The 2009 H1N1 pandemic influenza virus: what next?

abstract：:Silver (Ag+) and copper (Cu+) ions have been used for centuries in industry, as well as antimicrobial agents in agriculture and health care. Nowadays, Ag+ is also widely used in the field of nanotechnology. Yet, the underlying mechanisms driving toxicity of Ag+ ions in vivo are poorly characterized. It is well known t...

journal_title：mBio

authors： Tambosi R,Liotenberg S,Bourbon ML,Steunou AS,Babot M,Durand A,Kebaili N,Ouchane S

更新日期：2018-11-20 00:00:00

abstract：:Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic understanding of how bacteria evolve resistance against multiple phages is lacking, ...

journal_title：mBio

authors： Wright RCT,Friman VP,Smith MCM,Brockhurst MA

更新日期：2019-09-24 00:00:00

abstract：:We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by using chromatin immunoprecipitation experiments, that both PRC2 and euchromatic...

journal_title：mBio

authors： Nguyen K,Das B,Dobrowolski C,Karn J

更新日期：2017-02-28 00:00:00

abstract：:Inhibition of apoptotic death of macrophages by Mycobacterium tuberculosis represents an important mechanism of virulence that results in pathogen survival both in vitro and in vivo. To identify M. tuberculosis virulence determinants involved in the modulation of apoptosis, we previously screened a transposon bank of ...

journal_title：mBio

authors： Danelishvili L,Babrak L,Rose SJ,Everman J,Bermudez LE

更新日期：2014-08-19 00:00:00

abstract：UNLABELLED:The bacterial flagellum is driven by a bidirectional rotary motor, which propels bacteria to swim through liquids or swarm over surfaces. While the functions of the major structural and regulatory components of the flagellum are known, the function of the well-conserved FliL protein is not. In Salmonella and...

journal_title：mBio

authors： Partridge JD,Nieto V,Harshey RM

更新日期：2015-02-24 00:00:00

abstract：:UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar moiety is incorporated into glycosylphosphatidylinositol (GPI) glycolipids and N- and O-linked glycans. Apicomplexan parasites have a hexosamine pathway compa...

journal_title：mBio

authors： Chi J,Cova M,de Las Rivas M,Medina A,Borges RJ,Leivar P,Planas A,Usón I,Hurtado-Guerrero R,Izquierdo L

更新日期：2020-10-20 00:00:00

abstract：UNLABELLED:Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and outcome. As in many infectious diseases, this variability is commonly assigned to host factors. To investigate whether the diversity of Cryptococcus neoformans clinical (ClinCn) isolates influences the interaction with ...

journal_title：mBio

authors： Alanio A,Desnos-Ollivier M,Dromer F

更新日期：2011-08-09 00:00:00

abstract：UNLABELLED:As diet is considered the major regulator of the gut ecosystem, the overall objective of this work was to demonstrate that a detailed knowledge of the phytochemical composition of food could add to our understanding of observed changes in functionality and activity of the gut microbiota. We used metatranscri...

journal_title：mBio

authors： Ni Y,Li J,Panagiotou G

更新日期：2015-10-27 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：UNLABELLED:The intracellular parasite Toxoplasma gondii infects a wide variety of vertebrate species globally. Infection in most hosts causes a lifelong chronic infection and generates immunological memory responses that protect the host against new infections. In regions where the organism is endemic, multiple exposur...

journal_title：mBio

authors： Jensen KD,Camejo A,Melo MB,Cordeiro C,Julien L,Grotenbreg GM,Frickel EM,Ploegh HL,Young L,Saeij JP

更新日期：2015-02-24 00:00:00

abstract：:Emerging zoonotic viral diseases remain a challenge to global public health. Recent surveillance studies have implicated bats as potential reservoirs for a number of viral pathogens, including coronaviruses and Ebola viruses. Caliciviridae represent a major viral family contributing to emerging diseases in both human ...

journal_title：mBio

authors： Kocher JF,Lindesmith LC,Debbink K,Beall A,Mallory ML,Yount BL,Graham RL,Huynh J,Gates JE,Donaldson EF,Baric RS

