Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia.

abstract：:Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny. In contrast, adhesion and biofilm formation, which are potentially involved in gut colonization...

journal_title：mBio

authors： Béchon N,Mihajlovic J,Vendrell-Fernández S,Chain F,Langella P,Beloin C,Ghigo JM

更新日期：2020-06-23 00:00:00

abstract：UNLABELLED:The prominent host muramidase lysozyme cleaves bacterial peptidoglycan (PG), and the enzyme is abundant in mucosal secretions. The lytic enzyme susceptibility of Gram-negative bacteria and mechanisms they use to thwart lytic enzyme activity are poorly studied. We previously characterized a Helicobacter pylor...

journal_title：mBio

authors： Wang G,Lo LF,Forsberg LS,Maier RJ

更新日期：2012-12-04 00:00:00

abstract：:We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by using chromatin immunoprecipitation experiments, that both PRC2 and euchromatic...

journal_title：mBio

authors： Nguyen K,Das B,Dobrowolski C,Karn J

更新日期：2017-02-28 00:00:00

abstract：:Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response. Deletion of NS1 (DelNS1) would create a safer and more extensively immunogenic live attenuated influenza virus (LAIV) vaccine. However, DelNS1 vir...

journal_title：mBio

authors： Wang P,Zheng M,Lau SY,Chen P,Mok BW,Liu S,Liu H,Huang X,Cremin CJ,Song W,Chen Y,Wong YC,Huang H,To KK,Chen Z,Xia N,Yuen KY,Chen H

更新日期：2019-09-17 00:00:00

abstract：UNLABELLED:Epstein-Barr virus (EBV), along with other members of the herpesvirus family, requires a set of viral glycoproteins to mediate host cell attachment and entry. Viral glycoprotein B (gB), a highly conserved glycoprotein within the herpesvirus family, is thought to be the viral fusogen based on structural compa...

journal_title：mBio

authors： Garcia NJ,Chen J,Longnecker R

更新日期：2013-01-22 00:00:00

abstract：:Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro Human Pneumocystis infections present major challenges because of a limited therapeutic arsenal and the rise of drug resistance. To inv...

journal_title：mBio

authors： Cissé OH,Ma L,Wei Huang D,Khil PP,Dekker JP,Kutty G,Bishop L,Liu Y,Deng X,Hauser PM,Pagni M,Hirsch V,Lempicki RA,Stajich JE,Cuomo CA,Kovacs JA

更新日期：2018-05-08 00:00:00

abstract：:Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4+ cells expressing a Nullbasi...

journal_title：mBio

authors： Jin H,Sun Y,Li D,Lin MH,Lor M,Rustanti L,Harrich D

更新日期：2019-08-27 00:00:00

abstract：UNLABELLED:Filamentous, heterocyst-forming cyanobacteria exchange nutrients and regulators between cells for diazotrophic growth. Two alternative modes of exchange have been discussed involving transport either through the periplasm or through septal junctions linking adjacent cells. Septal junctions and channels in th...

journal_title：mBio

authors： Rudolf M,Tetik N,Ramos-León F,Flinner N,Ngo G,Stevanovic M,Burnat M,Pernil R,Flores E,Schleiff E

更新日期：2015-06-30 00:00:00

abstract：:Catabolite control protein A (CcpA) is the master regulator in Gram-positive bacteria that mediates carbon catabolite repression (CCR) and carbon catabolite activation (CCA), two fundamental regulatory mechanisms that enable competitive advantages in carbon catabolism. It is generally regarded that CcpA exerts its reg...

journal_title：mBio

authors： Yang Y,Zhang L,Huang H,Yang C,Yang S,Gu Y,Jiang W

更新日期：2017-01-24 00:00:00

abstract：UNLABELLED:We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and affinities, which are determined by the compactness o...

journal_title：mBio

authors： Goossens KV,Ielasi FS,Nookaew I,Stals I,Alonso-Sarduy L,Daenen L,Van Mulders SE,Stassen C,van Eijsden RG,Siewers V,Delvaux FR,Kasas S,Nielsen J,Devreese B,Willaert RG

