A Molecular-Level Landscape of Diet-Gut Microbiome Interactions: Toward Dietary Interventions Targeting Bacterial Genes.

abstract：UNLABELLED:Staphylococcus aureus is a human commensal that at times turns into a serious bacterial pathogen causing life-threatening infections. For the delicate control of virulence, S. aureus employs the agr quorum-sensing system that, via the intracellular effector molecule RNAIII, regulates virulence gene expressio...

journal_title：mBio

authors： Paulander W,Nissen Varming A,Bæk KT,Haaber J,Frees D,Ingmer H

更新日期：2013-01-02 00:00:00

abstract：:The Mo- and V-nitrogenases are two homologous members of the nitrogenase family that are distinguished mainly by the presence of different heterometals (Mo or V) at their respective cofactor sites (M- or V-cluster). However, the V-nitrogenase is ~600-fold more active than its Mo counterpart in reducing CO to hydrocarb...

journal_title：mBio

authors： Rebelein JG,Lee CC,Newcomb M,Hu Y,Ribbe MW

更新日期：2018-03-13 00:00:00

abstract：:Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal a conserved role for bacter...

journal_title：mBio

authors： Chaudhari SS,Kim M,Lei S,Razvi F,Alqarzaee AA,Hutfless EH,Powers R,Zimmerman MC,Fey PD,Thomas VC

更新日期：2017-08-01 00:00:00

abstract：UNLABELLED:Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a variety of environmental stimuli and play a critical r...

journal_title：mBio

authors： Agostoni M,Koestler BJ,Waters CM,Williams BL,Montgomery BL

更新日期：2013-08-13 00:00:00

abstract：:The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studi...

journal_title：mBio

authors： Alter HJ,Mikovits JA,Switzer WM,Ruscetti FW,Lo SC,Klimas N,Komaroff AL,Montoya JG,Bateman L,Levine S,Peterson D,Levin B,Hanson MR,Genfi A,Bhat M,Zheng H,Wang R,Li B,Hung GC,Lee LL,Sameroff S,Heneine W,Coffin J

更新日期：2012-09-18 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen whose success is largely attributed to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the human host. The expression of these virulence factors is controlled by the quorum sensing accessory gene regulator (Agr) system. ...

journal_title：mBio

authors： Gor V,Takemura AJ,Nishitani M,Higashide M,Medrano Romero V,Ohniwa RL,Morikawa K

更新日期：2019-08-06 00:00:00

abstract：:Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interference (RNAi) response are poorly understood. Here, we characterized antiviral RN...

journal_title：mBio

authors： Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW

更新日期：2020-08-04 00:00:00

abstract：:Forested ecosystems throughout the world are experiencing increases in the incidence and magnitude of insect-induced tree mortality with large ecologic ramifications. Interestingly, correlations between water quality and the extent of tree mortality in Colorado montane ecosystems suggest compensatory effects from adja...

journal_title：mBio

authors： Mikkelson KM,Brouillard BM,Bokman CM,Sharp JO

更新日期：2017-12-05 00:00:00

abstract：:Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy. They can also use poised electrodes as their electron donor via phototrophic extracellular electron uptake (phototrophic EEU). The e...

journal_title：mBio

authors： Gupta D,Sutherland MC,Rengasamy K,Meacham JM,Kranz RG,Bose A

更新日期：2019-11-05 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the natural evolution of ...

journal_title：mBio

authors： Broset E,Martín C,Gonzalo-Asensio J

更新日期：2015-10-20 00:00:00

abstract：UNLABELLED:This study demonstrates the prevalence, phylogenetic diversity, and physiology of nitrate-reducing microorganisms capable of utilizing reduced humic acids (HA) as electron donors in agricultural soils. Most probable number (MPN) enumeration of agricultural soils revealed large populations (10(4) to 10(6) cel...