更新日期：2018-05-22 00:00:00

abstract：UNLABELLED:A 32-nucleotide (nt) RNA motif located at the 3' end of the transmissible gastroenteritis coronavirus (TGEV) genome was found to specifically interact with the host proteins glutamyl-prolyl-tRNA synthetase (EPRS) and arginyl-tRNA synthetase (RRS). This RNA motif has high homology in sequence and secondary st...

journal_title：mBio

authors： Marquez-Jurado S,Nogales A,Zuñiga S,Enjuanes L,Almazán F

更新日期：2015-03-10 00:00:00

abstract：UNLABELLED:Promiscuous plasmids replicate in a wide range of bacteria and therefore play a key role in the dissemination of various host-beneficial traits, including antibiotic resistance. Despite the medical relevance, little is known about the evolutionary dynamics through which drug resistance plasmids adapt to new ...

journal_title：mBio

authors： Hughes JM,Lohman BK,Deckert GE,Nichols EP,Settles M,Abdo Z,Top EM

更新日期：2012-07-03 00:00:00

abstract：:Helicobacter pylori colonizes about half of humans worldwide, and its presence in the gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric lymphoma, and peptic ulcer disease. H. pylori strains carrying the cag pathogenicity island (cagPAI) are associated with increased risk of disease...

journal_title：mBio

authors： Hu B,Khara P,Song L,Lin AS,Frick-Cheng AE,Harvey ML,Cover TL,Christie PJ

更新日期：2019-05-14 00:00:00

abstract：UNLABELLED:Carbonate chimneys at the Lost City hydrothermal field are coated in biofilms dominated by a single phylotype of archaea known as Lost City Methanosarcinales. In this study, we have detected surprising physiological complexity in single-species biofilms, which is typically indicative of multispecies biofilm ...

journal_title：mBio

authors： Brazelton WJ,Mehta MP,Kelley DS,Baross JA

更新日期：2011-09-01 00:00:00

abstract：UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...

journal_title：mBio

authors： Memoli MJ,Shaw PA,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Fargis S,Risos K,Powers JH,Davey RT Jr,Taubenberger JK

更新日期：2016-04-19 00:00:00

abstract：:Pathogens frequently employ eukaryotic linear motif (ELM)-rich intrinsically disordered proteins (IDPs) to perturb and hijack host cell networks for a productive infection. Mycobacterium tuberculosis has a relatively high percentage of IDPs in its proteome, the significance of which is not known. The Mycobacterium-spe...

journal_title：mBio

authors： Ahmad J,Farhana A,Pancsa R,Arora SK,Srinivasan A,Tyagi AK,Babu MM,Ehtesham NZ,Hasnain SE

更新日期：2018-01-23 00:00:00

abstract：UNLABELLED:Despite their high genomic diversity, all known viruses are structurally constrained to a limited number of virion morphotypes. One morphotype of viruses infecting bacteria, archaea, and eukaryotes is the tailless icosahedral morphotype with an internal membrane. Although it is considered an abundant morphot...

journal_title：mBio

authors： Demina TA,Pietilä MK,Svirskaitė J,Ravantti JJ,Atanasova NS,Bamford DH,Oksanen HM

更新日期：2016-07-19 00:00:00

abstract：UNLABELLED:The strong restriction barrier present in Staphylococcus aureus and Staphylococcus epidermidis has limited functional genomic analysis to a small subset of strains that are amenable to genetic manipulation. Recently, a conserved type IV restriction system termed SauUSI (which specifically recognizes cytosine...

journal_title：mBio

authors： Monk IR,Shah IM,Xu M,Tan MW,Foster TJ

更新日期：2012-03-20 00:00:00

abstract：:Forested ecosystems throughout the world are experiencing increases in the incidence and magnitude of insect-induced tree mortality with large ecologic ramifications. Interestingly, correlations between water quality and the extent of tree mortality in Colorado montane ecosystems suggest compensatory effects from adja...

journal_title：mBio

authors： Mikkelson KM,Brouillard BM,Bokman CM,Sharp JO

更新日期：2017-12-05 00:00:00

abstract：UNLABELLED:The prominent host muramidase lysozyme cleaves bacterial peptidoglycan (PG), and the enzyme is abundant in mucosal secretions. The lytic enzyme susceptibility of Gram-negative bacteria and mechanisms they use to thwart lytic enzyme activity are poorly studied. We previously characterized a Helicobacter pylor...