更新日期：2015-04-14 00:00:00

abstract：:Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo We hypothesized that we could improve the specificity of LV targeting by coupling (i) reduction of their binding to off-target cells with (ii) redirection of the vect...

journal_title：mBio

authors： Parker CL,Jacobs TM,Huckaby JT,Harit D,Lai SK

更新日期：2020-01-21 00:00:00

abstract：:The human antibody repertoire has an exceptionally large capacity to recognize new or changing antigens through combinatorial and junctional diversity established at the time of V(D)J recombination and through somatic hypermutation. Influenza viruses exhibit a relentless capacity to escape the human antibody response ...

journal_title：mBio

authors： Crowe JE Jr

更新日期：2012-07-31 00:00:00

abstract：:Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with M. tuberculosis, and about 15 million people with latent tuberculosis infection (LTBI) reside in the United States. An estimated 10% of indiv...

journal_title：mBio

authors： Ayyappan JP,Ganapathi U,Lizardo K,Vinnard C,Subbian S,Perlin DS,Nagajyothi JF

更新日期：2019-04-16 00:00:00

abstract：UNLABELLED:Elongins B and C are members of complexes that increase the efficiency of transcriptional elongation by RNA polymerase II (RNAPII) and enhance the monoubiquitination of histone H2B, an epigenetic mark of actively transcribed genes. Here we show that, in addition to its role in facilitating transcription of t...

journal_title：mBio

authors： Hwang J,Saffert RT,Kalejta RF

更新日期：2011-03-29 00:00:00

abstract：UNLABELLED:Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE surface membrane. To investigate the relationship between ...

journal_title：mBio

authors： Subramani R,Quadt K,Jeppesen AE,Hempel C,Petersen JE,Hassenkam T,Hviid L,Barfod L

更新日期：2015-10-06 00:00:00

abstract：:Ocean viruses are ubiquitous and abundant and play important roles in global biogeochemical cycles by means of their mortality, horizontal gene transfer, and manipulation of host metabolism. However, the obstacles involved in linking viruses to their hosts in a high-throughput manner bottlenecks our ability to underst...

journal_title：mBio

authors： Deng L,Gregory A,Yilmaz S,Poulos BT,Hugenholtz P,Sullivan MB

更新日期：2012-10-30 00:00:00

abstract：UNLABELLED:Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. Like many coronaviruses, MERS-CoV carries genes that encode multiple accessory proteins that are not required for replicat...

journal_title：mBio

authors： Thornbrough JM,Jha BK,Yount B,Goldstein SA,Li Y,Elliott R,Sims AC,Baric RS,Silverman RH,Weiss SR

更新日期：2016-03-29 00:00:00

abstract：:Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by the enzyme UDP-4-keto-6-deo...

journal_title：mBio

authors： Ma L,Salas O,Bowler K,Bar-Peled M,Sharon A

更新日期：2017-11-21 00:00:00

abstract：:Enterococci are important human commensals and significant opportunistic pathogens. Biofilm-related enterococcal infections, such as endocarditis, urinary tract infections, wound and surgical site infections, and medical device-associated infections, often become chronic upon the formation of biofilm. The biofilm matr...

journal_title：mBio

authors： Keogh D,Lam LN,Doyle LE,Matysik A,Pavagadhi S,Umashankar S,Low PM,Dale JL,Song Y,Ng SP,Boothroyd CB,Dunny GM,Swarup S,Williams RBH,Marsili E,Kline KA

更新日期：2018-04-10 00:00:00

abstract：UNLABELLED:Competence for genetic transformation in Streptococcus pneumoniae develops in response to accumulation of a secreted peptide pheromone and was one of the initial examples of bacterial quorum sensing. Activation of this signaling system induces not only expression of the proteins required for transformation b...

journal_title：mBio

authors： Stevens KE,Chang D,Zwack EE,Sebert ME

更新日期：2011-09-20 00:00:00

abstract：:Photosynthetic bacteria are capable of producing their own food via photosynthesis. Unsurprisingly, they evolved the ability to move toward better light conditions (i.e., phototaxis). In a recent article in mBio, Chau et al. tuned the wavelength, flux, direction, and timing of light input and characterized the motilit...