journal_title：mBio

authors： Van Trump JI,Wrighton KC,Thrash JC,Weber KA,Andersen GL,Coates JD

更新日期：2011-07-12 00:00:00

abstract：UNLABELLED:Coagulase (Coa) and Efb, secreted Staphylococcus aureus proteins, are important virulence factors in staphylococcal infections. Coa interacts with fibrinogen (Fg) and induces the formation of fibrin(ogen) clots through activation of prothrombin. Efb attracts Fg to the bacterial surface and forms a shield to ...

journal_title：mBio

authors： Ko YP,Kang M,Ganesh VK,Ravirajan D,Li B,Höök M

更新日期：2016-01-05 00:00:00

abstract：:The Bacillus cereus group comprises numerous closely related species, including bioterrorism agent B. anthracis, foodborne pathogen B. cereus, and biopesticide B. thuringiensis Differentiating organisms capable of causing illness or death from those used in industry is essential for risk assessment and outbreak prepar...

journal_title：mBio

authors： Carroll LM,Wiedmann M,Kovac J

更新日期：2020-02-25 00:00:00

abstract：:With great apprehension, the world is now watching the birth of a novel pandemic already causing tremendous suffering, death, and disruption of normal life. Uncertainty and dread are exacerbated by the belief that what we are experiencing is new and mysterious. However, deadly pandemics and disease emergences are not ...

journal_title：mBio

authors： Morens DM,Daszak P,Markel H,Taubenberger JK

更新日期：2020-05-29 00:00:00

abstract：:Nineteen Thermococcus kodakarensis strains have been constructed, each of which synthesizes a different His(6)-tagged protein known or predicted to be a component of the archaeal DNA replication machinery. Using the His(6)-tagged proteins, stable complexes assembled in vivo have been isolated directly from clarified c...

journal_title：mBio

authors： Li Z,Santangelo TJ,Cuboňová L,Reeve JN,Kelman Z

更新日期：2010-10-26 00:00:00

abstract：:Most bacteria and archaea use the tubulin homologue FtsZ as its central organizer of cell division. In Gram-negative Escherichia coli bacteria, FtsZ recruits cytosolic, transmembrane, periplasmic, and outer membrane proteins, assembling the divisome that facilitates bacterial cell division. One such divisome component...

journal_title：mBio

authors： Kureisaite-Ciziene D,Varadajan A,McLaughlin SH,Glas M,Montón Silva A,Luirink R,Mueller C,den Blaauwen T,Grossmann TN,Luirink J,Löwe J

更新日期：2018-09-11 00:00:00

abstract：UNLABELLED:We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and affinities, which are determined by the compactness o...

journal_title：mBio

authors： Goossens KV,Ielasi FS,Nookaew I,Stals I,Alonso-Sarduy L,Daenen L,Van Mulders SE,Stassen C,van Eijsden RG,Siewers V,Delvaux FR,Kasas S,Nielsen J,Devreese B,Willaert RG

更新日期：2015-04-14 00:00:00

abstract：:Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an important phase in their development. Here, we present a systemati...

journal_title：mBio

authors： Obaldia N 3rd,Meibalan E,Sa JM,Ma S,Clark MA,Mejia P,Moraes Barros RR,Otero W,Ferreira MU,Mitchell JR,Milner DA,Huttenhower C,Wirth DF,Duraisingh MT,Wellems TE,Marti M

更新日期：2018-05-08 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the enzyme plays a prote...

journal_title：mBio

authors： Costa DL,Namasivayam S,Amaral EP,Arora K,Chao A,Mittereder LR,Maiga M,Boshoff HI,Barry CE 3rd,Goulding CW,Andrade BB,Sher A

更新日期：2016-10-25 00:00:00

abstract：:Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity and mortality and tend to be challenging to treat. Candida albicans and Staphylococcus aureus specifically are considered leading opportunistic fungal and bacterial pathogens, respect...

journal_title：mBio

authors： Kong EF,Tsui C,Kucharíková S,Andes D,Van Dijck P,Jabra-Rizk MA

更新日期：2016-10-11 00:00:00

abstract：:Typhoid fever, caused by Salmonella enterica serovar Typhi, is a global public health concern due to increasing antimicrobial resistance (AMR). Characterization of S Typhi genomes for AMR and the evolution of different lineages, especially in countries where typhoid fever is endemic such as Bangladesh, will help publi...

