacteria to quickly adapt to changes in their surro...

journal_title：mBio

authors： Russell MH,Bible AN,Fang X,Gooding JR,Campagna SR,Gomelsky M,Alexandre G

更新日期：2013-03-19 00:00:00

abstract：:Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity and mortality and tend to be challenging to treat. Candida albicans and Staphylococcus aureus specifically are considered leading opportunistic fungal and bacterial pathogens, respect...

journal_title：mBio

authors： Kong EF,Tsui C,Kucharíková S,Andes D,Van Dijck P,Jabra-Rizk MA

更新日期：2016-10-11 00:00:00

abstract：:Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response. Deletion of NS1 (DelNS1) would create a safer and more extensively immunogenic live attenuated influenza virus (LAIV) vaccine. However, DelNS1 vir...

journal_title：mBio

authors： Wang P,Zheng M,Lau SY,Chen P,Mok BW,Liu S,Liu H,Huang X,Cremin CJ,Song W,Chen Y,Wong YC,Huang H,To KK,Chen Z,Xia N,Yuen KY,Chen H

更新日期：2019-09-17 00:00:00

abstract：UNLABELLED:Pseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are major problems that can complicate antibiotic therapy. We evaluated the efficacy of using bacteriophages to kill the pathogen i...

journal_title：mBio

authors： Alemayehu D,Casey PG,McAuliffe O,Guinane CM,Martin JG,Shanahan F,Coffey A,Ross RP,Hill C

更新日期：2012-03-06 00:00:00

abstract：:Candida albicans has developmental programs that govern transitions between yeast and filamentous morphologies and between unattached and biofilm lifestyles. Here, we report that filamentation, intercellular adherence, and biofilm development were inhibited during interactions between Candida albicans and Pseudomonas ...

journal_title：mBio

authors： Morales DK,Grahl N,Okegbe C,Dietrich LE,Jacobs NJ,Hogan DA

更新日期：2013-01-29 00:00:00

abstract：:Emerging zoonotic viral diseases remain a challenge to global public health. Recent surveillance studies have implicated bats as potential reservoirs for a number of viral pathogens, including coronaviruses and Ebola viruses. Caliciviridae represent a major viral family contributing to emerging diseases in both human ...

journal_title：mBio

authors： Kocher JF,Lindesmith LC,Debbink K,Beall A,Mallory ML,Yount BL,Graham RL,Huynh J,Gates JE,Donaldson EF,Baric RS

更新日期：2018-05-22 00:00:00

abstract：:The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where t...

journal_title：mBio

authors： Alagaili AN,Briese T,Mishra N,Kapoor V,Sameroff SC,Burbelo PD,de Wit E,Munster VJ,Hensley LE,Zalmout IS,Kapoor A,Epstein JH,Karesh WB,Daszak P,Mohammed OB,Lipkin WI

更新日期：2014-02-25 00:00:00

abstract：UNLABELLED:Recent studies strongly suggest that the gene expression sustaining both normal and pathogenic bacterial growth is governed by the structural dynamics of the chromosome. However, the mechanistic device coordinating the chromosomal configuration with selective expression of the adaptive traits remains largely...

journal_title：mBio

authors： Jiang X,Sobetzko P,Nasser W,Reverchon S,Muskhelishvili G

更新日期：2015-04-28 00:00:00

abstract：:Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causat...

journal_title：mBio

authors： Idnurm A

更新日期：2013-04-30 00:00:00

abstract：:Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro Human Pneumocystis infections present major challenges because of a limited therapeutic arsenal and the rise of drug resistance. To inv...

journal_title：mBio

authors： Cissé OH,Ma L,Wei Huang D,Khil PP,Dekker JP,Kutty G,Bishop L,Liu Y,Deng X,Hauser PM,Pagni M,Hirsch V,Lempicki RA,Stajich JE,Cuomo CA,Kovacs JA

更新日期：2018-05-08 00:00:00

abstract：:The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA) contribute independently to protection against disease, antigen...

journal_title：mBio

authors： Gao J,Couzens L,Burke DF,Wan H,Wilson P,Memoli MJ,Xu X,Harvey R,Wrammert J,Ahmed R,Taubenberger JK,Smith DJ,Fouchier RAM,Eichelberger MC

更新日期：2019-04-09 00:00:00

abstract：UNLABELLED:Diverse colony morphologies are a hallmark of Burkholderia pseudomallei recovered from infected patients. We observed that stresses that inhibit aerobic respiration shifted populations of B. pseudomallei from the canonical white colony morphotype toward two distinct, reversible, yet relatively stable yellow ...

journal_title：mBio

authors： Austin CR,Goodyear AW,Bartek IL,Stewart A,Sutherland MD,Silva EB,Zweifel A,Vitko NP,Tuanyok A,Highnam G,Mittelman D,Keim P,Schweizer HP,Vázquez-Torres A,Dow SW,Voskuil MI

更新日期：2015-02-03 00:00:00

abstract：UNLABELLED:Protein-protein interactions are important for virtually every biological process, and a number of elegant approaches have been designed to detect and evaluate such interactions. However, few of these methods allow the detection of dynamic and real-time protein-protein interactions in bacteria. Here we descr...

journal_title：mBio

authors： Cui B,Wang Y,Song Y,Wang T,Li C,Wei Y,Luo ZQ,Shen X

更新日期：2014-05-20 00:00:00

abstract：UNLABELLED:Here we present an extensive genomic and genetic analysis of Escherichia coli strains of serotype O78 that represent the major cause of avian colisepticemia, an invasive infection caused by avian pathogenic Escherichia coli (APEC) strains. It is associated with high mortality and morbidity, resulting in sign...

journal_title：mBio

authors： Huja S,Oren Y,Trost E,Brzuszkiewicz E,Biran D,Blom J,Goesmann A,Gottschalk G,Hacker J,Ron EZ,Dobrindt U

更新日期：2015-01-13 00:00:00