journal_title：mBio

authors： Kim M

更新日期：2017-04-11 00:00:00

abstract：UNLABELLED:The promoter most strongly induced upon activation of the Cpx two-component envelope stress response is the cpxP promoter. The 3' untranscribed region (UTR) of the cpxP transcript is shown to produce a small RNA (sRNA), CpxQ. We investigated the role of CpxQ in combating envelope stress. Remarkably, the two ...

journal_title：mBio

authors： Grabowicz M,Koren D,Silhavy TJ

更新日期：2016-04-05 00:00:00

abstract：UNLABELLED:Enoyl-acyl carrier protein (enoyl-ACP) reductase catalyzes the last step of the elongation cycle in the synthesis of bacterial fatty acids. The Enterococcus faecalis genome contains two genes annotated as enoyl-ACP reductases, a FabI-type enoyl-ACP reductase and a FabK-type enoyl-ACP reductase. We report tha...

journal_title：mBio

authors： Zhu L,Bi H,Ma J,Hu Z,Zhang W,Cronan JE,Wang H

更新日期：2013-10-01 00:00:00

abstract：UNLABELLED:The bacterial flagellum is driven by a bidirectional rotary motor, which propels bacteria to swim through liquids or swarm over surfaces. While the functions of the major structural and regulatory components of the flagellum are known, the function of the well-conserved FliL protein is not. In Salmonella and...

journal_title：mBio

authors： Partridge JD,Nieto V,Harshey RM

更新日期：2015-02-24 00:00:00

abstract：UNLABELLED:Honeybees harbor well-defined bacterial communities in their guts. The major members of these communities appear to benefit the host, but little is known about how they interact with the host and specifically how they interface with the host immune system. In the pylorus, a short region between the midgut an...

journal_title：mBio

authors： Engel P,Bartlett KD,Moran NA

更新日期：2015-05-19 00:00:00

abstract：:Recent studies have greatly extended our understanding of the microbiota present in and on the human body. Here, advanced sequencing strategies have provided unprecedented analytical power. The important implications that the emerging data have for human health emphasize the need to intensify research in this area (D....

journal_title：mBio

authors： Rogers GB,Bruce KD

更新日期：2012-11-06 00:00:00

abstract：UNLABELLED:Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extrac...

journal_title：mBio

authors： Singh B,Alvarado-Kristensson M,Johansson M,Hallgren O,Westergren-Thorsson G,Mörgelin M,Riesbeck K

更新日期：2016-03-22 00:00:00

abstract：:Murein lipoprotein (Lpp) and peptidoglycan-associated lipoprotein (Pal) are major outer membrane lipoproteins in Escherichia coli Their roles in cell-envelope integrity have been documented in E. coli laboratory strains, and while Lpp has been linked to serum resistance in vitro, the underlying mechanism has not been ...

journal_title：mBio

authors： Diao J,Bouwman C,Yan D,Kang J,Katakam AK,Liu P,Pantua H,Abbas AR,Nickerson NN,Austin C,Reichelt M,Sandoval W,Xu M,Whitfield C,Kapadia SB

更新日期：2017-05-23 00:00:00

abstract：:The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studi...

journal_title：mBio

authors： Alter HJ,Mikovits JA,Switzer WM,Ruscetti FW,Lo SC,Klimas N,Komaroff AL,Montoya JG,Bateman L,Levine S,Peterson D,Levin B,Hanson MR,Genfi A,Bhat M,Zheng H,Wang R,Li B,Hung GC,Lee LL,Sameroff S,Heneine W,Coffin J

更新日期：2012-09-18 00:00:00

abstract：UNLABELLED:Salmonella enterica serovar Typhimurium is one of the most common S. enterica serovars associated with U.S. foodborne outbreaks. S. Typhimurium bacteria isolated from humans exhibit wide-ranging virulence phenotypes in inbred mice, leading to speculation that some strains are more virulent in nature. However...

journal_title：mBio

authors： Hayden HS,Matamouros S,Hager KR,Brittnacher MJ,Rohmer L,Radey MC,Weiss EJ,Kim KB,Jacobs MA,Sims-Day EH,Yue M,Zaidi MB,Schifferli DM,Manning SD,Walson JL,Miller SI

更新日期：2016-03-08 00:00:00