journal_title：mBio

authors： Tanmoy AM,Westeel E,De Bruyne K,Goris J,Rajoharison A,Sajib MSI,van Belkum A,Saha SK,Komurian-Pradel F,Endtz HP

更新日期：2018-11-13 00:00:00

abstract：:Colicins are toxins produced and released by Enterobacteriaceae to kill competitors in the gut. While group A colicins employ a division of labor strategy to liberate the toxin into the environment via colicin-specific lysis, group B colicin systems lack cognate lysis genes. In Salmonella enterica serovar Typhimurium ...

journal_title：mBio

authors： Spriewald S,Stadler E,Hense BA,Münch PC,McHardy AC,Weiss AS,Obeng N,Müller J,Stecher B

更新日期：2020-07-21 00:00:00

abstract：:Flavor production in yeast fermentation is of paramount importance for industrial production of alcoholic beverages. Although major enzymes of flavor compound biosynthesis have been identified, few specific mutations responsible for strain diversity in flavor production are known. The ATF1-encoded alcohol acetyl coenz...

journal_title：mBio

authors： Holt S,Trindade de Carvalho B,Foulquié-Moreno MR,Thevelein JM

更新日期：2018-08-28 00:00:00

abstract：:ABSTRACT The major clonal lineages of the human pathogen Staphylococcus aureus produce cell wall-anchored anionic poly-ribitol-phosphate (RboP) wall teichoic acids (WTA) substituted with d-Alanine and N-acetyl-d-glucosamine. The phylogenetically isolated S. aureus ST395 lineage has recently been found to produce a uni...

journal_title：mBio

authors： Winstel V,Sanchez-Carballo P,Holst O,Xia G,Peschel A

更新日期：2014-04-08 00:00:00

abstract：:Japanese encephalitis virus (JEV) remains a leading cause of viral encephalitis worldwide. Although JEV-specific antibodies have been described, an assessment of their ability to neutralize multiple genotypes of JEV has been limited. Here, we describe the development of a panel of mouse and human neutralizing monoclon...

journal_title：mBio

authors： Fernandez E,Kose N,Edeling MA,Adhikari J,Sapparapu G,Lazarte SM,Nelson CA,Govero J,Gross ML,Fremont DH,Crowe JE Jr,Diamond MS

更新日期：2018-02-27 00:00:00

abstract：:Catabolite control protein A (CcpA) is the master regulator in Gram-positive bacteria that mediates carbon catabolite repression (CCR) and carbon catabolite activation (CCA), two fundamental regulatory mechanisms that enable competitive advantages in carbon catabolism. It is generally regarded that CcpA exerts its reg...

journal_title：mBio

authors： Yang Y,Zhang L,Huang H,Yang C,Yang S,Gu Y,Jiang W

更新日期：2017-01-24 00:00:00

abstract：:The concept that anaerobic microorganisms can directly accept electrons from Fe(0) has been controversial because direct metal-microbe electron transfer has previously only been indirectly inferred. Fe(0) oxidation was studied with Geobacter sulfurreducens strain ACL, an autotrophic strain that was previously shown to...

journal_title：mBio

authors： Tang HY,Holmes DE,Ueki T,Palacios PA,Lovley DR

更新日期：2019-05-14 00:00:00

abstract：:Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro Human Pneumocystis infections present major challenges because of a limited therapeutic arsenal and the rise of drug resistance. To inv...

journal_title：mBio

authors： Cissé OH,Ma L,Wei Huang D,Khil PP,Dekker JP,Kutty G,Bishop L,Liu Y,Deng X,Hauser PM,Pagni M,Hirsch V,Lempicki RA,Stajich JE,Cuomo CA,Kovacs JA

更新日期：2018-05-08 00:00:00

abstract：:All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for ...

journal_title：mBio

authors： Guerardel Y,Sadovskaya I,Maes E,Furlan S,Chapot-Chartier MP,Mesnage S,Rigottier-Gois L,Serror P

更新日期：2020-04-28 00:00:00