journal_title：mBio

authors： Wang G,Lo LF,Forsberg LS,Maier RJ

更新日期：2012-12-04 00:00:00

abstract：:The Bacillus cereus group comprises numerous closely related species, including bioterrorism agent B. anthracis, foodborne pathogen B. cereus, and biopesticide B. thuringiensis Differentiating organisms capable of causing illness or death from those used in industry is essential for risk assessment and outbreak prepar...

journal_title：mBio

authors： Carroll LM,Wiedmann M,Kovac J

更新日期：2020-02-25 00:00:00

abstract：UNLABELLED:Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However,...

journal_title：mBio

authors： Nguyen Y,Nguyen NX,Rogers JL,Liao J,MacMillan JB,Jiang Y,Sperandio V

更新日期：2015-03-31 00:00:00

abstract：:Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with M. tuberculosis, and about 15 million people with latent tuberculosis infection (LTBI) reside in the United States. An estimated 10% of indiv...

journal_title：mBio

authors： Ayyappan JP,Ganapathi U,Lizardo K,Vinnard C,Subbian S,Perlin DS,Nagajyothi JF

更新日期：2019-04-16 00:00:00

abstract：UNLABELLED:Small RNAs play a critical role in host-pathogen interaction. Indeed, small RNA-mediated silencing or RNA interference (RNAi) is one of the earliest forms of antiviral immunity. Although it represents the main defense system against viruses in many organisms, the antiviral role of RNAi has not been clearly p...

journal_title：mBio

authors： Girardi E,Chane-Woon-Ming B,Messmer M,Kaukinen P,Pfeffer S

更新日期：2013-11-19 00:00:00

abstract：UNLABELLED:In vivo transcriptional analyses of microbial pathogens are often hampered by low proportions of pathogen biomass in host organs, hindering the coverage of full pathogen transcriptome. We aimed to address the transcriptome profiles of Candida albicans, the most prevalent fungal pathogen in systemically infec...

journal_title：mBio

authors： Amorim-Vaz S,Tran Vdu T,Pradervand S,Pagni M,Coste AT,Sanglard D

更新日期：2015-09-22 00:00:00

abstract：:Estrogen, a major female sex steroid hormone, has been shown to promote the selection of mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases, including cystic fibrosis. This results in long-term persistence, poorer clinical outcomes, and limited therapeutic options. In this study...

journal_title：mBio

authors： Vidaillac C,Yong VFL,Aschtgen MS,Qu J,Yang S,Xu G,Seng ZJ,Brown AC,Ali MK,Jaggi TK,Sankaran J,Foo YH,Righetti F,Nedumaran AM,Mac Aogáin M,Roizman D,Richard JA,Rogers TR,Toyofuku M,Luo D,Loh E,Wohland T,Czarny

更新日期：2020-09-29 00:00:00

abstract：:All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for ...

journal_title：mBio

authors： Guerardel Y,Sadovskaya I,Maes E,Furlan S,Chapot-Chartier MP,Mesnage S,Rigottier-Gois L,Serror P

更新日期：2020-04-28 00:00:00

abstract：:The fungus Paracoccidioides is a prevalent human pathogen endemic to South America. The genus is composed of five species. In this report, we use 37 whole-genome sequences to study the allocation of genetic variation in Paracoccidioides We tested three genome-wide predictions of advanced speciation, namely, that all s...

journal_title：mBio

authors： Mavengere H,Mattox K,Teixeira MM,Sepúlveda VE,Gomez OM,Hernandez O,McEwen J,Matute DR

更新日期：2020-12-22 00:00:00

abstract：:The flagellar motor can spin in both counterclockwise (CCW) and clockwise (CW) directions. The flagellar motor consists of a rotor and multiple stator units, which act as a proton channel. The rotor is composed of the transmembrane MS ring made of FliF and the cytoplasmic C ring consisting of FliG, FliM, and FliN. The...

journal_title：mBio

authors： Sakai T,Miyata T,Terahara N,Mori K,Inoue Y,Morimoto YV,Kato T,Namba K,Minamino T

更新日期：2019-04-02 00:00:00